The role of mucus viscoelasticity in cough clearance.

Abstract:

:The relationships between mucus rheology, depth of mucus layer and clearance by simulated cough were examined in a study employing a model plexiglass trachea lined with gels formed from locust bean gum crosslinked with sodium tetraborate. The viscoelastic properties of the mucus simulants were determined by magnetic rheometry at 100 rad/s and expressed as mechanical impedance (dynamic stress/strain ratio) and loss tangent. Cough was simulated by opening a solenoid valve connecting the model trachea to a pressurized tank, using an upstream flow-constrictive element to shape the flow profile to approximate the pattern seen in a normal adult. Mucus clearance was quantitated by observing the movement of contrasting marker particles placed in the mucus layer. The median particle displacement was defined as the clearance index, Cl. For any initial depth of mucus, Cl increased with driving pressure in the tank, and for a given driving pressure, Cl increased linearly with increasing mucus depth. For a given driving pressure and depth, Cl decreased with increasing mechanical impedance of the mucus. At constant mechanical impedance, Cl increased with increasing loss tangent, in other words, cough clearance was impeded more by elasticity than viscosity. Mucus clearance was associated with transient wave formation in the lining layer. Thus dependence on viscoelasticity is consistent with observations that airflow-mucus interaction and wave formation are impeded by elasticity. The clearance vs. loss tangent relationship for cough is opposite to that found for ciliary clearance (Biorheology 1980, 17, 249), suggesting a natural balance in viscosity and elasticity for mucus to be cleared by both mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Biorheology

journal_title

Biorheology

authors

King M

doi

10.3233/bir-1987-24611

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

589-97

issue

6

eissn

0006-355X

issn

1878-5034

journal_volume

24

pub_type

杂志文章
  • Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not.

    abstract::It has been hypothesized that bone cells have a hyaluronic acid (HA) rich glycocalyx (cell coat or pericellular matrix) and that this contributes to bone cell mechanotransduction via fluid flow. The glycocalyx of bone cells of the MC3T3-E1 osteoblastic cell line and the MLO-Y4 osteocytic cell line were characterized. ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Reilly GC,Haut TR,Yellowley CE,Donahue HJ,Jacobs CR

    更新日期:2003-01-01 00:00:00

  • Recovery time course of erythrocyte deformability following exposure to shear is dependent upon conditioning shear stress.

    abstract:BACKGROUND:Red blood cell (RBC) deformability may increase, or decrease, following application of shear stress ("shear conditioning"), depending upon the specific magnitude and duration of exposure. However, the time course of altered RBC deformability following shear remains unresolved. OBJECTIVE:We utilised shear co...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-17151

    authors: Kuck L,Grau M,Simmonds MJ

    更新日期:2018-01-01 00:00:00

  • In vivo correlates of altered blood rheology.

    abstract::It is has been known for more than 80 years that compared to in vitro determinations, blood behaves as a less viscous fluid under in vivo flow conditions. The experiments of Whittaker and Winton were among the first dealing with the in vivo effects of altered blood rheology, and experimental studies during the second ...

    journal_title:Biorheology

    pub_type: 杂志文章,评审

    doi:

    authors: Baskurt OK

    更新日期:2008-01-01 00:00:00

  • Biorheological characteristics of skin after expansion.

    abstract::This study investigated the changes in biorheological characteristics of skin after expansion. Expanders were implanted into the back of eight adult dogs, and after an eight-week expansion the expanded and the non-expanded control skins were transferred to an adjacent site. The expanded specimens and their controls we...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Zeng Y,Huang K,Xu C,Zhang J,Sun G

    更新日期:2001-01-01 00:00:00

  • Influence of parenteral nutrition on blood rheology and platelet aggregation in vitro.

    abstract:BACKGROUND:Parenteral nutrition (PN) is a hyperosmolar solution composed of glucose, amino acids and a lipid emulsion, which is often used despite well-known side effects and complications. OBJECTIVES:In this study the hypothesis was tested that PN could affect hemorheology. METHODS:The influence of increasing plasma...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-140652

    authors: Compagnoni SC,Schulzki T,Thoeny S,Reinhart WH

    更新日期:2014-01-01 00:00:00

  • Viscoelastic properties of the oxygenated sickle erythrocyte membrane.

    abstract::Although most apparent in permanently misshapen irreversibly sickled erythrocytes (ISC), biochemical and structural alterations are present in the majority of sickle cell membranes. The relationship of membrane rigidity to cell shape and its dependence upon the internal hemoglobin cytosol are not clarified. We therefo...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Drasler WJ,Smith CM 2nd,Keller KH

    更新日期:1989-01-01 00:00:00

  • Nitrite may serve as a combination partner and a biomarker for the anti-cancer activity of RRx-001.

    abstract:BACKGROUND:RRx-001 is an anti-cancer immunotherapeutic that increases the sensitivity of drug resistant tumors via multiple mechanisms which involve binding to hemoglobin and enhancing nitrite reductase activity of deoxyhemoglobin. OBJECTIVE:In the present study, the effect of clinically used doses of RRx-001 on eryth...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-190213

    authors: Cirrik S,Ugurel E,Aksu AC,Oronsky B,Cabrales P,Yalcin O

    更新日期:2019-01-01 00:00:00

  • Ciliary activity under normal conditions and under viscous load.

    abstract::Ciliary metachronism and motility were examined optically in muco-ciliary tissue cultures from three different systems: a) frog's palate epithelium, b) frog's oesophagus, and c) human nasal polyps. In addition, lateral cilia of Mytilus edulis (water transporting cilia) were examined. It was revealed that the degree of...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1990-273-433

    authors: Gheber L,Priel Z

    更新日期:1990-01-01 00:00:00

  • Segregation by size difference in binary suspensions of fluid droplets in channel flow.

    abstract::In channel flow of multicomponent suspensions, segregation behavior of suspended components perpendicular to the flow direction is often observed, which is considered to be caused by the differential properties of the lateral migration depending on their shape, size, flexibility, and other characteristics. In the pres...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-130638

    authors: Makino M,Sugihara-Seki M

    更新日期:2013-01-01 00:00:00

  • Intravital-microscopic observations on the intravascular behavior of blood cell components during dietary-induced hyperlipidemia in the male rabbit.

    abstract::In normal male rabbits loaded dietary cholesterol, intravital-microscopy revealed a marked acceleration of intravascular adhesiveness of white blood cells and aggregability of red blood cells and a swarming of lipid-laden macrophages in connective tissue space concurrently with a systemic hyperlipidemia and anemia. Po...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1988-251-242

    authors: Asano M,Ohkubo C,Hirokawa A,Sasaki A,Tochihara Y,Chiba Y

    更新日期:1988-01-01 00:00:00

  • Influence of plaque stiffness on deformation and blood flow patterns in models of stenosis.

    abstract:BACKGROUND:Blood flow in stenotic vessels strongly influences the progression of vascular diseases. Plaques in stenotic blood vessels vary in stiffness, which influences plaque behavior and deformation by pressure and flow. Concurrent changes in plaque geometry can, in turn, affect blood flow conditions. Thus, simultan...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-14016

    authors: Shimizu Y,Ohta M

    更新日期:2015-01-01 00:00:00

  • Cross-sectional distributions of normal and abnormal red blood cells in capillary tubes determined by a new technique.

    abstract:BACKGROUND:In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability. OBJECTIVE:To quantitatively evaluate the effect of RBC deformability on their axial ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-18166

    authors: Sasaki T,Seki J,Itano T,Sugihara-Seki M

    更新日期:2018-01-01 00:00:00

  • Rheological properties and wall structures of large veins.

    abstract::The static and dynamic viscoelastic properties were studied of longitudinal and circumferential strips excised from various large veins of dogs. The mechanical behavior in longitudinal direction could be regarded as elastic, while that in circumferential direction was highly viscoelastic. No distinct regionality was o...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1983-20510

    authors: Hasegawa M

    更新日期:1983-01-01 00:00:00

  • Osteoarthritic synovial fluid rheology and correlations with protein concentration.

    abstract:BACKGROUND:Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. Osteoarthritis is particularly common in the knees. The effects of osteoarthritis on the rheology of synovial fluid in the knees are not fully understood and consequently require further study. OBJECTIVE:Th...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-15078

    authors: Madkhali A,Chernos M,Grecov D,Kwok E

    更新日期:2016-11-09 00:00:00

  • Mechanisms underlying chaotic vasomotion in isolated resistance arteries: roles of calcium and EDRF.

    abstract::Nonlinear mathematical techniques now make it possible to quantify the complexity of an irregular time series through calculation of a parameter known as fractal dimension. In the present study, we use such an analysis to provide evidence that histamine-induced pressure oscillations in an isolated rabbit ear resistanc...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1993-305-605

    authors: Griffith TM,Edwards DH

    更新日期:1993-09-01 00:00:00

  • Stress relaxation in cherry fruit.

    abstract::Stress relaxation in three varieties of cherries was studied using the penetration test with a cylindrical pin, 4 mm in diameter, having a flat tip. One half of the fruit was modified by partial skinning, since experiments show that skin approximately doubles the apparent modulus of elasticity of the cherries. The ski...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.1016/s0006-355x(97)00033-4

    authors: Blahovec J

    更新日期:1996-11-01 00:00:00

  • Tensile behavior and extensional viscosity of bile.

    abstract:BACKGROUND:Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied. OBJECTIVE:We investigated the stretching of bile and evaluated its extensional viscosity using a fila...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-190216

    authors: Minh NN,Obara H,Shimokasa K,Zhu J

    更新日期:2019-01-01 00:00:00

  • The influence of repair tissue maturation on the response to oscillatory compression in a cartilage defect repair model.

    abstract::This study examined the effects of mechanical compression on engineered cartilage in a novel hybrid culture system. Cylindrical holes were cut in discs of bovine articular cartilage and filled with agarose gels containing chondrocytes. These constructs were compressed in radiolabeled medium under static or oscillatory...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Hunter CJ,Levenston ME

    更新日期:2002-01-01 00:00:00

  • Flow behaviour of a POSS biopolymer solution.

    abstract::A non-biodegradable polyhedral oligomeric silsesquioxane (POSS) nanocomposite biopolymer has been developed for fabrication of medical devices and for tissue engineering human organs. The polymer in solution, containing 2 wt% of POSS, has been synthesized, characterized and investigated to determine its key rheologica...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Kidane AG,Edirisinghe MJ,Bonhoeffer P,Seifalian AM

    更新日期:2007-01-01 00:00:00

  • Time-dependent rheological behaviour of blood flow at low shear in narrow horizontal tubes.

    abstract::Magnitude and time-dependence of the effects of red cell aggregation and sedimentation on the rheology of human blood were studied during low shear (tau W 2.5 to 92 mPa) flow through horizontal tubes (ID 25 to 105 microns). Immediately following reduction of perfusion pressure to a low value the red cell concentration...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1989-26210

    authors: Alonso C,Pries AR,Gaehtgens P

    更新日期:1989-01-01 00:00:00

  • An inflammation-responsive transcription factor in the pathophysiology of osteoarthritis.

    abstract::A number of risk factors including biomechanical stress on the articular cartilage imposed by joint overloading due to obesity, repetitive damage of the joint tissues by injury of the menisci and ligaments, and abnormal joint alignment play a significant role in the onset of osteoarthritis (OA). Genetic predisposition...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Ray A,Ray BK

    更新日期:2008-01-01 00:00:00

  • Hemorheological factors of oxygen transfer in capillary tissue unit.

    abstract::The supply of oxygen to tissue from capillaries may be influenced by hemorheological factors. A hemorheological model is developed for elucidating which factors play a major role in the oxygen transport to tissue. For a capillary tissue unit, a modified cylindrical model of Krogh is used. For blood, two fluids model o...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1983-20517

    authors: Niimi H,Sugihara M,Yamakawa T

    更新日期:1983-01-01 00:00:00

  • Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments.

    abstract::Over the past several decades, blood-soluble drag reducing polymers (DRPs) have been shown to significantly enhance hemodynamics in various animal models when added to blood at nanomolar concentrations. In the present study, the effects of the DRPs on blood circulation were tested in anesthetized rats exposed to acute...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Kameneva MV,Wu ZJ,Uraysh A,Repko B,Litwak KN,Billiar TR,Fink MP,Simmons RL,Griffith BP,Borovetz HS

    更新日期:2004-01-01 00:00:00

  • Acute effects of continuous and intermittent aerobic exercises on hemorheological parameters: a pilot study.

    abstract:BACKGROUND:Acute hemorheological responses to different types of aerobic exercises have never been compared in a single study in healthy people. OBJECTIVE:We aimed to compare acute effects of high intensity intermittent exercise (HIIE) and moderate intensity continuous exercise (MICE) on hemorheological parameters, in...

    journal_title:Biorheology

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/BIR-14012

    authors: Findikoglu G,Kilic-Toprak E,Kilic-Erkek O,Senol H,Bor-Kucukatay M

    更新日期:2014-01-01 00:00:00

  • Shear linear behavior of brain tissue over a large frequency range.

    abstract::The literature review about the shear linear properties of brain tissue reveals both a large discrepancy in the existing data and a crucial lack of information at high frequencies associated with traffic road and non-penetrating ballistic impacts. The purpose of this study is to clarify and to complement the linear ma...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Nicolle S,Lounis M,Willinger R,Palierne JF

    更新日期:2005-01-01 00:00:00

  • Experimental assessment of wall shear flow in models.

    abstract::The blood flow immediately adjacent to the wall of a blood vessel or an artificial surface is of great interest. This flow defines the shear stress at the wall and is known to have a great physiological importance. The use of models is a viable method to investigate this flow. However, even in models the shear stress ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Affeld K,Kertzscher U,Goubergrits L

    更新日期:2002-01-01 00:00:00

  • Effects of gender and age on thixotropic properties of whole blood from healthy adult subjects.

    abstract::The thixotropic parameters of whole blood from 314 healthy subjects (154 women, 160 men) were measured with our modified method by Low shear 30 Rheometer and calculated according Huang's equation. This communication offered the reference range of thixotropic parameters from man and woman group. The results demonstrate...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1991-283-409

    authors: Chen HQ,Zhong GH,Li L,Wang XY,Zhou T,Chen ZY

    更新日期:1991-01-01 00:00:00

  • A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes.

    abstract::In this paper we shall describe new mechanical models for the deformation of the actin filament bundles in kidney microvilli and osteocytic cell processes to see whether these cellular extensions, like the stereocilia on hair cells in the inner ear, can function as mechanotransducers when subject to physiological flow...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Weinbaum S,Guo P,You L

    更新日期:2001-01-01 00:00:00

  • Viscosity and order in erythrocyte membranes studied with nanosecond fluorometry.

    abstract::The viscosity and the order in the interior of human erythrocyte membranes were investigated by the fluorescence depolarization technique in the nanosecond region with 1,6-diphenyl-1,3,5-hexatriene (DPH). After pulsed excitation with a polarized light, the fluorescence anisotropy ratio of DPH in membranes rapidly decr...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1986-23504

    authors: Araiso T,Shindo Y,Arai T,Nitta J,Kikuchi Y,Kakiuchi Y,Koyama T

    更新日期:1986-01-01 00:00:00

  • Aggregation and disaggregation of red blood cells.

    abstract::The aggregation of red blood cells may be analyzed as an interaction of an adhesive surface energy and the elastic stored energy which results from deformation of the cell. The adhesive surface energy is the work required to separate a unit adhered area and is the resultant of adhesive forces due to the bridging molec...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1984-21406

    authors: Skalak R

    更新日期:1984-01-01 00:00:00