Paracetamol versus metamizol in the treatment of postoperative pain after breast surgery: a randomized, controlled trial.

Abstract:

BACKGROUND AND OBJECTIVE:Intravenously administered paracetamol is an effective analgesic in postoperative pain management. However, there is a lack of data on the effect of intravenous (i.v.) paracetamol on pain following soft tissue surgery. METHODS:Eighty-seven patients undergoing elective breast surgery with total i.v. anaesthesia (propofol/remifentanil) were randomized to three groups. Group para received 1 g i.v. paracetamol 20 min before and 4, 10 and 16 h after the end of the operation. Group meta and plac received 1 g i.v. metamizol or placebo, respectively, scheduled at the same time points. All patients had access to i.v. morphine on demand to achieve adequate pain relief. RESULTS:No significant difference in total morphine consumption between groups was detectable. The proportion of patients who did not receive any morphine in the postoperative period was significantly higher in group para (42%) than in group plac (4%). Ambulation was significantly (P < 0.05) earlier in group para (4.0 +/- 0.2 h) than in groups meta (4.6 +/- 0.2 h) and plac (5.5 +/- 1.0 h). No differences were observed between groups meta and plac. There were no differences between groups with regard to incidence of postoperative nausea and vomiting or changes in vigilance. CONCLUSION:Neither i.v. paracetamol nor i.v. metamizol provided a significant reduction in total postoperative morphine consumption compared with placebo in the management of postoperative pain after elective breast surgery. Administration of paracetamol resulted in a significant reduction in the number of patients needing opioid analgesics to achieve adequate postoperative pain relief.

journal_name

Eur J Anaesthesiol

authors

Ohnesorge H,Bein B,Hanss R,Francksen H,Mayer L,Scholz J,Tonner PH

doi

10.1097/EJA.0b013e328329b0fd

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

648-53

issue

8

eissn

0265-0215

issn

1365-2346

journal_volume

26

pub_type

杂志文章,随机对照试验
  • Respiratory effects of the kneeling prone position for low back surgery.

    abstract:BACKGROUND AND OBJECTIVE:The kneeling prone position is often used for low back surgery in order to decrease intraoperative bleeding and increase the surgical exposure of the vertebral canal. The aim of this study was to assess effects of the kneeling prone position on respiratory gas exchange focusing on oxygen consum...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021504004053

    authors: Radstrom M,Loswick AC,Bengtsson JP

    更新日期:2004-04-01 00:00:00

  • The effects of midazolam followed by administration of either vecuronium or atracurium on the QT interval in humans.

    abstract::Prolongation of the QT interval may produce potentially hazardous dysrhythmias. The effects on the QT interval of midazolam followed by administration of either vecuronium or atracurium have been investigated. Thirty patients, ASA I or II, without cardiovascular problems, electrolyte abnormalities or receiving any med...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Michaloudis DG,Kanakoudis FS,Xatzikraniotis A,Bischiniotis TS

    更新日期:1995-11-01 00:00:00

  • Nasotracheal intubation using the Blind Intubation Device in anaesthetised adults with Mallampati class 3: a comparison with the Macintosh laryngoscope.

    abstract:CONTEXT:We hypothesised that the Blind Intubation Device (BID) would be effective for nasotracheal intubation (NTI) in anaesthetised adults with Mallampati class 3. We also hypothesised that BID may cause less haemodynamic changes due to the avoidance of direct stimulation induced by the Macintosh blade. OBJECTIVE:The...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e328349a9f9

    authors: Sun Y,Liu JX,Zhu YS,Xu H,Huang Y,Jiang H

    更新日期:2011-11-01 00:00:00

  • McGRATH MAC video laryngoscope for insertion of a transoesophageal echocardiography probe: A randomised controlled trial.

    abstract:BACKGROUND:Transoesophageal echocardiography (TOE) probe insertion in anaesthetised patients can cause pharyngeal and oesophageal injuries. Kim et al. have shown that insertion assisted by a Macintosh laryngoscope can reduce such complications but it may sometimes be difficult to observe the passage of a TOE probe. The...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000367

    authors: Ishida T,Kiuchi C,Sekiguchi T,Tsujimoto T,Kawamata M

    更新日期:2016-04-01 00:00:00

  • Cerebral state index vs. bispectral index during sevoflurane-nitrous oxide anaesthesia.

    abstract:BACKGROUND AND OBJECTIVE:The cerebral state index (CSI) is a low-cost and compact electroencephalographic monitor alternative to the bispectral index (BIS). Although both indices are shown as the number between 0 and 100, owing to the different calculation algorithms, both indices might be different during anaesthesia....

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e328324e946

    authors: Nishiyama T

    更新日期:2009-08-01 00:00:00

  • Monitoring of respiratory function before and after cardiopulmonary bypass using side-stream spirometry.

    abstract::Pulmonary impairment is more frequent after cardiac surgery than after other major surgical procedures. The present study investigates whether, by using standard respiratory monitoring, i.e. side-stream spirometry and blood gas analysis, it is possible to detect changes in pulmonary function secondary to cardiopulmona...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章

    doi:10.1017/s026502159800009x

    authors: Bund M,Seitz W,Uthoff K,Krieg P,Strüber M,Piepenbrock S

    更新日期:1998-01-01 00:00:00

  • Vasorelaxant effect of opioid analgesics on the isolated human radial artery.

    abstract:BACKGROUND AND OBJECTIVE:Arterial grafts are prone to vasospasm. Opioid analgesics are commonly used in the perioperative course of cardiac surgical procedures. Therefore, we investigated the direct effects of morphine, meperidine, fentanyl and remifentanil on the human radial artery. METHODS:Radial artery segments, o...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/S0265021506000172

    authors: Gursoy S,Bagcivan I,Yildirim MK,Berkan O,Kaya T

    更新日期:2006-06-01 00:00:00

  • The relative potencies of thiopentone and propofol.

    abstract::The relative potencies of the intravenous anaesthetics propofol and thiopentone have been investigated by finding the dose necessary to produce unconsciousness in approximately 30%, 50% and 80% of patients. The estimated potency of propofol to thiopentone was 1:1.604 as obtained by the probit method of analysis which ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Grounds RM,Moore M,Morgan M

    更新日期:1986-01-01 00:00:00

  • Movement response to skin incision: analgesia vs. bispectral index and 95% spectral edge frequency.

    abstract::We studied the movement response to skin incision in 68 adult (males/females) ASA I-II patients receiving propofol +/- fentanyl intravenous anaesthesia using the bispectral index and 95% spectral edge frequency monitoring with an A-1050 EEG monitor. Following Ethics Committee approval, patients were randomly assigned ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2346.1999.00549.x

    authors: Singh H,Sakai T,Matsuki A

    更新日期:1999-09-01 00:00:00

  • Continuous epidural anaesthesia for major abdominal surgery in young children.

    abstract::The benefits of epidural anaesthesia combined with general anaesthesia were studied in young children scheduled for major abdominal surgical procedure (pull-through for Hirschsprung's disease). Two groups of nine children were studied receiving, respectively, general anaesthesia or general anaesthesia plus epidural an...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Murat I,Delleur MM,Levy J,Esteve C,Saint-Maurice C

    更新日期:1987-09-01 00:00:00

  • The displacement of the tracheal tube during robot-assisted radical prostatectomy.

    abstract:BACKGROUND AND OBJECTIVE:Robot-assisted prostatectomy requires pneumoperitoneum in a steep Trendelenburg position, which may induce endobronchial intubation or accidental extubation. The aim of the study was to evaluate the effect of pneumoperitoneum in 30 degrees Trendelenburg position on the displacement of the trach...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e328333d587

    authors: Chang CH,Lee HK,Nam SH

    更新日期:2010-05-01 00:00:00

  • Crystalloid versus red blood cell-containing medium in the Langendorff-perfused isolated heart preparation.

    abstract:BACKGROUND:The isolated heart model is widely used for the assessment of coronary vascular response under various experimental conditions. As medium perfusate influences oxygenation conditions, coronary vascular response and myocardial consumption performance may differ between isolated hearts perfused with from with K...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e328337cc0d

    authors: Mouren S,Vicaut E,Lamhaut L,Riou B,Ouattara A

    更新日期:2010-09-01 00:00:00

  • Hemiplegia following general anaesthesia: an unusual presentation of migraine.

    abstract::We report the case of a 33-year-old woman who developed a dense hemiplegia immediately after an uncomplicated general anaesthetic for diagnostic laparoscopy. She had a history of recurrent hemiplegic migraine with a strong family history. Her migraine was normally associated with visual disturbances and a unilateral h...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.1998.00368.x

    authors: Thurlow JA

    更新日期:1998-09-01 00:00:00

  • Comparison of inhalation induction with isoflurane or halothane in children.

    abstract::Thirty-six children (mean age 2.4 years) premedicated with oral chloral hydrate 70 mg kg-1 and atropine 0.03 mg kg-1 were anaesthetized with either 3.75% isoflurane or 2.5% halothane in 70% nitrous oxide in oxygen. The eyelash reflex disappeared in 39 +/- 7 s (mean +/- SD) with isoflurane and in 56 +/- 16 s with halot...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Lindgren L,Randell T,Saarnivaara L

    更新日期:1991-01-01 00:00:00

  • Epidural anaesthesia for insertion of a femoral neck prosthesis in a patient with phaeochromocytoma.

    abstract::A hemiarthroplasty for femoral neck fracture was successfully performed under combined epidural anaesthesia and light general anaesthesia before phaeochromocytoma removal. Pre-operative therapy was managed with doxazosin, enalapril and diltiazem. Peri-operative management facilitated maintenance of stable haemodynamic...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:

    authors: Kato T,Takase H,Waguri Y,Ikeda K,Takahashi M

    更新日期:1993-11-01 00:00:00

  • A comparison between the flexor hallucis brevis and adductor pollicis muscles in atracurium-induced neuromuscular blockade using acceleromyography: A prospective observational study.

    abstract:BACKGROUND:Neuromuscular blockade (NMB) monitoring is essential to avoid residual NMB. While the adductor pollicis is the recommended site for monitoring recovery, it is not always accessible. The flexor hallucis brevis could be an interesting alternative. OBJECTIVE:The aim of our study was to compare NMB onset and re...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000001090

    authors: Le Merrer M,Frasca D,Dupuis M,Debaene B,Boisson M

    更新日期:2020-01-01 00:00:00

  • Factors independently associated with increased risk of pain development after ophthalmic surgery.

    abstract:BACKGROUND AND OBJECTIVE:Little has been documented about the development of pain after ophthalmic surgery. This study was designed to assess the incidence and severity of postoperative pain following ophthalmic surgery, and to identify key factors independently associated with development of such pain. METHODS:In a p...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021504002042

    authors: Henzler D,Kramer R,Steinhorst UH,Piepenbrock S,Rossaint R,Kuhlen R

    更新日期:2004-02-01 00:00:00

  • Comparison of clonidine 1 microgram kg-1 with morphine 30 micrograms kg-1 for post-operative caudal analgesia in children.

    abstract::In a prospective randomized study in children, we compared caudal bupivacaine-clonidine with bupivacaine-morphine to evaluate whether clonidine can be used as an alternative to morphine in caudal anaesthesia. Caudal anaesthesia was administered in 36 children undergoing orchidopexy, hernia repair or circumcision, usin...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2346.1999.00430.x

    authors: Luz G,Innerhofer P,Oswald E,Salner E,Hager J,Sparr H

    更新日期:1999-01-01 00:00:00

  • Duration of stabilization of control responses affects the onset and duration of action of rocuronium but not suxamethonium.

    abstract::The effect of the duration of stabilization of control responses on the onset and duration of clinical relaxation of suxamethonium 1 mg kg-1 and rocuronium 0.6 mg kg-1 were investigated in 90 patients. The control responses were allowed to stabilize for 1, 5, 10, 15 or 20 min prior to administration of rocuronium and ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2346.1996.d01-379.x

    authors: Symington MJ,McCoy EP,Mirakhur RK,Kumar N

    更新日期:1996-07-01 00:00:00

  • Intrathecal hydromorphone added to hyperbaric bupivacaine for postoperative pain relief after knee arthroscopic surgery: a prospective, randomised, controlled trial.

    abstract:BACKGROUND AND OBJECTIVE:Adding opioid to spinal anaesthetic provides additional analgesia during the postoperative period. The purpose of this study was to determine the dose of intrathecal hydromorphone necessary to achieve postoperative pain relief after arthroscopic knee surgery. METHODS:In a prospective, double-b...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0b013e3283476055

    authors: Lee YS,Park YC,Kim JH,Kim WY,Yoon SZ,Moon MG,Min TJ

    更新日期:2012-01-01 00:00:00

  • European guidelines on perioperative venous thromboembolism prophylaxis: Mechanical prophylaxis.

    abstract::: Institutional protocols need to address the indications for pharmacological and mechanical thromboprophylaxis. The use of graduated compression stockings (GCS) and intermittent pneumatic compression (IPC) strongly differs between institutions. As a consequence, no strong recommendations can be made based on the cont...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,实务指引

    doi:10.1097/EJA.0000000000000726

    authors: Afshari A,Fenger-Eriksen C,Monreal M,Verhamme P,ESA VTE Guidelines Task Force.

    更新日期:2018-02-01 00:00:00

  • Effects of glibenclamide on hydroxyl radical formation in the postischaemic reperfused heart with or without inhalation anaesthetics.

    abstract:BACKGROUND AND OBJECTIVE:We investigated whether glibenclamide (glyburide) affects myocardial metabolism and hydroxyl radical formation in the rat heart-lung preparation with or without inhalation anaesthetics. METHODS:Thirty-seven male Wistar rats were allocated to four groups: (a) control group (C), received vehicle...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2346.2001.00927.x

    authors: Kashimoto S,Furuya A,Kume M,Yamaguchi T,Kumazawa T

    更新日期:2001-12-01 00:00:00

  • Neostigmine-based reversal of intermediate acting neuromuscular blocking agents to prevent postoperative residual paralysis: A systematic review.

    abstract:BACKGROUND:Neostigmine is widely used to antagonise residual paralysis. Over the last decades, the benchmark of acceptable neuromuscular recovery has increased progressively to a train-of-four (TOF) ratio of at least 0.9. Raising this benchmark may impact on the efficacy of neostigmine. OBJECTIVE(S):The systematic rev...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000741

    authors: Tajaate N,Schreiber JU,Fuchs-Buder T,Jelting Y,Kranke P

    更新日期:2018-03-01 00:00:00

  • Implementation of patient blood management remains extremely variable in Europe and Canada: the NATA benchmark project: An observational study.

    abstract:BACKGROUND:Preoperative anaemia is associated with increased postoperative morbidity and mortality. Patient blood management (PBM) is advocated to improve patient outcomes. OBJECTIVES:NATA, the 'Network for the advancement of patient blood management, haemostasis and thrombosis', initiated a benchmark project with the...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/EJA.0000000000000519

    authors: Van der Linden P,Hardy JF

    更新日期:2016-12-01 00:00:00

  • Gastric mucosal-to-end-tidal PCO2 difference during major abdominal surgery: influence of the arterial-to-end-tidal PCO2 difference?

    abstract:BACKGROUND AND OBJECTIVE:Because gastric mucosal PCO2 must be referenced to arterial values via a gastric-to-arterial PCO2 gap (Pg-aCO2), the gastric-to-end-tidal PCO2 difference (Pg-ETCO2) may be proposed as a surrogate method to monitor Pg-aCO2. However, the influence of arterial-to-end-tidal PCO2 (Pa-ETCO2) on its v...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1017/s0265021503000279

    authors: Lebuffe G,Onimus T,Vallet B

    更新日期:2003-02-01 00:00:00

  • Ultrasonographic finding of lung sliding in patients on mechanical ventilation with alveolar-interstitial syndrome.

    abstract:BACKGROUND AND OBJECTIVES:To determine the visibility of pleural lung sliding in alveolar-interstitial syndrome (AIS) in patients on mechanical ventilation at two different time points, as a confirmatory ultrasonographic method for excluding pneumothorax. METHODS:Fifty-two mechanically ventilated patients in the semir...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0b013e32833feb40

    authors: Rode B,Vučić M,Siranović M,Kovač N,Kelečić M,Gopčević A

    更新日期:2011-04-01 00:00:00

  • Pulse photoplethysmographic amplitude and heart rate variability during laparoscopic cholecystectomy: A prospective observational study.

    abstract:BACKGROUND:Surgical stress affects the autonomic nervous system by increasing sympathetic outflow. One method of monitoring sympathetic activity is pulse photoplethysmographic analysis. From this two indices can be derived - autonomic nervous system state (ANSS) and ANSS index (ANSSi). It has recently been claimed that...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000660

    authors: Colombo R,Raimondi F,Corona A,Marchi A,Borghi B,Pellegrin S,Bergomi P,Fossali T,Guzzetti S,Porta A

    更新日期:2017-08-01 00:00:00

  • Effects of a single subanaesthetic dose of ketamine on pain and mood after laparoscopic bariatric surgery: A randomised double-blind placebo controlled study.

    abstract:BACKGROUND:When administered as a continuous infusion, ketamine is known to be a potent analgesic and general anaesthetic. Recent studies suggest that a single low-dose administration of ketamine can provide a long-lasting effect on mood, but its effects when given in the postoperative period have not been studied. OB...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/EJA.0000000000000860

    authors: Wang J,Echevarria GC,Doan L,Ekasumara N,Calvino S,Chae F,Martinez E,Robinson E,Cuff G,Franco L,Muntyan I,Kurian M,Schwack BF,Bedrosian AS,Fielding GA,Ren-Fielding CJ

    更新日期:2019-01-01 00:00:00

  • Comparison between bougies and stylets for simulated tracheal intubation with the C-MAC D-blade videolaryngoscope.

    abstract:BACKGROUND:The C-MAC D-blade is a new, highly angulated, videolaryngoscope blade designed for use in patients with difficult airways. Directing a tracheal tube into the trachea with any indirect viewing laryngoscope can be difficult, even with a good view of the laryngeal inlet. OBJECTIVE:To determine which introducin...

    journal_title:European journal of anaesthesiology

    pub_type: 杂志文章

    doi:10.1097/EJA.0000000000000070

    authors: Batuwitage B,McDonald A,Nishikawa K,Lythgoe D,Mercer S,Charters P

    更新日期:2015-06-01 00:00:00

  • Diazepam for relief of irrigation pain after transurethral resection of the prostate.

    abstract::Irrigation of the bladder after transurethral resection of the prostate is often distressing because of pain arising from detrusor muscle spasm. The effect of post-operative oral diazepam was compared with sacral epidural (caudal) block at the time of surgery, both treatments together and a control group, assessed by ...

    journal_title:European journal of anaesthesiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2346.1997.00102.x

    authors: Nott MR,Jameson PM,Julious SA

    更新日期:1997-03-01 00:00:00