Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38.

abstract：:To study the role of L-type voltage-gated Ca++ channels in oligodendrocyte development, we used a mouse model of Timothy syndrome (TS) in which a gain-of-function mutation in the α1 subunit of the L-type Ca++ channel Cav1.2 gives rise to an autism spectrum disorder (ASD). Oligodendrocyte progenitor cells (OPCs) isolat...

journal_title：Glia

authors： Cheli VT,Santiago González DA,Zamora NN,Lama TN,Spreuer V,Rasmusson RL,Bett GC,Panagiotakos G,Paez PM

更新日期：2018-11-01 00:00:00

abstract：:Recent studies have suggested that Nkx6.2/Gtx and Nkx2.2 homeodomain transcription factors are involved in the regulation of oligodendrocyte maturation and/or myelination which occur predominantly in postnatal stages. However, their cellular specificity in postnatal central nervous system has not been characterized an...

journal_title：Glia

authors： Cai J,Zhu Q,Zheng K,Li H,Qi Y,Cao Q,Qiu M

更新日期：2010-03-01 00:00:00

abstract：:Allograft inflammatory factor-1 (AIF-1) is a Ca2+ binding peptide expressed predominantly by activated monocytes. In order to investigate the role of AIF-1 in autoimmune lesions of the rat nervous system, we have used a synthetic gene to express AIF-1 in E. coli and have produced monoclonal antibodies against AIF-1. A...

journal_title：Glia

authors： Schluesener HJ,Seid K,Kretzschmar J,Meyermann R

更新日期：1998-10-01 00:00:00

abstract：:Replication-defective Moloney murine leukemia virus expressing the GAD67 gene under the control of the GFAP promoter was produced using selected clones of a fibroblast-packaging cell line. A spontaneously immortalized astrocyte cell line was infected with this virus and cellular clones expressing GAD67 selected. Astro...

journal_title：Glia

authors： Sacchettoni SA,Benchaibi M,Sindou M,Belin MF,Jacquemont B

更新日期：1998-01-01 00:00:00

abstract：:Based on their typical pattern of membrane currents, four populations of glial cells could be identified in thin brain slices of the postnatal hippocampus. In the present study, we applied the patch-clamp technique to glial cells in the hippocampal CA1 region, which are characterized by a complex pattern of different ...

journal_title：Glia

authors： Akopian G,Kressin K,Derouiche A,Steinhäuser C

更新日期：1996-07-01 00:00:00

abstract：:Mechanisms of major histocompatibility complex (MHC) class I gene regulation in cells of the CNS have been studied in vitro. Astrocytes in primary cultures, but neither oligodendrocytes nor neurons, constitutively expressed cell surface MHC class I molecules. Interferon-gamma (IFN-gamma) treatment led to induction of ...

journal_title：Glia

authors： Massa PT,Ozato K,McFarlin DE

更新日期：1993-07-01 00:00:00

abstract：:Microglia, the innate immune cells of the brain, have recently been removed from the position of mere sentinels and promoted to the role of active sculptors of developing circuits and cells. Alongside their functions in normal brain development, microglia coordinate sexual differentiation of the brain, a set of proces...

journal_title：Glia

authors： VanRyzin JW,Marquardt AE,Pickett LA,McCarthy MM

更新日期：2020-06-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the main component of intermediate filaments in astrocytes. To assess its function in astrocyte swelling, we compared astrocyte membrane properties and swelling in spinal cord slices of 8- to 10-day-old wild-type control (GFAP(+/+)) and GFAP-knockout (GFAP(-/-)) mice. Membrane...

journal_title：Glia

authors： Anderová M,Kubinová S,Mazel T,Chvátal A,Eliasson C,Pekny M,Syková E

更新日期：2001-09-01 00:00:00

abstract：:External application of bradykinin (BK) to mouse neuroblastoma X mouse fibroblast hybrid NL308 cells and mouse neuroblastoma X rat glioma hybrid NG108-15 cells produced a transient outward (hyperpolarizing) current. In NG108-15 cells, BK also induced an inward (depolarizing) current associated with a decrease in input...

journal_title：Glia

authors： Higashida H,Okano Y,Hoshi N,Yada Y,Yokoyama S,Asaga T,Fu T,Nozawa Y

更新日期：1990-01-01 00:00:00

abstract：:The substantia gelatinosa (SG) of the spinal cord processes incoming painful information to ascending projection neurons. Whole-cell patch clamp recordings from SG spinal cord slices documented that in a low Ca(2+) /no Mg(2+) (low X(2+) ) external medium adenosine triphosphate (ATP)/dibenzoyl-ATP, Bz-ATP) caused inwar...

journal_title：Glia

authors： Ficker C,Rozmer K,Kató E,Andó RD,Schumann L,Krügel U,Franke H,Sperlágh B,Riedel T,Illes P

更新日期：2014-10-01 00:00:00

abstract：:Astrocytes release a variety of transmitter molecules, which mediate communication between glial cells in the brain and modulate synaptic transmission. ATP is a major glia-derived transmitter, but the mechanisms and kinetics of ATP release from astrocytes remain largely unknown. Here, we combined epifluorescence and t...

journal_title：Glia

authors： Pryazhnikov E,Khiroug L

更新日期：2008-01-01 00:00:00

abstract：:Accumulative evidence indicates that microglial cells influence the normal development of central nervous system (CNS) synapses. Yet, the functional properties of microglia in relation with synapse development remain unclear. We recently showed that in layer 4 of the whisker-related barrel field of the mouse somatosen...

journal_title：Glia

authors： Arnoux I,Hoshiko M,Mandavy L,Avignone E,Yamamoto N,Audinat E

更新日期：2013-10-01 00:00:00

abstract：:Water balance between cells and extracellular compartments is essential for proper functioning of the central nervous system, as demonstrated by its perturbations in pathological conditions. Aquaporin 4 (AQP4) is the predominant water channel in brain and spinal cord, where it is present mainly on astrocytic endfeet c...

journal_title：Glia

authors： Vitellaro-Zuccarello L,Mazzetti S,Bosisio P,Monti C,De Biasi S

更新日期：2005-08-01 00:00:00

abstract：:To investigate the possible role of neurons and astrocytes for oligodendrocyte development we prepared a pure population of precursor cells positive for the precursor marker GD3 with the help of fluorescence-activated cell sorting (FACS). Large numbers of highly purified cells were obtained from postnatal day 1 rat br...

journal_title：Glia

authors： Dutly F,Schwab ME

更新日期：1991-01-01 00:00:00

abstract：:Gamma-secretase is an aspartyl protease composed of four proteins: presenilin (PS), nicastrin (Nct), APH1, and PEN2. These proteins assemble into a membrane complex that cleaves a variety of substrates within the transmembrane domain. The gamma-secretase cleavage products play an important role in various biological p...

journal_title：Glia

authors： Nadler Y,Alexandrovich A,Grigoriadis N,Hartmann T,Rao KS,Shohami E,Stein R

更新日期：2008-04-01 00:00:00

abstract：:Inhibition of Rho-kinase (ROCK) with Y27632 stimulates sprouting by injured corticospinal tract and dorsal column tract axons, and accelerates functional recovery. However, regeneration of these axons across the glial scar was not observed. Here we examined the effects of Y27632 treatment on chondroitin sulfate proteo...

journal_title：Glia

authors： Chan CC,Wong AK,Liu J,Steeves JD,Tetzlaff W

更新日期：2007-03-01 00:00:00

abstract：:Microglia are known to regulate several aspects of the development of the central nervous system. When microglia colonize the spinal cord, from E11.5 in the mouse embryo, they interact with growing central axons of dorsal root ganglion sensory neurons (SNs), which suggests that they may have some functions in SN devel...

journal_title：Glia

authors： Angelim MKSC,Maia LMSS,Mouffle C,Ginhoux F,Low D,Amancio-Dos-Santos A,Makhoul J,Le Corronc H,Mangin JM,Legendre P

更新日期：2018-11-01 00:00:00

abstract：:Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain macrophage (microgl...

journal_title：Glia

authors： Solga AC,Pong WW,Walker J,Wylie T,Magrini V,Apicelli AJ,Griffith M,Griffith OL,Kohsaka S,Wu GF,Brody DL,Mardis ER,Gutmann DH

更新日期：2015-04-01 00:00:00

abstract：:Long-term, persistent central nervous system inflammation is commonly seen following brain infection. Using a murine model of viral encephalitis (murine cytomegalovirus, MCMV) we have previously shown that post-encephalitic brains are maintained in an inflammatory state consisting of glial cell reactivity, retention o...

journal_title：Glia

authors： Lokensgard JR,Schachtele SJ,Mutnal MB,Sheng WS,Prasad S,Hu S

更新日期：2015-11-01 00:00:00

abstract：:Astrocytes are thought to play a variety of key roles in the adult brain, such as their participation in synaptic transmission, in wound healing upon brain injury, and adult neurogenesis. However, to elucidate these functions in vivo has been difficult because of the lack of astrocyte-specific gene targeting. Here we ...

journal_title：Glia

authors： Mori T,Tanaka K,Buffo A,Wurst W,Kühn R,Götz M

更新日期：2006-07-01 00:00:00

abstract：:In the cerebellar cortex, Bergmann glia enclose the synapses of both parallel and climbing fiber inputs to the Purkinje neuron. The glia express Ca(2+)-permeable AMPA receptors, and the GLAST and GLT-1 classes of glutamate transporter, which are activated by glutamate released during synaptic transmission. We have pre...

journal_title：Glia

authors： Balakrishnan S,Bellamy TC

更新日期：2009-03-01 00:00:00

abstract：:Astrocytes express gap junction proteins and multiple types of P2Y receptors (P2YRs) that contribute to the propagation of intercellular Ca(2+) waves (ICW). To gain access to the role played by gap junctional communication in ICW propagation generated by P2YR activation, we selectively expressed P2Y(1,2,4)R subtypes a...

journal_title：Glia

authors： Suadicani SO,Flores CE,Urban-Maldonado M,Beelitz M,Scemes E

更新日期：2004-11-15 00:00:00

abstract：:The glial cells that ensheath olfactory axons are referred to as ensheathing cells. In vivo, these non-myelinating glial cells express a mixture of astrocyte-specific and Schwann cell-specific phenotypic features with the former cellular phenotype predominating, but in vitro can assemble a myelin sheath when co-cultur...

journal_title：Glia

authors： Doucette R,Devon R

更新日期：1994-04-01 00:00:00

abstract：:It is now generally accepted that massive neuronal death due to oxidative stress is a regular feature of brains in neurodegenerative diseases. However, much less attention has been given to the death of glial cells. In this study, we examined p53-sensitive apoptosis of cells by using human glioblastoma A172 cells and ...

journal_title：Glia

authors： Kitamura Y,Ota T,Matsuoka Y,Tooyama I,Kimura H,Shimohama S,Nomura Y,Gebicke-Haerter PJ,Taniguchi T

更新日期：1999-01-15 00:00:00

abstract：:Plaque deposition in Alzheimer's disease (AD) is known to decrease proliferation in neurogenic niches in AD mouse models, but the effects on cell proliferation and differentiation in other brain areas have not been studied in detail. We analyzed cell proliferation in the cortex of wild type (WT) and APPswePS1dE9 trans...

journal_title：Glia

authors： Kamphuis W,Orre M,Kooijman L,Dahmen M,Hol EM

更新日期：2012-04-01 00:00:00

abstract：:Neurosteroids, such as progesterone, influence central nervous system development and function by regulating a broad spectrum of physiological processes. Here, we investigated membrane-initiated actions of progesterone in the retina and identified the membrane-associated progesterone receptor component 1 (PGRMC1). We ...

journal_title：Glia

authors： Swiatek-De Lange M,Stampfl A,Hauck SM,Zischka H,Gloeckner CJ,Deeg CA,Ueffing M

更新日期：2007-08-01 00:00:00

abstract：:Transcriptional regulation of the glial fibrillary acidic protein gene (GFAP) is of interest because of its astrocyte specificity and its upregulation in response to CNS injuries. We have used a transgenic approach instead of cell transfection to identify promoter elements of the human GFAP gene, since previous observ...

journal_title：Glia

authors： Yeo S,Bandyopadhyay S,Messing A,Brenner M

更新日期：2013-09-01 00:00:00

abstract：:We examined the optic nerve, as an analogous tissue to brain white matter, to assess possible relationships between changes in the blood-nerve barrier, axonal integrity, and astrocyte morphology in the central nervous system during fatal murine cerebral malaria (FMCM). In the FMCM model, namely, CBA mice infected with...

journal_title：Glia

authors： Ma N,Madigan MC,Chan-Ling T,Hunt NH

更新日期：1997-02-01 00:00:00

abstract：:Glial cells from different brain regions and species are depolarized by the neurotransmitter glutamate. The depolarization or, if voltage-clamped at the resting membrane potential, the inward current induced by glutamate could be due either to activation of receptor-coupled ion channels or electrogenic uptake of the t...

journal_title：Glia

authors： Sontheimer H,Kettenmann H,Backus KH,Schachner M

更新日期：1988-01-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is a platelet-derived bioactive sphingolipid that evokes a variety of biological responses. To understand the role of S1P in the central nervous system, we have examined the effect of S1P on the production of glial cell line-derived neurotrophic factor (GDNF) and growth regulation of cort...

journal_title：Glia

authors： Yamagata K,Tagami M,Torii Y,Takenaga F,Tsumagari S,Itoh S,Yamori Y,Nara Y

更新日期：2003-01-15 00:00:00