Abstract：
BACKGROUND AND OBJECTIVE:Combined spinal-epidural is an alternative technique to epidural analgesia for labour, but its benefits are not clearly identified. METHODS:A prospective, blinded, randomized study was undertaken involving 113 women attending a university hospital obstetric department. Analgesia was initiated with intrathecal bupivacaine 0.25% 1 mL + sufentanil 5 microg in the combined spinal-epidural group (n = 54), and with bupivacaine 0.125% + epinephrine 2.5 microg mL(-1) + sufentanil 7.5 microg in the epidural group (n = 59). In both cases this was followed by patient-controlled epidural analgesia with bupivacaine 0.125% (+ sufentanil 0.25 microg mL(-1)). Duration of labour, quality of analgesia and side-effects were compared between groups. RESULTS:In the combined spinal-epidural group, the onset of analgesia was faster (5 vs. 15 min, P < 0.001), the consumption of bupivacaine was lower (7.5 vs. 11.3 mg h(-1), P = 0.003) and there was less unilateral analgesia (14.8% vs. 40.7%, P = 0.002) than in the epidural group. The characteristics of labour were similar in both groups. However, in the combined spinal-epidural group, there was a higher incidence of posterior presentation (25.9% vs. 10%, P = 0.03), pruritus (P < 0.001), hypotension (P = 0.002), somnolence (P = 0.01), nausea (P = 0.02) and one case of meningitis. CONCLUSIONS:The combined spinal-epidural technique provided more effective analgesia during labour than epidural analgesia alone but offered no other advantage. It induced more adverse effects and this should be considered before routinely using the combined spinal-epidural technique.
journal_name
Eur J Anaesthesioljournal_title
European journal of anaesthesiologyauthors
Vernis L,Dualé C,Storme B,Mission JP,Rol B,Schoeffler Pdoi
10.1017/s0265021504003047subject
Has Abstractpub_date
2004-03-01 00:00:00pages
186-92issue
3eissn
0265-0215issn
1365-2346journal_volume
21pub_type
临床试验,杂志文章,随机对照试验abstract：:Although there is a continual improvement in the understanding of the pathophysiology of brain ischaemia and reperfusion, the pharmacological approach of treating or preventing brain ischaemic injury has had limited clinical impact so far. The great majority of clinical trials testing neuroprotectants for the treatmen...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,评审
doi：10.1097/EJA.0b013e32832fa606
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In polymorphonuclear leucocytes, phagocytosis and respiratory burst activity are mainly responsible for bacterial killing. We aimed to investigate the effects of anaesthesia with desflurane, sevoflurane and propofol on these functional activities of polymorphonuclear leucocytes in bronchoalveol...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0b013e328319bfeb
更新日期：2009-02-01 00:00:00
abstract：:The effect in isolated rat aorta of propofol, thiopentone, midazolam, etomidate and fentanyl on the impairment of endothelium-dependent relaxation by reactive oxygen species is reported. Aortic rings were exposed to reactive oxygen species by the electrolysis of the bathing physiological buffer, and endothelium-depend...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1046/j.1365-2346.1997.00110.x
更新日期：1997-05-01 00:00:00
abstract：:Dantrolene plasma concentrations and renal clearance calculations in a patient undergoing major surgery are reported. The family history was positive for malignant hyperthermia. Following oral pretreatment the plasma concentrations in this patient were not noticeably different from values obtained in a study in awake ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：BACKGROUND:The C-MAC D-blade is a new, highly angulated, videolaryngoscope blade designed for use in patients with difficult airways. Directing a tracheal tube into the trachea with any indirect viewing laryngoscope can be difficult, even with a good view of the laryngeal inlet. OBJECTIVE:To determine which introducin...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000000070
更新日期：2015-06-01 00:00:00
abstract：:The relative potencies of the intravenous anaesthetics propofol and thiopentone have been investigated by finding the dose necessary to produce unconsciousness in approximately 30%, 50% and 80% of patients. The estimated potency of propofol to thiopentone was 1:1.604 as obtained by the probit method of analysis which ...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1986-01-01 00:00:00
abstract：:Sixty patients, ASA I-III, presenting for elective colonic surgery were studied to assess the stability of blood pressure and heart rate during anaesthesia with three equally potent anaesthetic techniques. Patients in group I (n = 20) received thiopentone induction, isoflurane and nitrous oxide; patients in group II (...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-05-01 00:00:00
abstract：:Cardiovascular and hormonal responses to reconstructive abdominal aortic surgery were studied in 20 patients anaesthetized either with moderate-dose fentanyl (20 micrograms kg-1) combined with isoflurane, nitrous oxide and oxygen (n = 10), or with thoracolumbar epidural bupivacaine combined with isoflurane, nitrous ox...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:The success of ventilation with a laryngeal mask depends crucially on the seal between the mask and the periglottic tissue. Increasing the laryngeal mask's cuff volume is known to reduce oral air leakage but may lead to gastric insufflation. OBJECTIVE:We hypothesised that a lower cuff pressure would result ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000001269
更新日期：2021-02-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/S0265021507000312
更新日期：2007-09-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:The effects of protamine (6 mg kg-1) injected after heparin (5 mg kg-1) have been studied in five groups of five New Zealand white rabbits. Group I was treated with the sequence heparin-protamine and group II with protamine alone. The animals of groups III and IV received respectively intravenous indomethacin (3 mg kg...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The aim of study was to investigate the electron microscopic changes in the medulla of the spinal cord that occur with intrathecal midazolam administration. METHODS:Twenty-eight albino rabbits of New Zealand type were randomized into two groups. Following anaesthesia, 16 rabbits were given 300...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/S0265021505001547
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:No clinical trials comparing the characteristics of sensory blockade caused by various local anaesthetics in thoracic paravertebral blockade have been published. The aim of this prospective study was a clinical assessment of sensory blockade after paravertebral injection of ropivacaine or bupiv...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1017/S0265021506000561
更新日期：2006-08-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000001130
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Septic encephalopathy is believed to be a result of neuro-inflammation possibly triggered by endotoxins, such as lipopolysaccharides (LPS). Modulation of the immune system is a property of volatile anaesthetics. OBJECTIVE:We aimed to investigate the systemic and cerebral inflammatory response in a LPS-induc...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000000668
更新日期：2017-11-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the current clinical attitude in enteral nutrition support and motility disorders in adult critically ill patients on German intensive care units. METHODS:A total of 1493 questionnaires, including 25 items on the medical environment, treatment of motility disorders and enteral nutr...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/S0265021507002657
更新日期：2008-01-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-01-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
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更新日期：2006-10-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 评论,杂志文章
doi：10.1097/EJA.0b013e32835819ca
更新日期：2012-11-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
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更新日期：2019-01-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-07-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0b013e3283309cea
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The reliability of the Bispectral Index for evaluating and monitoring the depth of general anaesthesia in children is not as great as for that in adults. Therefore we analysed Bispectral Index performance in children by comparing changes in Bispectral Index values during a standardized and equi...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
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更新日期：2008-11-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章,评审
doi：10.1097/EJA.0000000000000594
更新日期：2017-04-01 00:00:00
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journal_title：European journal of anaesthesiology
pub_type： 杂志文章,评审
doi：10.1097/EJA.0b013e32832fad8b
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Several approaches have been proposed for ultrasound-guided thoracic paravertebral block, but the best approach remains unclear. OBJECTIVE:We compared two ultrasound-guided in-plane approaches using a microconvex probe, transverse and parasagittal. We assessed whether either approach would facilitate succes...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
