Prenatal stress alters bacterial colonization of the gut in infant monkeys.

Abstract:

OBJECTIVE:The hypothesis that prenatal stress lowers the levels of protective microflora and increases the risk for postpartum Gram-negative pathogens was tested in infant monkeys. METHODS:Female monkeys were left undisturbed or were stressed during pregnancy using an acoustical startle paradigm for 6 weeks either early or late in their 24-week gestation. Several types of intestinal microflora were repeatedly enumerated by fecal culture while infants were reared normally by their mothers. RESULTS:Significant changes in microflora concentrations occurred during the first 6 months of life. The profile of total aerobes and facultative anaerobes was biphasic, with peak concentrations occurring between 2 and 16 weeks of age. The numbers of bifidobacteria and lactobacilli were low at 2 days after birth but rapidly increased to a peak between 8 and 16 weeks of age. Although similar temporal patterns were evident in all infants, prenatal stress reduced the overall numbers of bifidobacteria and lactobacilli. CONCLUSIONS:Moderate disturbance during pregnancy was sufficient to alter the intestinal microflora in the newborn infant. These alterations could result in enhanced susceptibility to infection and suggest a mechanism for some effects of maternal pregnancy conditions on infant health.

authors

Bailey MT,Lubach GR,Coe CL

doi

10.1097/00005176-200404000-00009

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

414-21

issue

4

eissn

0277-2116

issn

1536-4801

pii

00005176-200404000-00009

journal_volume

38

pub_type

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