Abstract:
:The effect of flunarizine and methylprednisolone on the recovery of somatosensory evoked potentials (SEPs) was evaluated in an experimental model of spinal cord impact injury in anesthetized cats. In addition, the effect of flunarizine on posttraumatic spinal cord blood flow (SCBF) (using the hydrogen clearance technique) and interstitial calcium and potassium activity (ion-selective electrodes) was investigated. After the injury (600 g.cm), SEPs disappeared, followed by a spontaneous recovery to 17% of the preinjury amplitude at the end of the 4 h observation period. Flunarizine treatment (0.1 mg/kg IV, given 5 and 120 min after injury) resulted in a significantly improved recovery of SEPs, reaching 52% of the preinjury amplitude. Methylprednisolone treatment (30 mg/kg IV, given 5 min after injury) resulted in a 30% recovery level, significantly better than in untreated animals but significantly inferior to flunarizine treatment. Combination of both treatments resulted in a 62% recovery level, significantly better than after methylprednisolone treatment alone. Flunarizine treatment had no significant effect on the postinjury evolution of SCBF and interstitial potassium activity; it did, however, significantly accelerate the recovery of interstitial calcium activity, which sharply decreased immediately after injury. It is concluded that intravenous administration of the calcium entry blocker flunarizine improves the functional recovery of the spinal cord in the acute phase after experimental spinal impact injury. The observed improvement is not achieved by an effect on local blood flow but is possibly related to an inhibitory effect of the drug on cellular calcium entry.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
De Ley G,Leybaert Ldoi
10.1089/neu.1993.10.25subject
Has Abstractpub_date
1993-04-01 00:00:00pages
25-35issue
1eissn
0897-7151issn
1557-9042journal_volume
10pub_type
杂志文章abstract::The object of this study was to investigate the relationships of age on neurologic and functional outcome, hospitalization length of stay (LOS), and hospital charges after spinal cord injury (SCI). At 20 medical centers, 2,169 consecutive adult patients with paraplegia SCI were assessed in acute care and inpatient reh...
journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:1998-11-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2020-12-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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更新日期:2004-03-01 00:00:00
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journal_title:Journal of neurotrauma
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更新日期:2013-07-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2009.0987
更新日期:2009-12-01 00:00:00
abstract::Traumatic Brain Injury (TBI) can be associated with partial or total smell loss. Recent studies have suggested that olfactory outcome can be positively modulated after olfactory training (OT). This study's aim was to investigate OT's potential role in smell recovery after TBI-induced olfactory loss. A prospective, ran...
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-11-15 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/089771503321532842
更新日期:2003-03-01 00:00:00
abstract::This study characterized the Infinite Horizon (IH) Impactor for use in mouse models of contusion spinal cord injury (SCI), and investigated the feasibility and reliability of using magnetic resonance imaging (MRI) as a method to accurately measure lesion volume after mouse contusion SCI. Eight-week-old female C57Bl/6 ...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2006.0204
更新日期:2007-04-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
abstract::The relationship between brain injury and attentional control (AC) long after a childhood traumatic brain injury (TBI) has received limited investigation. The aim of this article was to investigate the impact that lesion presence, location, and severity has on AC in a group of young persons who had sustained a moderat...
journal_title:Journal of neurotrauma
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更新日期:2014-04-15 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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abstract::We sought to determine whether the exposure to the sub-concussive blows that occur during division III collegiate collision sports affect later life neurobehavioral quality-of-life measures. We conducted a cross-sectional study of alumni from four division III colleges, targeting those between the ages of 40-70 years,...
journal_title:Journal of neurotrauma
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