Abstract:
BACKGROUND:Devices gauging viscoelastic properties of blood during coagulation like the thromboelastograph support fundamental research as well as point of care needs. Associated fibrinolysis data are based on endogenous species or plasminogen activator added to a homogeneous sample prior to clot formation. Digestion in a monolithic structure differs from the physical situation of thrombolytic therapy where surface reactions dominate. OBJECTIVE:This study aims to develop rheological testing for heterogeneous phase fibrinolysis. METHOD:Fibrinolysis rates were determined by phase change of a solid clot induced by autologous plasma/streptokinase (SK) in a rheometer sensitive to viscous damping. RESULTS:Initial slope or overall change in the logarithmic damping factor indicated fibrinolytic rates. Rates depended on clot geometry, phase volumes, clot composition and SK concentration. CONCLUSION:The damped oscillation rheometer can be adapted to determine relative rates of heterogeneous fibrinolysis in vitro.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Lee JS,Kaibara M,O'Rear EAdoi
10.3233/BIR-15089subject
Has Abstractpub_date
2016-07-29 00:00:00pages
81-92issue
2eissn
0006-355Xissn
1878-5034pii
BIR15089journal_volume
53pub_type
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