Abstract：
:The purpose of this study was to examine the theoretical impact of the local bifurcation geometry on the shear rate gradient in a divergent arteriolar-type bifurcation. Newtonian flow through an arteriolar bifurcation was modeled using 3-dimensional computational fluid dynamics (CFD). Branching angles of 30 degrees, 50 degrees, 70 degrees, 90 degrees, 110 degrees, 130 degrees, and 150 degrees were studied at a Reynolds number (Re) of 0.01 in seven separate models. Both the flow split (30%) and the branch to main vessel diameter ratio (4/5) were held constant. Velocity profiles were predicted to deviate significantly from a parabolic form, both immediately before and after the branch. This deviation was shown to be a function of the local bifurcation geometry of each model, which consisted of a branching angle and associated feed-branch intersection shape. Immediately before and after the branch, the shear rate along the lateral branching wall was predicted to exceed (5-fold) that calculated for fully developed flow in the feed. In vivo data were from the anesthetized (pentobarbital, 70 mg/kg) hamster cremaster muscle preparation. Red blood cells were used as flow markers in arteriolar branch points (n = 74) show that a significant gradient in shear rate occurs at the locations and branch shapes predicted by the computational model. Thus, for low Re divergent flow, the gradient in shear rate measured for non-Newtonian conditions, is approximated by a finite element fluid dynamics model of Newtonian flow.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Noren D,Palmer HJ,Frame MDsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
325-40issue
5-6eissn
0006-355Xissn
1878-5034journal_volume
37pub_type
杂志文章相关文献
BIORHEOLOGY文献大全abstract：:Pentoxifylline (PTX) has been reported to enhance the early accumulation of neutrophils at the site of Staphylococcus aureus subcutaneous infection in mice (1) and to stimulate in vitro PMN chemotaxis, particularly under dense agarose (2). Among the biochemical events contributing to chemotaxis are actin polymerizatio...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1990-273-421
更新日期：1990-01-01 00:00:00
abstract：:Although most apparent in permanently misshapen irreversibly sickled erythrocytes (ISC), biochemical and structural alterations are present in the majority of sickle cell membranes. The relationship of membrane rigidity to cell shape and its dependence upon the internal hemoglobin cytosol are not clarified. We therefo...
journal_title：Biorheology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:We have previously observed a stimulatory effect of fluid shear stress on the regeneration of cultured endothelial cell layers after mechanical denudation. In this study we examined how fluid shear stress affects endothelial cell DNA synthesis during regeneration. Following mechanical denudation of narrow linear areas...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1990-27505
更新日期：1990-01-01 00:00:00
abstract：:It is widely accepted that whilst exhibiting clinically useful anti-inflammatory and analgesic activity, the application of non-steroidal anti-inflammatory drugs (NSAIDs) does not affect the underlying pathogenesis of articular diseases such as rheumatoid arthritis. The demonstration of a role for COX-2 in the resolut...
journal_title：Biorheology
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：:The goal of this work is to better understand the association between renal artery aneurysms and secondary hypertension through modeling the blood flow and the mechanics of diseased arteries. A large number of patients with renal artery aneurysms exhibit hypertension. Following surgical intervention, some patients exp...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/BIR-130623
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Exposure to particulate air pollution is associated with an increased risk of cardiovascular disease. The mechanism by which exposure increases risk is poorly understood but could involve changes in the flow properties of blood. OBJECTIVE:The aim of this investigation was to assess the effect, in rats, of i...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/BIR-14027
更新日期：2014-01-01 00:00:00
abstract：:A rigidity index (RI) related to red blood cell deformability was measured by using the hemorheometre. The RI for 13 patients homozygous for sickle cell disease was 109 +/- 44 at 37 degrees C and at atmospheric pO2. The filtration time curve as a function of pO2 is biphasic for sickle cell suspensions. The pO2 at whic...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1989-26409
更新日期：1989-01-01 00:00:00
abstract：:This paper reports a novel, physiologically significant, microfluidic phenomenon generated by nanomolar concentrations of drag-reducing polymers (DRP) dissolved in flowing blood, which may explain previously demonstrated beneficial effects of DRP on tissue perfusion. In microfluidic systems used in this study, DRP add...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/BIR-2009-0543
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Devices gauging viscoelastic properties of blood during coagulation like the thromboelastograph support fundamental research as well as point of care needs. Associated fibrinolysis data are based on endogenous species or plasminogen activator added to a homogeneous sample prior to clot formation. Digestion i...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/BIR-15089
更新日期：2016-07-29 00:00:00
abstract：:Flow induced shear stress influences vascular cellular biology and pathophysiology in numerous ways. Previous in vitro studies on interactions between flow and endothelial cells using parallel-plate flow chambers involve two-dimensional flows, whereas flows in larger vessels are commonly three-dimensional. We have con...
journal_title：Biorheology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Human red cell aggregability and disaggregability represent important hemorheological parameters of blood. Several techniques have been proposed to evaluate the tendency of red cells to form aggregates and to disrupt in the presence of shear stress. One of the most recent approaches is based on the characterization of...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1993-305-615
更新日期：1993-09-01 00:00:00
abstract：:Sudden increase of viscosity in former times indicated the start of coagulation. Yet its measurement destroyed the structure of coagulum. By the precursor method of thrombelastography the author 1944 found elasticity to be the essential physiological property of coagulum. In the production of elastic fibrin structure ...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1988-251-221
更新日期：1988-01-01 00:00:00
abstract：:Drag-reducing polymers (DRPs) are blood-soluble macromolecules that can increase blood flow and reduce vascular resistance. The purpose of the present study is to examine the effects of DRPs on microcirculation in rat hind limb during acute femoral artery occlusion. Two groups of 20 male Wistar rats were subjected to ...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/BIR-2011-0592
更新日期：2011-01-01 00:00:00
abstract：:The biorheological properties and behavior of red blood cells (RBCs), as other types of cells, have a biochemical and molecular basis. The shape maintenance and deformability of RBCs depend on the structural and functional integrity of the membrane proteins. These proteins are composed of transmembrane proteins insert...
journal_title：Biorheology
pub_type： 杂志文章,评审
doi：10.3233/bir-1990-273-410
更新日期：1990-01-01 00:00:00
abstract：:The structure of pulsatile flow in a rigid aortic bifurcation model was studied by means of a flow visualization technique and three-dimensional laser-Doppler anemometry. The model was made of glass, having the same shape as that of the average human aortic bifurcation. It was installed into a mock circulatory loop th...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1995-32104
更新日期：1995-01-01 00:00:00
abstract：:Atherosclerosis is the most frequent cause of death and severe chronic disability in North America and Europe. The atherosclerosis-prone apolipoprotein E (apoE)-deficient mice contain the entire spectrum of lesions observed during atherogenesis. Significant remodelling of the artery occurs in atherosclerosis. The aim ...
journal_title：Biorheology
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:A theory for the rheological behavior and fluid flux in swelling tissues under small deformations is presented. Tissues are considered as bicomponent solid-fluid mixtures. Concentration effects are included. The driving forces (body, surface and interactive), are discussed and their constitutive relationships to the t...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1987-24210
更新日期：1987-01-01 00:00:00
abstract：:In this paper we shall describe new mechanical models for the deformation of the actin filament bundles in kidney microvilli and osteocytic cell processes to see whether these cellular extensions, like the stereocilia on hair cells in the inner ear, can function as mechanotransducers when subject to physiological flow...
journal_title：Biorheology
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Plasma fractionation by membrane filtration permits the reinfusion of the patient with his own albumin. In this study, the influence of membrane nature and plasma flux on plasma fractionation in dead-end mode is investigated with acetate hollow fiber filters. It is found that transmembrane pressure TMP rises exponenti...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1991-281-204
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied. OBJECTIVE:We investigated the stretching of bile and evaluated its extensional viscosity using a fila...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/BIR-190216
更新日期：2019-01-01 00:00:00
abstract：:Platelet margination (enhanced platelet concentration in the near wall region of a blood vessel) has been well documented in small vessels. In artery-sized vessels margination has only been demonstrated in one study, using ghost cell suspensions and under relatively non-physiologic conditions of steady flow and 50 cm ...
journal_title：Biorheology
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:A fine structure of blood flow through a curved vessel with an aneurysm was studied in in vitro experiments in relation to rheological factors of arterial diseases such as arteriosclerosis or thrombosis. On the basis of the in vivo data related to cerebral circulation, red blood cell suspension was flowed through curv...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1984-21418
更新日期：1984-01-01 00:00:00
abstract：:Elevated shear stress levels in pathologically stenosed vessels induce platelet activation and aggregation, and may play a role in the pathogenesis of arterial disease. Increased plasma catecholamine concentrations have also been implicated in the onset of acute coronary ischemic syndromes. This study was designed to ...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.1016/0006-355X(96)00018-2
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:Osteoarthritis is a common, localized joint disease that causes pain, stiffness and reduced mobility. Osteoarthritis is particularly common in the knees. The effects of osteoarthritis on the rheology of synovial fluid in the knees are not fully understood and consequently require further study. OBJECTIVE:Th...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/BIR-15078
更新日期：2016-11-09 00:00:00
abstract：:Shear stress-induced platelet aggregation requires von Willebrand factor (vWF), platelet glycoprotein (GP) Ib, GPIIb-IIIa, Ca2+, and adenosine diphosphate (ADP). Recent reports using vWF labeled with either 125I or fluorescein isothiocyanate (FITC) have demonstrated that in shear-fields, vWF binds to both GPIb and GPI...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.1016/S0006-355X(97)00004-8
更新日期：1997-01-01 00:00:00
abstract：:Adhesion of monocytes (U-937 cells) along a silicone tube deployed with circular ring stents was studied to test the hypothesis that by intentionally inducing swirling flow in an endovascular stent, the adhesion of monocytes would be suppressed. The results revealed that under a normal flow condition, the flow disturb...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/BIR-120622
更新日期：2012-01-01 00:00:00
abstract：:Flow-induced changes in the red cell microstructure of human blood are identified from mechanical and optical evidence. On initiation of steady flow, a new microstructure develops as the shear strain increases through unit strain. This structure is identified with the formation of layers of red cells that slide on pla...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1994-31206
更新日期：1994-03-01 00:00:00
abstract：:The well-known S-shaped settling curves are obtained as solutions of an autonomic dynamical system deduced mathematically from the generalized Stokes formula, the blood volume conservation law, and the Smoluchowski theory of particle coagulation. Numerical computations and parametric analysis of the deduced two nonlin...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.1016/0006-355x(96)00027-3
更新日期：1996-07-01 00:00:00
abstract：:The Cell Transit Analyser (CTA) provides a means to rapidly measure the deformability of large numbers of individual cells. It combines many of the advantages of micropipette studies with the simplicity and speed of filtrometry methods by measuring the duration of each resistive pulse generated as a cell passes throug...
journal_title：Biorheology
pub_type： 杂志文章
doi：10.3233/bir-1992-292-301
更新日期：1992-03-01 00:00:00
abstract：:It is has been known for more than 80 years that compared to in vitro determinations, blood behaves as a less viscous fluid under in vivo flow conditions. The experiments of Whittaker and Winton were among the first dealing with the in vivo effects of altered blood rheology, and experimental studies during the second ...
journal_title：Biorheology
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
