Should Young Children with Traumatic Brain Injury Be Compared with Community or Orthopedic Control Participants?

abstract：:Controlled cortical impact (CCI) is a contemporary model of experimental cerebral contusion. We examined the cerebrovascular and neuropathologic effects of a severe CCI in rats. The utility of magnetic resonance imaging (MRI) for the assessment of contusion volume after severe CCI was also established. Severe CCI (3.0...

journal_title：Journal of neurotrauma

authors： Kochanek PM,Marion DW,Zhang W,Schiding JK,White M,Palmer AM,Clark RS,O'Malley ME,Styren SD,Ho C

更新日期：1995-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a complex injury that has a multi-faceted recovery process. The current "gold standard" for classifying severity of TBI symptoms is the Glasgow Outcome Scale (GOSE), a crude measure of overall dysfunction after TBI. Exploratory factor analysis performed on TRACK-TBI Pilot (N = 297) iden...

journal_title：Journal of neurotrauma

authors： Zou LF,Pierce B,Nielson JL

更新日期：2021-01-15 00:00:00

abstract：:Posttraumatic ischemia appears to be largely responsible for the extension of lesions in acute injury of the spinal cord. In the present study, we have evaluated the putative improvement of axonal function by the calcium channel blocker nimodipine after acute trauma of the spinal cord. Three techniques were used: (1) ...

journal_title：Journal of neurotrauma

authors： Pointillart V,Gense D,Gross C,Bidabé AM,Gin AM,Rivel J,Caillé JM,Sénégas J

更新日期：1993-07-01 00:00:00

abstract：:Despite limited evidence to support the use of amantadine to enhance cognitive function after traumatic brain injury (TBI), the clinical use for this purpose is highly prevalent and is often based on inferred belief systems. The aim of this study was to assess effect of amantadine on cognition among individuals with a...

journal_title：Journal of neurotrauma

authors： Hammond FM,Sherer M,Malec JF,Zafonte RD,Dikmen S,Bogner J,Bell KR,Barber J,Temkin N

更新日期：2018-10-01 00:00:00

abstract：:In various animal and human studies, early administration of 17β-estradiol, a strong antioxidant, anti-inflammatory, and anti-apoptotic agent, significantly decreases the severity of injury in the brain associated with cell death. Estrone, the predominant estrogen in postmenopausal women, has been shown to be a promis...

journal_title：Journal of neurotrauma

authors： Gatson JW,Liu MM,Abdelfattah K,Wigginton JG,Smith S,Wolf S,Simpkins JW,Minei JP

更新日期：2012-08-10 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white ...

journal_title：Journal of neurotrauma

authors： Santhanam P,Teslovich T,Wilson SH,Yeh PH,Oakes TR,Weaver LK

更新日期：2019-04-01 00:00:00

abstract：:Prevention of the immediate excitotoxic phase occurring in response to spinal cord injury (SCI) is a major issue to reduce the neuronal damage responsible for any ensuing motor deficits. The present study evaluated the neuroprotective efficacy of three noncompetitive NMDA receptor antagonists: Gacyclidine (GK-11), a n...

journal_title：Journal of neurotrauma

authors： Feldblum S,Arnaud S,Simon M,Rabin O,D'Arbigny P

更新日期：2000-11-01 00:00:00

abstract：:It remains unclear whether the benefits of early surgical timing are significant in neurologically complete spinal cord injury (SCI). We wanted to compare the effects of early and late surgical timing on non-neurological outcomes in persons with traumatic complete SCI. All cases of traumatic complete SCI referred to a...

journal_title：Journal of neurotrauma

authors： Bourassa-Moreau E,Mac-Thiong JM,Feldman DE,Thompson C,Parent S

更新日期：2013-09-15 00:00:00

abstract：:Participation in contact sports places athletes at elevated risk for repeated head injuries and is associated with negative mental health outcomes later in life. The current study identified changes observable on neuroimaging that persisted beyond the apparent resolution of acute symptoms of concussion. Sixteen young ...

journal_title：Journal of neurotrauma

authors： Orr CA,Albaugh MD,Watts R,Garavan H,Andrews T,Nickerson JP,Gonyea J,Hipko S,Zweber C,Logan K,Hudziak JJ

更新日期：2016-05-01 00:00:00

abstract：:The degree of post-traumatic brain edema and dysfunction of the blood-brain barrier (BBB) influences the neurofunctional outcome after a traumatic brain injury (TBI). Previous studies have demonstrated that the administration of apolipoprotein E-mimetic peptide COG1410 reduces the brain water content after subarachnoi...

journal_title：Journal of neurotrauma

authors： Cao F,Jiang Y,Wu Y,Zhong J,Liu J,Qin X,Chen L,Vitek MP,Li F,Xu L,Sun X

更新日期：2016-01-15 00:00:00

abstract：:End-to-side neurorrhaphy is widely used in the peripheral nervous system for nerve repair; however, the application of this technique has been limited to somatic nerves. The feasibility of nerve regeneration through end-to-side neurorrhaphy between autonomic and somatic nerves with different characteristics in the per...

journal_title：Journal of neurotrauma

authors： Gao WS,Dong CJ,Li SQ,Kunwar KJ,Li B

更新日期：2012-05-20 00:00:00

abstract：:Outcome following traumatic brain injury (TBI) is not only dependent on the nature and severity of injury and subsequent treatment, but also on constituent characteristics of injured individuals. We aimed to describe and quantify the relationship between demographic characteristics and six month outcome assessed by th...

journal_title：Journal of neurotrauma

authors： Mushkudiani NA,Engel DC,Steyerberg EW,Butcher I,Lu J,Marmarou A,Slieker F,McHugh GS,Murray GD,Maas AI

更新日期：2007-02-01 00:00:00

abstract：:Spinal cord injury (SCI) is associated with immune deficiencies and life-threatening infections. However, the specific mechanisms underlying this pathological condition remain unclear. In recent years, increasing evidence has suggested that anabolic hormones may be involved in immunological complications. Here, we mon...

journal_title：Journal of neurotrauma

authors： Rouleau P,Ung RV,Lapointe NP,Guertin PA

更新日期：2007-02-01 00:00:00

abstract：:Anecdotal observations of blast victims indicate that significant neuropathological and neurobehavioral defects may develop at later stages of life. To pre-clinically model this phenomenon, we have examined neurobehavioral changes in rats up to 1 year after exposure to single and tightly coupled repeated blasts using ...

journal_title：Journal of neurotrauma

authors： Arun P,Wilder DM,Eken O,Urioste R,Batuure A,Sajja S,Van Albert S,Wang Y,Gist ID,Long JB

更新日期：2020-02-15 00:00:00

abstract：:There is an urgent need for both the scientific development and clinical validation of novel therapies for acute spinal cord injury (SCI). The scientific development of novel therapies would be facilitated by a better understanding of the acute pathophysiology of human SCI. Clinical validation of such therapies would ...

journal_title：Journal of neurotrauma

authors： Kwon BK,Stammers AM,Belanger LM,Bernardo A,Chan D,Bishop CM,Slobogean GP,Zhang H,Umedaly H,Giffin M,Street J,Boyd MC,Paquette SJ,Fisher CG,Dvorak MF

更新日期：2010-04-01 00:00:00

abstract：:We investigated the effect of sports activity on physically-disabled individuals using behavioral and electrophysiological techniques. Visual go/no-go discriminative and simple response tasks were used. Participants included 17 disabled athletes, 9 from open-skill (wheelchair basketball) and eight from closed-skill (s...

journal_title：Journal of neurotrauma

authors： Di Russo F,Bultrini A,Brunelli S,Delussu AS,Polidori L,Taddei F,Traballesi M,Spinelli D

更新日期：2010-12-01 00:00:00

abstract：:Following a traumatic brain injury (TBI), excessive release of proinflammatory cytokines is the major cause of cerebral edema and neuronal loss. This study was designed to examine changes in concentrations of some proinflammatory cytokines-including interleukin-1 beta (IL-1β), interleukin 6 (IL-6), tumor necrosis fact...

journal_title：Journal of neurotrauma

authors： Sarkaki AR,Khaksari Haddad M,Soltani Z,Shahrokhi N,Mahmoodi M

更新日期：2013-01-01 00:00:00

abstract：:We conducted a study to evaluate the degree of corticospinal tract (CST) dysfunction associated with diffuse axonal injury (DAI) through analyses of both diffusion-tensor magnetic resonance imaging (DTMRI) and motor-evoked potential (MEP). Using DTMRI and MEP with transcranial magnetic stimulation, we evaluated 138 in...

journal_title：Journal of neurotrauma

authors： Yasokawa YT,Shinoda J,Okumura A,Nakayama N,Miwa K,Iwama T

更新日期：2007-01-01 00:00:00

abstract：:Spinal cord injury can have a range of debilitating effects, permanently impacting a patient's quality of life. Initially thought to be an immune privileged site, the spinal cord is able to mount a timely and well organized inflammatory response to injury. Intricate immune cell interactions are triggered, typically co...

journal_title：Journal of neurotrauma

authors： Bowes AL,Yip PK

更新日期：2014-11-01 00:00:00

abstract：:Guidelines for patients with severe traumatic brain injury (sTBI) published in 2007 recommend providing early nutrition after trauma. Early enteral nutrition (EN) started within 48 h post-injury reduces clinical malnutrition, prevents bacterial translocation from the gastrointestinal tract, and improves outcome in sTB...

journal_title：Journal of neurotrauma

authors： Chiang YH,Chao DP,Chu SF,Lin HW,Huang SY,Yeh YS,Lui TN,Binns CW,Chiu WT

更新日期：2012-01-01 00:00:00

abstract：:Clinical studies have documented the importance of secondary brain insults in determining neurologic outcome after head injury. Delayed intracranial hematomas are one of the most easily remediable causes of secondary injury if identified early, but can cause significant disability or death if not promptly recognized a...

journal_title：Journal of neurotrauma

authors： Robertson CS,Gopinath SP,Chance B

更新日期：1995-08-01 00:00:00

abstract：:4-Aminopyridine (4AP), a potassium channel antagonist, can improve hindlimb motor function in dogs with chronic thoracolumbar spinal cord injury (SCI); however, individual response is variable. We hypothesized that injury characteristics would differ between dogs that do and do not respond to 4AP. Our objective was to...

journal_title：Journal of neurotrauma

authors： Lewis MJ,Laber E,Olby NJ

更新日期：2019-05-01 00:00:00

abstract：:Return to living at home is an important patient-reported outcome following traumatic spinal cord injury (tSCI). Specialized inpatient rehabilitation assists such patients in maximizing function and independence. Our project aim was to describe those patients receiving specialized rehabilitation after tSCI in Canada, ...

journal_title：Journal of neurotrauma

authors： Cheng CL,Plashkes T,Shen T,Fallah N,Humphreys S,O'Connell C,Linassi AG,Ho C,Short C,Ethans K,Charbonneau R,Paquet J,Noonan VK

更新日期：2017-10-15 00:00:00

abstract：:Although chronic sleepiness is common after head trauma, the cause remains unclear. Transcranial magnetic stimulation (TMS) represents a useful complementary approach in the study of sleep pathophysiology. We aimed to determine in this study whether post-traumatic sleep-wake disturbances (SWD) are associated with chan...

journal_title：Journal of neurotrauma

authors： Nardone R,Bergmann J,Kunz A,Caleri F,Seidl M,Tezzon F,Gerstenbrand F,Trinka E,Golaszewski S

更新日期：2011-07-01 00:00:00

abstract：:Acute subdural hematomas (ASDHs) are highly morbid and increasingly common. Hematoma expansion is a potentially fatal complication, and few studies have examined whether factors associated with hematoma expansion vary over time. To answer this, we performed a case-control study in a cohort of initially conservatively ...

journal_title：Journal of neurotrauma

authors： Robinson D,Pyle L,Foreman B,Ngwenya LB,Adeoye O,Woo D,Kreitzer N

更新日期：2020-12-14 00:00:00

abstract：:Despite clinical symptoms, a large majority of people with mild traumatic brain injury (TBI) have normal computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therefore, present-day neuroimaging tools are insufficient to diagnose or classify low grades of TBI. Advanced neuroimaging techniques, such as d...

journal_title：Journal of neurotrauma

authors： Sinke MRT,Otte WM,Meerwaldt AE,Franx BAA,Ali MHM,Rakib F,van der Toorn A,van Heijningen CL,Smeele C,Ahmed T,Blezer ELA,Dijkhuizen RM

更新日期：2021-01-11 00:00:00

abstract：:Traumatic Brain Injury (TBI) can be associated with partial or total smell loss. Recent studies have suggested that olfactory outcome can be positively modulated after olfactory training (OT). This study's aim was to investigate OT's potential role in smell recovery after TBI-induced olfactory loss. A prospective, ran...

journal_title：Journal of neurotrauma

authors： Langdon C,Lehrer E,Berenguer J,Laxe S,Alobid I,Quintó L,Mariño-Sánchez F,Bernabeu M,Marin C,Mullol J

更新日期：2018-11-15 00:00:00

abstract：:We investigated associations between blood glucose levels and clinical outcomes in participants of the multi-center randomized controlled Brain-Hypothermia (B-HYPO) study. Patients with severe traumatic brain injury (TBI, Glasgow Coma Scale 4-8) were assigned to therapeutic hypothermia (TH, 32-34°C, n = 98) or fever c...

journal_title：Journal of neurotrauma

authors： Kobata H,Sugie A,Suehiro E,Dohi K,Kaneko T,Fujita M,Oda Y,Kuroda Y,Yamashita S,Maekawa T

更新日期：2017-03-01 00:00:00

abstract：:To test if observed vs. expected mortality differs by age among traumatic brain injury (TBI) cases, a population-based, historical cohort study was conducted in Olmsted County, Minnesota. From all residents with any diagnosis suggestive of TBI 1985-1999, we randomly sampled 7,800 and reviewed their medical records to ...

journal_title：Journal of neurotrauma

authors： Flaada JT,Leibson CL,Mandrekar JN,Diehl N,Perkins PK,Brown AW,Malec JF

更新日期：2007-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophyseal pathology. Sushi repeat-containing protein X-linked 2 (SRPX2) is...

journal_title：Journal of neurotrauma

authors： Anwer M,Lara-Valderrabano L,Karttunen J,Ndode-Ekane XE,Puhakka N,Pitkänen A

更新日期：2020-04-01 00:00:00