External anal sphincter hyperreflexia following spinal transection in the rat.

abstract：:Sports-related concussion is a major public health problem in the United States and yet its biomechanical mechanisms remain unclear. In vitro studies demonstrate axonal elongation as a potential injury mechanism; however, current response-based injury predictors (e.g., maximum principal strain, ε(ep)) typically do not...

journal_title：Journal of neurotrauma

authors： Ji S,Zhao W,Ford JC,Beckwith JG,Bolander RP,Greenwald RM,Flashman LA,Paulsen KD,McAllister TW

更新日期：2015-04-01 00:00:00

abstract：:Heterogeneity within brain injury presents a challenge to the development of informative molecular diagnostics. Recent studies show progress, particularly in cerebrospinal fluid, with biomarker assays targeting one or a few structural proteins. Protein-based assays in peripheral fluids, however, have been more challen...

journal_title：Journal of neurotrauma

authors： Ottens AK,Stafflinger JE,Griffin HE,Kunz RD,Cifu DX,Niemeier JP

更新日期：2014-04-15 00:00:00

abstract：:Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging and the onset of AD pathology is not known. In this study, we have ex...

journal_title：Journal of neurotrauma

authors： Collins JM,King AE,Woodhouse A,Kirkcaldie MTK,Vickers JC

更新日期：2019-06-01 00:00:00

abstract：:Sensorimotor recovery after spinal cord injury (SCI) is of utmost importance to injured individuals and will rely on improved understanding of SCI pathology and recovery. Novel transgenic mouse lines facilitate discovery, but must be understood to be effective. The purpose of this study was to characterize the sensory...

journal_title：Journal of neurotrauma

authors： Faw TD,Lerch JK,Thaxton TT,Deibert RJ,Fisher LC,Basso DM

更新日期：2018-09-15 00:00:00

abstract：:Diagnosis and treatment of stroke and traumatic brain injury remain significant health care challenges to society. Patient care stands to benefit from an improved understanding of the interactive biochemistry underlying neurotrauma pathobiology. In this study, we assessed the power of neuroproteomics to contrast bioch...

journal_title：Journal of neurotrauma

authors： Ottens AK,Bustamante L,Golden EC,Yao C,Hayes RL,Wang KK,Tortella FC,Dave JR

更新日期：2010-10-01 00:00:00

abstract：:Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of the large, heterogeneous data sets involved. In this sense, tra...

journal_title：Journal of neurotrauma

authors： Nielson JL,Guandique CF,Liu AW,Burke DA,Lash AT,Moseanko R,Hawbecker S,Strand SC,Zdunowski S,Irvine KA,Brock JH,Nout-Lomas YS,Gensel JC,Anderson KD,Segal MR,Rosenzweig ES,Magnuson DS,Whittemore SR,McTigue DM,Popovic

更新日期：2014-11-01 00:00:00

abstract：:A significant outflow of neurotransmitters and metabolites with associated enhanced cortical excitation occurs after concussive head trauma. Cellular changes in the acute post-injury period cannot be observed directly in humans, and as such, require indirect evidence from systems sufficiently sensitive to central neur...

journal_title：Journal of neurotrauma

authors： La Fountaine MF,Toda M,Testa A,Bauman WA

更新日期：2016-05-01 00:00:00

abstract：:Increasing clinical and experimental evidence suggests that traumatic brain injury (TBI) is associated with progressive histopathological damage. The aim of the current study was to characterize the time course of motor function, memory performance, and depression-like behavior up to 1 year after experimental TBI, and...

journal_title：Journal of neurotrauma

authors： Mao X,Terpolilli NA,Wehn A,Cheng S,Hellal F,Liu B,Seker B,Plesnila N

更新日期：2020-06-01 00:00:00

abstract：:Older adults tend to have poorer outcomes compared to younger adults following moderate-to-severe traumatic brain injury (TBI). Currently, there is a need for research focusing on how elderly TBI has changed as the U.S. population shifts. This study provides a statewide account of moderate-to-severe TBI in regard to i...

journal_title：Journal of neurotrauma

authors： Ramanathan DM,McWilliams N,Schatz P,Hillary FG

更新日期：2012-05-01 00:00:00

abstract：:The effect of flunarizine and methylprednisolone on the recovery of somatosensory evoked potentials (SEPs) was evaluated in an experimental model of spinal cord impact injury in anesthetized cats. In addition, the effect of flunarizine on posttraumatic spinal cord blood flow (SCBF) (using the hydrogen clearance techni...

journal_title：Journal of neurotrauma

authors： De Ley G,Leybaert L

更新日期：1993-04-01 00:00:00

abstract：:Behavioral assessment after spinal cord contusion has long focused on open field locomotion using modifications of a rating scale developed by Tarlov and Klinger (1954). However, on-going modifications by several groups have made interlaboratory comparison of locomotor outcome measures difficult. The purpose of the pr...

journal_title：Journal of neurotrauma

authors： Basso DM,Beattie MS,Bresnahan JC

更新日期：1995-02-01 00:00:00

abstract：:Despite its importance to care, clinicians and researchers often discount patient-reported outcomes in favor of proxy reports, in persons with traumatic brain injury (TBI). The rationale relates to concerns about lack of awareness of patients regarding their functioning. However, although lack of awareness occurs in s...

journal_title：Journal of neurotrauma

authors： Machamer J,Temkin N,Dikmen S

更新日期：2013-11-15 00:00:00

abstract：:Statins constitute a class of medications commonly used in the treatment of elevated cholesterol. However, in experimental studies, statins also have other non-cholesterol-mediated mechanisms of action, which may have neuroprotective effects. The aim of this study was to determine whether administration of atorvastati...

journal_title：Journal of neurotrauma

authors： Robertson CS,McCarthy JJ,Miller ER,Levin H,McCauley SR,Swank PR

更新日期：2017-02-27 00:00:00

abstract：:Wars in Afghanistan and Iraq have resulted in thousands of military personnel suffering traumatic brain injury (TBI), including closed-head injuries. Of interest is whether these individuals and other TBI survivors are at increased risk for substance use disorder (SUD). While it has been well established that drug or ...

journal_title：Journal of neurotrauma

authors： Bjork JM,Grant SJ

更新日期：2009-07-01 00:00:00

abstract：:This study was designed to assess the effect of spinal cord injury on neurobehavioral, electrophysiological, structural, and biochemical changes in normal and diabetic rats. Experimental diabetes was induced in Sprague-Dawley male rats (weighing 250-280 g) with streptozotocin (50 mg/kg i.p.). Eight weeks after the tre...

journal_title：Journal of neurotrauma

authors： Tariq M,Morais C,Kishore PN,Biary N,Al Deeb S,Al Moutaery K

更新日期：1998-04-01 00:00:00

abstract：:Spinal cord injury (SCI) is a devastating condition that affects patients on both a personal and societal level. The objective of the study is to improve the prediction of long-term functional outcome following SCI based on the acute clinical findings. A total of 76 patients with acute traumatic SCI were prospectively...

journal_title：Journal of neurotrauma

authors： Kaminski L,Cordemans V,Cernat E,M'Bra KI,Mac-Thiong JM

更新日期：2017-06-15 00:00:00

abstract：:Penetrating traumatic brain injury (PTBI) is one of the major cause of death and disability worldwide. Previous studies with penetrating ballistic-like brain injury (PBBI), a PTBI rat model revealed widespread perilesional neurodegeneration, similar to that seen in humans following gunshot wound to the head, which is ...

journal_title：Journal of neurotrauma

authors： Spurlock MS,Ahmed AI,Rivera KN,Yokobori S,Lee SW,Sam PN,Shear DA,Hefferan MP,Hazel TG,Johe KK,Gajavelli S,Tortella FC,Bullock RM

更新日期：2017-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) induces vascular changes that may influence neurological outcome by causing the brain to be more susceptible to secondary ischemic insults. In rat models of TBI, L-arginine administration has been shown to restore cerebral blood flow and improve neurological outcome. The purpose of this st...

journal_title：Journal of neurotrauma

authors： Liu H,Goodman JC,Robertson CS

更新日期：2002-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a principal cause of long-term physical, cognitive, behavioral, and social deficits in young adults, which frequently coexist with a high incidence of substance abuse disorders. However, few studies have examined the long-term effects of TBI on the neuroendocrine-immune system. TBI was ...

journal_title：Journal of neurotrauma

authors： Taylor AN,Rahman SU,Tio DL,Sanders MJ,Bando JK,Truong AH,Prolo P

更新日期：2006-12-01 00:00:00

abstract：:Previous studies have shown that location and direction of injury may affect outcome in experimental models of traumatic brain injury. Significant variability in outcome data has also been noted in studies using the lateral fluid percussion brain injury model (FPI) in rats. In recent studies from our laboratory, we ob...

journal_title：Journal of neurotrauma

authors： Vink R,Mullins PG,Temple MD,Bao W,Faden AI

更新日期：2001-08-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) has gained considerable notoriety during the past decade of conflict in Afghanistan and Iraq. However, the relationship between combat-related mTBI and residual mTBI symptoms, post-traumatic stress disorder (PTSD) symptoms, and neurocognitive deficits remains unclear. The purpose of ...

journal_title：Journal of neurotrauma

authors： Kontos AP,Kotwal RS,Elbin RJ,Lutz RH,Forsten RD,Benson PJ,Guskiewicz KM

更新日期：2013-04-15 00:00:00

abstract：:We evaluated in rats, the time course of changes in extracellular levels of amino acids, lactate and pyruvate, which ensued spinal cord compression of mild, moderate, and severe degrees. The neurochemical findings measured by HPLC were compared with known outcome measures of this model. A laminectomy of vertebrae Th7 ...

journal_title：Journal of neurotrauma

authors： Farooque M,Hillered L,Holtz A,Olsson Y

更新日期：1996-09-01 00:00:00

abstract：:Many patients with mild traumatic brain injury (MTBI) concurrently sustain extracranial injuries; however, little is known about the impact of these additional injuries on outcome. We assessed the impact of additional injuries on the severity of postconcussional symptoms (PCS) and functional outcome 6 months post-inju...

journal_title：Journal of neurotrauma

authors： Stulemeijer M,van der Werf SP,Jacobs B,Biert J,van Vugt AB,Brauer JM,Vos PE

更新日期：2006-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and disability in the United States, with children who sustain a TBI having a greater risk of developing long-lasting cognitive, behavioral, and motor function deficits. This has led to increased interest in utilizing large animal models to study pathophysiologi...

journal_title：Journal of neurotrauma

authors： Kinder HA,Baker EW,Howerth EW,Duberstein KJ,West FD

更新日期：2019-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) results in varying degrees of disability in a significant number of persons annually. The mechanisms of cognitive dysfunction after TBI have been explored in both animal models and human clinical studies for decades. Dopaminergic, serotonergic, and noradrenergic dysfunction has been descri...

journal_title：Journal of neurotrauma

authors： Shin SS,Dixon CE

更新日期：2015-10-01 00:00:00

abstract：:The imaging and clinical examination (ICE) algorithm used in the Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure (BEST TRIP) randomized controlled trial is the only prospectively investigated clinical protocol for traumatic brain injury management without intracranial pressure (ICP) m...

journal_title：Journal of neurotrauma

authors： Chesnut RM,Temkin N,Dikmen S,Rondina C,Videtta W,Petroni G,Lujan S,Alanis V,Falcao A,de la Fuenta G,Gonzalez L,Jibaja M,Lavarden A,Sandi F,Mérida R,Romero R,Pridgeon J,Barber J,Machamer J,Chaddock K

更新日期：2018-01-01 00:00:00

abstract：:Several recent global traumatic brain injury (TBI) initiatives rely on practice variation in diagnostic and treatment methods to answer effectiveness questions. One of these scientific dilemmas, the surgical management of the traumatic acute subdural hematoma (ASDH) might be variable among countries, among centers wit...

journal_title：Journal of neurotrauma

authors： van Essen TA,de Ruiter GC,Kho KH,Peul WC

更新日期：2017-02-15 00:00:00

abstract：:Outcome following traumatic brain injury (TBI) is not only dependent on the nature and severity of injury and subsequent treatment, but also on constituent characteristics of injured individuals. We aimed to describe and quantify the relationship between demographic characteristics and six month outcome assessed by th...

journal_title：Journal of neurotrauma

authors： Mushkudiani NA,Engel DC,Steyerberg EW,Butcher I,Lu J,Marmarou A,Slieker F,McHugh GS,Murray GD,Maas AI

更新日期：2007-02-01 00:00:00

abstract：:Axon retraction greatly limits functional recovery after spinal cord injury (SCI) and neuron polarization, which affects processes including axon formation and development, is a promising target for promoting axon regeneration. Increasing microtubule stability has been demonstrated to improve intrinsic axon regenerati...

journal_title：Journal of neurotrauma

authors： Wang Q,Cai H,Hu Z,Wu Y,Guo X,Li J,Wang H,Liu Y,Liu Y,Xie L,Xu K,Xu H,He H,Zhang H,Xiao J

更新日期：2019-06-15 00:00:00

abstract：:The past 10 years have seen a rapid increase in the use of diffusion tensor imaging to identify biomarkers of traumatic brain injury (TBI). Although the literature generally indicates decreased anisotropic diffusion at more chronic injury periods and in more severe injuries, considerable debate remains regarding the d...

journal_title：Journal of neurotrauma

authors： Dodd AB,Epstein K,Ling JM,Mayer AR

更新日期：2014-07-15 00:00:00