Hemorheological factors of oxygen transfer in capillary tissue unit.

Abstract:

:The supply of oxygen to tissue from capillaries may be influenced by hemorheological factors. A hemorheological model is developed for elucidating which factors play a major role in the oxygen transport to tissue. For a capillary tissue unit, a modified cylindrical model of Krogh is used. For blood, two fluids model of red blood cells (RBCs) and plasma is used where hemoglobin release effect is included. Non-equilibrium flows as well as equilibrium flows are examined for various parameters (total flow Q or RBC velocity Vr, discharge hematocrit Hd and capillary hematocrit Hc). In equilibrium flow, Hd and Q determine the oxygen transport. In non-equilibrium flow, Hc also becomes important. Especially, hemoglobin release effect becomes significant in low Hc flow, which affects the area of lethal region in tissue.

journal_name

Biorheology

journal_title

Biorheology

authors

Niimi H,Sugihara M,Yamakawa T

doi

10.3233/bir-1983-20517

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

603-14

issue

5

eissn

0006-355X

issn

1878-5034

journal_volume

20

pub_type

杂志文章
  • Time-dependent rheological behaviour of blood flow at low shear in narrow horizontal tubes.

    abstract::Magnitude and time-dependence of the effects of red cell aggregation and sedimentation on the rheology of human blood were studied during low shear (tau W 2.5 to 92 mPa) flow through horizontal tubes (ID 25 to 105 microns). Immediately following reduction of perfusion pressure to a low value the red cell concentration...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1989-26210

    authors: Alonso C,Pries AR,Gaehtgens P

    更新日期:1989-01-01 00:00:00

  • Fibrin gels as biological filters and interfaces.

    abstract::We present data which show that fibrin gels are ordered network structures, the porosity of which is determined by the amount of thrombin being present during the activation step preceding gelation. On activation of fibrinogen, fibrinopeptides are released and simultaneously polymers are formed, obeying apparent first...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1984-211-214

    authors: Blombäck B,Okada M,Forslind B,Larsson U

    更新日期:1984-01-01 00:00:00

  • Biorheological characteristics of skin after expansion.

    abstract::This study investigated the changes in biorheological characteristics of skin after expansion. Expanders were implanted into the back of eight adult dogs, and after an eight-week expansion the expanded and the non-expanded control skins were transferred to an adjacent site. The expanded specimens and their controls we...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Zeng Y,Huang K,Xu C,Zhang J,Sun G

    更新日期:2001-01-01 00:00:00

  • Viscosity and order in erythrocyte membranes studied with nanosecond fluorometry.

    abstract::The viscosity and the order in the interior of human erythrocyte membranes were investigated by the fluorescence depolarization technique in the nanosecond region with 1,6-diphenyl-1,3,5-hexatriene (DPH). After pulsed excitation with a polarized light, the fluorescence anisotropy ratio of DPH in membranes rapidly decr...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1986-23504

    authors: Araiso T,Shindo Y,Arai T,Nitta J,Kikuchi Y,Kakiuchi Y,Koyama T

    更新日期:1986-01-01 00:00:00

  • Filterability of sickle cells as a function of pO2: role of physico-chemical factors.

    abstract::A rigidity index (RI) related to red blood cell deformability was measured by using the hemorheometre. The RI for 13 patients homozygous for sickle cell disease was 109 +/- 44 at 37 degrees C and at atmospheric pO2. The filtration time curve as a function of pO2 is biphasic for sickle cell suspensions. The pO2 at whic...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1989-26409

    authors: Kraiem A,Craescu CT,Galacteros F,Martin-Caburi J,Domenget C,Garel MC,Beuzard Y

    更新日期:1989-01-01 00:00:00

  • The influence of L-sorbose on red cell flow properties, shape and packing ability.

    abstract::Since the sweet ketohexose L-sorbose causes overt hemolysis in dogs but not in man, we examined the possibility that L-sorbose induces a "prehemolytic state" of human red cells, manifesting itself as impairment of rheological red cell properties. After 2 hours incubation at 37 degrees C relative viscosity of red cell ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1985-22302

    authors: Stäubli M,Wälchli P,Straub PW

    更新日期:1985-01-01 00:00:00

  • Erythrocytes sedimentation profiles under gravitational field as determined by He-Ne laser. VII. Influence of dextrans, albumin and saline on cellular aggregation and sedimentation rate.

    abstract::The erythrocytes sedimentation profiles (ESP) of normal blood and of blood mixed with saline, albumin (7%), and various molecular weight dextrans of different concentrations, at various height and widths of the sample holder are determined. These observations show that the sedimentation characteristics of the erythroc...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1987-24106

    authors: Singh M,Joseph KP

    更新日期:1987-01-01 00:00:00

  • COX-1, COX-2 and articular joint disease: a role for chondroprotective agents.

    abstract::It is widely accepted that whilst exhibiting clinically useful anti-inflammatory and analgesic activity, the application of non-steroidal anti-inflammatory drugs (NSAIDs) does not affect the underlying pathogenesis of articular diseases such as rheumatoid arthritis. The demonstration of a role for COX-2 in the resolut...

    journal_title:Biorheology

    pub_type: 杂志文章,评审

    doi:

    authors: Colville-Nash PR,Willoughby DA

    更新日期:2002-01-01 00:00:00

  • Fluid shear stress enhanced DNA synthesis in cultured endothelial cells during repair of mechanical denudation.

    abstract::We have previously observed a stimulatory effect of fluid shear stress on the regeneration of cultured endothelial cell layers after mechanical denudation. In this study we examined how fluid shear stress affects endothelial cell DNA synthesis during regeneration. Following mechanical denudation of narrow linear areas...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1990-27505

    authors: Ando J,Komatsuda T,Ishikawa C,Kamiya A

    更新日期:1990-01-01 00:00:00

  • Mechanical regulation of proteoglycan synthesis in normal and osteoarthritic human articular chondrocytes--roles for alpha5 and alphaVbeta5 integrins.

    abstract::The importance of biomechanical forces in regulating normal chondrocyte metabolism is well established and the mechanisms whereby mechanical forces are transduced into biochemical responses by chondrocytes are beginning to be understood. Previous studies have indicated that cyclical mechanical stimulation induces incr...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Holledge MM,Millward-Sadler SJ,Nuki G,Salter DM

    更新日期:2008-01-01 00:00:00

  • Model studies of leukocyte-endothelium-blood interactions. I. The fluid flow drag force on the adherent leukocyte.

    abstract::Using a large scale model and the concept of dimensional similarity, we have developed a dimensionless correlation which permits the estimation of the drag force of blood flow in an in vivo vessel on a leukocyte adherent to the vessel wall. This relationship is [formula: see text] where Re is a Reynolds number, Cd is ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.1016/0006-355X(96)00011-X

    authors: Chapman G,Cokelet G

    更新日期:1996-03-01 00:00:00

  • An inflammation-responsive transcription factor in the pathophysiology of osteoarthritis.

    abstract::A number of risk factors including biomechanical stress on the articular cartilage imposed by joint overloading due to obesity, repetitive damage of the joint tissues by injury of the menisci and ligaments, and abnormal joint alignment play a significant role in the onset of osteoarthritis (OA). Genetic predisposition...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Ray A,Ray BK

    更新日期:2008-01-01 00:00:00

  • Upregulation of aggrecan and type II collagen mRNA expression in bovine chondrocytes by the application of hydrostatic pressure.

    abstract::The aim of this study was to investigate the effect of hydrostatic pressure on the expression of messenger ribonucleic acid (mRNA) for specific extracellular matrix proteins in chondrocytes. Chondrocytes obtained from bovine metatarsophalangeal joints were embedded in cylindrical 2% agarose gels. A novel experimental ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Toyoda T,Seedhom BB,Kirkham J,Bonass WA

    更新日期:2003-01-01 00:00:00

  • Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT.

    abstract::In the past few years there has been a considerable interest in the role of bone in osteoarthritis. Despite the increasing evidence of the involvement of bone in osteoarthritis, it remains very difficult to attribute the cause or effect of changes in subchondral bone to the process of osteoarthritis. Although osteoart...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Botter SM,van Osch GJ,Waarsing JH,Day JS,Verhaar JA,Pols HA,van Leeuwen JP,Weinans H

    更新日期:2006-01-01 00:00:00

  • Alteration of red cell membrane viscoelasticity by heat treatment: effect on cell deformability and suspension viscosity.

    abstract::The membrane shear elastic modulus (mu) and the time constant for extensional shape recovery (tc) were measured for normal, control human red blood cells (RBC) and for RBC heat treated (HT) at 48 degrees C. Three separate methods for the measurement of mu were compared (two used a micropipette and one employed a flow ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1985-22106

    authors: Nash GB,Meiselman HJ

    更新日期:1985-01-01 00:00:00

  • Neurobiorheology. A new branch of biorheology. Historical background and current ideas.

    abstract::The application of principles of biorheology, hemorheology and perihemorheology on problems of the nervous system in health and disease was suggested by Alfred L. Copley (1982, 1987). Late in 1988 Copley and Sourander considered neurobiorheology to be an appropriate term for a new branch of biorheology bridging the ga...

    journal_title:Biorheology

    pub_type: 历史文章,杂志文章

    doi:10.3233/bir-1991-28603

    authors: Sourander P

    更新日期:1991-01-01 00:00:00

  • Pulse shape analysis of RBC micropore flow via new software for the cell transit analyser (CTA).

    abstract::The Cell Transit Analyser (CTA) provides a means to rapidly measure the deformability of large numbers of individual cells. It combines many of the advantages of micropipette studies with the simplicity and speed of filtrometry methods by measuring the duration of each resistive pulse generated as a cell passes throug...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1992-292-301

    authors: Fisher TC,Wenby RB,Meiselman HJ

    更新日期:1992-03-01 00:00:00

  • Epinephrine and shear stress synergistically induce platelet aggregation via a mechanism that partially bypasses VWF-GP IB interactions.

    abstract::Elevated shear stress levels in pathologically stenosed vessels induce platelet activation and aggregation, and may play a role in the pathogenesis of arterial disease. Increased plasma catecholamine concentrations have also been implicated in the onset of acute coronary ischemic syndromes. This study was designed to ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.1016/0006-355X(96)00018-2

    authors: Wagner CT,Kroll MH,Chow TW,Hellums JD,Schafer AI

    更新日期:1996-05-01 00:00:00

  • Hemorheological effects of secoisolariciresinol in ovariectomized rats.

    abstract:BACKGROUND:Postmenopausal women often develop hemorheological disorders which may affect the systemic blood circulation and present a cardiovascular risk factor. OBJECTIVE:We evaluated effects of secoisolariciresinol (SECO), a phytoestrogen, on hemorheological parameters and lipid peroxidation in a model of the age-re...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-15066

    authors: Maslov MY,Plotnikova TM,Anishchenko AM,Aliev OI,Nifantiev NE,Plotnikov MB

    更新日期:2016-01-07 00:00:00

  • Osteoarthritic synovial fluid rheology and correlations with protein concentration.

    abstract:BACKGROUND:Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. Osteoarthritis is particularly common in the knees. The effects of osteoarthritis on the rheology of synovial fluid in the knees are not fully understood and consequently require further study. OBJECTIVE:Th...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-15078

    authors: Madkhali A,Chernos M,Grecov D,Kwok E

    更新日期:2016-11-09 00:00:00

  • Effects of vessel size, cell sedimentation and haematocrit on the adhesion of leukocytes and platelets from flowing blood.

    abstract:BACKGROUND:Leukocytes and platelets typically fulfil their functions through adhesion to the walls of vessels with different size, haematocrit and shear rate. OBJECTIVE:We aimed to investigate differential effects of these variables on leukocyte and platelet adhesion. METHODS:Blood with varying haematocrit was perfus...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-15043

    authors: Watts T,Barigou M,Nash GB

    更新日期:2015-01-01 00:00:00

  • Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments.

    abstract::Over the past several decades, blood-soluble drag reducing polymers (DRPs) have been shown to significantly enhance hemodynamics in various animal models when added to blood at nanomolar concentrations. In the present study, the effects of the DRPs on blood circulation were tested in anesthetized rats exposed to acute...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Kameneva MV,Wu ZJ,Uraysh A,Repko B,Litwak KN,Billiar TR,Fink MP,Simmons RL,Griffith BP,Borovetz HS

    更新日期:2004-01-01 00:00:00

  • Flow cytometry analysis of human neutrophils labeled with rhodamine phalloidin: effect of pentoxifylline.

    abstract::Pentoxifylline (PTX) has been reported to enhance the early accumulation of neutrophils at the site of Staphylococcus aureus subcutaneous infection in mice (1) and to stimulate in vitro PMN chemotaxis, particularly under dense agarose (2). Among the biochemical events contributing to chemotaxis are actin polymerizatio...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1990-273-421

    authors: Freyburger G,Belloc F,Boisseau MR

    更新日期:1990-01-01 00:00:00

  • Macromolecular architecture and hydrodynamic properties of human cervical mucins.

    abstract::Cervical mucus glycoproteins (mucins) were extracted by using slow stirring in 6M-guanidinium chloride supplemented with proteinase inhibitors. Subsequent purification was achieved by isopycnic density-gradient centrifugation in CsCl/guanidinium chloride. The whole mucins (Mr 10 X 10(6) - 15 X 10(6)) were degraded int...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1984-211-225

    authors: Carlstedt I,Sheehan JK

    更新日期:1984-01-01 00:00:00

  • A macroscopic description of stress relaxation in a muscle subject to stepwise deformation.

    abstract::Stress relaxation regimes arising in a muscle subject to stepwise deformation are described on the basis of a recent phenomenological model of fully activated muscle tissue which is presented in the form of a second-order constitutive equation. It is shown that this model reproduces the qualitative form of relaxation ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1984-21606

    authors: Timanin EM

    更新日期:1984-01-01 00:00:00

  • A structural mathematical model for the viscoelastic anisotropic behaviour of trabecular bone.

    abstract::The presented paper is based on the conclusions of the preceding paper (1). On the basis of a general theoretical approach to the mechanics of heterogeneous materials published earlier / (2) , (3) , (4) / macroscopic constitutive equation of trabecular bone is deduced from the description of its microstructure. For th...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1983-20607

    authors: Kafka V,Jírová J

    更新日期:1983-01-01 00:00:00

  • Flow behaviour of a POSS biopolymer solution.

    abstract::A non-biodegradable polyhedral oligomeric silsesquioxane (POSS) nanocomposite biopolymer has been developed for fabrication of medical devices and for tissue engineering human organs. The polymer in solution, containing 2 wt% of POSS, has been synthesized, characterized and investigated to determine its key rheologica...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Kidane AG,Edirisinghe MJ,Bonhoeffer P,Seifalian AM

    更新日期:2007-01-01 00:00:00

  • Parallel-plate flow chamber for studies of 3D flow-endothelium interaction.

    abstract::Flow induced shear stress influences vascular cellular biology and pathophysiology in numerous ways. Previous in vitro studies on interactions between flow and endothelial cells using parallel-plate flow chambers involve two-dimensional flows, whereas flows in larger vessels are commonly three-dimensional. We have con...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Watkins NV,Caro CG,Wang W

    更新日期:2002-01-01 00:00:00

  • An LDA and flow visualization study of pulsatile flow in an aortic bifurcation model.

    abstract::The structure of pulsatile flow in a rigid aortic bifurcation model was studied by means of a flow visualization technique and three-dimensional laser-Doppler anemometry. The model was made of glass, having the same shape as that of the average human aortic bifurcation. It was installed into a mock circulatory loop th...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1995-32104

    authors: Naiki T,Hayashi K,Takemura S

    更新日期:1995-01-01 00:00:00

  • Influence of plaque stiffness on deformation and blood flow patterns in models of stenosis.

    abstract:BACKGROUND:Blood flow in stenotic vessels strongly influences the progression of vascular diseases. Plaques in stenotic blood vessels vary in stiffness, which influences plaque behavior and deformation by pressure and flow. Concurrent changes in plaque geometry can, in turn, affect blood flow conditions. Thus, simultan...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-14016

    authors: Shimizu Y,Ohta M

    更新日期:2015-01-01 00:00:00