Transketolase A, an enzyme in central metabolism, derepresses the marRAB multiple antibiotic resistance operon of Escherichia coli by interaction with MarR.

abstract：:In the yeast Saccharomyces cerevisiae, genes involved in phospholipid biosynthesis are activated by ICRE (inositol/choline-responsive element) up-stream motifs and the corresponding heterodimeric binding factor, Ino2 + Ino4. Both Ino2 and Ino4 contain basic helix-loop-helix (bHLH) domains required for ICRE binding, wh...

journal_title：Molecular microbiology

authors： Dietz M,Heyken WT,Hoppen J,Geburtig S,Schüller HJ

更新日期：2003-05-01 00:00:00

abstract：:Candida albicans hyphae grow in a highly polarized fashion from their tips. This polarized growth requires the continuous delivery of secretory vesicles to the tip region. Vesicle delivery depends on Sec2p, the Guanine Exchange Factor (GEF) for the Rab GTPase Sec4p. GTP bound Sec4p is required for the transit of secre...

journal_title：Molecular microbiology

authors： Caballero-Lima D,Hautbergue GM,Wilson SA,Sudbery PE

更新日期：2014-11-01 00:00:00

abstract：:The majority of characterized bacterial dipeptide permeases (Dpp) are membrane-associated complexes of five proteins belonging to the ABC-transporter family. They have been found to be involved in the uptake of essential amino acids, haem production, chemotaxis and sporulation. A 5.8 kb genomic DNA fragment of the ser...

journal_title：Molecular microbiology

authors： Podbielski A,Leonard BA

更新日期：1998-06-01 00:00:00

abstract：:Biofilm formation in Bacillus subtilis requires the differentiation of a subpopulation of cells responsible for the production of the extracellular matrix that structures the biofilm. Differentiation of matrix-producing cells depends, among other factors, on the FloT and YqfA proteins. These proteins are present exclu...

journal_title：Molecular microbiology

authors： Yepes A,Schneider J,Mielich B,Koch G,García-Betancur JC,Ramamurthi KS,Vlamakis H,López D

更新日期：2012-10-01 00:00:00

abstract：:The spoIIIG gene encodes a sigma factor that determines prespore-specific gene expression during sporulation in Bacillus subtilis. Correct spatial and temporal expression of the spoIIIG gene depends on a number of other sporulation (spo) genes, but only one of these genes, spoIIIE, has a specific effect on spoIIIG exp...

journal_title：Molecular microbiology

authors： Foulger D,Errington J

更新日期：1989-09-01 00:00:00

abstract：:The best studied role of ubiquitination is to mark proteins for destruction by the proteasome but, in addition, it has recently been shown to promote macromolecular assembly and function, and alter protein function, thus playing a regulatory role distinct from protein degradation. Deubiquinating enzymes, the ubiquitin...

journal_title：Molecular microbiology

authors： Lockington RA,Kelly JM

更新日期：2001-06-01 00:00:00

abstract：:Many filamentous cyanobacteria are capable of gliding motility by an undefined mechanism. Within the heterocyst-forming clades, some strains, such as the Nostoc spp. and Fisherella spp., are motile only as specialized filaments termed hormogonia. Here we report on the phenotype of inactivation of a methyl-accepting ch...

journal_title：Molecular microbiology

authors： Risser DD,Meeks JC

更新日期：2013-02-01 00:00:00

abstract：:Clostridium difficile, an emerging nosocomial pathogen of increasing clinical significance, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The precise mechanisms by which toxin synthesis is regulated in response to environmental change have yet to be discove...

journal_title：Molecular microbiology

authors： Matamouros S,England P,Dupuy B

更新日期：2007-06-01 00:00:00

abstract：:polY, a transcriptional regulatory gene in the polyoxin biosynthetic cluster of Streptomyces cacaoi, was analysed, and its deduced product (PolY) showed amino acid sequence homology to AfsR from Streptomyces coelicolor A3(2). PolY contains an OmpR-like DNA binding domain at its N-terminal and an ATPase domain in the m...

journal_title：Molecular microbiology

authors： Li R,Liu G,Xie Z,He X,Chen W,Deng Z,Tan H

更新日期：2010-01-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, plays a critical role in the orchestration of immune responses. S1P levels within the mammalian host are tightly regulated, in part through the activity of S1P lyase (S1PL) which catalyses its irreversible degradation. Herein, we describe the identifi...

journal_title：Molecular microbiology

authors： Custódio R,McLean CJ,Scott AE,Lowther J,Kennedy A,Clarke DJ,Campopiano DJ,Sarkar-Tyson M,Brown AR

更新日期：2016-12-01 00:00:00

abstract：:The bvg locus contains two genes, bvgA and bvgS, which control the expression of the virulence-associated genes in Bordetella species by a system similar to the two-component systems used by a variety of bacterial species to respond to environmental stimuli. We determined the nucleotide sequence of the bvg loci of Bor...

journal_title：Molecular microbiology

authors： Aricò B,Scarlato V,Monack DM,Falkow S,Rappuoli R

更新日期：1991-10-01 00:00:00

abstract：:Numerous eukaryotes have developed specific metabolic traits that are not present in extensively studied model organisms. For instance, the procyclic insect form of Trypanosoma brucei, a parasite responsible for sleeping sickness in its mammalian-specific bloodstream form, metabolizes glucose into excreted succinate a...

journal_title：Molecular microbiology

authors： Bringaud F,Biran M,Millerioux Y,Wargnies M,Allmann S,Mazet M

更新日期：2015-06-01 00:00:00

abstract：:Streptococcus mutans, a commensal of the human oral cavity, can survive in the bloodstream and cause infective endocarditis (IE). However, the virulence factors associated with this manifestation of disease are not known. Here, we demonstrate that AtlA, an autolysin of S. mutans is a newly identified fibronectin (Fn) ...

journal_title：Molecular microbiology

authors： Jung CJ,Zheng QH,Shieh YH,Lin CS,Chia JS

更新日期：2009-11-01 00:00:00

abstract：:Fungal cellulolytic and hemicellulolytic enzymes are promising tools for industrial hydrolysis of cellulosic biomass; however, the regulatory network underlying their production is not well understood. The recent discovery of the transcriptional activators ClrB and McmA in Aspergillus nidulans implied a novel regulato...

journal_title：Molecular microbiology

authors： Li N,Kunitake E,Aoyama M,Ogawa M,Kanamaru K,Kimura M,Koyama Y,Kobayashi T

更新日期：2016-12-01 00:00:00

abstract：:A fragment of mitochondrial DNA containing the Kluyveromyces lactis gene for valine-tRNA (tRNAVAL) was isolated as a multicopy suppressor of a respiratory-deficient mutant of this yeast. The mutant produced a truncated Cox14p because of a +1 frameshift mutation in COX14, a nuclear gene encoding a protein imported into...

journal_title：Molecular microbiology

authors： Fiori A,Francisci S,Falcone C

更新日期：2002-10-01 00:00:00

abstract：:The carboxyl-terminal region of diphtheria toxin (DT) has been analysed in order to determine regions of receptor recognition. Biochemical cleavage of the toxin with hydroxylamine (HA) was used to generate the peptides HA9DT (residues 454-535), HA6DT (residues 482-535), and HA3DT (residues 454-481). Characterization o...

journal_title：Molecular microbiology

authors： Rolf JM,Eidels L

更新日期：1993-02-01 00:00:00

abstract：:Chromosomal rearrangements are common in both clinical isolates and spontaneous mutants of Candida albicans. It appears that many of these rearrangements are caused by translocations around the major sequence repeat (MSR) that is present in all chromosomes except chromosome 3, suggesting that homologous recombination ...

journal_title：Molecular microbiology

authors： Ciudad T,Andaluz E,Steinberg-Neifach O,Lue NF,Gow NA,Calderone RA,Larriba G

更新日期：2004-08-01 00:00:00

abstract：:A 25 kbp DNA fragment from the chromosome of Rhodobacter capsulatus B10 carrying hydrogenase (hup) determinants was completely sequenced. Coding regions corresponding to 20 open reading frames were identified. The R. capsulatus hydrogenase-specific gene (hup and hyp) products bear significant structural identity to hy...

journal_title：Molecular microbiology

authors： Colbeau A,Richaud P,Toussaint B,Caballero FJ,Elster C,Delphin C,Smith RL,Chabert J,Vignais PM

更新日期：1993-04-01 00:00:00

abstract：:Two papers in this issue of Molecular Microbiology from Carol Gross and colleagues describe experiments that investigate how two alternative Escherichia coli sigma proteins recognize target promoter -10 regions. A combination of genetics, biochemistry and bioinformatics is used to show that determinants in two adjacen...

journal_title：Molecular microbiology

authors： Busby SJ

更新日期：2009-05-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are persistent and toxic environmental pollutants that accumulate in anoxic habitats. With the exception of naphthalene, nothing is known about the microbial degradation of PAH in these environments. The challenge that must be met in anaerobic PAH degradation is the destabilizat...

journal_title：Molecular microbiology

authors： Sawers RG

更新日期：2015-01-01 00:00:00

abstract：:Escherichia coli FtsN is a bitopic membrane protein that is essential for triggering active cell constriction. A small periplasmic subdomain ((E) FtsN) is required and sufficient for function, but its mechanism of action is unclear. We isolated extragenic (E) FtsN*-suppressing mutations that restore division in cells ...

journal_title：Molecular microbiology

authors： Liu B,Persons L,Lee L,de Boer PA

更新日期：2015-03-01 00:00:00

abstract：:Salmonella typhimurium responds to a variety of environmental stresses by accumulating the alternative sigma factor sigmaS. The repertoire of sigmaS -dependent genes that are subsequently expressed confers tolerance to a variety of potentially lethal conditions including low pH and stationary phase. The mechanism(s) r...

journal_title：Molecular microbiology

authors： Webb C,Moreno M,Wilmes-Riesenberg M,Curtiss R 3rd,Foster JW

更新日期：1999-10-01 00:00:00

abstract：:Escherichia coli and Salmonella can use chitin-derived oligosaccharides as carbon and nitrogen sources. Chitosugars traverse the outer membrane through a dedicated chitoporin, ChiP, and are transported across the cytoplasmic membrane by the chitobiose transporter (ChbBCA). Previous work revealed that synthesis of the ...

journal_title：Molecular microbiology

authors： Plumbridge J,Bossi L,Oberto J,Wade JT,Figueroa-Bossi N

更新日期：2014-05-01 00:00:00

abstract：:Ferrichrome-iron is actively transported across the outer membrane of Escherichia coli by the TonB-dependent receptor FhuA. To obtain FhuA in a form suitable for secondary-structure analyses, a hexahistidine tag was inserted into a surface-located site and the recombinant protein was purified by metal chelate chromato...

journal_title：Molecular microbiology

authors： Moeck GS,Tawa P,Xiang H,Ismail AA,Turnbull JL,Coulton JW

更新日期：1996-11-01 00:00:00

abstract：:The 9.5 kb virB operon is the largest of the six major operons in the Ti plasmid vir region. This operon contains eleven genes, the largest of which is virB4. This gene encodes an 84 kDa protein whose function has not been identified. Its roles in conferring virulence on Agrobacterium tumefaciens and in the T-DNA tran...

journal_title：Molecular microbiology

authors： Shirasu K,Koukolíková-Nicola Z,Hohn B,Kado CI

更新日期：1994-02-01 00:00:00

abstract：:Whereas in Bacillus subtilis, a general stress response stimulon under the control of a single sigma factor (SigB) is induced by different physiological and environmental stresses (heat, salt or ethanol shock), in Streptomyces coelicolor, these environmental stresses induce independent sets of proteins, and its genome...

journal_title：Molecular microbiology

authors： Viollier PH,Kelemen GH,Dale GE,Nguyen KT,Buttner MJ,Thompson CJ

更新日期：2003-02-01 00:00:00

abstract：:Bacteria can respond to a variety of environmental stimuli by means of systems generally composed of two proteins. The first protein (sensor or transmitter) is usually a transmembrane protein with cytoplasmic and extracytoplasmic domains. The extracytoplasmic domain (sensor) senses the environment and transfers the si...

journal_title：Molecular microbiology

authors： Gross R,Aricò B,Rappuoli R

更新日期：1989-11-01 00:00:00

abstract：:The interactions between bacterial pathogens and their eukaryotic hosts are vital in determining the outcome of infections. Bacterial pathogens employ molecular sensors to detect and facilitate adaptation to changes in their niche. The sensing of these extracellular signals enables the pathogen to navigate within mamm...

journal_title：Molecular microbiology

authors： Karavolos MH,Winzer K,Williams P,Khan CM

更新日期：2013-02-01 00:00:00

abstract：:The actin-like protein FtsA is present in many eubacteria, and genetic experiments have shown that it plays an important, sometimes essential, role in cell division. Here, we show that Bacillus subtilis FtsA is targeted to division sites in both vegetative and sporulating cells. As in other organisms FtsA is probably ...

journal_title：Molecular microbiology

authors： Feucht A,Lucet I,Yudkin MD,Errington J

更新日期：2001-04-01 00:00:00

abstract：:Several bacterial genera express proteins that contain collagen-like regions, which are associated with variable (V) non-collagenous regions. The streptococcal collagen-like proteins, Scl1 and Scl2, of group A Streptococcus (GAS) are members of this 'prokaryotic collagen' family, and they too contain an amino-terminal...

journal_title：Molecular microbiology

authors： Han R,Caswell CC,Lukomska E,Keene DR,Pawlowski M,Bujnicki JM,Kim JK,Lukomski S

更新日期：2006-07-01 00:00:00