Abstract：
:The effects of progressive curarization on spontaneous ventilation were studied in 23 patients during light halothane-nitrous oxide-oxygen anaesthesia. In 11 patients, in whom the end-expiratory CO2 concentration and evoked mechanical response were recorded, increasing curarization caused first a slow CO2 accumulation and later an abrupt ventilatory impairment at a twitch tension of between 5 and 50% of original muscle strength. In 12 patients, in whom the evoked integrated hypothenar EMG, spontaneous frontal EMG and mean frequency and amplitude of the EEG were recorded, the spontaneous frontal EMG and ventilation diminished within 3 min, following the first 5 mg dose of tubocurarine. At this stage muscle strength, indicated by the amplitude of the evoked EMG and the train-of-four ratio, was unchanged. Repeated 5 mg doses of tubocurarine caused an almost linear decrease in ventilation and an increase in end-tidal CO2 concentration without affecting the rate of breathing until the sudden impairment of ventilation that occurred usually after the fourth dose of tubocurarine. The EEG changes during curarization were minimal and no common trend was seen. The results suggest that tubocurarine may be given to anaesthetized patients in a dose which is too small to produce, using the evoked EMG, a detectable neuromuscular block, but is sufficient to cause ventilatory depression without a compensatory increase in the rate of breathing.
journal_name
Eur J Anaesthesioljournal_title
European journal of anaesthesiologyauthors
Linko K,Wirtavuori K,Tammisto Tsubject
Has Abstractpub_date
1984-06-01 00:00:00pages
105-12issue
2eissn
0265-0215issn
1365-2346journal_volume
1pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:The base excess gap (BE(gap)) method is commonly used for the quantification of unmeasured ions in critically ill patients. However, it has never been validated against the standard quantitative acid-base approach. OBJECTIVE:To compare the BE(gap) as a tool for the prediction of the excess of unmeasured ion...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0b013e32836412db
更新日期：2013-11-01 00:00:00
abstract：:Optimal control of long-term sedation during therapy in the intensive care unit is difficult to achieve in a number of patients when based on commonly used clinical sedation scores alone. We therefore used the median frequency of the EEG power spectrum as a quantitative measure for closed-loop administration of propof...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1046/j.1365-2346.1999.00557.x
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Patients have the right to be informed about the expected benefits and risks of medical and surgical procedures. Ideally this information should be scientifically based and presented to the patient in time. In morbidly obese patient undergoing general anaesthesia, postoperative pulmonary compli...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,meta分析
doi：10.1017/S0265021505002073
更新日期：2006-02-01 00:00:00
abstract：:In this case report an unusual complication is described following insertion of a Swan Ganz catheter. A 79-year-old male patient experienced knotting of the catheter. Methods of avoiding this problem and removal of a knotted catheter are discussed. ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1046/j.1365-2346.1997.00201.x
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:The creation of pneumoperitoneum during laparoscopic surgery can lead to adverse effects on the respiratory system. Positive end-expiratory pressure (PEEP) plays an important role in mechanical ventilation during laparoscopic surgery. OBJECTIVE:To evaluate whether PEEP setting guided by oesophageal pressure...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000001204
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the efficacy of 0.1% ropivacaine with fentanyl 2 microg mL(-1) via epidural for analgesia in labour. METHODS:In a randomized study, 80 nulliparous parturients in labour had epidural analgesia initiated with 0.2% ropivacaine and fentanyl and were then randomized to receive either 0....
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1017/s0265021504000031
更新日期：2004-10-01 00:00:00
abstract：:The suitability of tramadol suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated. In an open randomized trial, rectal tramadol was compared with our standard treatment acetaminophen/codeine suppositories. We expected tramadol to be equally effect...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2346.1999.00520.x
更新日期：1999-07-01 00:00:00
abstract：:Malignant hyperthermia is an autosomal-dominant inherited disorder of the skeletal muscle cell characterized by a hypermetabolic response to all commonly used inhalational anaesthetics and depolarizing muscle relaxants. The clinical syndrome includes muscle rigidity, hypercapnia, tachycardia and myoglobinuria as resul...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2346.2001.00888.x
更新日期：2001-10-01 00:00:00
abstract：:: Institutional protocols need to address the indications for pharmacological and mechanical thromboprophylaxis. The use of graduated compression stockings (GCS) and intermittent pneumatic compression (IPC) strongly differs between institutions. As a consequence, no strong recommendations can be made based on the cont...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,实务指引
doi：10.1097/EJA.0000000000000726
更新日期：2018-02-01 00:00:00
abstract：:The time profile of the neuromuscular block produced by a single bolus administration of vecuronium was simulated by a new model for the access of the relaxant to the receptors on the motor end plates. The receptors were assumed to be kinetically a part of the interstitial space of the muscle. The time course of the n...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Anaesthetic agents for day-case surgery ideally should have a short duration of action. This study was designed to compare the efficacy and safety of mivacurium and vecuronium for healthy adults undergoing dental day-case surgery. Thirty fit healthy adult patients (ASA I or II) randomly received either mivacurium 0.15...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2346.1994.00207.x
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Robot-assisted prostatectomy requires pneumoperitoneum in a steep Trendelenburg position, which may induce endobronchial intubation or accidental extubation. The aim of the study was to evaluate the effect of pneumoperitoneum in 30 degrees Trendelenburg position on the displacement of the trach...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0b013e328333d587
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Adding opioid to spinal anaesthetic provides additional analgesia during the postoperative period. The purpose of this study was to determine the dose of intrathecal hydromorphone necessary to achieve postoperative pain relief after arthroscopic knee surgery. METHODS:In a prospective, double-b...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0b013e3283476055
更新日期：2012-01-01 00:00:00
abstract：:Dantrolene plasma concentrations and renal clearance calculations in a patient undergoing major surgery are reported. The family history was positive for malignant hyperthermia. Following oral pretreatment the plasma concentrations in this patient were not noticeably different from values obtained in a study in awake ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：
更新日期：1986-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The study investigated the effect of intravenous dexmedetomidine on brachial plexus block in patients with end-stage renal disease sedated with dexmedetomidine or midazolam for the formation of arteriovenous fistula. METHODS:A supraclavicular brachial plexus block was performed in 68 patients ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0b013e32832a2244
更新日期：2009-10-01 00:00:00
abstract：:Sixty patients, ASA I-III, presenting for elective colonic surgery were studied to assess the stability of blood pressure and heart rate during anaesthesia with three equally potent anaesthetic techniques. Patients in group I (n = 20) received thiopentone induction, isoflurane and nitrous oxide; patients in group II (...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-05-01 00:00:00
abstract：:In this review, we shall consider the oral and intravenous fluid management of pregnant women during labour and operative delivery in the context of neuroaxial blockade. We shall also discuss the use of blood transfusion in the peripartum period, especially during postpartum haemorrhage. Current management of military...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,评审
doi：10.1097/EJA.0b013e32833c30e3
更新日期：2010-12-01 00:00:00
abstract：:Pulmonary hypertension is usually treated with intravenous (i.v.) vasodilators, but their use is limited by systemic effects. In the current study, we compared the effects of inhaled nitric oxide and intravenous nitroglycerine on pulmonary and systemic haemodynamic responses as well as on gas exchange measurements in ...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1046/j.1365-2346.1996.d01-384.x
更新日期：1996-09-01 00:00:00
abstract：:We have examined the effect of propofol on the neutrophil respiratory burst. Chemiluminescence was used as a measure of the respiratory burst following stimulation with 10(-5) M N-formyl-L-methionyl-L-leucyl-L-phenylalanine. Propofol 1.25, 2.5 and 5.0 x 10(-5) M inhibited neutrophil chemiluminescence by 29.6, 43.0 and...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1046/j.1365-2346.1996.00003.x
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:We explored the effects of morphine administration during reperfusion period after an index ischaemia as well as potential molecular mechanisms underlying this response. This is of important clinical value, as morphine is used routinely in cardiovascular anaesthesia and in the emergency manage...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0b013e32832a225a
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The gamma-aminobutyric acidA receptor (GABAAR) is a target for anaesthetic agents. We investigated the interactions of sevoflurane with a recombinant GABAAR. Emphasis was on the mechanism of block, as relevant open-channel block by a volatile anaesthetic would possibly explain prolonged GABAerg...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1046/j.0265-0215.2001.00848.x
更新日期：2001-06-01 00:00:00
abstract：:Sixty patients were randomly assigned to two equal groups. Group I received epidural morphine 1 mg after surgery and used a patient-controlled analgesia device programmed to deliver morphine 0. 2 mg h-1, 0.2 mg per bolus. Group II received an epidural loading dose of morphine 1 mg plus ketamine 5 mg and used a patient...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2346.1999.00592.x
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Intravenously administered paracetamol is an effective analgesic in postoperative pain management. However, there is a lack of data on the effect of intravenous (i.v.) paracetamol on pain following soft tissue surgery. METHODS:Eighty-seven patients undergoing elective breast surgery with total...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,随机对照试验
doi：10.1097/EJA.0b013e328329b0fd
更新日期：2009-08-01 00:00:00
abstract：:Twenty adult surgical patients were anaesthetized with high-dose midazolam and alfentanil by infusion, vecuronium, and intubated and ventilated with 50% N2O in O2. The midazolam and alfentanil infusions were stopped at the end of surgery. Residual neuromuscular blockade and ventilatory depression were antagonized and ...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1988-11-01 00:00:00
abstract：:The time-course of the neuromuscular effects of vecuronium (n = 25) and atracurium (n = 25) has been compared at three different levels of maintenance dose in anaesthetized patients. Following intubation with vecuronium 0.1 mg kg-1 or atracurium 0.5 mg kg-1, surgical muscle relaxation was maintained by using increment...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Because gastric mucosal PCO2 must be referenced to arterial values via a gastric-to-arterial PCO2 gap (Pg-aCO2), the gastric-to-end-tidal PCO2 difference (Pg-ETCO2) may be proposed as a surrogate method to monitor Pg-aCO2. However, the influence of arterial-to-end-tidal PCO2 (Pa-ETCO2) on its v...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1017/s0265021503000279
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:The dorsalis pedis artery (DPA) is a good alternative to the radial artery (RA) for invasive blood pressure monitoring when the upper limb is burned or injured, or if the RA is not available. Understanding the pattern of pressure difference between DPA and the commonly used RA during inhalational anaesthesia...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000000295
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Septic encephalopathy is believed to be a result of neuro-inflammation possibly triggered by endotoxins, such as lipopolysaccharides (LPS). Modulation of the immune system is a property of volatile anaesthetics. OBJECTIVE:We aimed to investigate the systemic and cerebral inflammatory response in a LPS-induc...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章
doi：10.1097/EJA.0000000000000668
更新日期：2017-11-01 00:00:00
abstract：:We describe the case of a 36-year-old woman, with a previous history of recurrent abortion due to protein S deficiency, undergoing an elective Caesarean section at 39-weeks gestation. During pregnancy no signs of hypertension or cardiovascular disease were reported, but at the end of the surgical procedure, the patien...
journal_title：European journal of anaesthesiology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2346.1999.00474.x
更新日期：1999-04-01 00:00:00
abstract：:Intrathecal midazolam for use as a post-operative analgesic when given alone and in conjunction with intrathecal diamorphine was assessed. Fifty-two patients scheduled for elective Caesarean section under spinal anaesthesia were randomly allocated to receive either bupivacaine (B), bupivacaine with diamorphine (BD), b...
journal_title：European journal of anaesthesiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2346.1996.00044.x
更新日期：1996-11-01 00:00:00
