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Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation.

Abstract：

:Regulation of the immune response directed against Leishmania is critical for the establishment of effective control of the disease. It is likely that some types of immune responses directed against Leishmania can lead to more severe clinical forms of leishmaniasis causing a poor control of the pathogen and/or pathology, while others lead to resolution of the infection with little pathology as in cutaneous leishmaniasis. To gain a better understanding of the possible role that subpopulations of T cells, and their associated cytokines have on disease progression and/or protective immune responses to L. braziliensis infection, a detailed study of the frequency of activated and memory T cells, as well as antigen specific, cytokine producing T cells was carried out. Following the determination of cytokine producing mononuclear cell populations in response to total Leishmania antigen (SLA), and to the recombinant antigen LACK, correlation analysis were performed between specific cytokine producing populations to identify models for cellular mechanisms of immunoregulation in human cutaneous leishmaniasis. These studies have shown: (1) a positive correlation between ex vivo CD45RO frequencies and antigen specific cytokine (IFN-gamma or IL-10) producing cells; (2) a negative correlation between ex vivo CD69 expression and the frequency of IFN-gamma producing cells; (3) a positive correlation amongst SLA specific, IFN-gamma or TNF-alpha and IL-10 producing lymphocytes with one another; and (4) a higher frequency of IL-10 producing, parasite specific (anti-SLA or anti-LACK), lymphocytes are correlated with a lower frequency of TNF-alpha producing monocytes, demonstrating an antigen specific delivery of IL-10 inducing negative regulation of monocyte activity.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Antonelli LR,Dutra WO,Almeida RP,Bacellar O,Gollob KJ

doi

10.1111/j.1365-2249.2004.02426.x

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

341-8

issue

eissn

0009-9104

issn

1365-2249

pii

CEI2426

journal_volume

136

pub_type

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Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation.