Heterogeneous phase fibrinolysis rates by damped oscillation rheometry.

Abstract:

BACKGROUND:Devices gauging viscoelastic properties of blood during coagulation like the thromboelastograph support fundamental research as well as point of care needs. Associated fibrinolysis data are based on endogenous species or plasminogen activator added to a homogeneous sample prior to clot formation. Digestion in a monolithic structure differs from the physical situation of thrombolytic therapy where surface reactions dominate. OBJECTIVE:This study aims to develop rheological testing for heterogeneous phase fibrinolysis. METHOD:Fibrinolysis rates were determined by phase change of a solid clot induced by autologous plasma/streptokinase (SK) in a rheometer sensitive to viscous damping. RESULTS:Initial slope or overall change in the logarithmic damping factor indicated fibrinolytic rates. Rates depended on clot geometry, phase volumes, clot composition and SK concentration. CONCLUSION:The damped oscillation rheometer can be adapted to determine relative rates of heterogeneous fibrinolysis in vitro.

journal_name

Biorheology

journal_title

Biorheology

authors

Lee JS,Kaibara M,O'Rear EA

doi

10.3233/BIR-15089

subject

Has Abstract

pub_date

2016-07-29 00:00:00

pages

81-92

issue

2

eissn

0006-355X

issn

1878-5034

pii

BIR15089

journal_volume

53

pub_type

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