Abstract:
:Estrogens are essential for normal reproductive function. In addition, they exert important, complex, and diverse nonreproductive actions on multiple tissues. Although accumulating evidence from basic science studies using animal models suggests that estradiol plays a critical neuroprotective role against multiple types of neurodegenerative diseases and injuries, recent clinical studies have reported either inconclusive or untoward effects of hormone therapy on the brain. We focus herein on the work that we have done during the past 6 yr that strongly suggests that low levels of estradiol therapy exert dramatic protective actions in the adult injured brain. Our results reveal that 17beta-estradiol slows the progression of this injury and diminishes the extent of cell death by suppressing apoptotic cell death pathways and enhancing expression of genes that optimize cell survival. Furthermore, we have found that estrogen receptors play a pivotal functional role in neuroprotection. Together, these results carry broad implications for the selective targeting of estrogen receptors in the treatment of neurodegenerative conditions resulting from disease or injury, particularly for aging, postmenopausal women.
journal_name
Endocr Revjournal_title
Endocrine reviewsauthors
Wise PM,Dubal DB,Rau SW,Brown CM,Suzuki Sdoi
10.1210/er.2004-0014subject
Has Abstractpub_date
2005-05-01 00:00:00pages
308-12issue
3eissn
0163-769Xissn
1945-7189pii
er.2004-0014journal_volume
26pub_type
杂志文章,评审abstract::Disruption of the GH receptor (GHR) gene eliminates GH-induced intracellular signaling and, thus, its biological actions. Therefore, the GHR gene disrupted mouse (GHR-/-) has been and is a valuable tool for helping to define various parameters of GH physiology. Since its creation in 1995, this mouse strain has been us...
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journal_title:Endocrine reviews
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journal_title:Endocrine reviews
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journal_title:Endocrine reviews
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journal_title:Endocrine reviews
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