COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury.

abstract：:Acupressure is a complementary and alternative medicine (CAM) treatment using fingertips to stimulate acupoints on the skin. Although suggested to improve cognitive function, acupressure has not been previously investigated with a controlled design in traumatic brain injury (TBI) survivors, who could particularly bene...

journal_title：Journal of neurotrauma

authors： McFadden KL,Healy KM,Dettmann ML,Kaye JT,Ito TA,Hernández TD

更新日期：2011-01-01 00:00:00

abstract：:Reactive oxygen species have been implicated in the pathogenesis of hypoxic-ischemic injury. It has been shown previously that treating an animal with N-acetyl-L-cysteine (NAC), a scavenger of free radicals, significantly minimizes hypoxic-ischemic-induced brain injury in various acute models. Using a subacute swine m...

journal_title：Journal of neurotrauma

authors： Liu JQ,Lee TF,Chen C,Bagim DL,Cheung PY

更新日期：2010-10-01 00:00:00

abstract：:Traumatic brain injuries (TBI) sustained in combat frequently co-occur with significant bodily injuries. Intuitively, more extensive bodily injuries might be associated with increased symptom reporting. In 2012, however, French et al. demonstrated an inverse relation between bodily injury severity and symptom reportin...

journal_title：Journal of neurotrauma

authors： French LM,Lange RT,Marshall K,Prokhorenko O,Brickell TA,Bailie JM,Asmussen SB,Ivins B,Cooper DB,Kennedy JE

更新日期：2014-10-01 00:00:00

abstract：:Risk factors for head injury are also risk factors for becoming homeless but there is little research on this vulnerable group, who can be neglected by health services that specialize in acquired brain injury. This study investigates the prevalence of admissions to hospital with a head injury in the homeless and assoc...

journal_title：Journal of neurotrauma

authors： McMillan TM,Laurie M,Oddy M,Menzies M,Stewart E,Wainman-Lefley J

更新日期：2015-01-15 00:00:00

abstract：:Multipotent neural progenitors and stem cells may integrate appropriately into the developing and degenerating central nervous system. They may also be effective in the replacement of genes, cells, and nondiffusible factors in either a widespread or a more circumscribed manner, depending on the therapeutic demands of ...

journal_title：Journal of neurotrauma

authors： Park KI,Liu S,Flax JD,Nissim S,Stieg PE,Snyder EY

更新日期：1999-08-01 00:00:00

abstract：:Spinal cord injury (SCI) leading to neurological deficits produces long-term effects that persist over a lifetime. Survival analysis of patients with SCI, at individual and population level, is important for public health management and the assessment of treatment achievements. The current study evaluated survival fol...

journal_title：Journal of neurotrauma

authors： van den Berg ME,Castellote JM,de Pedro-Cuesta J,Mahillo-Fernandez I

更新日期：2010-08-01 00:00:00

abstract：:Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we "speak the same language." Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons betwe...

journal_title：Journal of neurotrauma

authors： Maas AI,Harrison-Felix CL,Menon D,Adelson PD,Balkin T,Bullock R,Engel DC,Gordon W,Langlois-Orman J,Lew HL,Robertson C,Temkin N,Valadka A,Verfaellie M,Wainwright M,Wright DW,Schwab K

更新日期：2011-02-01 00:00:00

abstract：:Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxation magnetic resonance imaging (MRI) predicts the progression of perilesional cortical pathology and epileptogenesis. The ...

journal_title：Journal of neurotrauma

authors： Manninen E,Chary K,Lapinlampi N,Andrade P,Paananen T,Sierra A,Tohka J,Gröhn O,Pitkänen A

更新日期：2020-12-01 00:00:00

abstract：:Accurate localization of cerebrospinal fluid (CSF) fistula in a patient with CSF rhinorrhea is challenging and often involves multiple imaging studies with associated expense and patient discomfort. Intrathecal contrast-enhanced computed tomography (CT) and unenhanced magnetic resonance (MR) cisternography using const...

journal_title：Journal of neurotrauma

authors： Goel G,Ravishankar S,Jayakumar PN,Vasudev MK,Shivshankar JJ,Rose D,Anandh B

更新日期：2007-10-01 00:00:00

abstract：:Central nervous system injuries such as focal brain ischemia and trauma are known to initiate inflammatory reactions. To demonstrate the involvement of adhesion molecules in these inflammatory responses, we have observed significant increases of ICAM-1 and ELAM-1 mRNA expression in the ischemic cortex of rats by means...

journal_title：Journal of neurotrauma

authors： Wang X,Feuerstein GZ

更新日期：1995-10-01 00:00:00

abstract：:Striking gender differences have been reported in the pathophysiology and outcome of acute neurological injury. Greater neuroprotection in females versus males may be due, in part, to direct and indirect sex hormone-mediated antioxidant mechanisms. Progesterone administration decreases brain levels of F(2)-isoprostane...

journal_title：Journal of neurotrauma

authors： Bayir H,Marion DW,Puccio AM,Wisniewski SR,Janesko KL,Clark RS,Kochanek PM

更新日期：2004-01-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) accounts for the majority of head trauma cases. Despite some lasting cognitive, emotional, and behavioral deficits, there are frequently no overt morphological defects, suggesting that changes may result from alterations in the physiology of individual neurons. We investigated hippoc...

journal_title：Journal of neurotrauma

authors： Eakin K,Miller JP

更新日期：2012-04-10 00:00:00

abstract：:Previous studies from our laboratory have shown the neuroprotective potential of ketones after TBI in the juvenile brain. It is our premise that acutely after TBI, glucose may not be the optimum fuel and decreasing metabolism of glucose in the presence of an alternative substrate will improve cellular metabolism and r...

journal_title：Journal of neurotrauma

authors： Prins ML,Hovda DA

更新日期：2009-07-01 00:00:00

abstract：:Information on the nature of deficits and adaptive mechanisms occurring after spinal cord injury is essential to the design of strategies for promoting functional recovery. Motor impairments and compensations were quantified by three-dimensional kinematic analysis in freely walking rats, 6 months after mild cervical (...

journal_title：Journal of neurotrauma

authors： Collazos-Castro JE,Soto VM,Gutiérrez-Dávila M,Nieto-Sampedro M

更新日期：2005-05-01 00:00:00

abstract：:Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. They mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation o...

journal_title：Journal of neurotrauma

authors： Eldadah BA,Faden AI

更新日期：2000-10-01 00:00:00

abstract：:Alterations in glutamatergic transmission are thought to contribute to secondary neuronal damage following traumatic brain injury. Using an in vitro cell injury model, we previously demonstrated an apparent reduction in AMPA receptor desensitization and resultant potentiation of AMPA-evoked currents after stretch inju...

journal_title：Journal of neurotrauma

authors： Goforth PB,Ellis EF,Satin LS

更新日期：2004-06-01 00:00:00

abstract：:In various animal and human studies, early administration of 17β-estradiol, a strong antioxidant, anti-inflammatory, and anti-apoptotic agent, significantly decreases the severity of injury in the brain associated with cell death. Estrone, the predominant estrogen in postmenopausal women, has been shown to be a promis...

journal_title：Journal of neurotrauma

authors： Gatson JW,Liu MM,Abdelfattah K,Wigginton JG,Smith S,Wolf S,Simpkins JW,Minei JP

更新日期：2012-08-10 00:00:00

abstract：:Adequate nutritional support is a major challenge in brain injury patients, because malnutrition cannot be reversed by standard enteral nutrition. We hypothesized that an oligomeric formula could improve nutritional status by restoring intestinal trophicity. Eighteen male Sprague-Dawley rats (300-330 g) underwent gast...

journal_title：Journal of neurotrauma

authors： Moinard C,Delpierre E,Loï C,Neveux N,Butel MJ,Cynober L,Charrueau C

更新日期：2013-06-01 00:00:00

abstract：:Determining the priorities of individuals with spinal cord injury (SCI) can assist in choosing research priorities that will ultimately improve their quality of life. This systematic review examined studies that directly surveyed people with SCI to ascertain their health priorities and life domains of importance. Twen...

journal_title：Journal of neurotrauma

authors： Simpson LA,Eng JJ,Hsieh JT,Wolfe DL,Spinal Cord Injury Rehabilitation Evidence Scire Research Team.

更新日期：2012-05-20 00:00:00

abstract：:The rat hippocampus is hypersensitive to secondary cerebral ischemia after mild traumatic brain injury (TBI). An unconfirmed assumption in previous studies of mild TBI followed by forebrain ischemia has been that antecedent TBI did not alter cerebral blood flow (CBF) dynamics in response to secondary ischemia. Using l...

journal_title：Journal of neurotrauma

authors： Davis KL,Jenkins LW,DeWitt DS,Prough DS

更新日期：1998-08-01 00:00:00

abstract：:Growing evidence suggests that temporally proximal acute concussions and repetitive subconcussive head injuries may lead to long-term neurological deficits. However, the underlying mechanisms of injury and their relative time-scales are not well documented in human injury models. The current study therefore investigat...

journal_title：Journal of neurotrauma

authors： Mayer AR,Ling JM,Dodd AB,Gasparovic C,Klimaj SD,Meier TB

更新日期：2015-11-15 00:00:00

abstract：:In this review we consider recovery of function after spinal cord injury, and, in particular, recovery improved following intraspinal cellular transplants. Some recovery occurs spontaneously and this can be especially dramatic in neonates, supporting the notion that developing and adult spinal cord respond differently...

journal_title：Journal of neurotrauma

authors： Murray M,Fischer I,Smeraski C,Tessler A,Giszter S

更新日期：2004-04-01 00:00:00

abstract：:Microarray-based transcriptional profiling was used to determine the effect of progesterone in the cortical contusion (CCI) model. Gene ontology (GO) analysis then evaluated the effect of dose on relevant biological pathways. Treatment (vehicle, progesterone 10 mg/kg or 20 mg/kg given i.p.) was started 4 h post-injury...

journal_title：Journal of neurotrauma

authors： Anderson GD,Farin FM,Bammler TK,Beyer RP,Swan AA,Wilkerson HW,Kantor ED,Hoane MR

更新日期：2011-09-01 00:00:00

abstract：:The relationship between brain injury and attentional control (AC) long after a childhood traumatic brain injury (TBI) has received limited investigation. The aim of this article was to investigate the impact that lesion presence, location, and severity has on AC in a group of young persons who had sustained a moderat...

journal_title：Journal of neurotrauma

authors： Cooper JM,Catroppa C,Beauchamp MH,Eren S,Godfrey C,Ditchfield M,Anderson VA

更新日期：2014-04-15 00:00:00

abstract：:We investigated the role of the axon guidance molecule EphA4 following traumatic brain injury (TBI) in mice. Neutralization of EphA4 improved motor function and axonal regeneration following experimental spinal cord injury (SCI). We hypothesized that genetic absence of EphA4 could improve functional and histological o...

journal_title：Journal of neurotrauma

authors： Hånell A,Clausen F,Djupsjö A,Vallstedt A,Patra K,Israelsson C,Larhammar M,Björk M,Paixão S,Kullander K,Marklund N

更新日期：2012-11-20 00:00:00

abstract：:Traumatic brain injuries (TBI) are one of the least understood injuries to the body. Finite element (FE) models of the brain have been crucial for understanding concussion and for developing injury mitigation systems; however, the experimental brain deformation data currently used to validate these models are limited....

journal_title：Journal of neurotrauma

authors： Alshareef A,Giudice JS,Forman J,Salzar RS,Panzer MB

更新日期：2018-03-01 00:00:00

abstract：:Rotational acceleration of the head, as occurs in falls, car crashes, and sport injuries, may result in diffuse brain damage, with acute and chronic neurological and psychiatric symptoms. The present study addresses the effects of rotational trauma on the neuronal cytoskeleton, which stabilizes perikaryal, dendritic a...

journal_title：Journal of neurotrauma

authors： Hamberger A,Huang YL,Zhu H,Bao F,Ding M,Blennow K,Olsson A,Hansson HA,Viano D,Haglid KG

更新日期：2003-02-01 00:00:00

abstract：:Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). Isolated concussions frequently produce acute neurological impairments, and individuals typically recover spontaneously within a short time frame. In contrast, brain injuries resulting from multiple concussions can result i...

journal_title：Journal of neurotrauma

authors： Mountney A,Boutté AM,Cartagena CM,Flerlage WF,Johnson WD,Rho C,Lu XC,Yarnell A,Marcsisin S,Sousa J,Vuong C,Zottig V,Leung LY,Deng-Bryant Y,Gilsdorf J,Tortella FC,Shear DA

更新日期：2017-10-01 00:00:00

abstract：:Previous studies in our laboratory have shown that polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) or lidocaine treatment before experimental fluid-percussion brain injury in rats reduces the cortical hypoperfusion normally found in the early posttraumatic period. The purpose of the current study was to ...

journal_title：Journal of neurotrauma

authors： Hamm RJ,Temple MD,Pike BR,Ellis EF

更新日期：1996-06-01 00:00:00

abstract：:Previous meta-analyses of methylprednisolone (MPS) for patients with acute traumatic spinal cord injuries (TSCIs) have not addressed confidence in the quality of evidence used for pooled effect estimates, and new primary studies have been recently published. We aimed to determine whether MPS improves motor recovery an...

journal_title：Journal of neurotrauma

authors： Evaniew N,Belley-Côté EP,Fallah N,Noonan VK,Rivers CS,Dvorak MF

更新日期：2016-03-01 00:00:00