Abstract:
BACKGROUND:In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability. OBJECTIVE:To quantitatively evaluate the effect of RBC deformability on their axial accumulation at a flow condition comparable to that in arterioles by developing a new observation system for accurate measurements of radial RBC positions in the cross section of capillary tubes. METHODS:The cross-sectional distributions of normal and hardened RBCs as well as softened RBCs suspended in capillary tube flows were measured with high spatial resolution. A new observation system was developed in which enface views of the cross-section of the tube were obtained at small distances upstream of the outlet at various longitudinal positions in the tube. RESULTS:The radial positions of individual RBCs were detected within 1 μm accuracy. It was found that normal and softened RBCs rapidly migrated away from the wall towards the tube axis, whereas glutaraldehyde-hardened RBCs were dispersed widely over the tube cross-section, depending on the concentration of glutaraldehyde solution. CONCLUSIONS:The newly devised observation system revealed quantitatively the essential role of RBC deformability in their axial accumulation.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Sasaki T,Seki J,Itano T,Sugihara-Seki Mdoi
10.3233/BIR-18166subject
Has Abstractpub_date
2018-01-01 00:00:00pages
153-165issue
5-6eissn
0006-355Xissn
1878-5034pii
BIR18166journal_volume
54pub_type
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