Modulating inflammatory cell responses to spinal cord injury: all in good time.

abstract：:Wars in Afghanistan and Iraq have resulted in thousands of military personnel suffering traumatic brain injury (TBI), including closed-head injuries. Of interest is whether these individuals and other TBI survivors are at increased risk for substance use disorder (SUD). While it has been well established that drug or ...

journal_title：Journal of neurotrauma

authors： Bjork JM,Grant SJ

更新日期：2009-07-01 00:00:00

abstract：:Statins constitute a class of medications commonly used in the treatment of elevated cholesterol. However, in experimental studies, statins also have other non-cholesterol-mediated mechanisms of action, which may have neuroprotective effects. The aim of this study was to determine whether administration of atorvastati...

journal_title：Journal of neurotrauma

authors： Robertson CS,McCarthy JJ,Miller ER,Levin H,McCauley SR,Swank PR

更新日期：2017-02-27 00:00:00

abstract：:This study aimed to investigate the cortical motor excitability characteristics in diffuse axonal injury (DAI) due to severe traumatic brain injury (TBI). A variety of excitatory and inhibitory transcranial magnetic stimulation (TMS) paradigms were applied to primary motor cortices of 17 patients and 11 healthy contro...

journal_title：Journal of neurotrauma

authors： Bernabeu M,Demirtas-Tatlidede A,Opisso E,Lopez R,Tormos JM,Pascual-Leone A

更新日期：2009-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a health threat that affects every year millions of people involved in motor vehicle and sporting accidents, and thousands of soldiers in battlefields. Diffuse axonal injury (DAI) is one of the most frequent types of TBI leading to death. In DAI, the initial traumatic event is followed ...

journal_title：Journal of neurotrauma

authors： Zhu F,Gatti DL,Yang KH

更新日期：2016-05-01 00:00:00

abstract：:The mechanism by which mechanical impact to brain tissue is transduced to neuronal impairment remains poorly understood. Using an in vitro model of neuronal stretch, we found that mechanical stretch of neurons resulted in a transient plasma membrane permeability increase. Primary cortical neurons, seeded on silicone s...

journal_title：Journal of neurotrauma

authors： Geddes DM,Cargill RS 2nd,LaPlaca MC

更新日期：2003-10-01 00:00:00

abstract：:Predicting outcome after pediatric traumatic brain injury (TBI) is important for providing information to families and prescribing rehabilitation services. The study objective was to assess whether biomarkers concentrations obtained at the time of injury are associated with outcome. Serial serum concentrations of neur...

journal_title：Journal of neurotrauma

authors： Berger RP,Beers SR,Richichi R,Wiesman D,Adelson PD

更新日期：2007-12-01 00:00:00

abstract：:Stretching of cultured neurons has been used to model diffuse axonal injury associated with brain trauma. N-Methyl-D-aspartate receptor (NMDAR) activation and group I metabotropic glutamate receptors (mGluRs) are implicated in the pathophysiology of such injury. Here we detail the effects of culture condition and mGlu...

journal_title：Journal of neurotrauma

authors： Lea PM 4th,Custer SJ,Stoica BA,Faden AI

更新日期：2003-11-01 00:00:00

abstract：:Increasing evidence indicates that post-traumatic stress disorder (PTSD) may develop following traumatic brain injury (TBI), despite most patients having no conscious memory of their accident. This prospective study examined the frequency, timing of onset, symptom profile, and trajectory of PTSD and its psychiatric co...

journal_title：Journal of neurotrauma

authors： Alway Y,Gould KR,McKay A,Johnston L,Ponsford J

更新日期：2016-05-01 00:00:00

abstract：:The translation of therapeutic interventions to humans with spinal cord injury with the goal of promoting growth and repair in the central nervous system could, inadvertently, drive mechanisms associated with the development of neuropathic pain. A framework is needed to evaluate the probability that a therapeutic inte...

journal_title：Journal of neurotrauma

authors： Warner FM,Cragg JJ,Jutzeler CR,Finnerup NB,Werhagen L,Weidner N,Maier D,Kalke YB,Curt A,Kramer JLK

更新日期：2019-05-01 00:00:00

abstract：:It is now generally accepted that excitotoxic cell death involves bioenergetic failure resulting from the cycling of Ca2+ and the generation of reactive oxygen species (ROS) by mitochondria. Both Ca2+ cycling and ROS formation by mitochondria are dependent on the mitochondrial membrane potential (Deltapsi(m)) that res...

journal_title：Journal of neurotrauma

authors： Korde AS,Sullivan PG,Maragos WF

更新日期：2005-10-01 00:00:00

abstract：:Anatomical studies of spinal cord injury (SCI) using magnetic resonance imaging (MRI) report diverging observations, from "no changes" to "tissue atrophy in motor and non-motor regions." These discrepancies among studies can be attributed to heterogeneity in extent, level, and post-injury duration observed within the ...

journal_title：Journal of neurotrauma

authors： Karunakaran KD,He J,Zhao J,Cui JL,Zang YF,Zhang Z,Biswal BB

更新日期：2019-06-15 00:00:00

abstract：:. ...

journal_title：Journal of neurotrauma

authors： Maas A

更新日期：2018-08-04 00:00:00

abstract：:Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast...

journal_title：Journal of neurotrauma

authors： Struebing FL,King R,Li Y,Chrenek MA,Lyuboslavsky PN,Sidhu CS,Iuvone PM,Geisert EE

更新日期：2018-01-01 00:00:00

abstract：:Athletes who sustain a concussion demonstrate a variety of symptoms and neuropsychological alterations that could be brought on by neurometabolic abnormalities. However, no study has yet investigated these aspects in female athletes using magnetic resonance spectroscopy. The present study investigated the neurometabol...

journal_title：Journal of neurotrauma

authors： Chamard E,Henry L,Boulanger Y,Lassonde M,Théoret H

更新日期：2014-02-15 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:Following a controlled, severe contusion lesion to the lower thoracic spinal cord in adult rats, we found that apoptosis occurred in cells located in both gray and white matter. This suggested that both nonneuronal cells, including astrocytes, oligodendroglia and microglia, as well as neurons, might participate in pro...

journal_title：Journal of neurotrauma

authors： Yong C,Arnold PM,Zoubine MN,Citron BA,Watanabe I,Berman NE,Festoff BW

更新日期：1998-07-01 00:00:00

abstract：:Our aim for this study was to quantitatively develop an early epidural hematoma (EDH) natural evolutionary curve and assess association of the most common radiological signs of initially nonsurgical supratentorial EDHs on early computed tomography (CT), in addition to their CT time for EDH enlargement. We retrospectiv...

journal_title：Journal of neurotrauma

authors： Xiao B,Ma MY,Duan ZX,Liu JG,Chen RP,Mao Q

更新日期：2015-04-01 00:00:00

abstract：:Inflammatory lesions in the brain activate a systemic acute-phase response (APR), which is dependent on the release of extracellular vesicles (EVs) into the circulation. The resulting APR is responsible for regulating leukocyte mobilization and subsequent recruitment to the brain. Factors that either exacerbate or inh...

journal_title：Journal of neurotrauma

authors： Hazelton I,Yates A,Dale A,Roodselaar J,Akbar N,Ruitenberg MJ,Anthony DC,Couch Y

更新日期：2018-02-15 00:00:00

abstract：:Intraspinal injections of lysolecithin were used to produce unilateral demyelination in the dorsal columns of the rat spinal cord. The purpose of this study was to evaluate the effects of demyelination on the conductive properties of axons belonging to a spinal pathway of known origin and site of termination. At 5 and...

journal_title：Journal of neurotrauma

authors： Yezierski RP,Devon RM,Vicedomini JP,Broton JG

更新日期：1992-10-01 00:00:00

abstract：:Magnetic resonance imaging data were acquired at ∼24 h and ∼3 months post-injury on mild traumatic brain injury (mTBI; n = 75) and orthopedic injury (n = 60) cohorts. The mTBI subjects were randomly assigned to a treatment group with atorvastatin or a non-treatment mTBI group. The treatment group was further divided i...

journal_title：Journal of neurotrauma

authors： Govindarajan KA,Narayana PA,Hasan KM,Wilde EA,Levin HS,Hunter JV,Miller ER,Patel VK,Robertson CS,McCarthy JJ

更新日期：2016-10-15 00:00:00

abstract：:Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...

journal_title：Journal of neurotrauma

authors： Schwab JM,Seid K,Schluesener HJ

更新日期：2001-09-01 00:00:00

abstract：:We sought to determine sensitivity of the cortical impact injury model of traumatic brain injury (TBI) to severity of injury and to treatment. We examined the pattern of motor and cognitive deficits and recovery following TBI over a range of injury severities, and examined the efficacy of surface-induced moderate hypo...

journal_title：Journal of neurotrauma

authors： Markgraf CG,Clifton GL,Aguirre M,Chaney SF,Knox-Du Bois C,Kennon K,Verma N

更新日期：2001-02-01 00:00:00

abstract：:Traumatic brain injuries (TBI) are one of the least understood injuries to the body. Finite element (FE) models of the brain have been crucial for understanding concussion and for developing injury mitigation systems; however, the experimental brain deformation data currently used to validate these models are limited....

journal_title：Journal of neurotrauma

authors： Alshareef A,Giudice JS,Forman J,Salzar RS,Panzer MB

更新日期：2018-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur i...

journal_title：Journal of neurotrauma

authors： Abu Hamdeh S,Ciuculete DM,Sarkisyan D,Bakalkin G,Ingelsson M,Schiöth HB,Marklund N

更新日期：2021-01-08 00:00:00

abstract：:The Balance Error Scoring System (BESS) is a commonly used concussion assessment tool. Recent studies have questioned the stability and reliability of baseline BESS scores. The purpose of this longitudinal prospective cohort study is to examine differences in yearly baseline BESS scores in athletes participating on an...

journal_title：Journal of neurotrauma

authors： Mathiasen R,Hogrefe C,Harland K,Peterson A,Smoot MK

更新日期：2018-02-15 00:00:00

abstract：:The excessive generation of free radicals is thought to be one of the major mechanisms leading to tissue injury in various pathological conditions, including ischemia, inflammation, and trauma. Conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) contributes to the formation of superoxide, an oxygen rad...

journal_title：Journal of neurotrauma

authors： Xu J,Beckman JS,Hogan EL,Hsu CY

更新日期：1991-04-01 00:00:00

abstract：:Aging may be an important factor affecting brain injury by intracerebral hemorrhage (ICH). In the present study, we investigated the responses of glial cells and monocytes to intracerebral hemorrhage in normal and aged rats. ICH was induced by microinjecting autologous whole blood (15 microL) into the striatum of youn...

journal_title：Journal of neurotrauma

authors： Lee JC,Cho GS,Choi BO,Kim HC,Kim WK

更新日期：2009-09-01 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) and neuropsychological assessment were utilized in a longitudinal investigation of traumatic brain injury (TBI) in children. A spectroscopic imaging protocol was implemented, and neurometabolite ratios of NAA/Cre and Cho/Cre were calculated for anterior and posterior hal...

journal_title：Journal of neurotrauma

authors： Yeo RA,Phillips JP,Jung RE,Brown AJ,Campbell RC,Brooks WM

更新日期：2006-10-01 00:00:00

abstract：:This study created a framework incorporating provider perspectives of best practices for early psychosocial intervention to improve caregiver experiences and outcomes after severe pediatric traumatic brain injury (TBI). A purposive sample of 23 healthcare providers from the emergency, intensive care, and acute care de...

journal_title：Journal of neurotrauma

authors： Erlick MR,Vavilala MS,Jaffe KM,Blayney CB,Moore M

更新日期：2020-11-09 00:00:00

abstract：:Moderate to severe traumatic brain injury (TBI) in humans and rats induces measurable metabolic changes, including a sustained depression in cerebral glucose uptake. However, the effect of a mild TBI on brain glucose uptake is unclear, particularly in rodent models. This study aimed to determine the glucose uptake pat...

journal_title：Journal of neurotrauma

authors： Selwyn R,Hockenbury N,Jaiswal S,Mathur S,Armstrong RC,Byrnes KR

更新日期：2013-12-01 00:00:00