当前位置： SCI文献检索 > MOLECULAR MICROBIOLOGY期刊下所有文献 > Listeria monocytogenes virulence proteins induce surface expression of Fas ligand on T lymphocytes.

Listeria monocytogenes virulence proteins induce surface expression of Fas ligand on T lymphocytes.

Abstract：

:Virulence factors secreted by Listeria monocytogenes are known to interfere with host cellular signalling pathways. We investigated whether L. monocytogenes modulates T-cell receptor signalling by examining surface expression of proteins known to be upregulated on activated T cells. In vitro culture of murine splenocytes with L. monocytogenes resulted in a specific and dose-dependent upregulation of Fas ligand (FasL). Induction of FasL expression was also observed for pathogenic Listeria ivanovii but not for non-pathogenic Listeria innocua, indicating involvement of Listeria virulence protein(s). Examination of L. monocytogenes strains deficient in different virulence genes demonstrated that FasL upregulation was dependent on the expression of two secreted proteins: listeriolysin O (LLO) and phosphatidylcholine-preferring phospholipase C (PC-PLC). Treatment of cells with purified proteins demonstrated that LLO was sufficient for inducing FasL, while PC-PLC synergized with LLO for the induction of FasL expression. FasL-expressing cells induced by L. monocytogenes were capable of killing Fas-expressing target cells. Furthermore, L. monocytogenes infection results in upregulation of FasL on T cells in mice. These results describe a novel function for LLO and PC-PLC and suggest that L. monocytogenes may use these virulence factors to modulate the host immune response.

journal_name

Mol Microbiol

journal_title

Molecular microbiology

authors

Zenewicz LA,Skinner JA,Goldfine H,Shen H

doi

10.1111/j.1365-2958.2003.03931.x

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

1483-92

issue

5

eissn

0950-382X

issn

1365-2958

pii

MMI3931

journal_volume

51

pub_type

杂志文章

相关文献

MOLECULAR MICROBIOLOGY文献大全
  • A study of the DNA damage checkpoint in Candida albicans: uncoupling of the functions of Rad53 in DNA repair, cell cycle regulation and genotoxic stress-induced polarized growth.

    abstract：:In response to genotoxic stress (GS), Candida albicans can undergo polarized growth and massive genome rearrangements including loss-of-heterozygosity (LOH) events. We evaluated the contribution of the CaRad53p and CaDun1p kinases of the DNA damage checkpoint (DDCP) in these processes. Characterization of C. albicans ...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/mmi.12471

    authors： Loll-Krippleber R,d'Enfert C,Feri A,Diogo D,Perin A,Marcet-Houben M,Bougnoux ME,Legrand M

    更新日期：2014-02-01 00:00:00

  • Molecular characterization of catalase from Bordetella pertussis: identification of the katA promoter in an upstream insertion sequence.

    abstract：:In this report we evaluate the role of catalase in the survival of Bordetella pertussis within human polymorphonuclear leukocytes (PMNs). Crude extracts of B. pertussis exhibited a single catalase activity when subjected to non-denaturing polyacrylamide gel electrophoresis and assayed for catalase activity. A plasmid ...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.1994.tb01272.x

    authors： DeShazer D,Wood GE,Friedman RL

    更新日期：1994-10-01 00:00:00

  • Transcriptional fidelity and proofreading in Archaea and implications for the mechanism of TFS-induced RNA cleavage.

    abstract：:We have addressed the question whether TFS, a protein that stimulates the intrinsic cleavage activity of the archaeal RNA polymerase, is able to improve the fidelity of transcription in Methanococcus. Using non-specific transcription experiments, we could demonstrate that misincorporation of non-templated nucleotides ...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2004.04039.x

    authors： Lange U,Hausner W

    更新日期：2004-05-01 00:00:00

  • Multifunctional analysis of Chlamydia-specific genes in a yeast expression system.

    abstract：:Our understanding of how obligate intracellular pathogens co-opt eukaryotic cellular functions has been limited by their intractability to genetic manipulation and by the abundance of pathogen-specific genes with no known functional homologues. In this report we describe a gene expression system to characterize protei...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2006.05074.x

    authors： Sisko JL,Spaeth K,Kumar Y,Valdivia RH

    更新日期：2006-04-01 00:00:00

  • Cellobiohydrolase A (CbhA) from the cellulolytic bacterium Cellulomonas fimi is a beta-1,4-exocellobiohydrolase analogous to Trichoderma reesei CBH II.

    abstract：:The gene cbhA from the cellulolytic bacterium Cellulomonas fimi encodes a protein of 872 amino acids designated cellobiohydrolase A (CbhA). Mature CbhA contains 832 amino acid residues and has a predicted molecular mass of 85,349 Da. It is composed of five domains: an N-terminal catalytic domain, three repeated sequen...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.1994.tb01030.x

    authors： Meinke A,Gilkes NR,Kwan E,Kilburn DG,Warren RA,Miller RC Jr

    更新日期：1994-05-01 00:00:00

  • The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids.

    abstract：:In response to discrete environmental cues, Saccharomyces cerevisiae cells adjust patterns of gene expression and protein activity to optimize metabolism. Nutrient-sensing systems situated in the plasma membrane (PM) of yeast have only recently been discovered. Ssy1p is one of three identified components of the Ssy1p-...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2958.2001.02627.x

    authors： Forsberg H,Gilstring CF,Zargari A,Martínez P,Ljungdahl PO

    更新日期：2001-10-01 00:00:00

  • One if by land, two if by sea: signalling to the ranks with CSP and XIP.

    abstract：:In many streptococci, quorum sensing utilizes secreted, linear peptides that engage cognate receptors to coordinate gene expression among members of a local population. Streptococcus mutans employs the secreted peptides CSP and XIP to stimulate production of antimicrobial bacteriocins and to induce development of comp...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/mmi.12029

    authors： Federle MJ,Morrison DA

    更新日期：2012-10-01 00:00:00

  • Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system.

    abstract：:Survival and replication inside host cells by Brucella spp. requires a type IV secretion system (T4SS), encoded by the virB locus. However, the identity of the molecules secreted by the T4SS has remained elusive. We hypothesized that proteins translocated by the T4SS would be co-regulated with the virB operon. The Lux...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2008.06487.x

    authors： de Jong MF,Sun YH,den Hartigh AB,van Dijl JM,Tsolis RM

    更新日期：2008-12-01 00:00:00

  • Proteolytic regulation of alginate overproduction in Pseudomonas aeruginosa.

    abstract：:Pseudomonas aeruginosa, a Gram-negative bacterium, is a significant opportunistic pathogen associated with skin and soft tissue infections, nosocomial pneumonia and sepsis. In addition, it can chronically colonize the lungs of cystic fibrosis (CF) patients. Overproduction of the exopolysaccharide called alginate provi...

    journal_title：Molecular microbiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2958.2012.08049.x

    authors： Damron FH,Goldberg JB

    更新日期：2012-05-01 00:00:00

  • Control of translation by mRNA secondary structure: the importance of the kinetics of structure formation.

    abstract：:RNA secondary structure is important in a wide variety of biological processes, but relatively little is known about the pathways and kinetics of RNA folding. When the IS10 transposase (tnp) gene is transcribed from a promoter outside the element, little increase in tnp expression is observed. This protection from out...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.1994.tb01337.x

    authors： Ma CK,Kolesnikow T,Rayner JC,Simons EL,Yim H,Simons RW

    更新日期：1994-12-01 00:00:00

  • Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR.

    abstract：:The Escherichia coli marRAB operon specifies two regulatory proteins, MarR (which represses) and MarA (which activates expression of the operon). The latter controls expression of multiple other chromosomal genes implicated in cell physiology, multiple drug resistance and virulence. Using randomly cloned E. coli DNA f...

    journal_title：Molecular microbiology

    pub_type： 杂志文章,收录出版

    doi：10.1111/j.1365-2958.2007.05928.x

    authors： Domain F,Bina XR,Levy SB

    更新日期：2007-10-01 00:00:00

  • Increasing competence in the genus Streptococcus.

    abstract：:Streptococcus pneumoniae is one of the most important model organisms for studies on natural genetic transformation in bacteria. The prevalence of this gene exchange mechanism in the genus Streptococcus has not been subjected to systematic investigations, but it has been known for decades that only a few streptococcal...

    journal_title：Molecular microbiology

    pub_type： 评论,杂志文章

    doi：10.1111/j.1365-2958.2010.07380.x

    authors： Håvarstein LS

    更新日期：2010-11-01 00:00:00

  • The pathogenic persona of community-associated oral streptococci.

    abstract：:The mitis group streptococci (MGS) are widespread in the oral cavity and are traditionally associated with oral health. However, these organisms have many attributes that contribute to the development of pathogenic oral communities. MGS adhere rapidly to saliva-coated tooth surfaces, thereby providing an attachment su...

    journal_title：Molecular microbiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2958.2011.07707.x

    authors： Whitmore SE,Lamont RJ

    更新日期：2011-07-01 00:00:00

  • The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage.

    abstract：:We have cloned, characterized and inactivated genes encoding putative UspA paralogues in Escherichia coli. The yecG (uspC), yiiT (uspD) and ydaA (uspE) genes were demonstrated to encode protein pro-ducts and these were mapped to spots in the E. coli proteomic database. Expression analysis using chromosomal transcripti...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2958.2002.02720.x

    authors： Gustavsson N,Diez A,Nyström T

    更新日期：2002-01-01 00:00:00

  • Direct MinE-membrane interaction contributes to the proper localization of MinDE in E. coli.

    abstract：:Dynamic oscillation of the Min system in Escherichia coli determines the placement of the division plane at the midcell. In addition to stimulating MinD ATPase activity, we report here that MinE can directly interact with the membrane and this interaction contributes to the proper MinDE localization and dynamics. The ...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2009.07006.x

    authors： Hsieh CW,Lin TY,Lai HM,Lin CC,Hsieh TS,Shih YL

    更新日期：2010-01-01 00:00:00

  • The role of a cytoplasmic loop of MotA in load-dependent assembly and disassembly dynamics of the MotA/B stator complex in the bacterial flagellar motor.

    abstract：:The proton-driven flagellar motor of Salmonella enterica can accommodate a dozen MotA/B stators in a load-dependent manner. The C-terminal periplasmic domain of MotB acts as a structural switch to regulate the number of active stators in the motor in response to load change. The cytoplasmic loop termed MotAC is respon...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/mmi.13843

    authors： Pourjaberi SNS,Terahara N,Namba K,Minamino T

    更新日期：2017-11-01 00:00:00

  • Constraints in chromosomal inversions in Escherichia coli are not explained by replication pausing at inverted terminator-like sequences.

    abstract：:Regions close to the replication terminus of the Escherichia coli chromosome are strongly refractory to genomic inversions. Since these regions also harbour polar replication terminator-like sequences or pause sites, we have investigated the possibility that slowing of replication as a result of pausing at inverted pa...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.1990.tb00621.x

    authors： François V,Louarn J,Patte J,Rebollo JE,Louarn JM

    更新日期：1990-04-01 00:00:00

  • Identification of DNA binding sites for ComE, a key regulator of natural competence in Streptococcus pneumoniae.

    abstract：:Natural competence in Streptococcus pneumoniae is regulated by a quorum-sensing mechanism consisting of a competence-stimulating peptide (CSP), its dedicated secretion apparatus (ComAB), its histidine kinase receptor (ComD) and a response regulator (ComE). In this report, we show that ComE is a DNA-binding protein tha...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2958.1999.01528.x

    authors： Ween O,Gaustad P,Håvarstein LS

    更新日期：1999-08-01 00:00:00

  • Patatin-like phospholipases in microbial infections with emerging roles in fatty acid metabolism and immune regulation by Apicomplexa.

    abstract：:Emerging lipidomic technologies have enabled researchers to dissect the complex roles of phospholipases in lipid metabolism, cellular signaling and immune regulation. Host phospholipase products are involved in stimulating and resolving the inflammatory response to pathogens. While many pathogen-derived phospholipases...

    journal_title：Molecular microbiology

    pub_type： 杂志文章,评审

    doi：10.1111/mmi.13871

    authors： Wilson SK,Knoll LJ

    更新日期：2018-01-01 00:00:00

  • Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae.

    abstract：:Virstatin is a previously described small molecule inhibitor of Vibrio cholerae virulence. We have demonstrated that the molecule inhibits the activity of the transcriptional activator ToxT, thereby preventing elaboration of the toxin co-regulated pilus (TCP) and cholera toxin in vitro and in vivo in O1 strains of V. ...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2007.05984.x

    authors： Shakhnovich EA,Sturtevant D,Mekalanos JJ

    更新日期：2007-12-01 00:00:00

  • Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases.

    abstract：:The extracellular polysaccharide capsule is an essential virulence factor of Neisseria meningitidis, a leading cause of severe bacterial meningitis and sepsis. Serogroup B strains, the primary disease causing isolates in Europe and America, are encapsulated in alpha-2,8 polysialic acid (polySia). The capsular polymer ...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2007.05862.x

    authors： Freiberger F,Claus H,Günzel A,Oltmann-Norden I,Vionnet J,Mühlenhoff M,Vogel U,Vann WF,Gerardy-Schahn R,Stummeyer K

    更新日期：2007-09-01 00:00:00

  • Alteration in glycerol and metalloid permeability by a single mutation in the extracellular C-loop of Leishmania major aquaglyceroporin LmAQP1.

    abstract：:The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of antimonite [Sb(III)], an activated form of Pentostam or Glucantime. Downregulation of LmAQP1 provides resistance to trivalent antimony compounds and increased expression of LmAQP1 in drug-resistant parasites can reverse the resistance. ...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2008.06494.x

    authors： Uzcategui NL,Zhou Y,Figarella K,Ye J,Mukhopadhyay R,Bhattacharjee H

    更新日期：2008-12-01 00:00:00

  • An isogenic haemolysin-deficient mutant of Haemophilus ducreyi lacks the ability to produce cytopathic effects on human foreskin fibroblasts.

    abstract：:The haemolysin of Haemophilus ducreyi is the newest member of the Proteus/Serratia family of pore-forming toxins. In order to assess the role of the haemolysin in virulence, we constructed an isogenic haemolysin-deficient mutant of H. ducreyi strain 35000 This strain, designated 35000-3, lacks detectable haemolytic ac...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2958.1996.00615.x

    authors： Palmer KL,Goldman WE,Munson RS Jr

    更新日期：1996-07-01 00:00:00

  • Activated chemoreceptor arrays remain intact and hexagonally packed.

    abstract：:Bacterial chemoreceptors cluster into exquisitively sensitive, tunable, highly ordered, polar arrays. While these arrays serve as paradigms of cell signalling in general, it remains unclear what conformational changes transduce signals from the periplasmic tips, where attractants and repellents bind, to the cytoplasmi...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2011.07854.x

    authors： Briegel A,Beeby M,Thanbichler M,Jensen GJ

    更新日期：2011-11-01 00:00:00

  • Green fluorescent protein-tagged sarco(endo)plasmic reticulum Ca2+-ATPase overexpression in Paramecium cells: isoforms, subcellular localization, biogenesis of cortical calcium stores and functional aspects.

    abstract：:We have followed the time-dependent transfection of Paramecium cells with a vector containing the gene of green fluorescent protein (GFP) attached to the C-terminus of the PtSERCA1 gene. The outlines of alveolar sacs (ASs) are labelled, as is the endoplasmic reticulum (ER) throughout the cell. When GFP fluorescence is...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2958.2000.02038.x

    authors： Hauser K,Pavlovic N,Klauke N,Geissinger D,Plattner H

    更新日期：2000-08-01 00:00:00

  • The conserved proline-rich motif is not essential for energy transduction by Escherichia coli TonB protein.

    abstract：:TonB protein functions as an energy transducer, coupling cytoplasmic membrane electrochemical potential to the active transport of vitamin B12 and Fe(III)-siderophore complexes across the outer membrane of Escherichia coli and other Gram-negative bacteria. Accumulated evidence indicates that TonB is anchored in the cy...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.1993.tb00966.x

    authors： Larsen RA,Wood GE,Postle K

    更新日期：1993-12-01 00:00:00

  • A dual role of the transcriptional regulator TstR provides insights into cyanide detoxification in Lactobacillus brevis.

    abstract：:In this study we uncover two genes in Lactobacillus brevis ATCC 367, tstT and tstR, encoding for a rhodanese and a transcriptional regulator involved in cyanide detoxification. TstT (LVIS_0852) belongs to a new class of thiosulphate:cyanide sulphurtransferases. We found that TstR (LVIS_0853) modulates both the express...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/mmi.12598

    authors： Pagliai FA,Murdoch CC,Brown SM,Gonzalez CF,Lorca GL

    更新日期：2014-05-01 00:00:00

  • To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators.

    abstract：:Bacteria sense and respond to their environment through the use of two-component regulatory systems. The ability to adapt to a wide range of environmental stresses is directly related to the number of two-component systems an organism possesses. Recent advances in this area have identified numerous variations on the a...

    journal_title：Molecular microbiology

    pub_type： 杂志文章,评审

    doi：10.1111/mmi.13532

    authors： Desai SK,Kenney LJ

    更新日期：2017-01-01 00:00:00

  • Analysis of the topology of the cytochrome d terminal oxidase complex of Escherichia coli by alkaline phosphatase fusions.

    abstract：:The cytochrome d complex of Escherichia coli is a heterodimer located in the bacterial cytoplasmic membrane, where it functions as a terminal oxidase of the aerobic respiratory chain. The topology of each of the two subunits of the cytochrome d complex was analysed by the genetic method involving alkaline phosphatase ...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.1991.tb02097.x

    authors： Newton G,Yun CH,Gennis RB

    更新日期：1991-10-01 00:00:00

  • An unusual pattern of protein expression and localization of yeast alanyl-tRNA synthetase isoforms.

    abstract：:Previous studies have shown that in Saccharomyces cerevisiae the mitochondrial and cytoplasmic forms of alanyl-tRNA synthetase are encoded by a single nuclear gene, ALA1, through alternative use of in-frame successive ACG triplets and a downstream AUG triplet. Here we show that despite the obvious participation of the...

    journal_title：Molecular microbiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2958.2006.05083.x

    authors： Huang HY,Tang HL,Chao HY,Yeh LS,Wang CC

    更新日期：2006-04-01 00:00:00