Caspase pathways, neuronal apoptosis, and CNS injury.

abstract：:The goal of this investigation was to develop a method to study the neurophysiological integrity of the central motor tract using motor evoked potentials in the awake rat and assess the effects of different anesthetics in this model. Rats were implanted with six subcutaneous electrodes (pediatric myocardial pacing lea...

journal_title：Journal of neurotrauma

authors： Oria M,Chatauret N,Raguer N,Córdoba J

更新日期：2008-03-01 00:00:00

abstract：:Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we "speak the same language." Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons betwe...

journal_title：Journal of neurotrauma

authors： Maas AI,Harrison-Felix CL,Menon D,Adelson PD,Balkin T,Bullock R,Engel DC,Gordon W,Langlois-Orman J,Lew HL,Robertson C,Temkin N,Valadka A,Verfaellie M,Wainwright M,Wright DW,Schwab K

更新日期：2011-02-01 00:00:00

abstract：:Outcomes can be challenging to predict in children with mild traumatic brain injury (TBI). Transcranial Doppler (TCD) ultrasound has become an increasingly useful modality in adult and pediatric TBI by measuring blood flow velocities within the circle of Willis. In children with moderate-to-severe TBI, multiple studie...

journal_title：Journal of neurotrauma

authors： Deines JJ,Chang J,Reuter-Rice K

更新日期：2018-09-06 00:00:00

abstract：:Acute administration of a monoclonal antibody (mAb) raised against the CD11d subunit of the leukocyte CD11d/CD18 integrin after spinal cord injury (SCI) in the rat greatly improves neurological outcomes. This has been chiefly attributed to the reduced infiltration of neutrophils into the injured spinal cord in treated...

journal_title：Journal of neurotrauma

authors： Geremia NM,Bao F,Rosenzweig TE,Hryciw T,Weaver L,Dekaban GA,Brown A

更新日期：2012-02-10 00:00:00

abstract：:The mass media have recently pointed out the likelihood of diagnostic errors in post-coma patients. Late recoveries of consciousness, even after 20 years, might indicate hidden misdiagnoses that are not corrected over a long period of time. The rate of misdiagnoses of patients in a vegetative state is very high when b...

journal_title：Journal of neurotrauma

authors： Pistoia F,Sarà M

更新日期：2012-09-01 00:00:00

abstract：:Many patients with mild traumatic brain injury (MTBI) concurrently sustain extracranial injuries; however, little is known about the impact of these additional injuries on outcome. We assessed the impact of additional injuries on the severity of postconcussional symptoms (PCS) and functional outcome 6 months post-inju...

journal_title：Journal of neurotrauma

authors： Stulemeijer M,van der Werf SP,Jacobs B,Biert J,van Vugt AB,Brauer JM,Vos PE

更新日期：2006-10-01 00:00:00

abstract：:Fatalities or injuries following motorized and non-motorized vehicle accidents (MNMVA) are reported by police or health care systems. However, limited data exist for spinal injuries. Using an epidemiological database of road accidents occurring in a defined geographic area, we measured the incidence of major spinal tr...

journal_title：Journal of neurotrauma

authors： Lieutaud T,Ndiaye A,Frost F,Chiron M,Registry Group.

更新日期：2010-06-01 00:00:00

abstract：:Given the worldwide adverse impact of traumatic brain injury (TBI) on the human population, its diagnosis and prediction are of utmost importance. Historically, many studies have focused on associating head kinematics to brain injury risk. Recently, there has been a push toward using computationally expensive finite e...

journal_title：Journal of neurotrauma

authors： Laksari K,Fanton M,Wu LC,Nguyen TH,Kurt M,Giordano C,Kelly E,O'Keeffe E,Wallace E,Doherty C,Campbell M,Tiernan S,Grant G,Ruan J,Barbat S,Camarillo DB

更新日期：2020-04-01 00:00:00

abstract：:Restraint stress (RS) protects auditory function against acoustic trauma by activating glucocorticoid receptors (GR) in the cochlea. In a search for the signaling pathways downstream to GR that may be involved in RS-induced protection we report here (1) a downregulation of phosphorylated extracellular signal-regulated...

journal_title：Journal of neurotrauma

authors： Meltser I,Tahera Y,Canlon B

更新日期：2009-10-01 00:00:00

abstract：:Since free radicals play a role in the mechanisms of brain injury after hemorrhagic stroke, the effect of melatonin (a potent antioxidant and free-radical scavenger) on outcomes was investigated after intracerebral hemorrhage (ICH) in rats. ICH was induced by clostridial collagenase infusion into the right caudate put...

journal_title：Journal of neurotrauma

authors： Lekic T,Hartman R,Rojas H,Manaenko A,Chen W,Ayer R,Tang J,Zhang JH

更新日期：2010-03-01 00:00:00

abstract：:The Glasgow Coma Scale (GCS) score is used in clinical practice for patient assessment and communication among clinicians and also in outcome prediction models such as the Trauma and Injury Severity Score (TRIS). The objective of this study is to determine which GCS subscore is best associated with outcome, taking tim...

journal_title：Journal of neurotrauma

authors： Lesko MM,Jenks T,O'Brien SJ,Childs C,Bouamra O,Woodford M,Lecky F

更新日期：2013-01-01 00:00:00

abstract：:To test if observed vs. expected mortality differs by age among traumatic brain injury (TBI) cases, a population-based, historical cohort study was conducted in Olmsted County, Minnesota. From all residents with any diagnosis suggestive of TBI 1985-1999, we randomly sampled 7,800 and reviewed their medical records to ...

journal_title：Journal of neurotrauma

authors： Flaada JT,Leibson CL,Mandrekar JN,Diehl N,Perkins PK,Brown AW,Malec JF

更新日期：2007-03-01 00:00:00

abstract：:Previous studies from our laboratory have shown the neuroprotective potential of ketones after TBI in the juvenile brain. It is our premise that acutely after TBI, glucose may not be the optimum fuel and decreasing metabolism of glucose in the presence of an alternative substrate will improve cellular metabolism and r...

journal_title：Journal of neurotrauma

authors： Prins ML,Hovda DA

更新日期：2009-07-01 00:00:00

abstract：:Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...

journal_title：Journal of neurotrauma

authors： Schwab JM,Seid K,Schluesener HJ

更新日期：2001-09-01 00:00:00

abstract：:In various animal and human studies, early administration of 17β-estradiol, a strong antioxidant, anti-inflammatory, and anti-apoptotic agent, significantly decreases the severity of injury in the brain associated with cell death. Estrone, the predominant estrogen in postmenopausal women, has been shown to be a promis...

journal_title：Journal of neurotrauma

authors： Gatson JW,Liu MM,Abdelfattah K,Wigginton JG,Smith S,Wolf S,Simpkins JW,Minei JP

更新日期：2012-08-10 00:00:00

abstract：:The increase in the volume of a traumatic intracerebral hemorrhage (TICH) is a widely studied phenomenon that has a direct impact on the prognosis of patients. The objective of this study was to identify the risk factors associated with the progression of TICH. We retrospectively analyzed the records of 1970 adult pat...

journal_title：Journal of neurotrauma

authors： Cepeda S,Gómez PA,Castaño-Leon AM,Martínez-Pérez R,Munarriz PM,Lagares A

更新日期：2015-08-15 00:00:00

abstract：:This study was designed to assess the effect of spinal cord injury on neurobehavioral, electrophysiological, structural, and biochemical changes in normal and diabetic rats. Experimental diabetes was induced in Sprague-Dawley male rats (weighing 250-280 g) with streptozotocin (50 mg/kg i.p.). Eight weeks after the tre...

journal_title：Journal of neurotrauma

authors： Tariq M,Morais C,Kishore PN,Biary N,Al Deeb S,Al Moutaery K

更新日期：1998-04-01 00:00:00

abstract：:Injury to the meninges is not uncommon after traumatic brain injury (TBI), yet minimal research has been directed toward understanding the relevant biology. After a concussive event, the meninges are observed to abnormally enhance on post-contrast magnetic resonance imaging (MRI) in some patients, but not all. The aim...

journal_title：Journal of neurotrauma

authors： Livingston WS,Gill JM,Cota MR,Olivera A,O'Keefe JL,Martin C,Latour LL

更新日期：2017-02-15 00:00:00

abstract：:Rodent models of spinal cord injury are critical for the development of treatments for upper limb motor impairment in humans, but there are few methods for measuring forelimb strength of rodents, an important outcome measure. We developed a novel robotic device--the Robotic Rehabilitator of the Rodent Upper Extremity ...

journal_title：Journal of neurotrauma

authors： Sharp KG,Duarte JE,Gebrekristos B,Perez S,Steward O,Reinkensmeyer DJ

更新日期：2016-03-01 00:00:00

abstract：:Previous meta-analyses of methylprednisolone (MPS) for patients with acute traumatic spinal cord injuries (TSCIs) have not addressed confidence in the quality of evidence used for pooled effect estimates, and new primary studies have been recently published. We aimed to determine whether MPS improves motor recovery an...

journal_title：Journal of neurotrauma

authors： Evaniew N,Belley-Côté EP,Fallah N,Noonan VK,Rivers CS,Dvorak MF

更新日期：2016-03-01 00:00:00

abstract：:ABSTRACT Preliminary evidence has shown that intracerebral hemorrhages, either spontaneous (sICH) or traumatic (tICH) often expand over time. An association between hemorrhage expansion and clinical outcomes has been described for sICH. The intent of this prospective, observational study was to characterize the tempor...

journal_title：Journal of neurotrauma

authors： Narayan RK,Maas AI,Servadei F,Skolnick BE,Tillinger MN,Marshall LF,Traumatic Intracerebral Hemorrhage Study Group.

更新日期：2008-06-01 00:00:00

abstract：:Individuals with a mild traumatic brain injury (mTBI) often have executive control deficits; however, the underlying neural mechanisms of such deficits are yet to be clarified. Inhibitory control and cognitive monitoring are two fundamental aspects of executive control processes. This study investigated the executive ...

journal_title：Journal of neurotrauma

authors： Shen IH,Lin YJ,Chen CL,Liao CC

更新日期：2020-01-01 00:00:00

abstract：:Following a traumatic brain injury (TBI), excessive release of proinflammatory cytokines is the major cause of cerebral edema and neuronal loss. This study was designed to examine changes in concentrations of some proinflammatory cytokines-including interleukin-1 beta (IL-1β), interleukin 6 (IL-6), tumor necrosis fact...

journal_title：Journal of neurotrauma

authors： Sarkaki AR,Khaksari Haddad M,Soltani Z,Shahrokhi N,Mahmoodi M

更新日期：2013-01-01 00:00:00

abstract：:Patients sustaining severe traumatic brain injury (TBI) have variable long-term outcomes. We examined the association between Glasgow Outcome Scale (GOS) assessed at 3 months and long-term outcomes at 12 months after TBI. We studied 159 patients with severe, closed traumatic brain injuries (Glasgow Coma Scale [GCS]

journal_title：Journal of neurotrauma

authors： King JT Jr,Carlier PM,Marion DW

更新日期：2005-09-01 00:00:00

abstract：:We have investigated time course and characteristics of retinal ganglion cell (RGC) death after partial optic nerve injury. In situ end labeling of DNA fragments with the terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine (dUTP)-biotin nick end labeling (TUNEL) method revealed the presence of apoptotic ...

journal_title：Journal of neurotrauma

authors： Bien A,Seidenbecher CI,Böckers TM,Sabel BA,Kreutz MR

更新日期：1999-02-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) has gained considerable notoriety during the past decade of conflict in Afghanistan and Iraq. However, the relationship between combat-related mTBI and residual mTBI symptoms, post-traumatic stress disorder (PTSD) symptoms, and neurocognitive deficits remains unclear. The purpose of ...

journal_title：Journal of neurotrauma

authors： Kontos AP,Kotwal RS,Elbin RJ,Lutz RH,Forsten RD,Benson PJ,Guskiewicz KM

更新日期：2013-04-15 00:00:00

abstract：:Rotational acceleration of the head, as occurs in falls, car crashes, and sport injuries, may result in diffuse brain damage, with acute and chronic neurological and psychiatric symptoms. The present study addresses the effects of rotational trauma on the neuronal cytoskeleton, which stabilizes perikaryal, dendritic a...

journal_title：Journal of neurotrauma

authors： Hamberger A,Huang YL,Zhu H,Bao F,Ding M,Blennow K,Olsson A,Hansson HA,Viano D,Haglid KG

更新日期：2003-02-01 00:00:00

abstract：:The excessive generation of free radicals is thought to be one of the major mechanisms leading to tissue injury in various pathological conditions, including ischemia, inflammation, and trauma. Conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) contributes to the formation of superoxide, an oxygen rad...

journal_title：Journal of neurotrauma

authors： Xu J,Beckman JS,Hogan EL,Hsu CY

更新日期：1991-04-01 00:00:00

abstract：:For patients surviving serious traumatic brain injury (TBI), families and other stakeholders often desire information on long-term functional prognosis, but accurate and easy-to-use clinical tools are lacking. We aimed to build utilitarian decision trees from commonly collected clinical variables to predict Glasgow Ou...

journal_title：Journal of neurotrauma

authors： Walker WC,Stromberg KA,Marwitz JH,Sima AP,Agyemang AA,Graham KM,Harrison-Felix C,Hoffman JM,Brown AW,Kreutzer JS,Merchant R

更新日期：2018-07-15 00:00:00

abstract：:We investigated the effect of sports activity on physically-disabled individuals using behavioral and electrophysiological techniques. Visual go/no-go discriminative and simple response tasks were used. Participants included 17 disabled athletes, 9 from open-skill (wheelchair basketball) and eight from closed-skill (s...

journal_title：Journal of neurotrauma

authors： Di Russo F,Bultrini A,Brunelli S,Delussu AS,Polidori L,Taddei F,Traballesi M,Spinelli D

更新日期：2010-12-01 00:00:00