Gastric emptying in infants: response to metoclopramide depends on the underlying condition.

Abstract:

:In a double-blind, placebo-controlled, randomized study we measured the effect of 1 mg/kg intravenous metoclopramide on the gastric emptying of a 15 ml/kg 5% glucose meal, using a phenol red dye dilution technique. In a group of nine infants referred for multiple daily episodes of regurgitation, metoclopramide doubled the rate of gastric emptying (p less than 0.02). In six infants with prolonged gastroparesis following abdominal surgery, metoclopramide more than doubled the rate of gastric emptying (p less than 0.05). In contrast, in seven infants with gastroparesis related to prematurity, metoclopramide did not significantly change gastric emptying. No extrapyramidal side effects of metoclopramide occurred during the study.

authors

Hyman PE,Abrams CE,Dubois A

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

181-4

issue

2

eissn

0277-2116

issn

1536-4801

journal_volume

7

pub_type

临床试验,杂志文章,随机对照试验
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