Norepinephrine and serotonin release upon impact injury to rat spinal cord.

Abstract:

:Microdialysis sampling was used to characterize the release of norepinephrine and serotonin upon impact injury to the rat spinal cord. Increases in extracellular norepinephrine concentrations in response to injury were small and of short duration. In contrast, serotonin concentrations quickly rose 35-90 times following injury and took 30-45 min to return to control levels. Bleeding caused by injury was probably the major source of the increased serotonin levels. Our results allow a role for serotonin in secondary damage upon injury to the spinal cord but suggest that norepinephrine is not a very significant contributor to such damage.

journal_name

J Neurotrauma

journal_title

Journal of neurotrauma

authors

Liu DX,Valadez V,Sorkin LS,McAdoo DJ

doi

10.1089/neu.1990.7.219

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

219-27

issue

4

eissn

0897-7151

issn

1557-9042

journal_volume

7

pub_type

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