Abstract:
:A rigidity index (RI) related to red blood cell deformability was measured by using the hemorheometre. The RI for 13 patients homozygous for sickle cell disease was 109 +/- 44 at 37 degrees C and at atmospheric pO2. The filtration time curve as a function of pO2 is biphasic for sickle cell suspensions. The pO2 at which filtration time is maximum, pO2max., correlated with the rigidity index measured at atmospheric pO2. This pO2max. value was very sensitive to small changes in physico-chemical parameters such as osmolality, pH, temperature, hematocrit, and cell density. Conditions which reduced the Hb S polymerization induced a leftward shift of pO2max.. The experimental curves are in agreement with theoretical models based on the presence of two abnormal cell types: filtrable "slow cells" and infiltrable "sickled cells".
journal_name
Biorheologyjournal_title
Biorheologyauthors
Kraiem A,Craescu CT,Galacteros F,Martin-Caburi J,Domenget C,Garel MC,Beuzard Ydoi
10.3233/bir-1989-26409subject
Has Abstractpub_date
1989-01-01 00:00:00pages
771-84issue
4eissn
0006-355Xissn
1878-5034journal_volume
26pub_type
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