Association between Blood Glucose Levels the Day after Targeted Temperature Initiation and Outcome in Traumatic Brain Injury: A Post-Hoc Analysis of the B-HYPO Study.

abstract：:Information on the nature of deficits and adaptive mechanisms occurring after spinal cord injury is essential to the design of strategies for promoting functional recovery. Motor impairments and compensations were quantified by three-dimensional kinematic analysis in freely walking rats, 6 months after mild cervical (...

journal_title：Journal of neurotrauma

authors： Collazos-Castro JE,Soto VM,Gutiérrez-Dávila M,Nieto-Sampedro M

更新日期：2005-05-01 00:00:00

abstract：:Spinal cord injury damaging the rubrospinal tract (RST) interferes with skilled forelimb movement, but identification of the precise role of the RST in this behavior is impeded by the difficulty of surgically isolating the RST from other pathways running within the lateral funiculus (LF). The present study used a skil...

journal_title：Journal of neurotrauma

authors： Morris R,Tosolini AP,Goldstein JD,Whishaw IQ

更新日期：2011-12-01 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:Athletes who sustain a concussion demonstrate a variety of symptoms and neuropsychological alterations that could be brought on by neurometabolic abnormalities. However, no study has yet investigated these aspects in female athletes using magnetic resonance spectroscopy. The present study investigated the neurometabol...

journal_title：Journal of neurotrauma

authors： Chamard E,Henry L,Boulanger Y,Lassonde M,Théoret H

更新日期：2014-02-15 00:00:00

abstract：:Contusion injuries of cat spinal cords rapidly block action potential conduction across the impact site. Ion-selective microelectrode measurements revealed large and immediate extracellular ionic derangements, sufficient to block conduction. As extracellular potassium recovers, evoked potentials often return but are l...

journal_title：Journal of neurotrauma

authors： Young W

更新日期：1991-07-01 00:00:00

abstract：:Phosphorus 31 magnetic resonance spectroscopy (31P MRS) was used to study noninvasively the intracellular free Mg2+ concentration and cellular bioenergetic state of rat brain in vivo before and after fluid percussion-induced traumatic brain injury of graded severity. Brain injury was induced at four levels: low (1.0 +...

journal_title：Journal of neurotrauma

authors： Vink R,Faden AI,McIntosh TK

更新日期：1988-01-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) leads to an immunocompromised state responsible for an increased morbidity and mortality. Our understanding of the mechanisms responsible for this brain damage is incomplete. Damage maybe mediated by a complex cascade of neuroinflammation, and cytokine activation. In addition, trans...

journal_title：Journal of neurotrauma

authors： Mazzeo AT,Kunene NK,Gilman CB,Hamm RJ,Hafez N,Bullock MR

更新日期：2006-06-01 00:00:00

abstract：:The clinical manifestations that occur after traumatic brain injury (TBI) include a wide range of cognitive, emotional, and behavioral deficits. The loss of excitatory synapses could potentially explain why such diverse symptoms occur after TBI, and a recent preclinical study has demonstrated a loss of dendritic spine...

journal_title：Journal of neurotrauma

authors： Winston CN,Chellappa D,Wilkins T,Barton DJ,Washington PM,Loane DJ,Zapple DN,Burns MP

更新日期：2013-12-01 00:00:00

abstract：:How effectively the survivor of CNS trauma can function in society is the ultimate clinical outcome. Many victims of spinal cord injury (SCI) and traumatic brain injury (TBI) are frequently left with permanent impairment. Measurements of impairment, and the direct relationship to the functional loss and resultant disa...

journal_title：Journal of neurotrauma

authors： Ditunno JF Jr

更新日期：1992-03-01 00:00:00

abstract：:Mild traumatic brain injury (mTBI) patients frequently experience emotion dysregulation symptoms, including post-traumatic stress. Although mTBI likely affects cortical activation and structure, resulting in cognitive symptoms after mTBI, early effects of mTBI on cortical emotion processing circuits have rarely been e...

journal_title：Journal of neurotrauma

authors： Wang X,Xie H,Cotton AS,Brickman KR,Lewis TJ,Wall JT,Tamburrino MB,Bauer WR,Law K,McLean SA,Liberzon I

更新日期：2017-01-15 00:00:00

abstract：:Much recent research has focused on the pathological significance of calcium accumulation in the central nervous system (CNS) following cerebral ischemia, spinal cord injury (SCI), and traumatic brain injury (TBI). Disturbances in neuronal calcium homeostasis may result in the activation of several calcium-sensitive e...

journal_title：Journal of neurotrauma

authors： Kampfl A,Posmantur RM,Zhao X,Schmutzhard E,Clifton GL,Hayes RL

更新日期：1997-03-01 00:00:00

abstract：:We investigated the activation of lower limb motor pools by supraspinal and spinal networks after human spinal cord injury (SCI). We compared electromyographic (EMG) activity from six muscles during voluntarily attempted non-weight-bearing single-joint movements, multijoint movements approximating stepping in a supine...

journal_title：Journal of neurotrauma

authors： Maegele M,Müller S,Wernig A,Edgerton VR,Harkema SJ

更新日期：2002-10-01 00:00:00

abstract：:Glycosylation is a fundamental cellular process that has a dramatic impact on the functionality of glycoconjugates such as proteins or lipids and mediates many different biological interactions including cell migration, cellular signaling, and synaptic interactions in the nervous system. In spinal cord injury (SCI), a...

journal_title：Journal of neurotrauma

authors： Osimanjiang W,Roballo KCS,Houck BD,Ito M,Antonopoulos A,Dell A,Haslam SM,Bushman JS

更新日期：2020-09-15 00:00:00

abstract：:Mild traumatic brain injury (mTBI) has gained considerable notoriety during the past decade of conflict in Afghanistan and Iraq. However, the relationship between combat-related mTBI and residual mTBI symptoms, post-traumatic stress disorder (PTSD) symptoms, and neurocognitive deficits remains unclear. The purpose of ...

journal_title：Journal of neurotrauma

authors： Kontos AP,Kotwal RS,Elbin RJ,Lutz RH,Forsten RD,Benson PJ,Guskiewicz KM

更新日期：2013-04-15 00:00:00

abstract：:The Glasgow Coma Scale (GCS) was introduced 40 years ago and has received world-wide acceptance. The GCS rates eye, motor, and verbal responses to assess the level of consciousness. Concerns have been expressed with regard to reliability and consistency of assessments. We considered that lack of standardization in app...

journal_title：Journal of neurotrauma

authors： Reith FC,Brennan PM,Maas AI,Teasdale GM

更新日期：2016-01-01 00:00:00

abstract：:Although mechanisms involved in progression of cell death in spinal cord injury (SCI) have been studied extensively, few are clear targets for translation to clinical application. One of the best-understood mechanisms of cell survival in SCI is phosphatidylinositol-3-kinase (PI3K)/Akt and associated downstream signali...

journal_title：Journal of neurotrauma

authors： Walker CL,Wu X,Liu NK,Xu XM

更新日期：2019-09-15 00:00:00

abstract：:Anatomical studies of spinal cord injury (SCI) using magnetic resonance imaging (MRI) report diverging observations, from "no changes" to "tissue atrophy in motor and non-motor regions." These discrepancies among studies can be attributed to heterogeneity in extent, level, and post-injury duration observed within the ...

journal_title：Journal of neurotrauma

authors： Karunakaran KD,He J,Zhao J,Cui JL,Zang YF,Zhang Z,Biswal BB

更新日期：2019-06-15 00:00:00

abstract：:After a severe, high-level spinal cord injury (SCI), plasticity to intraspinal circuits below injury results in heightened spinal sympathetic reflex activity and detrimentally impacts peripheral organ systems. Such sympathetic hyperreflexia is immediately apparent as an episode of autonomic dysreflexia (AD), a life-th...

journal_title：Journal of neurotrauma

authors： O'Reilly M,Mironets E,Saltos T,Crowther K,Collyer E,Bethea J,Tom VJ

更新日期：2021-01-04 00:00:00

abstract：:The effects of ethanol intoxication on brain injury and cerebral blood flow (CBF) were investigated in a porcine fluid-percussion model of traumatic brain injury (TBI). Immature swine, under halothane anesthesia (1%), had a TBI delivered with a fluid-percussion device. The experimental group (n = 10) received ethanol ...

journal_title：Journal of neurotrauma

authors： Zink BJ,Walsh RF,Feustel PJ

更新日期：1993-10-01 00:00:00

abstract：:The present study evaluated the effects of two novel N-methyl-D-aspartate (NMDA) receptor blockers and ifenprodil derivatives, CP-101,606 and CP-101,581, and their racemic mixture CP-98,113, on spatial memory and regional cerebral edema following experimental fluid-percussion (FP) brain injury in the rat (n = 66). Fif...

journal_title：Journal of neurotrauma

authors： Okiyama K,Smith DH,White WF,Richter K,McIntosh TK

更新日期：1997-04-01 00:00:00

abstract：:Early decompression may improve neurological outcome after spinal cord injury (SCI), but is often difficult to achieve because of logistical issues. The aims of this study were to 1) determine the time to decompression in cases of isolated cervical SCI in Australia and New Zealand and 2) determine where substantial de...

journal_title：Journal of neurotrauma

authors： Battistuzzo CR,Armstrong A,Clark J,Worley L,Sharwood L,Lin P,Rooke G,Skeers P,Nolan S,Geraghty T,Nunn A,Brown DJ,Hill S,Alexander J,Millard M,Cox SF,Rao S,Watts A,Goods L,Allison GT,Agostinello J,Cameron PA,Mo

更新日期：2016-06-15 00:00:00

abstract：:The activation of oxidative damage, neuroinflammation, and mitochondrial dysfunction has been implicated in secondary pathomechanisms following spinal cord injury (SCI). These pathophysiological processes lead to cell death and are tightly regulated by nuclear factor E2-related factor 2/antioxidant response element (N...

journal_title：Journal of neurotrauma

authors： Wang X,de Rivero Vaccari JP,Wang H,Diaz P,German R,Marcillo AE,Keane RW

更新日期：2012-03-20 00:00:00

abstract：:Traumatic brain injury (TBI) is associated with loss of autoregulation due to impaired responsiveness to cerebrovascular dilator stimuli, which leads to cerebral hypoperfusion and neuronal impairment or death. Upregulation of tissue plasminogen activator (tPA) post-TBI exacerbates loss of cerebral autoregulation and N...

journal_title：Journal of neurotrauma

authors： Armstead WM,Riley J,Yarovoi S,Cines DB,Smith DH,Higazi AA

更新日期：2012-06-10 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the most acute degenerative pathologies in the central nervous system, and in vivo indices enabling an assessment of TBI on a mechanistic basis have yet to be established. The aim of this work was to pursue neuroinflammatory changes and their link to functional disruptions of tra...

journal_title：Journal of neurotrauma

authors： Yu I,Inaji M,Maeda J,Okauchi T,Nariai T,Ohno K,Higuchi M,Suhara T

更新日期：2010-08-01 00:00:00

abstract：:Laser Doppler flowmetry (LDF) was used to study acute ipsilateral and contralateral disturbances of regional cerebral blood flow (rCBF) in a rat model of cerebral cortical contusion trauma. Twelve rats were intubated and artificially ventilated during and after trauma. Injury was produced with a weight drop technique ...

journal_title：Journal of neurotrauma

authors： Nilsson P,Gazelius B,Carlson H,Hillered L

更新日期：1996-04-01 00:00:00

abstract：:We present data correlating the time courses of hydroxyl radical (.OH) production, lipid peroxidation, and blood-brain barrier (BBB) damage following unilateral head injury in the rat. Using a controlled cortical impact device to inflict head injury, we have directly measured brain .OH levels via the salicylate trappi...

journal_title：Journal of neurotrauma

authors： Smith SL,Andrus PK,Zhang JR,Hall ED

更新日期：1994-08-01 00:00:00

abstract：:This study created a framework incorporating provider perspectives of best practices for early psychosocial intervention to improve caregiver experiences and outcomes after severe pediatric traumatic brain injury (TBI). A purposive sample of 23 healthcare providers from the emergency, intensive care, and acute care de...

journal_title：Journal of neurotrauma

authors： Erlick MR,Vavilala MS,Jaffe KM,Blayney CB,Moore M

更新日期：2020-11-09 00:00:00

abstract：:The present study tested a hypothesis that early identification of injury severity with quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting increased seizure susceptibility and epileptogenesis after traumatic brain injury (TBI). TBI was induced by lateral fluid percussion injury (FPI) in a...

journal_title：Journal of neurotrauma

authors： Immonen R,Kharatishvili I,Gröhn O,Pitkänen A

更新日期：2013-07-15 00:00:00

abstract：:Midcervical contusion injuries disrupt descending ipsilateral excitatory bulbospinal projections to phrenic motoneurons, compromising ventilation. We hypothesized that a unilateral contusion injury at C3 versus C5 would differentially impact phrenic activity reflecting more prominent disruption of ipsilateral descendi...

journal_title：Journal of neurotrauma

authors： Alvarez-Argote S,Gransee HM,Mora JC,Stowe JM,Jorgenson AJ,Sieck GC,Mantilla CB

更新日期：2016-03-01 00:00:00