Abstract:
:Plasma fractionation by membrane filtration permits the reinfusion of the patient with his own albumin. In this study, the influence of membrane nature and plasma flux on plasma fractionation in dead-end mode is investigated with acetate hollow fiber filters. It is found that transmembrane pressure TMP rises exponentially with time, the rate of increase being proportional to plasma flux. The faster TMP rises, the faster the drop in sieving coefficient SC. It is also found that albumin SC is a function of TMP and not of plasma flux. Theoretical analysis of the dead-end filtration was performed. This theoretical model indicates that the observed variation of TMP with time is consistent with the assumptions that pore volume decreases proportionally to the filtrate plasma volume.
journal_name
Biorheologyjournal_title
Biorheologyauthors
Charcosset C,Ding LH,Jaffrin MYdoi
10.3233/bir-1991-281-204subject
Has Abstractpub_date
1991-01-01 00:00:00pages
27-37issue
1-2eissn
0006-355Xissn
1878-5034journal_volume
28pub_type
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