Abstract:
:The present study tested a hypothesis that early identification of injury severity with quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting increased seizure susceptibility and epileptogenesis after traumatic brain injury (TBI). TBI was induced by lateral fluid percussion injury (FPI) in adult rats. Quantitative T2, T1ρ, and diffusion were assessed with MRI at 9 days, 23 days, or 2 months post-TBI in the perilesional cortex, thalamus, and hippocampus. Seizure susceptibility was assessed at 12 months after TBI using the pentylenetetrazol seizure-susceptibility test. At 9 and 23 days post-TBI, a change in T1ρ of the perilesional cortex showed the greatest predictive value for increased seizure susceptibility at 12 months post-TBI [area under the curve (AUC), 0.929 and 0.952, respectively; p<0.01]. At 2 months post-TBI, Dav in the thalamus was the best of the biomarkers analyzed (AUC, 0.988; p<0.05). The highest predictive value of all biomarkers was achieved by combining the measurement of Dav in the perilesional cortex and the thalamus at 2 months post-TBI (AUC, 1.000; p<0.01). Our results provide proof-of-concept evidence that clinically relevant MRI biomarkers predict increased seizure susceptibility after experimental TBI.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Immonen R,Kharatishvili I,Gröhn O,Pitkänen Adoi
10.1089/neu.2012.2815subject
Has Abstractpub_date
2013-07-15 00:00:00pages
1305-9issue
14eissn
0897-7151issn
1557-9042journal_volume
30pub_type
杂志文章abstract::Although the citation index of an article is not a direct measure of its quality or importance, it is a measure of recognition that may suggest its impact on the scientific community. This study was undertaken to examine the characteristics of the top 100 most frequently cited articles (so-called "citation classics") ...
journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2013.2978
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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doi:10.1089/neu.2014.3387
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journal_title:Journal of neurotrauma
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doi:10.1089/089771501750170958
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,随机对照试验
doi:10.1089/neu.2013.3069
更新日期:2014-01-15 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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pub_type: 杂志文章
doi:10.1089/neu.1996.13.583
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pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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