Abstract:
BACKGROUND:Blood flow in stenotic vessels strongly influences the progression of vascular diseases. Plaques in stenotic blood vessels vary in stiffness, which influences plaque behavior and deformation by pressure and flow. Concurrent changes in plaque geometry can, in turn, affect blood flow conditions. Thus, simultaneous studies of blood flow and plaque deformation are needed to fully understand these interactions. OBJECTIVES:This study aims to identify the change of flow conditions attendant to plaque deformation in a model stenotic vessel. METHODS:Three plaques of differing stiffness were constructed on a vessel wall using poly (vinyl alcohol) hydrogels (PVA-H) with defined stiffness to facilitate simultaneous observations of blood flow and plaque deformation. Flow patterns were observed using particle image velocimetry (PIV). RESULTS:Decreases in Reynolds number (Re) with increased plaque deformation suggest that velocity decrease is more critical to establishment of the flow pattern than expansion of the model lumen. Upon exiting the stenosis, the location of the flow reattachment point, shifted further downstream in all models as plaque stiffness decreased and depended on the increase in upstream pressure. CONCLUSIONS:These results suggest that in addition to luminal area, plaque stiffness should be considered as a measure of the severity of the pathology.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Shimizu Y,Ohta Mdoi
10.3233/BIR-14016subject
Has Abstractpub_date
2015-01-01 00:00:00pages
171-82issue
3eissn
0006-355Xissn
1878-5034pii
BIR14016journal_volume
52pub_type
杂志文章相关文献
BIORHEOLOGY文献大全abstract::Shear stress-induced platelet aggregation requires von Willebrand factor (vWF), platelet glycoprotein (GP) Ib, GPIIb-IIIa, Ca2+, and adenosine diphosphate (ADP). Recent reports using vWF labeled with either 125I or fluorescein isothiocyanate (FITC) have demonstrated that in shear-fields, vWF binds to both GPIb and GPI...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/S0006-355X(97)00004-8
更新日期:1997-01-01 00:00:00
abstract::The static and dynamic viscoelastic properties were studied of longitudinal and circumferential strips excised from various large veins of dogs. The mechanical behavior in longitudinal direction could be regarded as elastic, while that in circumferential direction was highly viscoelastic. No distinct regionality was o...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1983-20510
更新日期:1983-01-01 00:00:00
abstract::The biorheological properties and behavior of red blood cells (RBCs), as other types of cells, have a biochemical and molecular basis. The shape maintenance and deformability of RBCs depend on the structural and functional integrity of the membrane proteins. These proteins are composed of transmembrane proteins insert...
journal_title:Biorheology
pub_type: 杂志文章,评审
doi:10.3233/bir-1990-273-410
更新日期:1990-01-01 00:00:00
abstract::Through cardiac looping during embryonic development, human and other vertebrate hearts adopt sinuous curvatures with marked changes in direction of flow at atrial, ventricular and arterial levels. We used magnetic resonance phase velocity mapping to study flow through the hearts of resting volunteers, and Doppler ult...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::This study aims at quantifying the cellular mechanical properties based on a partitioning of the cytoskeleton in a cortical and a cytosolic compartments. The mechanical response of epithelial cells obtained by magnetocytometry - a micromanipulation technique which uses twisted ferromagnetic beads specifically linked t...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Flow induced shear stress influences vascular cellular biology and pathophysiology in numerous ways. Previous in vitro studies on interactions between flow and endothelial cells using parallel-plate flow chambers involve two-dimensional flows, whereas flows in larger vessels are commonly three-dimensional. We have con...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The well-known S-shaped settling curves are obtained as solutions of an autonomic dynamical system deduced mathematically from the generalized Stokes formula, the blood volume conservation law, and the Smoluchowski theory of particle coagulation. Numerical computations and parametric analysis of the deduced two nonlin...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/0006-355x(96)00027-3
更新日期:1996-07-01 00:00:00
abstract::The blood flow immediately adjacent to the wall of a blood vessel or an artificial surface is of great interest. This flow defines the shear stress at the wall and is known to have a great physiological importance. The use of models is a viable method to investigate this flow. However, even in models the shear stress ...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Nonlinear mathematical techniques now make it possible to quantify the complexity of an irregular time series through calculation of a parameter known as fractal dimension. In the present study, we use such an analysis to provide evidence that histamine-induced pressure oscillations in an isolated rabbit ear resistanc...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1993-305-605
更新日期:1993-09-01 00:00:00
abstract::The assessment of vessel patency can be substantially improved by serial microvessel diameter measurements taken successively along an extensive length of the vessel. It is possible to avoid making the a priori assumptions about the existence or location of local constriction sites implicit in single diameter measurem...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1991-283-420
更新日期:1991-01-01 00:00:00
abstract::Sudden increase of viscosity in former times indicated the start of coagulation. Yet its measurement destroyed the structure of coagulum. By the precursor method of thrombelastography the author 1944 found elasticity to be the essential physiological property of coagulum. In the production of elastic fibrin structure ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1988-251-221
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Parenteral nutrition (PN) is a hyperosmolar solution composed of glucose, amino acids and a lipid emulsion, which is often used despite well-known side effects and complications. OBJECTIVES:In this study the hypothesis was tested that PN could affect hemorheology. METHODS:The influence of increasing plasma...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-140652
更新日期:2014-01-01 00:00:00
abstract::The viscosity: shear rate relationship of whole blood is shown to be described to a good approximation by a bi-linear plot on log: log axes. This has allowed an analytical solution to be obtained which gives a full description of the flow properties of blood in rigid tubes of a size where the Fahraeus-Lindqvist effect...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1983-20204
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Leukocytes and platelets typically fulfil their functions through adhesion to the walls of vessels with different size, haematocrit and shear rate. OBJECTIVE:We aimed to investigate differential effects of these variables on leukocyte and platelet adhesion. METHODS:Blood with varying haematocrit was perfus...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-15043
更新日期:2015-01-01 00:00:00
abstract::Arterial hemodynamic forces may play a role in the localization of early atherosclerotic lesions. We have been developing numerical techniques based on overset or "Chimera" type formulations to solve the Navier-Stokes equations in complex geometries simulating arterial bifurcations. This paper presents three-dimension...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/s0006-355x(99)80020-1
更新日期:1998-11-01 00:00:00
abstract::Over the past several decades, blood-soluble drag reducing polymers (DRPs) have been shown to significantly enhance hemodynamics in various animal models when added to blood at nanomolar concentrations. In the present study, the effects of the DRPs on blood circulation were tested in anesthetized rats exposed to acute...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The aim of this study was to investigate the effect of hydrostatic pressure on the expression of messenger ribonucleic acid (mRNA) for specific extracellular matrix proteins in chondrocytes. Chondrocytes obtained from bovine metatarsophalangeal joints were embedded in cylindrical 2% agarose gels. A novel experimental ...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The separation process of blood and RBC suspensions in a hematocrit range between 0.3-0.7 was investigated with a centrifuge allowed to run at low accelerations (100 xg-1000 xg). The position of the interface between the supernatant of plasma and the RBC column was continuously recorded by a new optoelectronic measuri...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1988-251-233
更新日期:1988-01-01 00:00:00
abstract::Plasma fractionation by membrane filtration permits the reinfusion of the patient with his own albumin. In this study, the influence of membrane nature and plasma flux on plasma fractionation in dead-end mode is investigated with acetate hollow fiber filters. It is found that transmembrane pressure TMP rises exponenti...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1991-281-204
更新日期:1991-01-01 00:00:00
abstract::Orbitometry (Hartert) is a rheological ex-vivo method to follow up physical assembly of a coagulum in layers during natural intensity of flow by orbital movement. Fibrin elasticity in the Orbitometers mode of Resonance Thrombography is differentiated from platelet activity as well as e.g. from the effects of dissemina...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1990-27613
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Postmenopausal women often develop hemorheological disorders which may affect the systemic blood circulation and present a cardiovascular risk factor. OBJECTIVE:We evaluated effects of secoisolariciresinol (SECO), a phytoestrogen, on hemorheological parameters and lipid peroxidation in a model of the age-re...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-15066
更新日期:2016-01-07 00:00:00
abstract::The AC electric field-driven manipulation of suspended polarizable particles has become a major technique in micro- and nano-devices. In the present study, suspensions of cultured HeLa cells in isotonic solution were used to explore the mechanisms underlying the suspension behaviors during exposure to a uniform AC ele...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-130644
更新日期:2013-01-01 00:00:00
abstract::A study using both experimental and numerical methods was conducted to determine flow dynamics in the vicinity of an end-to-end anastomosis. In vitro experiments were performed to determine the variations in the conduit cross-section at the anastomosis in specimens under static loading. The experimentally determined g...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1993-30203
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability. OBJECTIVE:To quantitatively evaluate the effect of RBC deformability on their axial ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-18166
更新日期:2018-01-01 00:00:00
abstract::In this work, we studied the effects of tensile strain on limb bud mesenchymal cells (MSC) cultured on a collagen type I tubular scaffold. A novel bioreactor was designed to culture the cells while subjecting the tubular scaffold to tensile stress and strain. Control samples included unseeded and MSC-seeded tubes cult...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-2009-0553
更新日期:2009-01-01 00:00:00
abstract::The aim of this study was to investigate the effects of a surgical limb lengthening procedure on the biorheological features of some lengthened soft tissues. In this procedure external fixators were applied to goats' right radius to stretch the tissues. The right forelegs of goats were lengthened by 2, 4 cm, respectiv...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/S0006-355X(99)80016-X
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established. OBJECTIVE:To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to convention...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-16091
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied. OBJECTIVE:We investigated the stretching of bile and evaluated its extensional viscosity using a fila...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-190216
更新日期:2019-01-01 00:00:00
abstract::Pentoxifylline (PTX) has been reported to enhance the early accumulation of neutrophils at the site of Staphylococcus aureus subcutaneous infection in mice (1) and to stimulate in vitro PMN chemotaxis, particularly under dense agarose (2). Among the biochemical events contributing to chemotaxis are actin polymerizatio...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1990-273-421
更新日期:1990-01-01 00:00:00
abstract::This paper reports a novel, physiologically significant, microfluidic phenomenon generated by nanomolar concentrations of drag-reducing polymers (DRP) dissolved in flowing blood, which may explain previously demonstrated beneficial effects of DRP on tissue perfusion. In microfluidic systems used in this study, DRP add...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-2009-0543
更新日期:2009-01-01 00:00:00