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Comparison of rocuronium requirement in children with continuous infusion versus intermittent bolus: A randomised controlled trial.

Abstract：

BACKGROUND:Minimising rocuronium administration during paediatric surgery helps to reduce the incidence of residual muscular blockade. OBJECTIVE:To determine whether intermittent bolus injection (Bolus group) or continuous infusion (group) requires the lesser amount of rocuronium. DESIGN:A randomised, single-blind controlled trial. SETTING:A single university hospital from March to June 2017. PATIENTS:Sixty-six children undergoing general anaesthesia. INTERVENTIONS:Dose of rocuronium for maintenance of muscle relaxation in either Bolus or continuous infusion group. Train-of-four (TOF) count of two was maintained during surgery. When TOF count reached three, 0.1 mg kg of rocuronium was administered in Bolus group or infused at an increased rate of 0.1 mg kg h in continuous infusion group. MAIN OUTCOME MEASURES:Primary outcome was the dose of rocuronium given (μg kg min). The recovery time from the TOF count four to TOF 0.7 (RT0.7), and 0.9 (RT0.9) were recorded. All adverse events were recorded up to 30 min after extubation. RESULTS:Mean (SD) rocuronium dose in the Bolus group was 6.1 (0.9), [95% confidence interval (95% CI) 5.7 to 6.4] μg kg min and 4.9 (1.0), (95% CI 4.6 to 5.3) μg kg min in the continuous infusion group (P = 0.001). RT0.7 was 24.0 (13.7), 95% CI 19.3 to 28.7) min in the Bolus group, and 25.7 (16.0), (95% CI 20.2 to 31.2) min in the continuous infusion group (P = 0.73). RT0.9 was 30.7 (17.1), (95% CI 24.9 to 36.5) min in the Bolus group, and 30.0 (17.6), (95% CI 24.0 to 36.0) min in the continuous infusion group (P = 0.91). The incidence of adverse events was not significantly different between two groups. CONCLUSION:In children undergoing general anaesthesia, the dose of rocuronium given by continuous administration was less than that with intermittent bolus. TRIAL REGISTRATION:ClinicalTrials.gov (identifier: NCT03060707).

journal_name

Eur J Anaesthesiol

journal_title

European journal of anaesthesiology

authors

Choi SN,Jang YE,Lee JH,Kim EH,Kim JT,Kim HS

doi

10.1097/EJA.0000000000000934

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

194-199

issue

eissn

0265-0215

issn

1365-2346

journal_volume

pub_type

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Comparison of rocuronium requirement in children with continuous infusion versus intermittent bolus: A randomised controlled trial.