Head injury and mortality in the homeless.

abstract：:Given the worldwide adverse impact of traumatic brain injury (TBI) on the human population, its diagnosis and prediction are of utmost importance. Historically, many studies have focused on associating head kinematics to brain injury risk. Recently, there has been a push toward using computationally expensive finite e...

journal_title：Journal of neurotrauma

authors： Laksari K,Fanton M,Wu LC,Nguyen TH,Kurt M,Giordano C,Kelly E,O'Keeffe E,Wallace E,Doherty C,Campbell M,Tiernan S,Grant G,Ruan J,Barbat S,Camarillo DB

更新日期：2020-04-01 00:00:00

abstract：:An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In thi...

journal_title：Journal of neurotrauma

authors： Kwon BK,Okon EB,Plunet W,Baptiste D,Fouad K,Hillyer J,Weaver LC,Fehlings MG,Tetzlaff W

更新日期：2011-08-01 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:Predicting outcome after pediatric traumatic brain injury (TBI) is important for providing information to families and prescribing rehabilitation services. The study objective was to assess whether biomarkers concentrations obtained at the time of injury are associated with outcome. Serial serum concentrations of neur...

journal_title：Journal of neurotrauma

authors： Berger RP,Beers SR,Richichi R,Wiesman D,Adelson PD

更新日期：2007-12-01 00:00:00

abstract：:Arginine-vasopressin (AVP) V1 receptors are known to mediate brain edema formation after traumatic brain injury (TBI). So far, however, AVP V1 receptors were only inhibited by genetic deletion or prior to trauma. Therefore, the current study aimed to determine the therapeutic window of AVP V1 receptor antagonization a...

journal_title：Journal of neurotrauma

authors： Krieg SM,Trabold R,Plesnila N

更新日期：2017-04-01 00:00:00

abstract：:Headache attributed to traumatic injury to the head (HAIH) is claimed to be the most common sequela following mild traumatic brain injury (MTBI), but epidemiological evidence is scarce. We explored whether patients with MTBI had an increase in headache suffering following injury compared with controls. We also studied...

journal_title：Journal of neurotrauma

authors： Nordhaug LH,Linde M,Follestad T,Skandsen ØN,Bjarkø VV,Skandsen T,Vik A

更新日期：2019-12-01 00:00:00

abstract：:Midcervical contusion injuries disrupt descending ipsilateral excitatory bulbospinal projections to phrenic motoneurons, compromising ventilation. We hypothesized that a unilateral contusion injury at C3 versus C5 would differentially impact phrenic activity reflecting more prominent disruption of ipsilateral descendi...

journal_title：Journal of neurotrauma

authors： Alvarez-Argote S,Gransee HM,Mora JC,Stowe JM,Jorgenson AJ,Sieck GC,Mantilla CB

更新日期：2016-03-01 00:00:00

abstract：:Changes in the modes of cerebrovascular pressure transmission during cerebral vasodilation induced by hypercapnic challenge were examined as a means for developing the basis for a bedside method to evaluate regulation of cerebral blood flow. Recordings of arterial blood pressure (ABP) and intracranial pressure (ICP) o...

journal_title：Journal of neurotrauma

authors： Daley ML,Pourcyrous M,Timmons SD,Leffler CW

更新日期：2007-03-01 00:00:00

abstract：:Central nervous system (CNS) axons recover poorly following injury because of the expression of myelin-derived inhibitors of axonal outgrowth such as Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), all of which bind to the Nogo-66 receptor 1 (NgR1). Herein we examine the rol...

journal_title：Journal of neurotrauma

authors： Tong J,Liu W,Wang X,Han X,Hyrien O,Samadani U,Smith DH,Huang JH

更新日期：2013-02-15 00:00:00

abstract：:In the present study, long-term and short-term rat preparations were used to develop a model for investigating external anal sphincter (EAS) reflexes in intact and spinal cord-injured (SCI) rats. In this model, EAS distension with an external probe elicits reflex contractions of the EAS in intact, unanesthetized anima...

journal_title：Journal of neurotrauma

authors： Holmes GM,Rogers RC,Bresnahan JC,Beattie MS

更新日期：1998-06-01 00:00:00

abstract：:The physiological characteristics of spinal cord responses recorded from the spinal epidural space of the cat to transcranial brain stimulation were studied, in comparison with the spinal cord responses to direct stimulation of the motor cortex or cerebellum. The conduction velocity of the initial wave of the response...

journal_title：Journal of neurotrauma

authors： Yamamoto T,Xing JA,Katayama Y,Tsubokawa T,Hirayama T,Maejima S

更新日期：1990-01-01 00:00:00

abstract：:The family of the collapsin response mediator proteins (CRMPs) plays a significant physiological role in neuronal cell bodies and axons within the integrated mammalian central nervous system (CNS). Trauma-induced damage to the CNS results in variable degrees of axonal degeneration, and this may lead to neuronal cell d...

journal_title：Journal of neurotrauma

authors： Taghian K,Lee JY,Petratos S

更新日期：2012-06-10 00:00:00

abstract：:Surviving motoneurons undergo dendritic atrophy after spinal cord injury (SCI), suggesting an important therapeutic target for neuroprotective strategies to improve recovery of function after SCI. Our previous studies showed that phospholipase A2 (PLA2) may play an important role in the pathogenesis of SCI. In the pre...

journal_title：Journal of neurotrauma

authors： Liu NK,Byers JS,Lam T,Lu QB,Sengelaub DR,Xu XM

更新日期：2014-11-11 00:00:00

abstract：:The generation of oxygen radicals and the process of lipid peroxidation have become a focus of attention for investigators in the fields of central nervous system (CNS) injury and stroke (e.g., ischemia). While absolute proof for their involvement in the pathophysiology of traumatic and ischemic damage to the CNS rema...

journal_title：Journal of neurotrauma

authors： Braughler JM,Hall ED

更新日期：1992-03-01 00:00:00

abstract：:The canine double hemorrhage model is an established model to study cerebral vasospasm, the late sequelae of subarachnoid hemorrhage (SAH). The present study uses magnetic resonance imaging (MRI) to examine the recently reported early brain injury after SAH. Double hemorrhage SAH modeling was obtained by injecting 0.5...

journal_title：Journal of neurotrauma

authors： Jadhav V,Sugawara T,Zhang J,Jacobson P,Obenaus A

更新日期：2008-09-01 00:00:00

abstract：:Intraspinal injections of lysolecithin were used to produce unilateral demyelination in the dorsal columns of the rat spinal cord. The purpose of this study was to evaluate the effects of demyelination on the conductive properties of axons belonging to a spinal pathway of known origin and site of termination. At 5 and...

journal_title：Journal of neurotrauma

authors： Yezierski RP,Devon RM,Vicedomini JP,Broton JG

更新日期：1992-10-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) has been suggested to play a complex role in the response to central nervous system insults such as traumatic brain injury (TBI) and cerebral ischemia. In the current study, we quantified maps of regional cerebral blood flow (CBF) using an arterial spin-labeling magnetic resonanc...

journal_title：Journal of neurotrauma

authors： Foley LM,Hitchens TK,Melick JA,Bayir H,Ho C,Kochanek PM

更新日期：2008-04-01 00:00:00

abstract：:Recent calls have been made for the inclusion of health-related quality of life (HRQoL) in traumatic brain injury studies. This study reports the impact of TBI on traditional measures (general health, depression, social isolation, labor force participation), self-assessed health function status using the SF-36 version...

journal_title：Journal of neurotrauma

authors： Hawthorne G,Gruen RL,Kaye AH

更新日期：2009-10-01 00:00:00

abstract：:Striatal-enriched tyrosine phosphatase (STEP) has been identified as a component of physiological and pathophysiological signaling pathways mediated by N-methyl-d-aspartate (NMDA) receptor/calcineurin/calpain activation. Activation of these pathways produces a subsequent change in STEP isoform expression or activation...

journal_title：Journal of neurotrauma

authors： Mesfin MN,von Reyn CR,Mott RE,Putt ME,Meaney DF

更新日期：2012-07-01 00:00:00

abstract：:. ...

journal_title：Journal of neurotrauma

authors： Maas A

更新日期：2018-08-04 00:00:00

abstract：:There are no established biomarkers for mild traumatic brain injury (mTBI), in part because post-concussive symptoms (PCS) are subjective and conventional imaging is typically unremarkable. To test whether diffuse axonal abnormalities quantified with three-dimensional (3D) proton magnetic resonance spectroscopic imagi...

journal_title：Journal of neurotrauma

authors： Kirov II,Tal A,Babb JS,Reaume J,Bushnik T,Ashman TA,Flanagan S,Grossman RI,Gonen O

更新日期：2013-07-01 00:00:00

abstract：:Heterogeneity within brain injury presents a challenge to the development of informative molecular diagnostics. Recent studies show progress, particularly in cerebrospinal fluid, with biomarker assays targeting one or a few structural proteins. Protein-based assays in peripheral fluids, however, have been more challen...

journal_title：Journal of neurotrauma

authors： Ottens AK,Stafflinger JE,Griffin HE,Kunz RD,Cifu DX,Niemeier JP

更新日期：2014-04-15 00:00:00

abstract：:Spinal cord injury (SCI) is associated with immune deficiencies and life-threatening infections. However, the specific mechanisms underlying this pathological condition remain unclear. In recent years, increasing evidence has suggested that anabolic hormones may be involved in immunological complications. Here, we mon...

journal_title：Journal of neurotrauma

authors： Rouleau P,Ung RV,Lapointe NP,Guertin PA

更新日期：2007-02-01 00:00:00

abstract：:This article addresses the need for age-relevant outcome measures for traumatic brain injury (TBI) research and summarizes the recommendations by the inter-agency Pediatric TBI Outcomes Workgroup. The Pediatric Workgroup's recommendations address primary clinical research objectives including characterizing course of ...

journal_title：Journal of neurotrauma

authors： McCauley SR,Wilde EA,Anderson VA,Bedell G,Beers SR,Campbell TF,Chapman SB,Ewing-Cobbs L,Gerring JP,Gioia GA,Levin HS,Michaud LJ,Prasad MR,Swaine BR,Turkstra LS,Wade SL,Yeates KO,Pediatric TBI Outcomes Workgroup.

更新日期：2012-03-01 00:00:00

abstract：:Fluid percussion brain injury is associated with an immediate rise in mean arterial pressure (MAP). However, the cerebral morphologic basis for this response is still not clear. Thirty-four anesthetized rats were injured using a lateral craniotomy preparation. In 19 rats, impact level was set at 1.73 +/- 0.04 atm, and...

journal_title：Journal of neurotrauma

authors： Yuan XQ,Wade CE,Clifford CB

更新日期：1991-10-01 00:00:00

abstract：:Previous work in this laboratory has demonstrated that rats show substantial deficits on the cued and hidden versions of the Morris water maze, as well as an apparent time-dependent recovery over a period of months, following moderate parasagittal fluid-percussion (FP) injury. However, the longitudinal nature of those...

journal_title：Journal of neurotrauma

authors： Sanders MJ,Dietrich WD,Green EJ

更新日期：1999-10-01 00:00:00

abstract：:Traumatic axonal injury (TAI) is a critical public health issue with its pathogenesis remaining largely elusive. Finite element (FE) head models are promising tools to bridge the gap between mechanical insult, localized brain response, and resultant injury. In particular, the FE-derived deformation along the direction...

journal_title：Journal of neurotrauma

authors： Zhou Z,Domel AG,Li X,Grant G,Kleiven S,Camarillo DB,Zeineh M

更新日期：2021-01-15 00:00:00

abstract：:Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI); however, the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following T...

journal_title：Journal of neurotrauma

authors： Wolf JA,Johnson BN,Johnson VE,Putt ME,Browne KD,Mietus CJ,Brown DP,Wofford KL,Smith DH,Grady MS,Cohen AS,Cullen DK

更新日期：2017-07-15 00:00:00

abstract：:Traumatic brain injury (TBI) is frequently complicated by acute lung injury, which is predictive for poor outcome. However, it is unclear whether lung injury develops independently or as a result of mechanical ventilation after TBI. Further, TBI is strongly associated with the development of pneumonia, suggesting a sp...

journal_title：Journal of neurotrauma

authors： Vermeij JD,Aslami H,Fluiter K,Roelofs JJ,van den Bergh WM,Juffermans NP,Schultz MJ,Van der Sluijs K,van de Beek D,van Westerloo DJ

更新日期：2013-12-15 00:00:00

abstract：:Muscle strength was assessed from the maximum force that could be exerted voluntarily by triceps brachii muscles of 72 people with chronic cervical spinal cord injury (SCI) at or above C7, and 18 able-bodied (A-B) subjects. The magnitude of co-activation was estimated from the ratio of biceps brachii surface EMG to tr...

journal_title：Journal of neurotrauma

authors： Thomas CK,Tucker ME,Bigland-Ritchie B

更新日期：1998-02-01 00:00:00