Is there a relationship between chronic pain and autonomic dysreflexia in persons with cervical spinal cord injury?

abstract：:Traumatic brain injury (TBI) affects millions of individuals each year and is a leading cause of death and disability worldwide. TBI is heterogeneous and outcome is influenced by a combination of factors that include injury location, severity, genetics, and environmental factors. More recently, sex as a biological var...

journal_title：Journal of neurotrauma

authors： Giordano KR,Rojas-Valencia LM,Bhargava V,Lifshitz J

更新日期：2020-12-01 00:00:00

abstract：:Mood disturbances, including depression and anxiety disorders, are common and disabling long-term sequelae of traumatic brain injury (TBI). These psychiatric conditions have generally been considered psychosocial consequences of the trauma, but neurobiological alterations and causes have also been implicated. Using a ...

journal_title：Journal of neurotrauma

authors： Jones NC,Cardamone L,Williams JP,Salzberg MR,Myers D,O'Brien TJ

更新日期：2008-11-01 00:00:00

abstract：:Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological ...

journal_title：Journal of neurotrauma

authors： Noain D,Büchele F,Schreglmann SR,Valko PO,Gavrilov YV,Morawska MM,Imbach LL,Baumann CR

更新日期：2018-01-01 00:00:00

abstract：:After experimental traumatic brain injury (TBI), calcineurin is upregulated; blocking calcineurin is associated with improved outcomes. In humans, variation in the calcineurin A-gamma gene (PPP3CC) has been associated with neuropsychiatric disorders, though any role in TBI recovery remains unknown. This study examines...

journal_title：Journal of neurotrauma

authors： Osier ND,Bales JW,Pugh B,Shin S,Wyrobek J,Puccio AM,Okonkwo DO,Ren D,Alexander S,Conley YP,Dixon CE

更新日期：2017-01-01 00:00:00

abstract：:Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI); however, the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following T...

journal_title：Journal of neurotrauma

authors： Wolf JA,Johnson BN,Johnson VE,Putt ME,Browne KD,Mietus CJ,Brown DP,Wofford KL,Smith DH,Grady MS,Cohen AS,Cullen DK

更新日期：2017-07-15 00:00:00

abstract：:The detection of reactive oxygen species (ROS) after traumatic brain injury (TBI) is based on indirect methods due to the high reactivity and short half-life of ROS in biological tissue. The commonly used salicylate trapping method has several disadvantages making it unsuitable for human use. We have evaluated 4-hydro...

journal_title：Journal of neurotrauma

authors： Marklund N,Clausen F,Lewander T,Hillered L

更新日期：2001-11-01 00:00:00

abstract：:Previous studies convincingly suggest that the biopsychosocial fear-avoidance model (FAM) may be of added value in understanding chronic disability after traumatic brain injury (TBI). In this model, persistent symptoms occur as a result of catastrophizing and fear-avoidance regarding initial symptoms, leading to depre...

journal_title：Journal of neurotrauma

authors： Wijenberg MLM,Hicks AJ,Downing MG,van Heugten CM,Stapert SZ,Ponsford JL

更新日期：2020-12-15 00:00:00

abstract：:Previous studies have shown that oxygen radical scavengers prevent the reduced cerebral blood flow that occurs following experimental traumatic brain injury. The exact chemical species responsible for the posttraumatic reduction in flow is unknown. We tested whether isoprostanes, which are formed by non-cyclooxygenase...

journal_title：Journal of neurotrauma

authors： Hoffman SW,Rzigalinski BA,Willoughby KA,Ellis EF

更新日期：2000-05-01 00:00:00

abstract：:Multipotent neural progenitors and stem cells may integrate appropriately into the developing and degenerating central nervous system. They may also be effective in the replacement of genes, cells, and nondiffusible factors in either a widespread or a more circumscribed manner, depending on the therapeutic demands of ...

journal_title：Journal of neurotrauma

authors： Park KI,Liu S,Flax JD,Nissim S,Stieg PE,Snyder EY

更新日期：1999-08-01 00:00:00

abstract：:In this study we investigated regional cerebral glucose metabolism abnormalities of [(18)F] fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in traumatic brain injury (TBI). PET images of 81 TBI patients and 68 normal controls were acquired and a word list learning task was administered during the u...

journal_title：Journal of neurotrauma

authors： Zhang J,Mitsis EM,Chu K,Newmark RE,Hazlett EA,Buchsbaum MS

更新日期：2010-01-01 00:00:00

abstract：:In terms of human suffering, medical expenses, and lost productivity, head injury is one of the major health care problems in the United States, and inadequate cerebral blood flow is an important contributor to mortality and morbidity after traumatic brain injury. Despite the importance of cerebral vascular dysfunctio...

journal_title：Journal of neurotrauma

authors： DeWitt DS,Prough DS

更新日期：2003-09-01 00:00:00

abstract：:The horizontal ladder task is an established method to assess skilled locomotor recovery after neurological dysfunction. Walking speed is often used as a standardized measure in locomotor assessment of overground walking in human and pre-clinical studies, but the assessment of walking speed is typically ignored during...

journal_title：Journal of neurotrauma

authors： Richards TM,Sharma P,Kuang A,Whitty D,Ahmed Z,Shah PK

更新日期：2019-09-15 00:00:00

abstract：:Anesthetics can either promote or inhibit the development of neurogenic pulmonary edema (NPE) after central nervous system (CNS) injury. The influence of isoflurane was examined in male Wistar rats using 1.5%, 2%, 2.5%, 3%, 4%, or 5% isoflurane in air. Epidural balloon compression of the thoracic spinal cord was perfo...

journal_title：Journal of neurotrauma

authors： Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Burian M,Jendelová P,Zicha J,Kunes J,Syková E

更新日期：2007-09-01 00:00:00

abstract：:Current thinking views mild head impact (i.e., subconcussion) as an underrecognized phenomenon that has the ability to cause significant current and future detrimental neurological effects. Repeated mild impacts to the head, however, often display no observable behavioral deficits based on standard clinical tests, whi...

journal_title：Journal of neurotrauma

authors： Hwang S,Ma L,Kawata K,Tierney R,Jeka JJ

更新日期：2017-01-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death for individuals with spinal cord injury (SCI). Because of a lack of a standardized and accessible animal model for cardiovascular disease after SCI, few laboratories have conducted pre-clinical trials aimed at reinstating descending cardiovascular control. Here, we ...

journal_title：Journal of neurotrauma

authors： Squair JW,West CR,Popok D,Assinck P,Liu J,Tetzlaff W,Krassioukov AV

更新日期：2017-02-01 00:00:00

abstract：:This study created a framework incorporating provider perspectives of best practices for early psychosocial intervention to improve caregiver experiences and outcomes after severe pediatric traumatic brain injury (TBI). A purposive sample of 23 healthcare providers from the emergency, intensive care, and acute care de...

journal_title：Journal of neurotrauma

authors： Erlick MR,Vavilala MS,Jaffe KM,Blayney CB,Moore M

更新日期：2020-11-09 00:00:00

abstract：:A therapeutic strategy for acute spinal cord injury would be to reduce the progressive degeneration and disconnection of axons from their targets. Here, we describe a model to evaluate degeneration of the ascending sensory projections to the nuclei in the medulla following graded spinal cord contusions in adult female...

journal_title：Journal of neurotrauma

authors： Baker KA,Hagg T

更新日期：2005-04-01 00:00:00

abstract：:A systematic review of the literature was performed to address pertinent clinical questions regarding deep vein thrombosis (DVT) prophylaxis in the setting of acute spinal cord injury (SCI). Deep vein thromboses are a common occurrence following SCI. Administration of low-molecular-weight heparin (LMWH) within 72 h of...

journal_title：Journal of neurotrauma

authors： Christie S,Thibault-Halman G,Casha S

更新日期：2011-08-01 00:00:00

abstract：:Strategies aimed at improving spinal cord regeneration after trauma are still challenging neurologists and neuroscientists throughout the world. Many cell-based therapies have been tested, with limited success in terms of functional outcome. In this study, we investigated the effects of human dental pulp cells (HDPCs)...

journal_title：Journal of neurotrauma

authors： de Almeida FM,Marques SA,Ramalho Bdos S,Rodrigues RF,Cadilhe DV,Furtado D,Kerkis I,Pereira LV,Rehen SK,Martinez AM

更新日期：2011-09-01 00:00:00

abstract：:It is the aim of the present paper to correlate clinical symptoms of auditory dysfunction (tinnitus, hyperacusis, hearing loss) one year on average after a blunt trauma of the head with objective audiological test results (otoacoustic emission and auditory brainstem response testing, impedance audiometry) and to compa...

journal_title：Journal of neurotrauma

authors： Nölle C,Todt I,Seidl RO,Ernst A

更新日期：2004-03-01 00:00:00

abstract：:Prior studies have shown that neurons within the spinal cord are sensitive to response-outcome relations, a form of instrumental learning. Spinally transected rats that receive shock to one hind leg learn to maintain the leg in a flexed position that minimizes net shock exposure (controllable shock). Prior exposure to...

journal_title：Journal of neurotrauma

authors： Grau JW,Washburn SN,Hook MA,Ferguson AR,Crown ED,Garcia G,Bolding KA,Miranda RC

更新日期：2004-12-01 00:00:00

abstract：:Human head trauma is frequently associated with respiratory problems resulting in secondary hypoxic insult. To document the behavioral consequences of secondary hypoxia in an established model of traumatic brain injury (TBI), intubated anesthetized animals were subjected to fluid percussion (FP) injury (1.87-2.17 atm)...

journal_title：Journal of neurotrauma

authors： Bramlett HM,Dietrich WD,Green EJ

更新日期：1999-11-01 00:00:00

abstract：:Lesions in specific areas of the rat motor cortex generate deficits related to fine movement performance affecting the forelimb. We have previously shown that transplants of embryonic frontal cortex ameliorate these motor deficits. Amelioration has been associated with a functional integration of the transplant due to...

journal_title：Journal of neurotrauma

authors： Santos-Torres J,Heredia M,Riolobos AS,Jiménez-Díaz L,Gómez-Bautista V,de la Fuente A,Criado JM,Navarro-López J,Yajeya J

更新日期：2009-09-01 00:00:00

abstract：:Remarkable advances have been made in pharmacologic treatments of acute and chronic spinal cord injury. The recent National Acute Spinal Cord Injury Study (NASCIS) showed that very high dose methylprednisolone given within 8 hr after injury improves neurologic recovery. The mechanism is believed to be inhibition of li...

journal_title：Journal of neurotrauma

authors： Nockels R,Young W

更新日期：1992-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and disability. Yet, despite immense research efforts, treatment options remain elusive. Translational failures in TBI are often attributed to the heterogeneity of the TBI population and limited methods to capture these individual variabilities. Advances in mach...

journal_title：Journal of neurotrauma

authors： Radabaugh H,Bonnell J,Schwartz O,Sarkar D,Dietrich WD,Bramlett HM

更新日期：2021-01-13 00:00:00

abstract：:Spinal cord injury (SCI) leading to neurological deficits produces long-term effects that persist over a lifetime. Survival analysis of patients with SCI, at individual and population level, is important for public health management and the assessment of treatment achievements. The current study evaluated survival fol...

journal_title：Journal of neurotrauma

authors： van den Berg ME,Castellote JM,de Pedro-Cuesta J,Mahillo-Fernandez I

更新日期：2010-08-01 00:00:00

abstract：:Penetrating traumatic brain injury (PTBI) is one of the major cause of death and disability worldwide. Previous studies with penetrating ballistic-like brain injury (PBBI), a PTBI rat model revealed widespread perilesional neurodegeneration, similar to that seen in humans following gunshot wound to the head, which is ...

journal_title：Journal of neurotrauma

authors： Spurlock MS,Ahmed AI,Rivera KN,Yokobori S,Lee SW,Sam PN,Shear DA,Hefferan MP,Hazel TG,Johe KK,Gajavelli S,Tortella FC,Bullock RM

更新日期：2017-06-01 00:00:00

abstract：:Cytokine measurement directly from the brain parenchyma by means of microdialysis has documented the activation of certain procedures in vivo, after brain trauma in humans. However, the intercalation of the micro-catheter insertion with the phenomena triggered by the head trauma renders the assessment of the findings ...

journal_title：Journal of neurotrauma

authors： Bouras TI,Gatzonis SS,Georgakoulias N,Karatza M,Sianouni A,Stranjalis G,Boviatsis E,Vasileiou S,Sakas DE

更新日期：2011-11-18 00:00:00

abstract：:Traumatic brain injury (TBI) results in an accumulation of edema and loss of brain tissue. Progesterone (PROG) has been reported to reduce edema and cortical tissue loss in a bilateral prefrontal cortex injury. This study tests the hypothesis that PROG is neuroprotective following a unilateral parietal cortical contus...

journal_title：Journal of neurotrauma

authors： Gilmer LK,Roberts KN,Scheff SW

更新日期：2008-06-01 00:00:00

abstract：:The efficacy of end-to-side repair as a method of nerve reconstruction has been questioned, and most studies that characterize the mode of re-innervation are marred by inappropriate experimental design and lack quantitative analysis. This makes characterization of re-innervating neurons confusing and consequently cont...

journal_title：Journal of neurotrauma

authors： Sananpanich K,Galea MP,Morrison WA,Messina A

更新日期：2007-05-01 00:00:00