Platelet near-wall excess in porcine whole blood in artery-sized tubes under steady and pulsatile flow conditions.

Abstract:

:Platelet margination (enhanced platelet concentration in the near wall region of a blood vessel) has been well documented in small vessels. In artery-sized vessels margination has only been demonstrated in one study, using ghost cell suspensions and under relatively non-physiologic conditions of steady flow and 50 cm development length. Local sampling experiments were performed to confirm platelet margination in artery-sized stainless steel tubes, for a typical anatomical length and under pulsatile flow, using fresh EDTA-anticoagulated porcine whole blood (N=21). Experiments were designed using three-dimensional Computational Fluid Dynamics (CFD) to model the sample region with greater fidelity. Steady flow experiments in 50 cm long tubes verify published laser Doppler measurements of platelet margination in 3 mm ID tubes at normal arterial shear rate (500 s(-1). Margination persists under pulsatile flow conditions (63.8 pulses/min), but in steady flow at length of 10 cm, margination is reduced. Platelet margination ratio (the ratio of the platelet concentration near the wall to bulk average platelet count) ranges from 1.21 to 2.48. No significant effects of calculated sampling thickness (20 microm and 50 microm) or pulsatility were detected. Hematocrit margination ratio is 0.68 to 0.90. Two model platelet concentration profiles are fit to the experimental results.

journal_name

Biorheology

journal_title

Biorheology

authors

Xu C,Wootton DM

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

113-25

issue

2

eissn

0006-355X

issn

1878-5034

journal_volume

41

pub_type

杂志文章
  • Effect of nonaxisymmetric hematocrit distribution on non-Newtonian blood flow in small tubes.

    abstract::Hematocrit distribution and red blood cell aggregation are the major determinants of blood flow in narrow tubes at low flow rates. It has been observed experimentally that in microcirculation the hematocrit distribution is not uniform. This nonuniformity may result from plasma skimming and cell screening effects and a...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.1016/S0006-355X(98)00018-3

    authors: Das B,Johnson PC,Popel AS

    更新日期:1998-01-01 00:00:00

  • Swirling flow can suppress monocyte adhesion in the flow disturbance zones of the endovascular stent.

    abstract::Adhesion of monocytes (U-937 cells) along a silicone tube deployed with circular ring stents was studied to test the hypothesis that by intentionally inducing swirling flow in an endovascular stent, the adhesion of monocytes would be suppressed. The results revealed that under a normal flow condition, the flow disturb...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-120622

    authors: Chen Z,Zhang X,Deng X

    更新日期:2012-01-01 00:00:00

  • Acute effects of continuous and intermittent aerobic exercises on hemorheological parameters: a pilot study.

    abstract:BACKGROUND:Acute hemorheological responses to different types of aerobic exercises have never been compared in a single study in healthy people. OBJECTIVE:We aimed to compare acute effects of high intensity intermittent exercise (HIIE) and moderate intensity continuous exercise (MICE) on hemorheological parameters, in...

    journal_title:Biorheology

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/BIR-14012

    authors: Findikoglu G,Kilic-Toprak E,Kilic-Erkek O,Senol H,Bor-Kucukatay M

    更新日期:2014-01-01 00:00:00

  • Aggregation and disaggregation of red blood cells.

    abstract::The aggregation of red blood cells may be analyzed as an interaction of an adhesive surface energy and the elastic stored energy which results from deformation of the cell. The adhesive surface energy is the work required to separate a unit adhered area and is the resultant of adhesive forces due to the bridging molec...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1984-21406

    authors: Skalak R

    更新日期:1984-01-01 00:00:00

  • Electrostatic free energy and spontaneous curvature of spherical charged layered membrane.

    abstract::A biophysical model for the equilibrium curvature of a composite membrane element is derived taking into account the mechanical bilayer properties and the adjacent charged protein layers. The minimum of the total free energy density with respect to the curvature of such a membrane curved was estimated from the sum of ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1987-24104

    authors: Lerche D,Kozlov MM,Markin VS

    更新日期:1987-01-01 00:00:00

  • Contactless cell trapping by the use of a uniform AC electric field.

    abstract::The AC electric field-driven manipulation of suspended polarizable particles has become a major technique in micro- and nano-devices. In the present study, suspensions of cultured HeLa cells in isotonic solution were used to explore the mechanisms underlying the suspension behaviors during exposure to a uniform AC ele...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-130644

    authors: Tada S,Natsuya T,Tsukamoto A,Santo Y

    更新日期:2013-01-01 00:00:00

  • Fission and refusion of red blood cells using a micropipette technique.

    abstract::In micropipette experiments with small capillaries and moderate high pressure difference (approximately 1000 Pa) cell fragmentation (fission) of human red blood cells without hemolysis was observed by TV-system for a large number of fresh red blood cells of different donors. After separation, the fragment moves away f...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1987-24302

    authors: Meier W,Lerche D,Wendt MO,Paulitschke M

    更新日期:1987-01-01 00:00:00

  • COX-1, COX-2 and articular joint disease: a role for chondroprotective agents.

    abstract::It is widely accepted that whilst exhibiting clinically useful anti-inflammatory and analgesic activity, the application of non-steroidal anti-inflammatory drugs (NSAIDs) does not affect the underlying pathogenesis of articular diseases such as rheumatoid arthritis. The demonstration of a role for COX-2 in the resolut...

    journal_title:Biorheology

    pub_type: 杂志文章,评审

    doi:

    authors: Colville-Nash PR,Willoughby DA

    更新日期:2002-01-01 00:00:00

  • Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments.

    abstract::Over the past several decades, blood-soluble drag reducing polymers (DRPs) have been shown to significantly enhance hemodynamics in various animal models when added to blood at nanomolar concentrations. In the present study, the effects of the DRPs on blood circulation were tested in anesthetized rats exposed to acute...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Kameneva MV,Wu ZJ,Uraysh A,Repko B,Litwak KN,Billiar TR,Fink MP,Simmons RL,Griffith BP,Borovetz HS

    更新日期:2004-01-01 00:00:00

  • Improvement of the microcirculation in the acute ischemic rat limb during intravenous infusion of drag-reducing polymers.

    abstract::Drag-reducing polymers (DRPs) are blood-soluble macromolecules that can increase blood flow and reduce vascular resistance. The purpose of the present study is to examine the effects of DRPs on microcirculation in rat hind limb during acute femoral artery occlusion. Two groups of 20 male Wistar rats were subjected to ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-2011-0592

    authors: Hu F,Zha D,Du R,Chen X,Zhou B,Xiu J,Bin J,Liu Y

    更新日期:2011-01-01 00:00:00

  • Alterations in the biorheological features of some soft tissues after limb lengthening.

    abstract::The aim of this study was to investigate the effects of a surgical limb lengthening procedure on the biorheological features of some lengthened soft tissues. In this procedure external fixators were applied to goats' right radius to stretch the tissues. The right forelegs of goats were lengthened by 2, 4 cm, respectiv...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.1016/S0006-355X(99)80016-X

    authors: Huang K,Zeng Y,Xia H,Liu C

    更新日期:1998-07-01 00:00:00

  • Viscoelastic properties of normal rat liver measured by ultrasound elastography: Comparison with oscillatory rheometry.

    abstract:BACKGROUND:Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established. OBJECTIVE:To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to convention...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-16091

    authors: Lin H,Shen Y,Chen X,Zhu Y,Zheng Y,Zhang X,Guo Y,Wang T,Chen S

    更新日期:2016-01-01 00:00:00

  • Lubricated squeezing flow: a useful method for measuring the viscoelastic properties of soft tissues.

    abstract::Conducting experiments on very soft biological tissues can be difficult. Traditionally, unconfined compression and shear have been used. Here, an improved method of compression testing, lubricated squeezing flow is described. This gives a uniform compression along the squeezing axis and almost uniform equi-biaxial elo...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Nasseri S,Bilston L,Tanner R

    更新日期:2003-01-01 00:00:00

  • Mechanisms underlying chaotic vasomotion in isolated resistance arteries: roles of calcium and EDRF.

    abstract::Nonlinear mathematical techniques now make it possible to quantify the complexity of an irregular time series through calculation of a parameter known as fractal dimension. In the present study, we use such an analysis to provide evidence that histamine-induced pressure oscillations in an isolated rabbit ear resistanc...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1993-305-605

    authors: Griffith TM,Edwards DH

    更新日期:1993-09-01 00:00:00

  • Epinephrine and shear stress synergistically induce platelet aggregation via a mechanism that partially bypasses VWF-GP IB interactions.

    abstract::Elevated shear stress levels in pathologically stenosed vessels induce platelet activation and aggregation, and may play a role in the pathogenesis of arterial disease. Increased plasma catecholamine concentrations have also been implicated in the onset of acute coronary ischemic syndromes. This study was designed to ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.1016/0006-355X(96)00018-2

    authors: Wagner CT,Kroll MH,Chow TW,Hellums JD,Schafer AI

    更新日期:1996-05-01 00:00:00

  • Segregation by size difference in binary suspensions of fluid droplets in channel flow.

    abstract::In channel flow of multicomponent suspensions, segregation behavior of suspended components perpendicular to the flow direction is often observed, which is considered to be caused by the differential properties of the lateral migration depending on their shape, size, flexibility, and other characteristics. In the pres...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-130638

    authors: Makino M,Sugihara-Seki M

    更新日期:2013-01-01 00:00:00

  • The role of aggregation kinetics in the sedimentation of erythtocytes.

    abstract::The well-known S-shaped settling curves are obtained as solutions of an autonomic dynamical system deduced mathematically from the generalized Stokes formula, the blood volume conservation law, and the Smoluchowski theory of particle coagulation. Numerical computations and parametric analysis of the deduced two nonlin...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.1016/0006-355x(96)00027-3

    authors: Petrov VG,Edissonov I

    更新日期:1996-07-01 00:00:00

  • Hemorheological effects of secoisolariciresinol in ovariectomized rats.

    abstract:BACKGROUND:Postmenopausal women often develop hemorheological disorders which may affect the systemic blood circulation and present a cardiovascular risk factor. OBJECTIVE:We evaluated effects of secoisolariciresinol (SECO), a phytoestrogen, on hemorheological parameters and lipid peroxidation in a model of the age-re...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-15066

    authors: Maslov MY,Plotnikova TM,Anishchenko AM,Aliev OI,Nifantiev NE,Plotnikov MB

    更新日期:2016-01-07 00:00:00

  • Cross-sectional distributions of normal and abnormal red blood cells in capillary tubes determined by a new technique.

    abstract:BACKGROUND:In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability. OBJECTIVE:To quantitatively evaluate the effect of RBC deformability on their axial ...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-18166

    authors: Sasaki T,Seki J,Itano T,Sugihara-Seki M

    更新日期:2018-01-01 00:00:00

  • An LDA and flow visualization study of pulsatile flow in an aortic bifurcation model.

    abstract::The structure of pulsatile flow in a rigid aortic bifurcation model was studied by means of a flow visualization technique and three-dimensional laser-Doppler anemometry. The model was made of glass, having the same shape as that of the average human aortic bifurcation. It was installed into a mock circulatory loop th...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1995-32104

    authors: Naiki T,Hayashi K,Takemura S

    更新日期:1995-01-01 00:00:00

  • Effects of vessel size, cell sedimentation and haematocrit on the adhesion of leukocytes and platelets from flowing blood.

    abstract:BACKGROUND:Leukocytes and platelets typically fulfil their functions through adhesion to the walls of vessels with different size, haematocrit and shear rate. OBJECTIVE:We aimed to investigate differential effects of these variables on leukocyte and platelet adhesion. METHODS:Blood with varying haematocrit was perfus...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-15043

    authors: Watts T,Barigou M,Nash GB

    更新日期:2015-01-01 00:00:00

  • About the importance of account of some microcirculation parameters dispersion in modelling oxygen transport.

    abstract::During the recent years various investigators have developed the technique of kryophotometric measurements of oxyhemoglobin saturation with oxygen (psi) in small vessels. In this paper, on the basis of the statistical model of the organ developed by the authors, a theoretical relationship is established between the di...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1982-191-235

    authors: Sharikov AN,Zaiko VM

    更新日期:1982-01-01 00:00:00

  • Optical twisting to monitor the rheology of single cells.

    abstract:BACKGROUND:Biological cells exhibit complex mechanical properties which determine their responses to applied force. OBJECTIVE:We developed an optical method to probe the temporal evolution of power-law rheology of single cells. METHODS:The method consisted in applying optically a constant mechanical torque to a biref...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-15084

    authors: de Saint Vincent MR

    更新日期:2016-05-26 00:00:00

  • Shear stress-induced binding of von Willebrand factor to platelets.

    abstract::Shear stress-induced platelet aggregation requires von Willebrand factor (vWF), platelet glycoprotein (GP) Ib, GPIIb-IIIa, Ca2+, and adenosine diphosphate (ADP). Recent reports using vWF labeled with either 125I or fluorescein isothiocyanate (FITC) have demonstrated that in shear-fields, vWF binds to both GPIb and GPI...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.1016/S0006-355X(97)00004-8

    authors: Konstantopoulos K,Chow TW,Turner NA,Hellums JD,Moake JL

    更新日期:1997-01-01 00:00:00

  • Tensile behavior and extensional viscosity of bile.

    abstract:BACKGROUND:Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied. OBJECTIVE:We investigated the stretching of bile and evaluated its extensional viscosity using a fila...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/BIR-190216

    authors: Minh NN,Obara H,Shimokasa K,Zhu J

    更新日期:2019-01-01 00:00:00

  • Biorheological characteristics of skin after expansion.

    abstract::This study investigated the changes in biorheological characteristics of skin after expansion. Expanders were implanted into the back of eight adult dogs, and after an eight-week expansion the expanded and the non-expanded control skins were transferred to an adjacent site. The expanded specimens and their controls we...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Zeng Y,Huang K,Xu C,Zhang J,Sun G

    更新日期:2001-01-01 00:00:00

  • Viscoelastic and transient network properties of hyaluronic acid as a function of the concentration.

    abstract::Rheological measurements on a high molecular weight Hyaluronic Acid (from rooster combs) were performed to obtain information on the viscoelastic and temporary network characteristics of Hyaluronic Acid solutions as a function of the concentration. From rheological experiments, the critical concentration c* and the co...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: De Smedt SC,Dekeyser P,Ribitsch V,Lauwers A,Demeester J

    更新日期:1993-01-01 00:00:00

  • Macromolecular architecture and hydrodynamic properties of human cervical mucins.

    abstract::Cervical mucus glycoproteins (mucins) were extracted by using slow stirring in 6M-guanidinium chloride supplemented with proteinase inhibitors. Subsequent purification was achieved by isopycnic density-gradient centrifugation in CsCl/guanidinium chloride. The whole mucins (Mr 10 X 10(6) - 15 X 10(6)) were degraded int...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1984-211-225

    authors: Carlstedt I,Sheehan JK

    更新日期:1984-01-01 00:00:00

  • Viscoelastic properties of the oxygenated sickle erythrocyte membrane.

    abstract::Although most apparent in permanently misshapen irreversibly sickled erythrocytes (ISC), biochemical and structural alterations are present in the majority of sickle cell membranes. The relationship of membrane rigidity to cell shape and its dependence upon the internal hemoglobin cytosol are not clarified. We therefo...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:

    authors: Drasler WJ,Smith CM 2nd,Keller KH

    更新日期:1989-01-01 00:00:00

  • The role of mucus viscoelasticity in cough clearance.

    abstract::The relationships between mucus rheology, depth of mucus layer and clearance by simulated cough were examined in a study employing a model plexiglass trachea lined with gels formed from locust bean gum crosslinked with sodium tetraborate. The viscoelastic properties of the mucus simulants were determined by magnetic r...

    journal_title:Biorheology

    pub_type: 杂志文章

    doi:10.3233/bir-1987-24611

    authors: King M

    更新日期:1987-01-01 00:00:00