Abstract：
:Cervical mucus glycoproteins (mucins) were extracted by using slow stirring in 6M-guanidinium chloride supplemented with proteinase inhibitors. Subsequent purification was achieved by isopycnic density-gradient centrifugation in CsCl/guanidinium chloride. The whole mucins (Mr 10 X 10(6) - 15 X 10(6)) were degraded into subunits (Mr 2 X 10(6) - 3 X 10(6)) by reduction. Trypsin digestion of subunits afforded glycopeptides (T-domains) with Mr 0.4 X 10(6). The relationship between the intrinsic viscosity and Mr for the whole mucins and the fragments suggests that cervical mucins are linear flexible macromolecules. This view is supported by hydrodynamic data.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Carlstedt I,Sheehan JKdoi
10.3233/bir-1984-211-225subject
Has Abstractpub_date
1984-01-01 00:00:00pages
225-33issue
1-2eissn
0006-355Xissn
1878-5034journal_volume
21pub_type
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