Abstract:
:The expression of the heat shock proteins hsp27 and hsp70 was examined in the spinal cord and sciatic nerves of developing rats. Using immunohistochemistry, we found that hsp27 is present in many motoneurones at birth. With development, the intensity of staining increases, reaching adult levels by 21 days, when all sciatic motoneurones express hsp27. In the sciatic nerve, hsp27 is strongly expressed throughout postnatal development. In contrast, hsp70 immunoreactivity in motoneurones and the sciatic nerve is weak at birth and does not change with development. The expression of heat shock proteins has been shown to increase in cells under conditions of stress, where they have beneficial effects on cell survival. The effect of neonatal nerve injury on hsp27 and hsp70 expression was also examined in this study. Four days after injury, staining for hsp27 increases in motoneurones, whereas hsp70 does not change. However, there is a significant increase in hsp70 staining in glial cells surrounding the injured motor pool, predominantly in astrocytes. Since neonatal nerve injury induces apoptotic motoneurone death, we also studied the co-expression of hsp27 with markers of apoptosis. No hsp27-positive motoneurones were found to be apoptotic, as assessed by both TUNEL and caspase-3 immunoreactivity. Therefore, it is possible that the upregulation of hsp27 observed in injured motoneurones may play a role in protecting motoneurones from apoptotic cell death following nerve injury.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Kalmár B,Burnstock G,Vrbová G,Greensmith Ldoi
10.1089/089771502753754127subject
Has Abstractpub_date
2002-05-01 00:00:00pages
667-79issue
5eissn
0897-7151issn
1557-9042journal_volume
19pub_type
杂志文章abstract::This study investigated corticomotor excitability and inhibition, cognitive functioning, and fine motor dexterity in retired elite and amateur Australian football (AF) players who had sustained concussions during their playing careers. Forty male AF players who played at the elite level (n=20; mean age 49.7±5.7 years)...
journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-03-01 00:00:00
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更新日期:2017-10-01 00:00:00
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更新日期:2010-02-01 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 临床试验,杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Journal of neurotrauma
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doi:10.1089/neu.2006.0028
更新日期:2007-02-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.1998.15.199
更新日期:1998-03-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2019.6602
更新日期:2020-01-15 00:00:00
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journal_title:Journal of neurotrauma
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doi:10.1089/neu.2016.4446
更新日期:2017-01-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2017.5402
更新日期:2018-05-15 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
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doi:10.1089/089771503767869944
更新日期:2003-08-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,多中心研究
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更新日期:1999-09-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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