Influence of plaque stiffness on deformation and blood flow patterns in models of stenosis.

Abstract:

BACKGROUND:Blood flow in stenotic vessels strongly influences the progression of vascular diseases. Plaques in stenotic blood vessels vary in stiffness, which influences plaque behavior and deformation by pressure and flow. Concurrent changes in plaque geometry can, in turn, affect blood flow conditions. Thus, simultaneous studies of blood flow and plaque deformation are needed to fully understand these interactions. OBJECTIVES:This study aims to identify the change of flow conditions attendant to plaque deformation in a model stenotic vessel. METHODS:Three plaques of differing stiffness were constructed on a vessel wall using poly (vinyl alcohol) hydrogels (PVA-H) with defined stiffness to facilitate simultaneous observations of blood flow and plaque deformation. Flow patterns were observed using particle image velocimetry (PIV). RESULTS:Decreases in Reynolds number (Re) with increased plaque deformation suggest that velocity decrease is more critical to establishment of the flow pattern than expansion of the model lumen. Upon exiting the stenosis, the location of the flow reattachment point, shifted further downstream in all models as plaque stiffness decreased and depended on the increase in upstream pressure. CONCLUSIONS:These results suggest that in addition to luminal area, plaque stiffness should be considered as a measure of the severity of the pathology.

journal_name

Biorheology

journal_title

Biorheology

authors

Shimizu Y,Ohta M

doi

10.3233/BIR-14016

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

171-82

issue

3

eissn

0006-355X

issn

1878-5034

pii

BIR14016

journal_volume

52

pub_type

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