MRI biomarkers for post-traumatic epileptogenesis.


:The present study tested a hypothesis that early identification of injury severity with quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting increased seizure susceptibility and epileptogenesis after traumatic brain injury (TBI). TBI was induced by lateral fluid percussion injury (FPI) in adult rats. Quantitative T2, T1ρ, and diffusion were assessed with MRI at 9 days, 23 days, or 2 months post-TBI in the perilesional cortex, thalamus, and hippocampus. Seizure susceptibility was assessed at 12 months after TBI using the pentylenetetrazol seizure-susceptibility test. At 9 and 23 days post-TBI, a change in T1ρ of the perilesional cortex showed the greatest predictive value for increased seizure susceptibility at 12 months post-TBI [area under the curve (AUC), 0.929 and 0.952, respectively; p<0.01]. At 2 months post-TBI, Dav in the thalamus was the best of the biomarkers analyzed (AUC, 0.988; p<0.05). The highest predictive value of all biomarkers was achieved by combining the measurement of Dav in the perilesional cortex and the thalamus at 2 months post-TBI (AUC, 1.000; p<0.01). Our results provide proof-of-concept evidence that clinically relevant MRI biomarkers predict increased seizure susceptibility after experimental TBI.


J Neurotrauma


Journal of neurotrauma


Immonen R,Kharatishvili I,Gröhn O,Pitkänen A




Has Abstract


2013-07-15 00:00:00












  • Traumatic Intracerebral Hemorrhage: Risk Factors Associated with Progression.

    abstract::The increase in the volume of a traumatic intracerebral hemorrhage (TICH) is a widely studied phenomenon that has a direct impact on the prognosis of patients. The objective of this study was to identify the risk factors associated with the progression of TICH. We retrospectively analyzed the records of 1970 adult pat...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Cepeda S,Gómez PA,Castaño-Leon AM,Martínez-Pérez R,Munarriz PM,Lagares A

    更新日期:2015-08-15 00:00:00

  • Provider Perspectives on Early Psychosocial Interventions after Pediatric Severe Traumatic Brain Injury: An Implementation Framework.

    abstract::This study created a framework incorporating provider perspectives of best practices for early psychosocial intervention to improve caregiver experiences and outcomes after severe pediatric traumatic brain injury (TBI). A purposive sample of 23 healthcare providers from the emergency, intensive care, and acute care de...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Erlick MR,Vavilala MS,Jaffe KM,Blayney CB,Moore M

    更新日期:2020-11-09 00:00:00

  • Early enteral nutrition and clinical outcomes of severe traumatic brain injury patients in acute stage: a multi-center cohort study.

    abstract::Guidelines for patients with severe traumatic brain injury (sTBI) published in 2007 recommend providing early nutrition after trauma. Early enteral nutrition (EN) started within 48 h post-injury reduces clinical malnutrition, prevents bacterial translocation from the gastrointestinal tract, and improves outcome in sTB...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,多中心研究


    authors: Chiang YH,Chao DP,Chu SF,Lin HW,Huang SY,Yeh YS,Lui TN,Binns CW,Chiu WT

    更新日期:2012-01-01 00:00:00

  • Morphological characterization of photochemical graded spinal cord injury in the rat.

    abstract::This study characterizes the histological and immunohistochemical changes in the adult rat spinal cord following photochemically induced spinal cord lesions. The spinal cord was exposed by laminectomy (T12-L1 vertebrae) and bathed with 1.5% rose bengal solution for 10 min. The excess dye was removed by saline rinse an...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Verdú E,García-Alías G,Forés J,Vela JM,Cuadras J,López-Vales R,Navarro X

    更新日期:2003-05-01 00:00:00

  • Pharmacological Stimulation of Mitochondrial Biogenesis Using the Food and Drug Administration-Approved β2-Adrenoreceptor Agonist Formoterol for the Treatment of Spinal Cord Injury.

    abstract::A hallmark of the progressive cascade of damage referred to as secondary spinal cord injury (SCI) is vascular disruption resulting in decreased oxygen delivery and loss of mitochondria homeostasis. While therapeutics targeting restoration of single facets of mitochondrial function have proven largely ineffective clini...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Scholpa NE,Williams H,Wang W,Corum D,Narang A,Tomlinson S,Sullivan PG,Rabchevsky AG,Schnellmann RG

    更新日期:2019-03-19 00:00:00

  • Relationship between severity of spinal cord injury and abnormalities in neurogenic cardiovascular control in conscious rats.

    abstract::Abnormal sympathetic tone after spinal cord injury (SCI) initially results in hypotension and is subsequently associated with autonomic dysreflexia characterized by paroxysmal hypertension and bradycardia in response to noxious or visceral stimuli. To evaluate the effect of a clinically relevant compression model of S...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Maiorov DN,Fehlings MG,Krassioukov AV

    更新日期:1998-05-01 00:00:00

  • Enduring vulnerability to transient reinstatement of hemiplegia by prazosin after traumatic brain injury.

    abstract::A single dose of an alpha1-noradrenergic antagonist transiently reinstates hemiplegia after recovery from brain injury, which suggests that noradrenaline (NA) is required to maintain recovery. No systematic studies have determined the postinjury duration of this vulnerability. This study used a within-subject, dose-re...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Stibick DL,Feeney DM

    更新日期:2001-03-01 00:00:00

  • Cortical Thickness in Mild Traumatic Brain Injury.

    abstract::Magnetic resonance imaging data were acquired at ∼24 h and ∼3 months post-injury on mild traumatic brain injury (mTBI; n = 75) and orthopedic injury (n = 60) cohorts. The mTBI subjects were randomly assigned to a treatment group with atorvastatin or a non-treatment mTBI group. The treatment group was further divided i...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,随机对照试验


    authors: Govindarajan KA,Narayana PA,Hasan KM,Wilde EA,Levin HS,Hunter JV,Miller ER,Patel VK,Robertson CS,McCarthy JJ

    更新日期:2016-10-15 00:00:00

  • Re-innervation of the bladder through end-to-side neurorrhaphy of autonomic nerve and somatic nerve in rats.

    abstract::End-to-side neurorrhaphy is widely used in the peripheral nervous system for nerve repair; however, the application of this technique has been limited to somatic nerves. The feasibility of nerve regeneration through end-to-side neurorrhaphy between autonomic and somatic nerves with different characteristics in the per...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Gao WS,Dong CJ,Li SQ,Kunwar KJ,Li B

    更新日期:2012-05-20 00:00:00

  • Mild traumatic brain injury is associated with impaired hippocampal spatiotemporal representation in the absence of histological changes.

    abstract::Mild traumatic brain injury (mTBI) accounts for the majority of head trauma cases. Despite some lasting cognitive, emotional, and behavioral deficits, there are frequently no overt morphological defects, suggesting that changes may result from alterations in the physiology of individual neurons. We investigated hippoc...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Eakin K,Miller JP

    更新日期:2012-04-10 00:00:00

  • Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats.

    abstract::Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active noncompetitive antagonist of the AMPA subtype of glutamate excitatory amino acid receptors. The purpose of this study was to determine whether treatment with talampanel would protect in a rat ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Belayev L,Alonso OF,Liu Y,Chappell AS,Zhao W,Ginsberg MD,Busto R

    更新日期:2001-10-01 00:00:00

  • Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion.

    abstract::Progesterone is an anti-inflammatory and promyelinating agent after spinal cord injury, but its effectiveness on functional recovery is still controversial. In the current study, we tested the effects of chronic progesterone administration on tissue preservation and functional recovery in a clinically relevant model o...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Garcia-Ovejero D,González S,Paniagua-Torija B,Lima A,Molina-Holgado E,De Nicola AF,Labombarda F

    更新日期:2014-05-01 00:00:00

  • A follow-up study of neurometabolic alterations in female concussed athletes.

    abstract::Athletes who sustain a concussion demonstrate a variety of symptoms and neuropsychological alterations that could be brought on by neurometabolic abnormalities. However, no study has yet investigated these aspects in female athletes using magnetic resonance spectroscopy. The present study investigated the neurometabol...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Chamard E,Henry L,Boulanger Y,Lassonde M,Théoret H

    更新日期:2014-02-15 00:00:00

  • Effective ICP reduction by decompressive craniectomy in patients with severe traumatic brain injury treated by an ICP-targeted therapy.

    abstract::Severe traumatic brain injury (TBI) is one of the major causes of death in younger age groups. In Umeå, Sweden, an intracranial pressure (ICP) targeted therapy protocol, the Lund concept, has been used in treatment of severe TBI since 1994. Decompressive craniectomy is used as a protocol-guided treatment step. The pri...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Olivecrona M,Rodling-Wahlström M,Naredi S,Koskinen LO

    更新日期:2007-06-01 00:00:00

  • The impact of hypercarbia on the evolution of brain injury in a porcine model of traumatic brain injury and systemic hemorrhage.

    abstract::Carbon dioxide is perhaps the most potent available modulator of cerebrovascular tone and thus cerebral blood flow (CBF). These experiments evaluate the impact of induced hypercarbia on the matching of blood flow and metabolism in the injured brain. We explore the hypothesis that hypercarbia will restore the relations...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Glass TF,Fabian MJ,Schweitzer JB,Weinberg JA,Proctor KG

    更新日期:2001-01-01 00:00:00

  • Immediate hypertensive response to fluid percussion brain injury may be related to intracerebral hemorrhage and hypothalamic damage.

    abstract::Fluid percussion brain injury is associated with an immediate rise in mean arterial pressure (MAP). However, the cerebral morphologic basis for this response is still not clear. Thirty-four anesthetized rats were injured using a lateral craniotomy preparation. In 19 rats, impact level was set at 1.73 +/- 0.04 atm, and...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Yuan XQ,Wade CE,Clifford CB

    更新日期:1991-10-01 00:00:00

  • Acute cerebral perfusion CT abnormalities associated with posttraumatic amnesia in mild head injury.

    abstract::Posttraumatic amnesia (PTA) is a common symptom following traumatic brain injury. Although this transient memory deficit implies specific impairment of higher brain function, the actual pathophysiology of PTA is not well understood. The aim of this study was to assess regional cerebral hemodynamics with perfusion comp...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Metting Z,Rödiger LA,de Jong BM,Stewart RE,Kremer BP,van der Naalt J

    更新日期:2010-12-01 00:00:00

  • Neurological recovery in diabetic rats following spinal cord injury.

    abstract::This study was designed to assess the effect of spinal cord injury on neurobehavioral, electrophysiological, structural, and biochemical changes in normal and diabetic rats. Experimental diabetes was induced in Sprague-Dawley male rats (weighing 250-280 g) with streptozotocin (50 mg/kg i.p.). Eight weeks after the tre...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Tariq M,Morais C,Kishore PN,Biary N,Al Deeb S,Al Moutaery K

    更新日期:1998-04-01 00:00:00

  • Psychiatric disorders and health-related quality of life after severe traumatic brain injury: a prospective study.

    abstract::Traumatic brain injury (TBI) is a major cause of death and disability and impairs health-related quality of life (HRQOL). Psychiatric disorders have been recognized as major components of TBI morbidity, yet few studies have addressed the relationship between these outcomes. Sample size, selection bias, and retrospecti...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Diaz AP,Schwarzbold ML,Thais ME,Hohl A,Bertotti MM,Schmoeller R,Nunes JC,Prediger R,Linhares MN,Guarnieri R,Walz R

    更新日期:2012-04-10 00:00:00

  • Postinjury administration of pituitary adenylate cyclase activating polypeptide (PACAP) attenuates traumatically induced axonal injury in rats.

    abstract::Pituitary adenylate cyclase activating polypeptide (PACAP) has several different actions in the nervous system. Numerous studies have shown its neuroprotective effects both in vitro and in vivo. Previously, it has been demonstrated that PACAP reduces brain damage in rat models of global and focal cerebral ischemia. Ba...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Tamás A,Zsombok A,Farkas O,Reglödi D,Pál J,Büki A,Lengvári I,Povlishock JT,Dóczi T

    更新日期:2006-05-01 00:00:00

  • Predicting Long-Term Global Outcome after Traumatic Brain Injury: Development of a Practical Prognostic Tool Using the Traumatic Brain Injury Model Systems National Database.

    abstract::For patients surviving serious traumatic brain injury (TBI), families and other stakeholders often desire information on long-term functional prognosis, but accurate and easy-to-use clinical tools are lacking. We aimed to build utilitarian decision trees from commonly collected clinical variables to predict Glasgow Ou...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Walker WC,Stromberg KA,Marwitz JH,Sima AP,Agyemang AA,Graham KM,Harrison-Felix C,Hoffman JM,Brown AW,Kreutzer JS,Merchant R

    更新日期:2018-07-15 00:00:00

  • Nodal versus Total Axonal Strain and the Role of Cholesterol in Traumatic Brain Injury.

    abstract::Traumatic brain injury (TBI) is a health threat that affects every year millions of people involved in motor vehicle and sporting accidents, and thousands of soldiers in battlefields. Diffuse axonal injury (DAI) is one of the most frequent types of TBI leading to death. In DAI, the initial traumatic event is followed ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Zhu F,Gatti DL,Yang KH

    更新日期:2016-05-01 00:00:00

  • The novel compound LOE 908 attenuates acute neuromotor dysfunction but not cognitive impairment or cortical tissue loss following traumatic brain injury in rats.

    abstract::Experimental traumatic brain injury (TBI) initiates massive disturbances in Ca2+ concentrations in the brain that may contribute to neuronal damage. Intracellular Ca2+ may be elevated via influx through voltage-operated cation channels, ligand-gated ionotropic channels, and store-operated cation channels (SOCs). In th...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Cheney JA,Brown AL,Bareyre FM,Russ AB,Weisser JD,Ensinger HA,Leusch A,Raghupathi R,Saatman KE

    更新日期:2000-01-01 00:00:00

  • Vestibular Dysfunction after Subconcussive Head Impact.

    abstract::Current thinking views mild head impact (i.e., subconcussion) as an underrecognized phenomenon that has the ability to cause significant current and future detrimental neurological effects. Repeated mild impacts to the head, however, often display no observable behavioral deficits based on standard clinical tests, whi...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Hwang S,Ma L,Kawata K,Tierney R,Jeka JJ

    更新日期:2017-01-01 00:00:00

  • Type I interferon inhibits astrocytic gliosis and promotes functional recovery after spinal cord injury by deactivation of the MEK/ERK pathway.

    abstract::Formation of a glial scar is one of the major obstacles to axonal growth after injury to the adult CNS. In this study, we have addressed this issue by focusing on reactive astrocytes in a mouse model of spinal cord injury (SCI). First, we attempted to identify profile changes in the expression of astrocytic gliosis 10...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Ito M,Natsume A,Takeuchi H,Shimato S,Ohno M,Wakabayashi T,Yoshida J

    更新日期:2009-01-01 00:00:00

  • Formation of microparticles in the injured brain of patients with severe isolated traumatic brain injury.

    abstract::The potential pathophysiological role of circulating microparticles (MPs) has been recognized in various conditions, such as cardiovascular and thrombotic diseases. Traumatic brain injury (TBI) has a complex pathophysiology that involves coagulopathy and inflammation. We investigated endothelial-, platelet-, and leuko...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Nekludov M,Mobarrez F,Gryth D,Bellander BM,Wallen H

    更新日期:2014-12-01 00:00:00

  • Progression of traumatic intracerebral hemorrhage: a prospective observational study.

    abstract::ABSTRACT Preliminary evidence has shown that intracerebral hemorrhages, either spontaneous (sICH) or traumatic (tICH) often expand over time. An association between hemorrhage expansion and clinical outcomes has been described for sICH. The intent of this prospective, observational study was to characterize the tempor...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,多中心研究


    authors: Narayan RK,Maas AI,Servadei F,Skolnick BE,Tillinger MN,Marshall LF,Traumatic Intracerebral Hemorrhage Study Group.

    更新日期:2008-06-01 00:00:00

  • Association between Blood Glucose Levels the Day after Targeted Temperature Initiation and Outcome in Traumatic Brain Injury: A Post-Hoc Analysis of the B-HYPO Study.

    abstract::We investigated associations between blood glucose levels and clinical outcomes in participants of the multi-center randomized controlled Brain-Hypothermia (B-HYPO) study. Patients with severe traumatic brain injury (TBI, Glasgow Coma Scale 4-8) were assigned to therapeutic hypothermia (TH, 32-34°C, n = 98) or fever c...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kobata H,Sugie A,Suehiro E,Dohi K,Kaneko T,Fujita M,Oda Y,Kuroda Y,Yamashita S,Maekawa T

    更新日期:2017-03-01 00:00:00

  • L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats.

    abstract::To examine the mechanism of the increase in cerebral blood flow induced by L-arginine administration after traumatic brain injury, the cerebral hemodynamic effects of L-arginine, D-arginine, and the free radical scavengers superoxide dismutase (SOD) and catalase were compared in the controlled cortical impact injury m...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Cherian L,Robertson CS

    更新日期:2003-01-01 00:00:00

  • Should Young Children with Traumatic Brain Injury Be Compared with Community or Orthopedic Control Participants?

    abstract::Pediatric traumatic brain injury (TBI) research depends on comparisons of profiles and outcomes between brain-injured individuals and groups consisting either of injured controls (e.g., orthopedic injuries, OI) or uninjured, typically developing children recruited from the community (community controls, CC). Children ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章


    authors: Beauchamp MH,Landry-Roy C,Gravel J,Beaudoin C,Bernier A

    更新日期:2017-09-01 00:00:00