The effect of progesterone dose on gene expression after traumatic brain injury.

abstract：:This study was designed to assess the effect of spinal cord injury on neurobehavioral, electrophysiological, structural, and biochemical changes in normal and diabetic rats. Experimental diabetes was induced in Sprague-Dawley male rats (weighing 250-280 g) with streptozotocin (50 mg/kg i.p.). Eight weeks after the tre...

journal_title：Journal of neurotrauma

authors： Tariq M,Morais C,Kishore PN,Biary N,Al Deeb S,Al Moutaery K

更新日期：1998-04-01 00:00:00

abstract：:The purpose of this study was to define the relationships among clinical characteristics of chronic pain, injury characteristics, affective factors and autonomic dysreflexia (AD) in people with chronic cervical spinal cord injury (SCI). A survey containing questions concerning the presence of AD, demographic factors, ...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Cruz-Almeida Y,Krassioukov A

更新日期：2004-02-01 00:00:00

abstract：:Several behavioral factors such as violence, impulsivity, and alcohol-related problems are associated with traumatic spinal cord injury (TSCI). Such factors have been associated with inherently low neuronal serotonergic capacity that in turn is reflected in low activity of monoamine oxidase (MAO) as measured in platel...

journal_title：Journal of neurotrauma

authors： Sabre L,Harro J,Eensoo D,Vaht M,Kabel V,Pakkanen M,Asser T,Kõrv J

更新日期：2016-11-01 00:00:00

abstract：:Minimal traumatic brain injury (mTBI) is partially defined by the existence of retrograde amnesia and is associated with microscopic bleeds containing activated coagulation factors. In a previous study, we have found that mTBI immediately releases thrombin-like activity in the brain, which induces amnesia by activatin...

journal_title：Journal of neurotrauma

authors： Itsekson-Hayosh Z,Shavit-Stein E,Katzav A,Rubovitch V,Maggio N,Chapman J,Harnof S,Pick CG

更新日期：2016-10-15 00:00:00

abstract：:Microdialysis sampling was used to characterize the release of norepinephrine and serotonin upon impact injury to the rat spinal cord. Increases in extracellular norepinephrine concentrations in response to injury were small and of short duration. In contrast, serotonin concentrations quickly rose 35-90 times followin...

journal_title：Journal of neurotrauma

authors： Liu DX,Valadez V,Sorkin LS,McAdoo DJ

更新日期：1990-01-01 00:00:00

abstract：:This article addresses the need for age-relevant outcome measures for traumatic brain injury (TBI) research and summarizes the recommendations by the inter-agency Pediatric TBI Outcomes Workgroup. The Pediatric Workgroup's recommendations address primary clinical research objectives including characterizing course of ...

journal_title：Journal of neurotrauma

authors： McCauley SR,Wilde EA,Anderson VA,Bedell G,Beers SR,Campbell TF,Chapman SB,Ewing-Cobbs L,Gerring JP,Gioia GA,Levin HS,Michaud LJ,Prasad MR,Swaine BR,Turkstra LS,Wade SL,Yeates KO,Pediatric TBI Outcomes Workgroup.

更新日期：2012-03-01 00:00:00

abstract：:Lesions in specific areas of the rat motor cortex generate deficits related to fine movement performance affecting the forelimb. We have previously shown that transplants of embryonic frontal cortex ameliorate these motor deficits. Amelioration has been associated with a functional integration of the transplant due to...

journal_title：Journal of neurotrauma

authors： Santos-Torres J,Heredia M,Riolobos AS,Jiménez-Díaz L,Gómez-Bautista V,de la Fuente A,Criado JM,Navarro-López J,Yajeya J

更新日期：2009-09-01 00:00:00

abstract：:Patients with spinal cord injury (SCI) typically experience body weight loss, motor function deficits, and a general decline of physical fitness. Animal models with these characteristics can serve to study the detailed adaptive changes following SCI. In the present study, we report the use of an adult paraplegic mouse...

journal_title：Journal of neurotrauma

authors： Landry E,Frenette J,Guertin PA

更新日期：2004-08-01 00:00:00

abstract：:The physiological characteristics of spinal cord responses recorded from the spinal epidural space of the cat to transcranial brain stimulation were studied, in comparison with the spinal cord responses to direct stimulation of the motor cortex or cerebellum. The conduction velocity of the initial wave of the response...

journal_title：Journal of neurotrauma

authors： Yamamoto T,Xing JA,Katayama Y,Tsubokawa T,Hirayama T,Maejima S

更新日期：1990-01-01 00:00:00

abstract：:Controlled cortical impact (CCI) is a relatively new model of traumatic brain injury in the mouse, which, in combination with behavioral and histological methods, has potential for elucidating underlying mechanisms of neurodegeneration using genetically altered animals. Previously, we have demonstrated impaired spatia...

journal_title：Journal of neurotrauma

authors： Fox GB,Fan L,LeVasseur RA,Faden AI

更新日期：1998-12-01 00:00:00

abstract：:The effect of flunarizine and methylprednisolone on the recovery of somatosensory evoked potentials (SEPs) was evaluated in an experimental model of spinal cord impact injury in anesthetized cats. In addition, the effect of flunarizine on posttraumatic spinal cord blood flow (SCBF) (using the hydrogen clearance techni...

journal_title：Journal of neurotrauma

authors： De Ley G,Leybaert L

更新日期：1993-04-01 00:00:00

abstract：:Abstract Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial-mediated neurodegeneration in vitro, and is neuroprotective in experimental models of CNS injury. In vitro studies also suggest ...

journal_title：Journal of neurotrauma

authors： Loane DJ,Stoica BA,Byrnes KR,Jeong W,Faden AI

更新日期：2013-03-01 00:00:00

abstract：:Outcomes can be challenging to predict in children with mild traumatic brain injury (TBI). Transcranial Doppler (TCD) ultrasound has become an increasingly useful modality in adult and pediatric TBI by measuring blood flow velocities within the circle of Willis. In children with moderate-to-severe TBI, multiple studie...

journal_title：Journal of neurotrauma

authors： Deines JJ,Chang J,Reuter-Rice K

更新日期：2018-09-06 00:00:00

abstract：:Traumatic brain injury (TBI) evokes diffuse (traumatic) axonal injury (TAI), which contributes to morbidity and mortality. Damaged axons display progressive alterations gradually evolving to axonal disconnection. In severe TAI, the tensile forces of injury lead to a focal influx of Ca2+, initiating a series of proteol...

journal_title：Journal of neurotrauma

authors： Buki A,Farkas O,Doczi T,Povlishock JT

更新日期：2003-03-01 00:00:00

abstract：:End-to-side neurorrhaphy is widely used in the peripheral nervous system for nerve repair; however, the application of this technique has been limited to somatic nerves. The feasibility of nerve regeneration through end-to-side neurorrhaphy between autonomic and somatic nerves with different characteristics in the per...

journal_title：Journal of neurotrauma

authors： Gao WS,Dong CJ,Li SQ,Kunwar KJ,Li B

更新日期：2012-05-20 00:00:00

abstract：:Pediatric traumatic brain injury (TBI) research depends on comparisons of profiles and outcomes between brain-injured individuals and groups consisting either of injured controls (e.g., orthopedic injuries, OI) or uninjured, typically developing children recruited from the community (community controls, CC). Children ...

journal_title：Journal of neurotrauma

authors： Beauchamp MH,Landry-Roy C,Gravel J,Beaudoin C,Bernier A

更新日期：2017-09-01 00:00:00

abstract：:The lectin pathway of the complement system has been implicated in secondary ischemic/inflammatory injury after traumatic brain injury (TBI). However, previous experimental studies have yielded conflicting results, and human studies are scarce. In this exploratory study, we investigated associations of several lectin ...

journal_title：Journal of neurotrauma

authors： Osthoff M,Walder B,Delhumeau C,Trendelenburg M,Turck N

更新日期：2017-09-01 00:00:00

abstract：:A retrospective case-control study was undertaken to determine the best technique to measure neural canal encroachment at each lumbar level following burst fracture and its relationship to the presence of neurologic deficit. Only patients with postinjury CT scans demonstrating a disrupted posterior body with a retropu...

journal_title：Journal of neurotrauma

authors： Rasmussen PA,Rabin MH,Mann DC,Perl JR 2nd,Lorenz MA,Vrbos LA

更新日期：1994-12-01 00:00:00

abstract：:We sought to determine whether the exposure to the sub-concussive blows that occur during division III collegiate collision sports affect later life neurobehavioral quality-of-life measures. We conducted a cross-sectional study of alumni from four division III colleges, targeting those between the ages of 40-70 years,...

journal_title：Journal of neurotrauma

authors： Meehan WP 3rd,Taylor AM,Berkner P,Sandstrom NJ,Peluso MW,Kurtz MM,Pascual-Leone A,Mannix R

更新日期：2016-01-15 00:00:00

abstract：:Traumatic Brain Injury (TBI) can be associated with partial or total smell loss. Recent studies have suggested that olfactory outcome can be positively modulated after olfactory training (OT). This study's aim was to investigate OT's potential role in smell recovery after TBI-induced olfactory loss. A prospective, ran...

journal_title：Journal of neurotrauma

authors： Langdon C,Lehrer E,Berenguer J,Laxe S,Alobid I,Quintó L,Mariño-Sánchez F,Bernabeu M,Marin C,Mullol J

更新日期：2018-11-15 00:00:00

abstract：:The rat hippocampus is hypersensitive to secondary cerebral ischemia after mild traumatic brain injury (TBI). An unconfirmed assumption in previous studies of mild TBI followed by forebrain ischemia has been that antecedent TBI did not alter cerebral blood flow (CBF) dynamics in response to secondary ischemia. Using l...

journal_title：Journal of neurotrauma

authors： Davis KL,Jenkins LW,DeWitt DS,Prough DS

更新日期：1998-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in varying degrees of disability in a significant number of persons annually. The mechanisms of cognitive dysfunction after TBI have been explored in both animal models and human clinical studies for decades. Dopaminergic, serotonergic, and noradrenergic dysfunction has been descri...

journal_title：Journal of neurotrauma

authors： Shin SS,Dixon CE

更新日期：2015-10-01 00:00:00

abstract：:How effectively the survivor of CNS trauma can function in society is the ultimate clinical outcome. Many victims of spinal cord injury (SCI) and traumatic brain injury (TBI) are frequently left with permanent impairment. Measurements of impairment, and the direct relationship to the functional loss and resultant disa...

journal_title：Journal of neurotrauma

authors： Ditunno JF Jr

更新日期：1992-03-01 00:00:00

abstract：:Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active noncompetitive antagonist of the AMPA subtype of glutamate excitatory amino acid receptors. The purpose of this study was to determine whether treatment with talampanel would protect in a rat ...

journal_title：Journal of neurotrauma

authors： Belayev L,Alonso OF,Liu Y,Chappell AS,Zhao W,Ginsberg MD,Busto R

更新日期：2001-10-01 00:00:00

abstract：:Diagnosis and early prognosis of the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and its differentiation from the minimally-conscious state still rest on the clinical observation of responsiveness. The incidence of established clinical indicators of responsiveness also has proven variable in the single...

journal_title：Journal of neurotrauma

authors： Riganello F,Cortese MD,Dolce G,Lucca LF,Sannita WG

更新日期：2015-07-15 00:00:00

abstract：:Stretching of cultured neurons has been used to model diffuse axonal injury associated with brain trauma. N-Methyl-D-aspartate receptor (NMDAR) activation and group I metabotropic glutamate receptors (mGluRs) are implicated in the pathophysiology of such injury. Here we detail the effects of culture condition and mGlu...

journal_title：Journal of neurotrauma

authors： Lea PM 4th,Custer SJ,Stoica BA,Faden AI

更新日期：2003-11-01 00:00:00

abstract：:Studies have shown reduced life expectancy following moderate-severe traumatic brain injury (TBI) with death from unintentional poisoning (UP) being 11 times higher following TBI than in the general population. The characteristics of those who die of unintentional poisoning are compared with the characteristics of tho...

journal_title：Journal of neurotrauma

authors： Hammond FM,Ketchum J,Dams-O'Connor K,Corrigan JD,Miller C,Haarbauer-Krupa J,Faul M,Trexler LE,Harrison-Felix C

更新日期：2020-12-01 00:00:00

abstract：:Fluid percussion brain injury is associated with an immediate rise in mean arterial pressure (MAP). However, the cerebral morphologic basis for this response is still not clear. Thirty-four anesthetized rats were injured using a lateral craniotomy preparation. In 19 rats, impact level was set at 1.73 +/- 0.04 atm, and...

journal_title：Journal of neurotrauma

authors： Yuan XQ,Wade CE,Clifford CB

更新日期：1991-10-01 00:00:00

abstract：:The increase in the volume of a traumatic intracerebral hemorrhage (TICH) is a widely studied phenomenon that has a direct impact on the prognosis of patients. The objective of this study was to identify the risk factors associated with the progression of TICH. We retrospectively analyzed the records of 1970 adult pat...

journal_title：Journal of neurotrauma

authors： Cepeda S,Gómez PA,Castaño-Leon AM,Martínez-Pérez R,Munarriz PM,Lagares A

更新日期：2015-08-15 00:00:00

abstract：:Rodent models of spinal cord injury are critical for the development of treatments for upper limb motor impairment in humans, but there are few methods for measuring forelimb strength of rodents, an important outcome measure. We developed a novel robotic device--the Robotic Rehabilitator of the Rodent Upper Extremity ...

journal_title：Journal of neurotrauma

authors： Sharp KG,Duarte JE,Gebrekristos B,Perez S,Steward O,Reinkensmeyer DJ

更新日期：2016-03-01 00:00:00