Traumatic cerebral vascular injury: the effects of concussive brain injury on the cerebral vasculature.

abstract：:Previous studies have shown that location and direction of injury may affect outcome in experimental models of traumatic brain injury. Significant variability in outcome data has also been noted in studies using the lateral fluid percussion brain injury model (FPI) in rats. In recent studies from our laboratory, we ob...

journal_title：Journal of neurotrauma

authors： Vink R,Mullins PG,Temple MD,Bao W,Faden AI

更新日期：2001-08-01 00:00:00

abstract：:Previous studies have shown that oxygen radical scavengers prevent the reduced cerebral blood flow that occurs following experimental traumatic brain injury. The exact chemical species responsible for the posttraumatic reduction in flow is unknown. We tested whether isoprostanes, which are formed by non-cyclooxygenase...

journal_title：Journal of neurotrauma

authors： Hoffman SW,Rzigalinski BA,Willoughby KA,Ellis EF

更新日期：2000-05-01 00:00:00

abstract：:Physician prescribed rest after traumatic brain injury (TBI) is both commonplace and an increasingly scrutinized approach to TBI treatment. Although this practice remains a standard of patient care for TBI, research of patient outcomes reveals little to no benefit of prescribed rest after TBI, and in some cases prolon...

journal_title：Journal of neurotrauma

authors： Karelina K,Schneiderman K,Shah S,Fitzgerald J,Velazquez Cruz R,Oliverio R,Whitehead B,Yang J,Weil Z

更新日期：2021-01-20 00:00:00

abstract：:Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of the large, heterogeneous data sets involved. In this sense, tra...

journal_title：Journal of neurotrauma

authors： Nielson JL,Guandique CF,Liu AW,Burke DA,Lash AT,Moseanko R,Hawbecker S,Strand SC,Zdunowski S,Irvine KA,Brock JH,Nout-Lomas YS,Gensel JC,Anderson KD,Segal MR,Rosenzweig ES,Magnuson DS,Whittemore SR,McTigue DM,Popovic

更新日期：2014-11-01 00:00:00

abstract：:This prospective longitudinal study compares the ability of conventional and diffusion tensor imaging (DTI) parameters made at the cervical spinal cord injury (CSCI) site to predict long-term neurological and functional outcomes. Twenty patients with CSCI, with follow-up at 6 or 12 months, and 15 control volunteers we...

journal_title：Journal of neurotrauma

authors： Shanmuganathan K,Zhuo J,Bodanapally UK,Kuladeep S,Aarabi B,Adams J,Miller C,Gullapallie RP,Menakar J

更新日期：2020-02-01 00:00:00

abstract：:The physiological characteristics of spinal cord responses recorded from the spinal epidural space of the cat to transcranial brain stimulation were studied, in comparison with the spinal cord responses to direct stimulation of the motor cortex or cerebellum. The conduction velocity of the initial wave of the response...

journal_title：Journal of neurotrauma

authors： Yamamoto T,Xing JA,Katayama Y,Tsubokawa T,Hirayama T,Maejima S

更新日期：1990-01-01 00:00:00

abstract：:This study investigated corticomotor excitability and inhibition, cognitive functioning, and fine motor dexterity in retired elite and amateur Australian football (AF) players who had sustained concussions during their playing careers. Forty male AF players who played at the elite level (n=20; mean age 49.7±5.7 years)...

journal_title：Journal of neurotrauma

authors： Pearce AJ,Hoy K,Rogers MA,Corp DT,Maller JJ,Drury HG,Fitzgerald PB

更新日期：2014-07-01 00:00:00

abstract：:Here we investigate the effect of hypothermia on the expression of apoptosis-regulating protein TIMP-3 after fluid percussion traumatic brain injury (TBI) in rats. We began with 210 adult male Sprague-Dawley rats and randomly assigned them to three groups: TBI with hypothermia treatment (32°C), TBI with normothermia (...

journal_title：Journal of neurotrauma

authors： Jia F,Mao Q,Liang YM,Jiang JY

更新日期：2014-02-15 00:00:00

abstract：:The effect of flunarizine and methylprednisolone on the recovery of somatosensory evoked potentials (SEPs) was evaluated in an experimental model of spinal cord impact injury in anesthetized cats. In addition, the effect of flunarizine on posttraumatic spinal cord blood flow (SCBF) (using the hydrogen clearance techni...

journal_title：Journal of neurotrauma

authors： De Ley G,Leybaert L

更新日期：1993-04-01 00:00:00

abstract：:Head injury patients not meeting the American Congress of Rehabilitation Medicine (ACRM)'s criteria for mild traumatic brain injury (mTBI), referred to hereafter as HIBRID (Head Injury BRain Injury Debatable), are often excluded from studies. The prognostic importance of HIBRID is unclear. We investigated the differen...

journal_title：Journal of neurotrauma

authors： Korley FK,Diaz-Arrastia R,Falk HJ,Peters ME,Leoutsakos JS,Roy D,Rao V,Sair HI,Ofoche U,Hall AJ,Akbari F,Van Meter TE,Everett AD,Van Eyk JE,Bechtold KT

更新日期：2017-04-15 00:00:00

abstract：:Spinal cord injury (SCI) leading to neurological deficits produces long-term effects that persist over a lifetime. Survival analysis of patients with SCI, at individual and population level, is important for public health management and the assessment of treatment achievements. The current study evaluated survival fol...

journal_title：Journal of neurotrauma

authors： van den Berg ME,Castellote JM,de Pedro-Cuesta J,Mahillo-Fernandez I

更新日期：2010-08-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) is one of the major causes of death in younger age groups. In Umeå, Sweden, an intracranial pressure (ICP) targeted therapy protocol, the Lund concept, has been used in treatment of severe TBI since 1994. Decompressive craniectomy is used as a protocol-guided treatment step. The pri...

journal_title：Journal of neurotrauma

authors： Olivecrona M,Rodling-Wahlström M,Naredi S,Koskinen LO

更新日期：2007-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with enhanced osteogenesis. The aim of this study was to investigate the effect of serum from TBI rats on fracture healing. Results from this study showed that the serum from TBI rats enhanced the expression of bone gamma carboxyglutamate protein (BGLAP), and promoted in vitr...

journal_title：Journal of neurotrauma

authors： Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu S

更新日期：2012-11-20 00:00:00

abstract：:The exact mechanism of hypothermic cerebroprotection after traumatic brain injury (TBI) is not fully understood. The present study was conducted to investigate the effects of mild hypothermia on trauma-induced synthesis of nitric oxide (NO), which has been implicated in the pathogenesis of ischemic brain damage associ...

journal_title：Journal of neurotrauma

authors： Sakamoto KI,Fujisawa H,Koizumi H,Tsuchida E,Ito H,Sadamitsu D,Maekawa T

更新日期：1997-05-01 00:00:00

abstract：:Following a controlled, severe contusion lesion to the lower thoracic spinal cord in adult rats, we found that apoptosis occurred in cells located in both gray and white matter. This suggested that both nonneuronal cells, including astrocytes, oligodendroglia and microglia, as well as neurons, might participate in pro...

journal_title：Journal of neurotrauma

authors： Yong C,Arnold PM,Zoubine MN,Citron BA,Watanabe I,Berman NE,Festoff BW

更新日期：1998-07-01 00:00:00

abstract：:The Balance Error Scoring System (BESS) is a commonly used concussion assessment tool. Recent studies have questioned the stability and reliability of baseline BESS scores. The purpose of this longitudinal prospective cohort study is to examine differences in yearly baseline BESS scores in athletes participating on an...

journal_title：Journal of neurotrauma

authors： Mathiasen R,Hogrefe C,Harland K,Peterson A,Smoot MK

更新日期：2018-02-15 00:00:00

abstract：:Axon retraction greatly limits functional recovery after spinal cord injury (SCI) and neuron polarization, which affects processes including axon formation and development, is a promising target for promoting axon regeneration. Increasing microtubule stability has been demonstrated to improve intrinsic axon regenerati...

journal_title：Journal of neurotrauma

authors： Wang Q,Cai H,Hu Z,Wu Y,Guo X,Li J,Wang H,Liu Y,Liu Y,Xie L,Xu K,Xu H,He H,Zhang H,Xiao J

更新日期：2019-06-15 00:00:00

abstract：:The activation of oxidative damage, neuroinflammation, and mitochondrial dysfunction has been implicated in secondary pathomechanisms following spinal cord injury (SCI). These pathophysiological processes lead to cell death and are tightly regulated by nuclear factor E2-related factor 2/antioxidant response element (N...

journal_title：Journal of neurotrauma

authors： Wang X,de Rivero Vaccari JP,Wang H,Diaz P,German R,Marcillo AE,Keane RW

更新日期：2012-03-20 00:00:00

abstract：:Dementia pugilistica (DP) is associated with chronic traumatic brain injury (CTBI), and leads to a "punch drunk" syndrome characterized by impairments in memory and executive function, behavioral changes, and motor signs. Microscopic features include the accumulation of neurofibrillary tangles (NFTs), beta-amyloid (Aβ...

journal_title：Journal of neurotrauma

authors： Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head E

更新日期：2012-04-10 00:00:00

abstract：:Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxation magnetic resonance imaging (MRI) predicts the progression of perilesional cortical pathology and epileptogenesis. The ...

journal_title：Journal of neurotrauma

authors： Manninen E,Chary K,Lapinlampi N,Andrade P,Paananen T,Sierra A,Tohka J,Gröhn O,Pitkänen A

更新日期：2020-12-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) elicits a complex cascade of cellular and molecular inflammatory events. Although certain aspects of the inflammatory response are essential to wound healing and repair, post-SCI inflammation is, on balance, thought to be detrimental to recovery by causing "bystander damage" and the ...

journal_title：Journal of neurotrauma

authors： Gillespie ER,Ruitenberg MJ

更新日期：2020-08-26 00:00:00

abstract：:To evaluate new pharmacologic agents with potentially beneficial effects on posttraumatic spinal cord function, we used a modified weight drop (WD) technique to induce spinal cord injuries. These contusive spinal cord injuries in the rat closely mimic the human clinicopathologic situation. Especially for drug screenin...

journal_title：Journal of neurotrauma

authors： van de Meent H,Hamers FP,Lankhorst AJ,Buise MP,Joosten EA,Gispen WH

更新日期：1996-12-01 00:00:00

abstract：:Hearing impairment can be one of the more subtle deficits seen after closed head injury (CHI), and it may not be diagnosed until late in the recovery phase if at all. Most studies have assessed patients immediately after CHI. Repeated assessments at regular intervals were not performed in the majority of studies done ...

journal_title：Journal of neurotrauma

authors： Munjal SK,Panda NK,Pathak A

更新日期：2010-02-01 00:00:00

abstract：:Contusion-type cervical spinal cord injury (SCI) is one of the most common forms of SCI observed in patients. In particular, injuries targeting the C3-C5 region affect the pool of phrenic motor neurons (PhMNs) that innervates the diaphragm, resulting in significant and often chronic respiratory dysfunction. Using a pr...

journal_title：Journal of neurotrauma

authors： Nicaise C,Frank DM,Hala TJ,Authelet M,Pochet R,Adriaens D,Brion JP,Wright MC,Lepore AC

更新日期：2013-06-15 00:00:00

abstract：:A critical component for accelerating the clinical uptake of research data in the area of pediatric concussion or mild traumatic brain injury (MTBI) pertains to the establishment and utilization of common databases. The objective of the first phase of our CanPedCDE initiative was to agree upon pediatric common data el...

journal_title：Journal of neurotrauma

authors： Gagnon I,Friedman D,Beauchamp MH,Christie B,DeMatteo C,Macartney G,McFadyen BJ,Sirois K,Taneja C,Zabjek K,Zemek R,Mrazik M

更新日期：2018-08-15 00:00:00

abstract：:. ...

journal_title：Journal of neurotrauma

authors： Maas A

更新日期：2018-08-04 00:00:00

abstract：:The past 10 years have seen a rapid increase in the use of diffusion tensor imaging to identify biomarkers of traumatic brain injury (TBI). Although the literature generally indicates decreased anisotropic diffusion at more chronic injury periods and in more severe injuries, considerable debate remains regarding the d...

journal_title：Journal of neurotrauma

authors： Dodd AB,Epstein K,Ling JM,Mayer AR

更新日期：2014-07-15 00:00:00

abstract：:Accurate localization of cerebrospinal fluid (CSF) fistula in a patient with CSF rhinorrhea is challenging and often involves multiple imaging studies with associated expense and patient discomfort. Intrathecal contrast-enhanced computed tomography (CT) and unenhanced magnetic resonance (MR) cisternography using const...

journal_title：Journal of neurotrauma

authors： Goel G,Ravishankar S,Jayakumar PN,Vasudev MK,Shivshankar JJ,Rose D,Anandh B

更新日期：2007-10-01 00:00:00

abstract：:The serum phosphorylated neurofilament heavy subunit (pNF-H) is a nervous system-specific protein that is released from damaged neural tissue after traumatic brain injury (TBI). The aim of this study was to elucidate the usefulness of serum pNF-H as a predictive marker for the outcome of patients after TBI. Patients w...

journal_title：Journal of neurotrauma

authors： Shibahashi K,Doi T,Tanaka S,Hoda H,Chikuda H,Sawada Y,Takasu Y,Chiba K,Nozaki T,Hamabe Y,Ogata T

更新日期：2016-10-15 00:00:00

abstract：:Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI); however, the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following T...

journal_title：Journal of neurotrauma

authors： Wolf JA,Johnson BN,Johnson VE,Putt ME,Browne KD,Mietus CJ,Brown DP,Wofford KL,Smith DH,Grady MS,Cohen AS,Cullen DK

更新日期：2017-07-15 00:00:00