Abstract:
:Atherosclerosis is the most frequent cause of death and severe chronic disability in North America and Europe. The atherosclerosis-prone apolipoprotein E (apoE)-deficient mice contain the entire spectrum of lesions observed during atherogenesis. Significant remodelling of the artery occurs in atherosclerosis. The aim was to study the remodelling of the zero-stress state of the aorta in apoE-deficient mice up to 56 weeks of age. Normal wild-type mice served as control groups. The mice were euthanised at ages 10, 28 and 56 weeks and tissue rings where excised from several locations along the aorta. The rings where photographed in the no-load state (without any external forces applied), then cut radially to obtain the zero-stress state and photographed again. The cross-sectional wall area and wall thickness increased over time in apoE-deficient mice compared to controls (P<0.001). The residual strains at the inner and outer surface varied as function of aortic location both in controls and apoE-deficient mice (P<0.001). From age 28 to age 56 weeks a gradual increase in positive strain at the outer surface and negative strain at the inner surface was found in the apoE-deficient mice when compared to age-matched control mice (P<0.001). Furthermore, the inner residual strain in the plaque location was significantly smaller than in the non-plaque location in the rings with atherosclerotic plaques (P<0.001). The change over time of the opening angle was especially pronounced in the aortic arch. The opening angle increased to app. 200 degrees in the aortic arch in apoE-deficient mice at 56 weeks of age whereas it in age-matched controls was app. 125 degrees. Correspondingly, atherosclerotic plaques were prominent in the apoE-deficient mice, especially at week 56 in the ascending aorta and the aortic arch. In conclusion, a pronounced remodelling of the biomechanical properties in aorta was found in apoE-deficient mice. The stress gradient across the vessel wall in the plaque region is likely larger in vivo due to the smaller residual strain in the plaque area.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Gregersen H,Zhao J,Lu X,Zhou J,Falk Esubject
Has Abstractpub_date
2007-01-01 00:00:00pages
75-89issue
2eissn
0006-355Xissn
1878-5034journal_volume
44pub_type
杂志文章相关文献
BIORHEOLOGY文献大全abstract:BACKGROUND:Foam sclerotherapy is the process of using an aqueous foam to deliver surfactant to a varicose vein to damage vein wall endothelial cells, causing the vein to spasm, collapse and ultimately be re-absorbed into the body. Aqueous foams are complex fluids that can exhibit a significant yield stress and high eff...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-201004
更新日期:2021-01-13 00:00:00
abstract::The goal of this work is to better understand the association between renal artery aneurysms and secondary hypertension through modeling the blood flow and the mechanics of diseased arteries. A large number of patients with renal artery aneurysms exhibit hypertension. Following surgical intervention, some patients exp...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-130623
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Exposure to particulate air pollution is associated with an increased risk of cardiovascular disease. The mechanism by which exposure increases risk is poorly understood but could involve changes in the flow properties of blood. OBJECTIVE:The aim of this investigation was to assess the effect, in rats, of i...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-14027
更新日期:2014-01-01 00:00:00
abstract::Magnitude and time-dependence of the effects of red cell aggregation and sedimentation on the rheology of human blood were studied during low shear (tau W 2.5 to 92 mPa) flow through horizontal tubes (ID 25 to 105 microns). Immediately following reduction of perfusion pressure to a low value the red cell concentration...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1989-26210
更新日期:1989-01-01 00:00:00
abstract::The relationships between mucus rheology, depth of mucus layer and clearance by simulated cough were examined in a study employing a model plexiglass trachea lined with gels formed from locust bean gum crosslinked with sodium tetraborate. The viscoelastic properties of the mucus simulants were determined by magnetic r...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1987-24611
更新日期:1987-01-01 00:00:00
abstract::The aim of this study was to investigate the effects of a surgical limb lengthening procedure on the biorheological features of some lengthened soft tissues. In this procedure external fixators were applied to goats' right radius to stretch the tissues. The right forelegs of goats were lengthened by 2, 4 cm, respectiv...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/S0006-355X(99)80016-X
更新日期:1998-07-01 00:00:00
abstract::It is widely accepted that whilst exhibiting clinically useful anti-inflammatory and analgesic activity, the application of non-steroidal anti-inflammatory drugs (NSAIDs) does not affect the underlying pathogenesis of articular diseases such as rheumatoid arthritis. The demonstration of a role for COX-2 in the resolut...
journal_title:Biorheology
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
abstract::A model of intima thickening proposed by Friedman and his coworkers (1,2) is incorporated in our computer code to simulate the growth of intima under shear. The computer code is based on a finite volume method in a boundary-fitted coordinate system. It is found that the model yields an evenly-distributed thickening ov...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1992-292-312
更新日期:1992-03-01 00:00:00
abstract::The literature review about the shear linear properties of brain tissue reveals both a large discrepancy in the existing data and a crucial lack of information at high frequencies associated with traffic road and non-penetrating ballistic impacts. The purpose of this study is to clarify and to complement the linear ma...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The purpose of this study was to examine the theoretical impact of the local bifurcation geometry on the shear rate gradient in a divergent arteriolar-type bifurcation. Newtonian flow through an arteriolar bifurcation was modeled using 3-dimensional computational fluid dynamics (CFD). Branching angles of 30 degrees, 5...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::In this study, we simulated multiple red blood cells flowing through straight microvessels with the immersed-boundary lattice-Boltzmann model to examine the shear stress variation on the microvessel surface and its relation to the properties of cell-free layer. Significant variation in shear stress has been observed d...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-2012-0608
更新日期:2012-01-01 00:00:00
abstract::A non-linear elastic model taking into account the microscopic structure of biological soft tissues is briefly presented and extended to quasi linear viscoelasticity. The modelling of the rheological behavior for near zero stress values is then discussed. ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1988-251-216
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Blood flow in stenotic vessels strongly influences the progression of vascular diseases. Plaques in stenotic blood vessels vary in stiffness, which influences plaque behavior and deformation by pressure and flow. Concurrent changes in plaque geometry can, in turn, affect blood flow conditions. Thus, simultan...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-14016
更新日期:2015-01-01 00:00:00
abstract::The importance of biomechanical forces in regulating normal chondrocyte metabolism is well established and the mechanisms whereby mechanical forces are transduced into biochemical responses by chondrocytes are beginning to be understood. Previous studies have indicated that cyclical mechanical stimulation induces incr...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::The Cell Transit Analyser (CTA) provides a means to rapidly measure the deformability of large numbers of individual cells. It combines many of the advantages of micropipette studies with the simplicity and speed of filtrometry methods by measuring the duration of each resistive pulse generated as a cell passes throug...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1992-292-301
更新日期:1992-03-01 00:00:00
abstract::The present study was designed to investigate the oxidant susceptibility of red blood cells (RBC) from four species (echidna, human, koala, Tasmanian devil) based on changes in cellular deformability. These species were specifically chosen based on differences in lifestyle and/or biology associated with varied levels ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-2012-0599
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Parenteral nutrition (PN) is a hyperosmolar solution composed of glucose, amino acids and a lipid emulsion, which is often used despite well-known side effects and complications. OBJECTIVES:In this study the hypothesis was tested that PN could affect hemorheology. METHODS:The influence of increasing plasma...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-140652
更新日期:2014-01-01 00:00:00
abstract::The viscosity: shear rate relationship of whole blood is shown to be described to a good approximation by a bi-linear plot on log: log axes. This has allowed an analytical solution to be obtained which gives a full description of the flow properties of blood in rigid tubes of a size where the Fahraeus-Lindqvist effect...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1983-20204
更新日期:1983-01-01 00:00:00
abstract::The structure of pulsatile flow in a rigid aortic bifurcation model was studied by means of a flow visualization technique and three-dimensional laser-Doppler anemometry. The model was made of glass, having the same shape as that of the average human aortic bifurcation. It was installed into a mock circulatory loop th...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1995-32104
更新日期:1995-01-01 00:00:00
abstract::A dilute suspension of Spirulina Microalgae is found to exhibit radial migration in laminar flow in a 650 micron vertical tube. As the tube Reynolds number increases, the particles concentrate in a narrower region around the tube axis. When the turbulent regime is approached, the particles disperse as expected. ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1987-24626
更新日期:1987-01-01 00:00:00
abstract::Blood vessels are always subjected to hemodynamic stresses including blood pressure and blood flow. The cerebral artery is particularly sensitive to hemodynamic stresses such as pressure and stretch, and shows contractions that are myogenic in nature; i.e., the mechanical response is generated by the vascular smooth m...
journal_title:Biorheology
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::The membrane shear elastic modulus (mu) and the time constant for extensional shape recovery (tc) were measured for normal, control human red blood cells (RBC) and for RBC heat treated (HT) at 48 degrees C. Three separate methods for the measurement of mu were compared (two used a micropipette and one employed a flow ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1985-22106
更新日期:1985-01-01 00:00:00
abstract::It has long been recognized that understanding the rheological properties of blood is essential to a full understanding of the function of the circulatory system. Given the difficulty of obtaining carefully controlled measurements in vivo, most of our current concepts of the flow behavior of blood in vivo are based on...
journal_title:Biorheology
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::The effects of platelet margination and enhanced platelet diffusivity, as induced by red blood cells, on the adhesion of platelets, were investigated for a range of haematocrits, under 2D axi-symmetric flow, simulating previous in vitro experiments [Microvasc. Res. 17 (1979), 238-262]. The effect of margination was in...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::A rigidity index (RI) related to red blood cell deformability was measured by using the hemorheometre. The RI for 13 patients homozygous for sickle cell disease was 109 +/- 44 at 37 degrees C and at atmospheric pO2. The filtration time curve as a function of pO2 is biphasic for sickle cell suspensions. The pO2 at whic...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1989-26409
更新日期:1989-01-01 00:00:00
abstract::Conducting experiments on very soft biological tissues can be difficult. Traditionally, unconfined compression and shear have been used. Here, an improved method of compression testing, lubricated squeezing flow is described. This gives a uniform compression along the squeezing axis and almost uniform equi-biaxial elo...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The compressive stiffness of an elastic material is traditionally characterized by its Young's modulus. Young's modulus of articular cartilage can be directly measured using unconfined compression geometry by assuming the cartilage to be homogeneous and isotropic. In isotropic materials, Young's modulus can also be de...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Through cardiac looping during embryonic development, human and other vertebrate hearts adopt sinuous curvatures with marked changes in direction of flow at atrial, ventricular and arterial levels. We used magnetic resonance phase velocity mapping to study flow through the hearts of resting volunteers, and Doppler ult...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The application of principles of biorheology, hemorheology and perihemorheology on problems of the nervous system in health and disease was suggested by Alfred L. Copley (1982, 1987). Late in 1988 Copley and Sourander considered neurobiorheology to be an appropriate term for a new branch of biorheology bridging the ga...
journal_title:Biorheology
pub_type: 历史文章,杂志文章
doi:10.3233/bir-1991-28603
更新日期:1991-01-01 00:00:00
abstract::The well-known S-shaped settling curves are obtained as solutions of an autonomic dynamical system deduced mathematically from the generalized Stokes formula, the blood volume conservation law, and the Smoluchowski theory of particle coagulation. Numerical computations and parametric analysis of the deduced two nonlin...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/0006-355x(96)00027-3
更新日期:1996-07-01 00:00:00