Abstract:
:This paper proposes a model for wall shear stress in arterial stenosis based on boundary layer theory. Wall shear stress estimates are obtained by solving the momentum integral equation using the method proposed by Walz and applying this method to various stenosis geometries for Reynolds numbers (Re) of Re = 59-1000. Elevated wall shear stress may be of importance when considering thrombosis and vascular erosion in stenosis, as well as the potential for debris from the stenotic area to 'break away' and cause further pathology. The values of shear stress obtained using the model in this study agree well with published values of wall shear stress. When compared to a previously published boundary layer model utilizing the Thwaites method (Reese and Thompson, 1998), the model proposed herein performs better at higher Re while the model utilizing the Thwaites method performs better at lower Re. Wall shear stresses are shown to increase with increasing stenosis (increased area reduction) for a given stenosis length, increase with increasing Re for a given stenosis geometry, and increase for steeper stenosis of the same constriction. The boundary layer model proposed can be easily implemented by clinical researchers to provide in vivo estimates of wall shear stress through arterial stenoses.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Provenzano PP,Rutland CJsubject
Has Abstractpub_date
2002-01-01 00:00:00pages
743-54issue
6eissn
0006-355Xissn
1878-5034journal_volume
39pub_type
杂志文章相关文献
BIORHEOLOGY文献大全abstract::The presented paper is based on the conclusions of the preceding paper (1). On the basis of a general theoretical approach to the mechanics of heterogeneous materials published earlier / (2) , (3) , (4) / macroscopic constitutive equation of trabecular bone is deduced from the description of its microstructure. For th...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1983-20607
更新日期:1983-01-01 00:00:00
abstract::A non-linear elastic model taking into account the microscopic structure of biological soft tissues is briefly presented and extended to quasi linear viscoelasticity. The modelling of the rheological behavior for near zero stress values is then discussed. ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1988-251-216
更新日期:1988-01-01 00:00:00
abstract::This study aims at quantifying the cellular mechanical properties based on a partitioning of the cytoskeleton in a cortical and a cytosolic compartments. The mechanical response of epithelial cells obtained by magnetocytometry - a micromanipulation technique which uses twisted ferromagnetic beads specifically linked t...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Using a large scale model and the concept of dimensional similarity, we have developed a dimensionless correlation which permits the estimation of the drag force of blood flow in an in vivo vessel on a leukocyte adherent to the vessel wall. This relationship is [formula: see text] where Re is a Reynolds number, Cd is ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/0006-355X(96)00011-X
更新日期:1996-03-01 00:00:00
abstract::The goal of this study was to determine the duration of time that ligaments from a study group need to be loaded in order to adequately determine their collective viscoelastic behavior. Rat ligaments were subjected either to creep or stress relaxation for 1,000 s or stress relaxation for 10,000 s to compare estimates ...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Conducting experiments on very soft biological tissues can be difficult. Traditionally, unconfined compression and shear have been used. Here, an improved method of compression testing, lubricated squeezing flow is described. This gives a uniform compression along the squeezing axis and almost uniform equi-biaxial elo...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The purpose of this study was to determine the shear rate at the wall in a symmetrically branched tube with a branch-to-trunk area ratio and angle of branching that were comparable to the human abdominal aorta. Velocity profiles were measured with a laser Doppler anemometer during steady and pulsatile flow in which th...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1982-191-233
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Devices gauging viscoelastic properties of blood during coagulation like the thromboelastograph support fundamental research as well as point of care needs. Associated fibrinolysis data are based on endogenous species or plasminogen activator added to a homogeneous sample prior to clot formation. Digestion i...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-15089
更新日期:2016-07-29 00:00:00
abstract::Pentoxifylline (PTX) has been reported to enhance the early accumulation of neutrophils at the site of Staphylococcus aureus subcutaneous infection in mice (1) and to stimulate in vitro PMN chemotaxis, particularly under dense agarose (2). Among the biochemical events contributing to chemotaxis are actin polymerizatio...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1990-273-421
更新日期:1990-01-01 00:00:00
abstract::It has long been recognized that understanding the rheological properties of blood is essential to a full understanding of the function of the circulatory system. Given the difficulty of obtaining carefully controlled measurements in vivo, most of our current concepts of the flow behavior of blood in vivo are based on...
journal_title:Biorheology
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::Nonlinear mathematical techniques now make it possible to quantify the complexity of an irregular time series through calculation of a parameter known as fractal dimension. In the present study, we use such an analysis to provide evidence that histamine-induced pressure oscillations in an isolated rabbit ear resistanc...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1993-305-605
更新日期:1993-09-01 00:00:00
abstract::The goal of this work is to better understand the association between renal artery aneurysms and secondary hypertension through modeling the blood flow and the mechanics of diseased arteries. A large number of patients with renal artery aneurysms exhibit hypertension. Following surgical intervention, some patients exp...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-130623
更新日期:2013-01-01 00:00:00
abstract::Atherosclerosis is the most frequent cause of death and severe chronic disability in North America and Europe. The atherosclerosis-prone apolipoprotein E (apoE)-deficient mice contain the entire spectrum of lesions observed during atherogenesis. Significant remodelling of the artery occurs in atherosclerosis. The aim ...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::The Cell Transit Analyser (CTA) provides a means to rapidly measure the deformability of large numbers of individual cells. It combines many of the advantages of micropipette studies with the simplicity and speed of filtrometry methods by measuring the duration of each resistive pulse generated as a cell passes throug...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1992-292-301
更新日期:1992-03-01 00:00:00
abstract::The separation process of blood and RBC suspensions in a hematocrit range between 0.3-0.7 was investigated with a centrifuge allowed to run at low accelerations (100 xg-1000 xg). The position of the interface between the supernatant of plasma and the RBC column was continuously recorded by a new optoelectronic measuri...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1988-251-233
更新日期:1988-01-01 00:00:00
abstract::Elevated shear stress levels in pathologically stenosed vessels induce platelet activation and aggregation, and may play a role in the pathogenesis of arterial disease. Increased plasma catecholamine concentrations have also been implicated in the onset of acute coronary ischemic syndromes. This study was designed to ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.1016/0006-355X(96)00018-2
更新日期:1996-05-01 00:00:00
abstract::Flow induced shear stress influences vascular cellular biology and pathophysiology in numerous ways. Previous in vitro studies on interactions between flow and endothelial cells using parallel-plate flow chambers involve two-dimensional flows, whereas flows in larger vessels are commonly three-dimensional. We have con...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Blood vessels are always subjected to hemodynamic stresses including blood pressure and blood flow. The cerebral artery is particularly sensitive to hemodynamic stresses such as pressure and stretch, and shows contractions that are myogenic in nature; i.e., the mechanical response is generated by the vascular smooth m...
journal_title:Biorheology
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Exposure to particulate air pollution is associated with an increased risk of cardiovascular disease. The mechanism by which exposure increases risk is poorly understood but could involve changes in the flow properties of blood. OBJECTIVE:The aim of this investigation was to assess the effect, in rats, of i...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-14027
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to investigate the effect of hydrostatic pressure on the expression of messenger ribonucleic acid (mRNA) for specific extracellular matrix proteins in chondrocytes. Chondrocytes obtained from bovine metatarsophalangeal joints were embedded in cylindrical 2% agarose gels. A novel experimental ...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::In the past few years there has been a considerable interest in the role of bone in osteoarthritis. Despite the increasing evidence of the involvement of bone in osteoarthritis, it remains very difficult to attribute the cause or effect of changes in subchondral bone to the process of osteoarthritis. Although osteoart...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::A biophysical model for the equilibrium curvature of a composite membrane element is derived taking into account the mechanical bilayer properties and the adjacent charged protein layers. The minimum of the total free energy density with respect to the curvature of such a membrane curved was estimated from the sum of ...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1987-24104
更新日期:1987-01-01 00:00:00
abstract::The blood flow immediately adjacent to the wall of a blood vessel or an artificial surface is of great interest. This flow defines the shear stress at the wall and is known to have a great physiological importance. The use of models is a viable method to investigate this flow. However, even in models the shear stress ...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Mechanical forces influence articular cartilage structure by regulating chondrocyte activity. Mechanical stimulation results in activation of an alpha5beta1 integrin dependent intracellular signal cascade involving focal adhesion kinase and protein kinase C, triggering the release of interleukin-4 from the cell. In no...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::We present data which show that fibrin gels are ordered network structures, the porosity of which is determined by the amount of thrombin being present during the activation step preceding gelation. On activation of fibrinogen, fibrinopeptides are released and simultaneously polymers are formed, obeying apparent first...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1984-211-214
更新日期:1984-01-01 00:00:00
abstract::Orbitometry (Hartert) is a rheological ex-vivo method to follow up physical assembly of a coagulum in layers during natural intensity of flow by orbital movement. Fibrin elasticity in the Orbitometers mode of Resonance Thrombography is differentiated from platelet activity as well as e.g. from the effects of dissemina...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1990-27613
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established. OBJECTIVE:To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to convention...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/BIR-16091
更新日期:2016-01-01 00:00:00
abstract::The application of principles of biorheology, hemorheology and perihemorheology on problems of the nervous system in health and disease was suggested by Alfred L. Copley (1982, 1987). Late in 1988 Copley and Sourander considered neurobiorheology to be an appropriate term for a new branch of biorheology bridging the ga...
journal_title:Biorheology
pub_type: 历史文章,杂志文章
doi:10.3233/bir-1991-28603
更新日期:1991-01-01 00:00:00
abstract::Over the past several decades, blood-soluble drag reducing polymers (DRPs) have been shown to significantly enhance hemodynamics in various animal models when added to blood at nanomolar concentrations. In the present study, the effects of the DRPs on blood circulation were tested in anesthetized rats exposed to acute...
journal_title:Biorheology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::A theory for the rheological behavior and fluid flux in swelling tissues under small deformations is presented. Tissues are considered as bicomponent solid-fluid mixtures. Concentration effects are included. The driving forces (body, surface and interactive), are discussed and their constitutive relationships to the t...
journal_title:Biorheology
pub_type: 杂志文章
doi:10.3233/bir-1987-24210
更新日期:1987-01-01 00:00:00