Residual effects of combat-related mild traumatic brain injury.

abstract：:Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. They mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation o...

journal_title：Journal of neurotrauma

authors： Eldadah BA,Faden AI

更新日期：2000-10-01 00:00:00

abstract：:The family of the collapsin response mediator proteins (CRMPs) plays a significant physiological role in neuronal cell bodies and axons within the integrated mammalian central nervous system (CNS). Trauma-induced damage to the CNS results in variable degrees of axonal degeneration, and this may lead to neuronal cell d...

journal_title：Journal of neurotrauma

authors： Taghian K,Lee JY,Petratos S

更新日期：2012-06-10 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with enhanced osteogenesis. The aim of this study was to investigate the effect of serum from TBI rats on fracture healing. Results from this study showed that the serum from TBI rats enhanced the expression of bone gamma carboxyglutamate protein (BGLAP), and promoted in vitr...

journal_title：Journal of neurotrauma

authors： Yang S,Ma Y,Liu Y,Que H,Zhu C,Liu S

更新日期：2012-11-20 00:00:00

abstract：:High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is passively released from damaged and necrotic cells, and actively released from immune cells. In contrast, cytochrome c is released from mitochondria in apoptotic cells, and is considered a reliable biomarker of apoptosis. Thus, HMGB1 and cytochr...

journal_title：Journal of neurotrauma

authors： Au AK,Aneja RK,Bell MJ,Bayir H,Feldman K,Adelson PD,Fink EL,Kochanek PM,Clark RS

更新日期：2012-07-20 00:00:00

abstract：:Glycosylation is a fundamental cellular process that has a dramatic impact on the functionality of glycoconjugates such as proteins or lipids and mediates many different biological interactions including cell migration, cellular signaling, and synaptic interactions in the nervous system. In spinal cord injury (SCI), a...

journal_title：Journal of neurotrauma

authors： Osimanjiang W,Roballo KCS,Houck BD,Ito M,Antonopoulos A,Dell A,Haslam SM,Bushman JS

更新日期：2020-09-15 00:00:00

abstract：:Functional recovery is markedly restricted following traumatic brain injury (TBI), partly due to myelin-associated inhibitors including Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), that all bind to the Nogo-66 receptor-1 (NgR1). In previous studies, pharmacological neutr...

journal_title：Journal of neurotrauma

authors： Hånell A,Clausen F,Björk M,Jansson K,Philipson O,Nilsson LN,Hillered L,Weinreb PH,Lee D,McIntosh TK,Gimbel DA,Strittmatter SM,Marklund N

更新日期：2010-07-01 00:00:00

abstract：:Patients sustaining severe traumatic brain injury (TBI) have variable long-term outcomes. We examined the association between Glasgow Outcome Scale (GOS) assessed at 3 months and long-term outcomes at 12 months after TBI. We studied 159 patients with severe, closed traumatic brain injuries (Glasgow Coma Scale [GCS]

journal_title：Journal of neurotrauma

authors： King JT Jr,Carlier PM,Marion DW

更新日期：2005-09-01 00:00:00

abstract：:A therapeutic strategy for acute spinal cord injury would be to reduce the progressive degeneration and disconnection of axons from their targets. Here, we describe a model to evaluate degeneration of the ascending sensory projections to the nuclei in the medulla following graded spinal cord contusions in adult female...

journal_title：Journal of neurotrauma

authors： Baker KA,Hagg T

更新日期：2005-04-01 00:00:00

abstract：:Given the worldwide adverse impact of traumatic brain injury (TBI) on the human population, its diagnosis and prediction are of utmost importance. Historically, many studies have focused on associating head kinematics to brain injury risk. Recently, there has been a push toward using computationally expensive finite e...

journal_title：Journal of neurotrauma

authors： Laksari K,Fanton M,Wu LC,Nguyen TH,Kurt M,Giordano C,Kelly E,O'Keeffe E,Wallace E,Doherty C,Campbell M,Tiernan S,Grant G,Ruan J,Barbat S,Camarillo DB

更新日期：2020-04-01 00:00:00

abstract：:The Glasgow Coma Scale (GCS) was introduced 40 years ago and has received world-wide acceptance. The GCS rates eye, motor, and verbal responses to assess the level of consciousness. Concerns have been expressed with regard to reliability and consistency of assessments. We considered that lack of standardization in app...

journal_title：Journal of neurotrauma

authors： Reith FC,Brennan PM,Maas AI,Teasdale GM

更新日期：2016-01-01 00:00:00

abstract：:We investigated associations between blood glucose levels and clinical outcomes in participants of the multi-center randomized controlled Brain-Hypothermia (B-HYPO) study. Patients with severe traumatic brain injury (TBI, Glasgow Coma Scale 4-8) were assigned to therapeutic hypothermia (TH, 32-34°C, n = 98) or fever c...

journal_title：Journal of neurotrauma

authors： Kobata H,Sugie A,Suehiro E,Dohi K,Kaneko T,Fujita M,Oda Y,Kuroda Y,Yamashita S,Maekawa T

更新日期：2017-03-01 00:00:00

abstract：:Urokinase (uPA) and tissue plasminogen activator (tPA) are serine proteases implicated in fibrinolysis, but their role in the regulation of the cerebrovascular response to brain trauma has not been investigated. This study was designed to (1) characterize the cerebrovascular activity of uPA and tPA, (2) investigate th...

journal_title：Journal of neurotrauma

authors： Armstead WM,Cines DB,Al-Roof Higazi A

更新日期：2004-09-01 00:00:00

abstract：:Adolescents are one of the highest groups at risk for sustaining both traumatic brain injury (TBI) and repeat TBI (RTBI). Consequences of endocrine dysfunction following TBI have been routinely explored in adults, but studies in adolescents are limited, and show an incidence rate of endocrine dysfunction in 16-61% in ...

journal_title：Journal of neurotrauma

authors： Greco T,Hovda D,Prins M

更新日期：2013-12-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) leads to an immunocompromised state responsible for an increased morbidity and mortality. Our understanding of the mechanisms responsible for this brain damage is incomplete. Damage maybe mediated by a complex cascade of neuroinflammation, and cytokine activation. In addition, trans...

journal_title：Journal of neurotrauma

authors： Mazzeo AT,Kunene NK,Gilman CB,Hamm RJ,Hafez N,Bullock MR

更新日期：2006-06-01 00:00:00

abstract：:Spinal cord injury (SCI) is associated with immune deficiencies and life-threatening infections. However, the specific mechanisms underlying this pathological condition remain unclear. In recent years, increasing evidence has suggested that anabolic hormones may be involved in immunological complications. Here, we mon...

journal_title：Journal of neurotrauma

authors： Rouleau P,Ung RV,Lapointe NP,Guertin PA

更新日期：2007-02-01 00:00:00

abstract：:The aim of this study is to assess the utility and effectiveness of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) of the entire pediatric cervical and thoracic spinal cord toward discrimination of typically developing (TD) controls and subjects with spinal cord injury (SCI). A total of 43 pedi...

journal_title：Journal of neurotrauma

authors： Alizadeh M,Fisher J,Saksena S,Sultan Y,Conklin CJ,Middleton DM,Finsterbusch J,Krisa L,Flanders AE,Faro SH,Mulcahey MJ,Mohamed FB

更新日期：2018-02-01 00:00:00

abstract：:How effectively the survivor of CNS trauma can function in society is the ultimate clinical outcome. Many victims of spinal cord injury (SCI) and traumatic brain injury (TBI) are frequently left with permanent impairment. Measurements of impairment, and the direct relationship to the functional loss and resultant disa...

journal_title：Journal of neurotrauma

authors： Ditunno JF Jr

更新日期：1992-03-01 00:00:00

abstract：:Fatalities or injuries following motorized and non-motorized vehicle accidents (MNMVA) are reported by police or health care systems. However, limited data exist for spinal injuries. Using an epidemiological database of road accidents occurring in a defined geographic area, we measured the incidence of major spinal tr...

journal_title：Journal of neurotrauma

authors： Lieutaud T,Ndiaye A,Frost F,Chiron M,Registry Group.

更新日期：2010-06-01 00:00:00

abstract：:Cognitive deficits are the most enduring and disabling sequelae of human traumatic brain injury (TBI), but quantifying the magnitude, duration, and pattern of cognitive deficits produced by different types of TBI has received little emphasis in preclinical animal models. The objective of the present study was to use a...

journal_title：Journal of neurotrauma

authors： Lindner MD,Plone MA,Cain CK,Frydel B,Francis JM,Emerich DF,Sutton RL

更新日期：1998-03-01 00:00:00

abstract：:Central nervous system (CNS) axons recover poorly following injury because of the expression of myelin-derived inhibitors of axonal outgrowth such as Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), all of which bind to the Nogo-66 receptor 1 (NgR1). Herein we examine the rol...

journal_title：Journal of neurotrauma

authors： Tong J,Liu W,Wang X,Han X,Hyrien O,Samadani U,Smith DH,Huang JH

更新日期：2013-02-15 00:00:00

abstract：:Chronic verbal retrieval deficits have been noted in traumatic brain injury (TBI), but no U.S. Food and Drug Administration-approved interventions are available. The present study investigated whether 10 sessions of 20 min of 1 mA anodal high-definition transcranial direct current stimulation (HD-tDCS) targeting pre-s...

journal_title：Journal of neurotrauma

authors： Motes MA,Spence JS,Yeatman K,Jones PM,Lutrell M,O'Hair R,Shakal S,DeLaRosa BL,To W,Vanneste S,Kraut MA,Hart J , Jr

更新日期：2020-01-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) transplanted into the contused spinal cord may support repair by improving tissue sparing. We injected allogeneic BMSC into the moderately contused adult rat thoracic spinal cord at 15 min (acute) and at 3, 7, and 21 days (delayed) post-injury and quantified tissue sparing and BMSC sur...

journal_title：Journal of neurotrauma

authors： Nandoe Tewarie RD,Hurtado A,Ritfeld GJ,Rahiem ST,Wendell DF,Barroso MM,Grotenhuis JA,Oudega M

更新日期：2009-12-01 00:00:00

abstract：:Rotational acceleration of the head, as occurs in falls, car crashes, and sport injuries, may result in diffuse brain damage, with acute and chronic neurological and psychiatric symptoms. The present study addresses the effects of rotational trauma on the neuronal cytoskeleton, which stabilizes perikaryal, dendritic a...

journal_title：Journal of neurotrauma

authors： Hamberger A,Huang YL,Zhu H,Bao F,Ding M,Blennow K,Olsson A,Hansson HA,Viano D,Haglid KG

更新日期：2003-02-01 00:00:00

abstract：:Direct lateral cortical impact through the intact leptomeninges using a pneumatically driven piston produces increasingly severe pathophysiologic derangements with increasing cortical deformation. We studied the histopathologic correlates of cortical impact injury produced by 2 mm, 2.5 mm, and 3 mm deformation in the ...

journal_title：Journal of neurotrauma

authors： Goodman JC,Cherian L,Bryan RM Jr,Robertson CS

更新日期：1994-10-01 00:00:00

abstract：:The rate of paroxysmal sympathetic hyperactivity (PSH) was retrospectively assessed using the Paroxysmal Sympathetic Hyperactivity-Assessment Measure (PSH-AM) scale in patients with disorders of consciousness attributed to traumatic and non-traumatic acquired brain injury during the rehabilitation phase. These results...

journal_title：Journal of neurotrauma

authors： Lucca LF,Pignolo L,Leto E,Ursino M,Rogano S,Cerasa A

更新日期：2019-08-15 00:00:00

abstract：:Levetiracetam (LEV) is an antiepileptic agent targeting novel pathways. Coupled with a favorable safety profile and increasing empirical clinical use, it was the fifth drug tested by Operation Brain Trauma Therapy (OBTT). We assessed the efficacy of a single 15 min post-injury intravenous (IV) dose (54 or 170 mg/kg) o...

journal_title：Journal of neurotrauma

authors： Browning M,Shear DA,Bramlett HM,Dixon CE,Mondello S,Schmid KE,Poloyac SM,Dietrich WD,Hayes RL,Wang KK,Povlishock JT,Tortella FC,Kochanek PM

更新日期：2016-03-15 00:00:00

abstract：:Despite an improved understanding of traumatic head and neck injury mechanisms, the impact tests required by major motorcycle helmet standards have remained unchanged for decades. Development of new test methods must reflect the specific impact loads causing injury in real crashes as well as test criteria appropriate ...

journal_title：Journal of neurotrauma

authors： Whyte T,Gibson T,Anderson R,Eager D,Milthorpe B

更新日期：2016-10-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1) is expressed widely in the central nervous system and is activated by various stimuli. Inhibiting TRPV1 has neuroprotective effects in cerebral ischemia. The role of inhibiting TRPV1 to maintain blood-brain barrier (BBB) integrity after traumatic brain injury (TBI) rema...

journal_title：Journal of neurotrauma

authors： Yang DX,Jing Y,Liu YL,Xu ZM,Yuan F,Wang ML,Geng Z,Tian HL

更新日期：2019-04-15 00:00:00

abstract：:Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in axonal damage and subsequent loss of communication between neuronal networks, causing long-term functional deficits. For CNS regeneration, repair strategies need ...

journal_title：Journal of neurotrauma

authors： Ruitenberg MJ,Vukovic J,Sarich J,Busfield SJ,Plant GW

更新日期：2006-03-01 00:00:00

abstract：:This study was designed to investigate the additional benefits of a multimodal early onset stimulation (MEOS) paradigm when combined with enriched environment (EE) versus EE only and standard housing (SH) on the recovery after experimental traumatic brain injury (TBI). Male Sprague- Dawley rats were subjected to moder...

journal_title：Journal of neurotrauma

authors： Maegele M,Lippert-Gruener M,Ester-Bode T,Sauerland S,Schäfer U,Molcanyi M,Lefering R,Bouillon B,Neiss WF,Angelov DN,Klug N,McIntosh TK,Neugebauer EA

更新日期：2005-07-01 00:00:00