Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System.

abstract：:Persistent post-traumatic headache (PPTH) is often the most common injury after mild traumatic brain injury (mTBI), reported by 47-95% of patients. Progressive muscle relaxation (PMR) has level A evidence in preventing migraine and tension headaches. However, research on this behavioral therapy for PPTH, let alone sma...

journal_title：Journal of neurotrauma

authors： Usmani S,Balcer L,Galetta S,Minen M

更新日期：2021-01-01 00:00:00

abstract：:Athletes in contact sports sustain repetitive subconcussive head impacts in a brief window, yet neurophysiological sequelae from repetitive subconcussion remain unclear. This prospective longitudinal study examined a relationship between changes in plasma Tau protein levels and subconcussive impact kinematic data in 2...

journal_title：Journal of neurotrauma

authors： Kawata K,Rubin LH,Wesley L,Lee JH,Sim T,Takahagi M,Bellamy A,Tierney R,Langford D

更新日期：2018-01-15 00:00:00

abstract：:Neuroinflammation and dysfunction of the blood-brain barrier (BBB) are two prominent mechanisms of secondary injury in neurotrauma. It has been suggested that Toll-like receptors (TLRs) play important roles in initiating and propagating neuroinflammation resulting from traumatic brain injury (TBI), but potential benef...

journal_title：Journal of neurotrauma

authors： Bennett M,Chin A,Lee HJ,Morales Cestero E,Strazielle N,Ghersi-Egea JF,Threlkeld SW,Schmidt TA,Richendrfer HA,Szmydynger-Chodobska J,Jay GD,Chodobski A

更新日期：2020-10-19 00:00:00

abstract：:The relationship between psychotropic medication use and traumatic brain injury (TBI) is not well understood. The objective of this study was to describe patterns of psychotropic medication use during the months before and after TBI and compare with a non-TBI cohort. We conducted a retrospective cohort study using adm...

journal_title：Journal of neurotrauma

authors： Albrecht JS,Wickwire EM,Mullins CD,Rao V

更新日期：2020-04-15 00:00:00

abstract：:Individuals with a mild traumatic brain injury (mTBI) often have executive control deficits; however, the underlying neural mechanisms of such deficits are yet to be clarified. Inhibitory control and cognitive monitoring are two fundamental aspects of executive control processes. This study investigated the executive ...

journal_title：Journal of neurotrauma

authors： Shen IH,Lin YJ,Chen CL,Liao CC

更新日期：2020-01-01 00:00:00

abstract：:A systematic review of the literature was performed to address pertinent clinical questions regarding deep vein thrombosis (DVT) prophylaxis in the setting of acute spinal cord injury (SCI). Deep vein thromboses are a common occurrence following SCI. Administration of low-molecular-weight heparin (LMWH) within 72 h of...

journal_title：Journal of neurotrauma

authors： Christie S,Thibault-Halman G,Casha S

更新日期：2011-08-01 00:00:00

abstract：:Striatal-enriched tyrosine phosphatase (STEP) has been identified as a component of physiological and pathophysiological signaling pathways mediated by N-methyl-d-aspartate (NMDA) receptor/calcineurin/calpain activation. Activation of these pathways produces a subsequent change in STEP isoform expression or activation...

journal_title：Journal of neurotrauma

authors： Mesfin MN,von Reyn CR,Mott RE,Putt ME,Meaney DF

更新日期：2012-07-01 00:00:00

abstract：:Improving survival and brain function after initial resuscitation from cardiac arrest remains a critical challenge with few therapeutic options. The publication of several randomized controlled trials supporting the use of therapeutic hypothermia in cardiac arrest survivors has provided a remarkable opportunity to red...

journal_title：Journal of neurotrauma

authors： Sugerman NT,Abella BS

更新日期：2009-03-01 00:00:00

abstract：:The striatum, together with the hippocampus, is one of the most vulnerable regions in the brain. Recently, genetic abnormalities or mutations have been linked to various neurodegenerative diseases, that is, Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), etc., but the processes from gen...

journal_title：Journal of neurotrauma

authors： Nishino H,Hida H,Kumazaki M,Shimano Y,Nakajima K,Shimizu H,Ooiwa T,Baba H

更新日期：2000-03-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) elicits a complex cascade of cellular and molecular inflammatory events. Although certain aspects of the inflammatory response are essential to wound healing and repair, post-SCI inflammation is, on balance, thought to be detrimental to recovery by causing "bystander damage" and the ...

journal_title：Journal of neurotrauma

authors： Gillespie ER,Ruitenberg MJ

更新日期：2020-08-26 00:00:00

abstract：:Traumatic brain injury (TBI) is a silent epidemic affecting approximately 1.4 million Americans annually, at an estimated annual cost of $60 billion in the United States alone. Despite an increased understanding of the pathophysiology of closed head injury, there remains no pharmacological intervention proven to impro...

journal_title：Journal of neurotrauma

authors： Laskowitz DT,McKenna SE,Song P,Wang H,Durham L,Yeung N,Christensen D,Vitek MP

更新日期：2007-07-01 00:00:00

abstract：:Clinical trials aimed at developing therapies for traumatic brain injury (TBI) require outcome measures that are reliable, validated, and easily administered. The most widely used of these measures, the Glasgow Outcome Scale (GOS) and the GOS-Extended (GOS-E), have been criticized as suffering from ceiling effects. In...

journal_title：Journal of neurotrauma

authors： Hudak AM,Caesar RR,Frol AB,Krueger K,Harper CR,Temkin NR,Dikmen SS,Carlile M,Madden C,Diaz-Arrastia R

更新日期：2005-11-01 00:00:00

abstract：:Studies have shown reduced life expectancy following moderate-severe traumatic brain injury (TBI) with death from unintentional poisoning (UP) being 11 times higher following TBI than in the general population. The characteristics of those who die of unintentional poisoning are compared with the characteristics of tho...

journal_title：Journal of neurotrauma

authors： Hammond FM,Ketchum J,Dams-O'Connor K,Corrigan JD,Miller C,Haarbauer-Krupa J,Faul M,Trexler LE,Harrison-Felix C

更新日期：2020-12-01 00:00:00

abstract：:This study characterized the Infinite Horizon (IH) Impactor for use in mouse models of contusion spinal cord injury (SCI), and investigated the feasibility and reliability of using magnetic resonance imaging (MRI) as a method to accurately measure lesion volume after mouse contusion SCI. Eight-week-old female C57Bl/6 ...

journal_title：Journal of neurotrauma

authors： Nishi RA,Liu H,Chu Y,Hamamura M,Su MY,Nalcioglu O,Anderson AJ

更新日期：2007-04-01 00:00:00

abstract：:Traumatic brain injuries (TBI) are one of the least understood injuries to the body. Finite element (FE) models of the brain have been crucial for understanding concussion and for developing injury mitigation systems; however, the experimental brain deformation data currently used to validate these models are limited....

journal_title：Journal of neurotrauma

authors： Alshareef A,Giudice JS,Forman J,Salzar RS,Panzer MB

更新日期：2018-03-01 00:00:00

abstract：:Complications in upper and lower urinary function arise after spinal cord injury (SCI), which creates a significant impact on quality of life for those affected. One upper urinary complication is SCI-induced polyuria, or the overproduction of urine, of which the underlying mechanisms have yet to be elucidated. Activit...

journal_title：Journal of neurotrauma

authors： Gumbel JH,Montgomery LR,Yang CB,Hubscher CH

更新日期：2020-02-01 00:00:00

abstract：:In various animal and human studies, early administration of 17β-estradiol, a strong antioxidant, anti-inflammatory, and anti-apoptotic agent, significantly decreases the severity of injury in the brain associated with cell death. Estrone, the predominant estrogen in postmenopausal women, has been shown to be a promis...

journal_title：Journal of neurotrauma

authors： Gatson JW,Liu MM,Abdelfattah K,Wigginton JG,Smith S,Wolf S,Simpkins JW,Minei JP

更新日期：2012-08-10 00:00:00

abstract：:This study aimed to investigate the cortical motor excitability characteristics in diffuse axonal injury (DAI) due to severe traumatic brain injury (TBI). A variety of excitatory and inhibitory transcranial magnetic stimulation (TMS) paradigms were applied to primary motor cortices of 17 patients and 11 healthy contro...

journal_title：Journal of neurotrauma

authors： Bernabeu M,Demirtas-Tatlidede A,Opisso E,Lopez R,Tormos JM,Pascual-Leone A

更新日期：2009-12-01 00:00:00

abstract：:Traumatic axonal injury (TAI) is a critical public health issue with its pathogenesis remaining largely elusive. Finite element (FE) head models are promising tools to bridge the gap between mechanical insult, localized brain response, and resultant injury. In particular, the FE-derived deformation along the direction...

journal_title：Journal of neurotrauma

authors： Zhou Z,Domel AG,Li X,Grant G,Kleiven S,Camarillo DB,Zeineh M

更新日期：2021-01-15 00:00:00

abstract：:Traumatic brain injury (TBI) in humans and in animals leads to an acute and sustained increase in tissue glutamate concentrations within the brain, triggering glutamate-mediated excitotoxicity. Excitatory amino acid transporters (EAATs) are responsible for maintaining extracellular central nervous system glutamate con...

journal_title：Journal of neurotrauma

authors： Fontana AC,Fox DP,Zoubroulis A,Mortensen OV,Raghupathi R

更新日期：2016-06-01 00:00:00

abstract：:The physiological characteristics of spinal cord responses recorded from the spinal epidural space of the cat to transcranial brain stimulation were studied, in comparison with the spinal cord responses to direct stimulation of the motor cortex or cerebellum. The conduction velocity of the initial wave of the response...

journal_title：Journal of neurotrauma

authors： Yamamoto T,Xing JA,Katayama Y,Tsubokawa T,Hirayama T,Maejima S

更新日期：1990-01-01 00:00:00

abstract：:Magnetic resonance imaging data were acquired at ∼24 h and ∼3 months post-injury on mild traumatic brain injury (mTBI; n = 75) and orthopedic injury (n = 60) cohorts. The mTBI subjects were randomly assigned to a treatment group with atorvastatin or a non-treatment mTBI group. The treatment group was further divided i...

journal_title：Journal of neurotrauma

authors： Govindarajan KA,Narayana PA,Hasan KM,Wilde EA,Levin HS,Hunter JV,Miller ER,Patel VK,Robertson CS,McCarthy JJ

更新日期：2016-10-15 00:00:00

abstract：:Abstract Although several functional magnetic resonance imaging (fMRI) studies have been conducted in human models of mild traumatic brain injury (mTBI), to date no studies have explicitly examined how injury may differentially affect both the positive phase of the hemodynamic response function (HRF) as well as the po...

journal_title：Journal of neurotrauma

authors： Mayer AR,Toulouse T,Klimaj S,Ling JM,Pena A,Bellgowan PS

更新日期：2014-01-15 00:00:00

abstract：:The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in rats following a mild to moderate spinal cord contusion injury. Animals received intraperitoneal injections of vehicle (DMSO) or 5 mg/mL of DNP prior to injury. Twenty-four hour...

journal_title：Journal of neurotrauma

authors： Jin Y,McEwen ML,Nottingham SA,Maragos WF,Dragicevic NB,Sullivan PG,Springer JE

更新日期：2004-10-01 00:00:00

abstract：:The Basso, Bresnahan and Beattie (BBB) locomotor scale has not been tested to evaluate functional consequences of peripheral nerve lesions. Alternative methods to evaluate animal functional recovery after sciatic nerve injury are desirable. Male Wistar rats had a right sciatic nerve segment exposed and were divided in...

journal_title：Journal of neurotrauma

authors： Schiaveto de Souza A,da Silva CA,Del Bel EA

更新日期：2004-05-01 00:00:00

abstract：:To evaluate new pharmacologic agents with potentially beneficial effects on posttraumatic spinal cord function, we used a modified weight drop (WD) technique to induce spinal cord injuries. These contusive spinal cord injuries in the rat closely mimic the human clinicopathologic situation. Especially for drug screenin...

journal_title：Journal of neurotrauma

authors： van de Meent H,Hamers FP,Lankhorst AJ,Buise MP,Joosten EA,Gispen WH

更新日期：1996-12-01 00:00:00

abstract：:How effectively the survivor of CNS trauma can function in society is the ultimate clinical outcome. Many victims of spinal cord injury (SCI) and traumatic brain injury (TBI) are frequently left with permanent impairment. Measurements of impairment, and the direct relationship to the functional loss and resultant disa...

journal_title：Journal of neurotrauma

authors： Ditunno JF Jr

更新日期：1992-03-01 00:00:00

abstract：:The rate of paroxysmal sympathetic hyperactivity (PSH) was retrospectively assessed using the Paroxysmal Sympathetic Hyperactivity-Assessment Measure (PSH-AM) scale in patients with disorders of consciousness attributed to traumatic and non-traumatic acquired brain injury during the rehabilitation phase. These results...

journal_title：Journal of neurotrauma

authors： Lucca LF,Pignolo L,Leto E,Ursino M,Rogano S,Cerasa A

更新日期：2019-08-15 00:00:00

abstract：:Optic nerve crush injury leads to death of retinal ganglion cells (RGCs), both as a direct result of the primary injury and via secondary degeneration induced by neurotoxins secreted by dying RGCs. Studies have shown that, if optic nerve crush is preceded by an unrelated injury to another part of the central nervous s...

journal_title：Journal of neurotrauma

authors： Ben Simon GJ,Hovda DA,Harris NG,Gomez-Pinilla F,Goldberg RA

更新日期：2006-07-01 00:00:00

abstract：:Moderate hypothermia may reduce subsequent neuronal damage after traumatic brain injury. Interleukin (IL)-6 may have a role in the pathogenesis of traumatic neuronal damage or repair. Using the enzyme-linked immunological sorbent assay (ELISA), we serially measured IL-6 levels in plasma obtained from the radial artery...

journal_title：Journal of neurotrauma

authors： Aibiki M,Maekawa S,Ogura S,Kinoshita Y,Kawai N,Yokono S

更新日期：1999-03-01 00:00:00