Functional assessment measures in CNS trauma.

abstract：:Abstract Although several functional magnetic resonance imaging (fMRI) studies have been conducted in human models of mild traumatic brain injury (mTBI), to date no studies have explicitly examined how injury may differentially affect both the positive phase of the hemodynamic response function (HRF) as well as the po...

journal_title：Journal of neurotrauma

authors： Mayer AR,Toulouse T,Klimaj S,Ling JM,Pena A,Bellgowan PS

更新日期：2014-01-15 00:00:00

abstract：:Axon retraction greatly limits functional recovery after spinal cord injury (SCI) and neuron polarization, which affects processes including axon formation and development, is a promising target for promoting axon regeneration. Increasing microtubule stability has been demonstrated to improve intrinsic axon regenerati...

journal_title：Journal of neurotrauma

authors： Wang Q,Cai H,Hu Z,Wu Y,Guo X,Li J,Wang H,Liu Y,Liu Y,Xie L,Xu K,Xu H,He H,Zhang H,Xiao J

更新日期：2019-06-15 00:00:00

abstract：:Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI); however, the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following T...

journal_title：Journal of neurotrauma

authors： Wolf JA,Johnson BN,Johnson VE,Putt ME,Browne KD,Mietus CJ,Brown DP,Wofford KL,Smith DH,Grady MS,Cohen AS,Cullen DK

更新日期：2017-07-15 00:00:00

abstract：:Athletes in contact sports sustain repetitive subconcussive head impacts in a brief window, yet neurophysiological sequelae from repetitive subconcussion remain unclear. This prospective longitudinal study examined a relationship between changes in plasma Tau protein levels and subconcussive impact kinematic data in 2...

journal_title：Journal of neurotrauma

authors： Kawata K,Rubin LH,Wesley L,Lee JH,Sim T,Takahagi M,Bellamy A,Tierney R,Langford D

更新日期：2018-01-15 00:00:00

abstract：:Glycosylation is a fundamental cellular process that has a dramatic impact on the functionality of glycoconjugates such as proteins or lipids and mediates many different biological interactions including cell migration, cellular signaling, and synaptic interactions in the nervous system. In spinal cord injury (SCI), a...

journal_title：Journal of neurotrauma

authors： Osimanjiang W,Roballo KCS,Houck BD,Ito M,Antonopoulos A,Dell A,Haslam SM,Bushman JS

更新日期：2020-09-15 00:00:00

abstract：:There has been a recent call for longitudinal cohort studies to track the physiological recovery of sport-related concussion (SRC) and its relationship with clinical recovery. Resting-state functional magnetic resonance imaging (rs-fMRI) has shown potential for detecting subtle changes in brain function after SRC. We ...

journal_title：Journal of neurotrauma

authors： Meier TB,Giraldo-Chica M,España LY,Mayer AR,Harezlak J,Nencka AS,Wang Y,Koch KM,Wu YC,Saykin AJ,Giza CC,Goldman J,DiFiori JP,Guskiewicz KM,Mihalik JP,Brooks A,Broglio SP,McAllister T,McCrea MA

更新日期：2020-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in an accumulation of edema and loss of brain tissue. Progesterone (PROG) has been reported to reduce edema and cortical tissue loss in a bilateral prefrontal cortex injury. This study tests the hypothesis that PROG is neuroprotective following a unilateral parietal cortical contus...

journal_title：Journal of neurotrauma

authors： Gilmer LK,Roberts KN,Scheff SW

更新日期：2008-06-01 00:00:00

abstract：:The aim of this systematic review was to critically evaluate the evidence on interventions for depression following traumatic brain injury (TBI) and provide recommendations for clinical practice and future research. We reviewed pharmacological, other biological, psychotherapeutic, and rehabilitation interventions for ...

journal_title：Journal of neurotrauma

authors： Fann JR,Hart T,Schomer KG

更新日期：2009-12-01 00:00:00

abstract：:Athletes who sustain a concussion demonstrate a variety of symptoms and neuropsychological alterations that could be brought on by neurometabolic abnormalities. However, no study has yet investigated these aspects in female athletes using magnetic resonance spectroscopy. The present study investigated the neurometabol...

journal_title：Journal of neurotrauma

authors： Chamard E,Henry L,Boulanger Y,Lassonde M,Théoret H

更新日期：2014-02-15 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating condition affecting young, healthy individuals worldwide. Existing agents have inadequate therapeutic efficacy, and some are associated with side effects. Our objective is to summarize and critically assess the neurological recovery and antioxidant effects of curcumin for trea...

journal_title：Journal of neurotrauma

authors： Yao M,Yang L,Wang J,Sun YL,Dun RL,Wang YJ,Cui XJ

更新日期：2015-03-15 00:00:00

abstract：:Traumatic Brain Injury (TBI) can be associated with partial or total smell loss. Recent studies have suggested that olfactory outcome can be positively modulated after olfactory training (OT). This study's aim was to investigate OT's potential role in smell recovery after TBI-induced olfactory loss. A prospective, ran...

journal_title：Journal of neurotrauma

authors： Langdon C,Lehrer E,Berenguer J,Laxe S,Alobid I,Quintó L,Mariño-Sánchez F,Bernabeu M,Marin C,Mullol J

更新日期：2018-11-15 00:00:00

abstract：:Repair of the spinal cord and improvement of mobility after injury has been a matter of basic and clinical research for several decades. A number of repair approaches were performed in animals, mainly rodent models of spinal cord injury (SCI). Some of these experimental therapies resulted in significant regeneration o...

journal_title：Journal of neurotrauma

authors： Dietz V,Schwab ME

更新日期：2017-05-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) leads to an immunocompromised state responsible for an increased morbidity and mortality. Our understanding of the mechanisms responsible for this brain damage is incomplete. Damage maybe mediated by a complex cascade of neuroinflammation, and cytokine activation. In addition, trans...

journal_title：Journal of neurotrauma

authors： Mazzeo AT,Kunene NK,Gilman CB,Hamm RJ,Hafez N,Bullock MR

更新日期：2006-06-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS) is still not well known. Previous data show conflicting results regarding the association between MS and prior brain trauma. This study aims to investigate the risk for MS following a traumatic brain injury (TBI) using a large-scale cohort study design. This study used data from...

journal_title：Journal of neurotrauma

authors： Kang JH,Lin HC

更新日期：2012-01-01 00:00:00

abstract：:Oxidative energy metabolism is depressed after mild/moderate traumatic brain injury (TBI) during early development, accompanied by behavioral debilitation and secondary neuronal death. A TBI metabolome analysis revealed broad effects with a striking impact on energy metabolism. Our studies on mitochondrial modulators ...

journal_title：Journal of neurotrauma

authors： Chitturi J,Santhakumar V,Kannurpatti SS

更新日期：2019-04-15 00:00:00

abstract：:Traumatic brain injury (TBI) alters function and behavior, which can be characterized by changes in electrophysiological function in vitro. A common cognitive deficit after mild-to-moderate TBI is disruption of persistent working memory, of which the in vitro correlate is long-lasting, neuronal network synchronization...

journal_title：Journal of neurotrauma

authors： Kang WH,Cao W,Graudejus O,Patel TP,Wagner S,Meaney DF,Morrison B 3rd

更新日期：2015-07-01 00:00:00

abstract：:The purpose of this study was to compare spontaneous functional recovery after different spinal motor tract lesions in the rat spinal cord using three methods of analysis, the BBB, the rope test, and the CatWalk. We transected the dorsal corticospinal tract (CSTx) or the rubrospinal tract (RSTx) or the complete dorsal...

journal_title：Journal of neurotrauma

authors： Hendriks WT,Eggers R,Ruitenberg MJ,Blits B,Hamers FP,Verhaagen J,Boer GJ

更新日期：2006-01-01 00:00:00

abstract：:A therapeutic strategy for acute spinal cord injury would be to reduce the progressive degeneration and disconnection of axons from their targets. Here, we describe a model to evaluate degeneration of the ascending sensory projections to the nuclei in the medulla following graded spinal cord contusions in adult female...

journal_title：Journal of neurotrauma

authors： Baker KA,Hagg T

更新日期：2005-04-01 00:00:00

abstract：:Acupressure is a complementary and alternative medicine (CAM) treatment using fingertips to stimulate acupoints on the skin. Although suggested to improve cognitive function, acupressure has not been previously investigated with a controlled design in traumatic brain injury (TBI) survivors, who could particularly bene...

journal_title：Journal of neurotrauma

authors： McFadden KL,Healy KM,Dettmann ML,Kaye JT,Ito TA,Hernández TD

更新日期：2011-01-01 00:00:00

abstract：:Recovery of fine motor skills after traumatic brain injury (TBI) is variable, with some patients showing progressive improvements over time while others show poor recovery. We therefore studied possible cellular mechanisms accompanying the recovery process in a non-human primate model system, in which the lateral fron...

journal_title：Journal of neurotrauma

authors： Nagamoto-Combs K,Morecraft RJ,Darling WG,Combs CK

更新日期：2010-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is known to be accompanied by an increase in intracranial pressure (ICP) and in some cases, by spontaneous generation of cortical spreading depression (CSD) cycles. However, the role of CSD in the pathophysiology of cerebral contusion is still unknown. A multiparametric monitoring assembly...

journal_title：Journal of neurotrauma

authors： Rogatsky GG,Sonn J,Kamenir Y,Zarchin N,Mayevsky A

更新日期：2003-12-01 00:00:00

abstract：:Endothelial barrier antigen (EBA) is a protein triplet located in the plasma membrane of microvascular endothelium and selectively expressed in the normal nervous system. In this study, microvascular alterations following traumatic brain injury were studied using EBA immunohistochemistry. Anesthetized, physiologically...

journal_title：Journal of neurotrauma

authors： Lin B,Ginsberg MD,Zhao W,Alonso OF,Belayev L,Busto R

更新日期：2001-04-01 00:00:00

abstract：:Few studies have assessed the long-term functional outcomes of patients with a disorder of consciousness due to traumatic brain injury (TBI). This study examined functional status during the first 10 years after TBI among a cohort with disorders of consciousness (i.e., coma, vegetative state, minimally conscious state...

journal_title：Journal of neurotrauma

authors： Hammond FM,Giacino JT,Nakase Richardson R,Sherer M,Zafonte RD,Whyte J,Arciniegas DB,Tang X

更新日期：2019-04-01 00:00:00

abstract：:Older adults tend to have poorer outcomes compared to younger adults following moderate-to-severe traumatic brain injury (TBI). Currently, there is a need for research focusing on how elderly TBI has changed as the U.S. population shifts. This study provides a statewide account of moderate-to-severe TBI in regard to i...

journal_title：Journal of neurotrauma

authors： Ramanathan DM,McWilliams N,Schatz P,Hillary FG

更新日期：2012-05-01 00:00:00

abstract：:Neuropathic pain and motor deficits are detrimental consequences of injury to the spinal cord. In experimental settings, numerous neuroprotective agents are being explored for their therapeutic benefits. Vascular endothelial growth factor (VEGF) is an interesting candidate molecule in this respect since it is not only...

journal_title：Journal of neurotrauma

authors： van Neerven S,Joosten EA,Brook GA,Lambert CA,Mey J,Weis J,Marcus MA,Steinbusch HW,van Kleef M,Patijn J,Deumens R

更新日期：2010-10-01 00:00:00

abstract：:Spinal cord injury can have a range of debilitating effects, permanently impacting a patient's quality of life. Initially thought to be an immune privileged site, the spinal cord is able to mount a timely and well organized inflammatory response to injury. Intricate immune cell interactions are triggered, typically co...

journal_title：Journal of neurotrauma

authors： Bowes AL,Yip PK

更新日期：2014-11-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP), ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1), and S100B have been shown to be predictive of patients with brain injury. Kinetics of these biomarkers in injured humans have not been extensively examined. This prospective multi-center study included patients with mild-to-mode...

journal_title：Journal of neurotrauma

authors： Welch RD,Ellis M,Lewis LM,Ayaz SI,Mika VH,Millis S,Papa L

更新日期：2017-06-01 00:00:00

abstract：:Despite clinical symptoms, a large majority of people with mild traumatic brain injury (TBI) have normal computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therefore, present-day neuroimaging tools are insufficient to diagnose or classify low grades of TBI. Advanced neuroimaging techniques, such as d...

journal_title：Journal of neurotrauma

authors： Sinke MRT,Otte WM,Meerwaldt AE,Franx BAA,Ali MHM,Rakib F,van der Toorn A,van Heijningen CL,Smeele C,Ahmed T,Blezer ELA,Dijkhuizen RM

更新日期：2021-01-11 00:00:00

abstract：:Heterogeneity within brain injury presents a challenge to the development of informative molecular diagnostics. Recent studies show progress, particularly in cerebrospinal fluid, with biomarker assays targeting one or a few structural proteins. Protein-based assays in peripheral fluids, however, have been more challen...

journal_title：Journal of neurotrauma

authors： Ottens AK,Stafflinger JE,Griffin HE,Kunz RD,Cifu DX,Niemeier JP

更新日期：2014-04-15 00:00:00

abstract：:Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be effective. The purpose of this study was to characterize the sensory...

journal_title：Journal of neurotrauma

authors： Faw TD,Lerch JK,Thaxton TT,Deibert RJ,Fisher LC,Basso DM

更新日期：2018-09-15 00:00:00