Abstract:
:We previously reported that intraarticular injections of hyaluronan (HA), administered prophylactically to dogs in whom knee osteoarthritis had been induced by transection of the anterior cruicate ligament, did not significantly modify the intraarticular pathology but decreased the proteogylcan concentration of the articular cartilage by as much as 30%. Because the cartilage proteoglycan concentration is directly related to the stiffness of the tissue, these results raised the possibility that intraarticular HA therapy could exacerbate OA. In the present study, using a different HA formulation, with a longer interval between intraarticular HA injection and examination of joint tissues, we found that neither prophylactic nor therapeutic administration of HA had an effect on the severity of OA pathology, the magnitude of vertical ground reaction forces generated by the unstable hind limb (a surrogate for joint pain), or the cartilage proteoglycan concentration. The data suggest that the suppression of proteoglycan synthesis induced by HA is temporary and fully reversible and that HA injections do not result in overloading of the OA extremity. A significant correlation was noted between the severity of chondropathy and the magnitude of the vertical ground reaction forces generated by the unstable limb.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Brandt KD,Smith GN,Myers SLsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
493-502issue
3-4eissn
0006-355Xissn
1878-5034journal_volume
41pub_type
杂志文章相关文献
BIORHEOLOGY文献大全abstract::The present study was designed to investigate the oxidant susceptibility of red blood cells (RBC) from four species (echidna, human, koala, Tasmanian devil) based on changes in cellular deformability. These species were specifically chosen based on differences in lifestyle and/or biology associated with varied levels ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-2012-0599
更新日期:2011-01-01 00:00:00
abstract::In the past few years there has been a considerable interest in the role of bone in osteoarthritis. Despite the increasing evidence of the involvement of bone in osteoarthritis, it remains very difficult to attribute the cause or effect of changes in subchondral bone to the process of osteoarthritis. Although osteoart...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::A generalized dispersion model is used to obtain exact solution for unsteady convective diffusion in the presence of couple stresses. The effect of the couple stress parameter 'a' on the most dominant dispersion coefficient is clearly depicted. The dimensionless mean concentration distribution is obtained as a functio...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1986-23404
更新日期:1986-01-01 00:00:00
abstract::The relationships between mucus rheology, depth of mucus layer and clearance by simulated cough were examined in a study employing a model plexiglass trachea lined with gels formed from locust bean gum crosslinked with sodium tetraborate. The viscoelastic properties of the mucus simulants were determined by magnetic r...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1987-24611
更新日期:1987-01-01 00:00:00
abstract::The AC electric field-driven manipulation of suspended polarizable particles has become a major technique in micro- and nano-devices. In the present study, suspensions of cultured HeLa cells in isotonic solution were used to explore the mechanisms underlying the suspension behaviors during exposure to a uniform AC ele...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-130644
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to examine the theoretical impact of the local bifurcation geometry on the shear rate gradient in a divergent arteriolar-type bifurcation. Newtonian flow through an arteriolar bifurcation was modeled using 3-dimensional computational fluid dynamics (CFD). Branching angles of 30 degrees, 5...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Atherosclerosis is the most frequent cause of death and severe chronic disability in North America and Europe. The atherosclerosis-prone apolipoprotein E (apoE)-deficient mice contain the entire spectrum of lesions observed during atherogenesis. Significant remodelling of the artery occurs in atherosclerosis. The aim ...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Articular cartilage is a tissue designed to withstand compression during joint movement and, in vivo, is subjected to a wide range of mechanical loading forces. Mechanosensitivity has been demonstrated to influence chondrocyte metabolism and cartilage homeostasis, but the mechanisms underlying mechanotransduction in t...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::A number of risk factors including biomechanical stress on the articular cartilage imposed by joint overloading due to obesity, repetitive damage of the joint tissues by injury of the menisci and ligaments, and abnormal joint alignment play a significant role in the onset of osteoarthritis (OA). Genetic predisposition...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:RRx-001 is an anti-cancer immunotherapeutic that increases the sensitivity of drug resistant tumors via multiple mechanisms which involve binding to hemoglobin and enhancing nitrite reductase activity of deoxyhemoglobin. OBJECTIVE:In the present study, the effect of clinically used doses of RRx-001 on eryth...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-190213
更新日期:2019-01-01 00:00:00
abstract::A rigidity index (RI) related to red blood cell deformability was measured by using the hemorheometre. The RI for 13 patients homozygous for sickle cell disease was 109 +/- 44 at 37 degrees C and at atmospheric pO2. The filtration time curve as a function of pO2 is biphasic for sickle cell suspensions. The pO2 at whic...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1989-26409
更新日期:1989-01-01 00:00:00
abstract::Drag-reducing polymers (DRPs) are blood-soluble macromolecules that can increase blood flow and reduce vascular resistance. The purpose of the present study is to examine the effects of DRPs on microcirculation in rat hind limb during acute femoral artery occlusion. Two groups of 20 male Wistar rats were subjected to ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-2011-0592
更新日期:2011-01-01 00:00:00
abstract::In vitro experiments were conducted to measure the oscillatory flow pressure gradient along an elastic tube in order to assess the recent nonlinear theory of Wang and Tarbell. According to this theory, in an elastic tube with oscillatory flow, the mean (time-averaged) pressure gradient cannot be calculated using Poise...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/0006-355X(95)00023-3
更新日期:1995-07-01 00:00:00
abstract::Mechanical forces can stimulate the production of extracellular matrix molecules. We tested the efficacy of ultrasound to increase proteoglycan synthesis in bovine primary chondrocytes. The ultrasound-induced temperature rise was measured and its contribution to the synthesis was investigated using bare heat stimulus....
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Aqueous solutions calf thymus DNA at three concentrations were studied by viscosity measurements at ambient pressure. A gravitational capillary viscometer and a rotating cylinder viscometer were employed. Three polycations were tested as viscosity-reducing agents with measurements from 25°C to 50°C. The most significa...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-140649
更新日期:2014-01-01 00:00:00
abstract::It is has been known for more than 80 years that compared to in vitro determinations, blood behaves as a less viscous fluid under in vivo flow conditions. The experiments of Whittaker and Winton were among the first dealing with the in vivo effects of altered blood rheology, and experimental studies during the second ...
journal_title:Biorheology
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract::Ciliary metachronism and motility were examined optically in muco-ciliary tissue cultures from three different systems: a) frog's palate epithelium, b) frog's oesophagus, and c) human nasal polyps. In addition, lateral cilia of Mytilus edulis (water transporting cilia) were examined. It was revealed that the degree of...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1990-273-433
更新日期:1990-01-01 00:00:00
abstract::A biophysical model for the equilibrium curvature of a composite membrane element is derived taking into account the mechanical bilayer properties and the adjacent charged protein layers. The minimum of the total free energy density with respect to the curvature of such a membrane curved was estimated from the sum of ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1987-24104
更新日期:1987-01-01 00:00:00
abstract::The application of principles of biorheology, hemorheology and perihemorheology on problems of the nervous system in health and disease was suggested by Alfred L. Copley (1982, 1987). Late in 1988 Copley and Sourander considered neurobiorheology to be an appropriate term for a new branch of biorheology bridging the ga...
journal_title:Biorheology
pub_type: 历史文章,杂志文章
doi:10.3233/bir-1991-28603
更新日期:1991-01-01 00:00:00
abstract::The Cell Transit Analyser (CTA) provides a means to rapidly measure the deformability of large numbers of individual cells. It combines many of the advantages of micropipette studies with the simplicity and speed of filtrometry methods by measuring the duration of each resistive pulse generated as a cell passes throug...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1992-292-301
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:In order to play different roles in vascular functions as a mechanosensor to blood flows and as a barrier to transvascular exchange, the endothelial surface glycocalyx (ESG) should have an organized structure. Due to the limitations of optical and electron microscopy, the ultra-structure of ESG has not been ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-180204
更新日期:2019-01-01 00:00:00
abstract::Stress relaxation in three varieties of cherries was studied using the penetration test with a cylindrical pin, 4 mm in diameter, having a flat tip. One half of the fruit was modified by partial skinning, since experiments show that skin approximately doubles the apparent modulus of elasticity of the cherries. The ski...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/s0006-355x(97)00033-4
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established. OBJECTIVE:To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to convention...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-16091
更新日期:2016-01-01 00:00:00
abstract::In micropipette experiments with small capillaries and moderate high pressure difference (approximately 1000 Pa) cell fragmentation (fission) of human red blood cells without hemolysis was observed by TV-system for a large number of fresh red blood cells of different donors. After separation, the fragment moves away f...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1987-24302
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied. OBJECTIVE:We investigated the stretching of bile and evaluated its extensional viscosity using a fila...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-190216
更新日期:2019-01-01 00:00:00
abstract::This study aims at quantifying the cellular mechanical properties based on a partitioning of the cytoskeleton in a cortical and a cytosolic compartments. The mechanical response of epithelial cells obtained by magnetocytometry - a micromanipulation technique which uses twisted ferromagnetic beads specifically linked t...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The contribution of proteoglycan 4 (PRG4) to synovial fluid and hyaluronan (HA) solution rheology are poorly understood. The effects of PRG4 disulfide-bonded structure on viscosity and viscosity of newly available full-length recombinant human PRG4 (rhPRG4) have not previously been reported. OBJECTIVE:This ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-14037
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Blood flow in stenotic vessels strongly influences the progression of vascular diseases. Plaques in stenotic blood vessels vary in stiffness, which influences plaque behavior and deformation by pressure and flow. Concurrent changes in plaque geometry can, in turn, affect blood flow conditions. Thus, simultan...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-14016
更新日期:2015-01-01 00:00:00
abstract::In this paper we shall describe new mechanical models for the deformation of the actin filament bundles in kidney microvilli and osteocytic cell processes to see whether these cellular extensions, like the stereocilia on hair cells in the inner ear, can function as mechanotransducers when subject to physiological flow...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Shear stress-induced platelet aggregation requires von Willebrand factor (vWF), platelet glycoprotein (GP) Ib, GPIIb-IIIa, Ca2+, and adenosine diphosphate (ADP). Recent reports using vWF labeled with either 125I or fluorescein isothiocyanate (FITC) have demonstrated that in shear-fields, vWF binds to both GPIb and GPI...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/S0006-355X(97)00004-8
更新日期:1997-01-01 00:00:00