Autophagy Modulation by Lanthionine Ketimine Ethyl Ester Improves Long-Term Outcome after Central Fluid Percussion Injury in the Mouse.

Abstract:

:Diffuse axonal injury is recognized as a progressive and long-term consequence of traumatic brain injury. Axonal injury can have sustained negative consequences on neuronal functions such as anterograde and retrograde transport and cellular processes such as autophagy that depend on cytoarchitecture and axon integrity. These changes can lead to somatic atrophy and an inability to repair and promote plasticity. Obstruction of the autophagic process has been noted after brain injury, and rapamycin, a drug used to stimulate autophagy, has demonstrated positive effects in brain injury models. The optimization of drugs to promote beneficial autophagy without negative side effects could be used to attenuate traumatic brain injury and promote improved outcome. Lanthionine ketimine ethyl ester, a bioavailable derivative of a natural sulfur amino acid metabolite, has demonstrated effects on autophagy both in vitro and in vivo. Thirty minutes after a moderate central fluid percussion injury and throughout the survival period, lanthionine ketimine ethyl ester was administered, and mice were subsequently evaluated for learning and memory impairments and biochemical and histological changes over a 5-week period. Lanthionine ketimine ethyl ester, which we have shown previously to modulate autophagy markers and alleviate pathology and slow cognitive decline in the 3 × TgAD mouse model, spared cognition and pathology after central fluid percussion injury through a mechanism involving autophagy modulation.

journal_name

J Neurotrauma

journal_title

Journal of neurotrauma

authors

Hensley K,Poteshkina A,Johnson MF,Eslami P,Gabbita SP,Hristov AM,Venkova-Hristova KM,Harris-White ME

doi

10.1089/neu.2015.4196

subject

Has Abstract

pub_date

2016-08-15 00:00:00

pages

1501-13

issue

16

eissn

0897-7151

issn

1557-9042

journal_volume

33

pub_type

杂志文章
  • Low concentration of isoflurane promotes the development of neurogenic pulmonary edema in spinal cord injured rats.

    abstract::Anesthetics can either promote or inhibit the development of neurogenic pulmonary edema (NPE) after central nervous system (CNS) injury. The influence of isoflurane was examined in male Wistar rats using 1.5%, 2%, 2.5%, 3%, 4%, or 5% isoflurane in air. Epidural balloon compression of the thoracic spinal cord was perfo...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2006.0252

    authors: Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Burian M,Jendelová P,Zicha J,Kunes J,Syková E

    更新日期:2007-09-01 00:00:00

  • Subacute Pain after Traumatic Brain Injury Is Associated with Lower Insular N-Acetylaspartate Concentrations.

    abstract::Persistent pain is experienced by more than 50% of persons who sustain a traumatic brain injury (TBI), and more than 30% experience significant pain as early as 6 weeks after injury. Although neuropathic pain is a common consequence after CNS injuries, little attention has been given to neuropathic pain symptoms after...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2015.4098

    authors: Widerström-Noga E,Govind V,Adcock JP,Levin BE,Maudsley AA

    更新日期:2016-07-15 00:00:00

  • Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance study.

    abstract::Proton magnetic resonance spectroscopy (1H-MRS) offers a unique insight into brain cellular metabolism following traumatic brain injury (TBI). The aim of the present study was to assess change in neurometabolite markers of brain injury during the recovery period following TBI. We studied 19 TBI patients at 1.5, 3, and...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/089771500415382

    authors: Brooks WM,Stidley CA,Petropoulos H,Jung RE,Weers DC,Friedman SD,Barlow MA,Sibbitt WL Jr,Yeo RA

    更新日期:2000-08-01 00:00:00

  • Olfactory Training in Post-Traumatic Smell Impairment: Mild Improvement in Threshold Performances: Results from a Randomized Controlled Trial.

    abstract::Traumatic Brain Injury (TBI) can be associated with partial or total smell loss. Recent studies have suggested that olfactory outcome can be positively modulated after olfactory training (OT). This study's aim was to investigate OT's potential role in smell recovery after TBI-induced olfactory loss. A prospective, ran...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,随机对照试验

    doi:10.1089/neu.2017.5230

    authors: Langdon C,Lehrer E,Berenguer J,Laxe S,Alobid I,Quintó L,Mariño-Sánchez F,Bernabeu M,Marin C,Mullol J

    更新日期:2018-11-15 00:00:00

  • Decreases in White Matter Integrity of Ventro-Limbic Pathway Linked to Post-Traumatic Stress Disorder in Mild Traumatic Brain Injury.

    abstract::Post-traumatic stress disorder (PTSD) is commonly observed in military service members with mild traumatic brain injury (mTBI); however, the relationship between mTBI and PTSD is complex and not well understood. The present study aims to elucidate a link between the degree of alteration in limbic system-related white ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2017.5541

    authors: Santhanam P,Teslovich T,Wilson SH,Yeh PH,Oakes TR,Weaver LK

    更新日期:2019-04-01 00:00:00

  • Quinolinic acid accumulation in injured spinal cord: time course, distribution, and species differences between rat and guinea pig.

    abstract::Experimental compression injury of the spinal cord in guinea pigs results in delayed neurologic deficits that continue to increase in severity for several days following trauma, coincident with inflammatory responses, including invasion of the lesion by mononuclear phagocytes and increased levels of the neurotoxin qui...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.1997.14.89

    authors: Blight AR,Leroy EC Jr,Heyes MP

    更新日期:1997-02-01 00:00:00

  • Standardizing data collection in traumatic brain injury.

    abstract::Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we "speak the same language." Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons betwe...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2010.1617

    authors: Maas AI,Harrison-Felix CL,Menon D,Adelson PD,Balkin T,Bullock R,Engel DC,Gordon W,Langlois-Orman J,Lew HL,Robertson C,Temkin N,Valadka A,Verfaellie M,Wainwright M,Wright DW,Schwab K

    更新日期:2011-02-01 00:00:00

  • Functional outcome scales in traumatic brain injury: a comparison of the Glasgow Outcome Scale (Extended) and the Functional Status Examination.

    abstract::Clinical trials aimed at developing therapies for traumatic brain injury (TBI) require outcome measures that are reliable, validated, and easily administered. The most widely used of these measures, the Glasgow Outcome Scale (GOS) and the GOS-Extended (GOS-E), have been criticized as suffering from ceiling effects. In...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2005.22.1319

    authors: Hudak AM,Caesar RR,Frol AB,Krueger K,Harper CR,Temkin NR,Dikmen SS,Carlile M,Madden C,Diaz-Arrastia R

    更新日期:2005-11-01 00:00:00

  • Living systematic reviews: A novel approach to create a living evidence base.

    abstract::. ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2018.6059

    authors: Maas A

    更新日期:2018-08-04 00:00:00

  • Diffusion Tensor Imaging in Contact and Non-Contact University-Level Sport Athletes.

    abstract::Subconcussive hits to the head and physical fitness both have been associated with alterations in white matter (WM) microstructure in partly overlapping areas of the brain. The aim of the present study was to determine whether WM damage associated with repeated exposure to subconcussive hits to the head in university ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2020.7170

    authors: Lefebvre G,Guay S,Chamard E,Theaud G,de Guise E,Bacon BA,Descoteaux M,De Beaumont L,Théoret H

    更新日期:2020-08-10 00:00:00

  • A New Risk Factor for Traumatic Spinal Cord Injury.

    abstract::Several behavioral factors such as violence, impulsivity, and alcohol-related problems are associated with traumatic spinal cord injury (TSCI). Such factors have been associated with inherently low neuronal serotonergic capacity that in turn is reflected in low activity of monoamine oxidase (MAO) as measured in platel...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2016.4462

    authors: Sabre L,Harro J,Eensoo D,Vaht M,Kabel V,Pakkanen M,Asser T,Kõrv J

    更新日期:2016-11-01 00:00:00

  • The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Role of antiseizure prophylaxis following head injury.

    abstract::The majority of studies do not support the use of the prophylactic anticonvulsants studied thus far for the prevention of late PTS. Routine seizure prophylaxis later than 1 week following head injury is, therefore, not recommended. If late PTS occur, patients should be managed in accordance with standard approaches to...

    journal_title:Journal of neurotrauma

    pub_type: 指南,杂志文章,实务指引,评审

    doi:10.1089/neu.2000.17.549

    authors:

    更新日期:2000-06-01 00:00:00

  • Group-wise evaluation and comparison of white matter fiber strain and maximum principal strain in sports-related concussion.

    abstract::Sports-related concussion is a major public health problem in the United States and yet its biomechanical mechanisms remain unclear. In vitro studies demonstrate axonal elongation as a potential injury mechanism; however, current response-based injury predictors (e.g., maximum principal strain, ε(ep)) typically do not...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2013.3268

    authors: Ji S,Zhao W,Ford JC,Beckwith JG,Bolander RP,Greenwald RM,Flashman LA,Paulsen KD,McAllister TW

    更新日期:2015-04-01 00:00:00

  • Age, outcome, and rehabilitation costs after paraplegia caused by traumatic injury of the thoracic spinal cord, conus medullaris, and cauda equina.

    abstract::The object of this study was to investigate the relationships of age on neurologic and functional outcome, hospitalization length of stay (LOS), and hospital charges after spinal cord injury (SCI). At 20 medical centers, 2,169 consecutive adult patients with paraplegia SCI were assessed in acute care and inpatient reh...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章,多中心研究

    doi:10.1089/neu.1999.16.805

    authors: Cifu DX,Huang ME,Kolakowsky-Hayner SA,Seel RT

    更新日期:1999-09-01 00:00:00

  • Acute Cardiovascular Responses to Vagus Nerve Stimulation after Experimental Spinal Cord Injury.

    abstract::Pairing vagus nerve stimulation (VNS) with rehabilitation has emerged as a potential strategy to enhance plasticity and improve recovery in a range of neurological disorders. A recent study highlights the therapeutic promise of VNS in promoting motor recovery after spinal cord injury (SCI). We investigated the safety ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2019.6828

    authors: Sachdeva R,Krassioukov AV,Bucksot JE,Hays SA

    更新日期:2020-05-01 00:00:00

  • The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Indications for intracranial pressure monitoring.

    abstract::ICP monitoring per se has never been subjected to a prospective randomized clinical trial (PRCT) to establish its efficacy (or lack thereof) in improving outcome from severe head injury. Hence, there are insufficient data to support its use as a standard. However, there is a large body of published clinical experience...

    journal_title:Journal of neurotrauma

    pub_type: 指南,杂志文章,实务指引,评审

    doi:10.1089/neu.2000.17.479

    authors:

    更新日期:2000-06-01 00:00:00

  • Formation of microparticles in the injured brain of patients with severe isolated traumatic brain injury.

    abstract::The potential pathophysiological role of circulating microparticles (MPs) has been recognized in various conditions, such as cardiovascular and thrombotic diseases. Traumatic brain injury (TBI) has a complex pathophysiology that involves coagulopathy and inflammation. We investigated endothelial-, platelet-, and leuko...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2013.3168

    authors: Nekludov M,Mobarrez F,Gryth D,Bellander BM,Wallen H

    更新日期:2014-12-01 00:00:00

  • The effect of postinjury administration of polyethylene glycol-conjugated superoxide dismutase (pegorgotein, Dismutec) or lidocaine on behavioral function following fluid-percussion brain injury in rats.

    abstract::Previous studies in our laboratory have shown that polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) or lidocaine treatment before experimental fluid-percussion brain injury in rats reduces the cortical hypoperfusion normally found in the early posttraumatic period. The purpose of the current study was to ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.1996.13.325

    authors: Hamm RJ,Temple MD,Pike BR,Ellis EF

    更新日期:1996-06-01 00:00:00

  • Spectral analyses of cardiovascular control in rodents with spinal cord injury.

    abstract::The severity of injury to cardiovascular autonomic pathways following clinical spinal cord injury (SCI) can be evaluated with spectral analyses. Whether this technique provides a translatable assessment of cardiovascular autonomic function in rodent SCI is unknown. Beat-to-beat blood pressure and pulse interval were m...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2011.2145

    authors: Inskip JA,Ramer LM,Ramer MS,Krassioukov AV,Claydon VE

    更新日期:2012-05-20 00:00:00

  • Long-Term Effects of Blast Exposure: A Functional Study in Rats Using an Advanced Blast Simulator.

    abstract::Anecdotal observations of blast victims indicate that significant neuropathological and neurobehavioral defects may develop at later stages of life. To pre-clinically model this phenomenon, we have examined neurobehavioral changes in rats up to 1 year after exposure to single and tightly coupled repeated blasts using ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2019.6591

    authors: Arun P,Wilder DM,Eken O,Urioste R,Batuure A,Sajja S,Van Albert S,Wang Y,Gist ID,Long JB

    更新日期:2020-02-15 00:00:00

  • Axonal cytoskeletal responses to nondisruptive axonal injury and the short-term effects of posttraumatic hypothermia.

    abstract::In human diffuse axonal injury (DAI), axons are exposed to transient tensile strain. Over the ensuing several hours, injured axons enter a "pathological cascade" of events that lead to secondary axotomy. Use of animal models of traumatic axonal injury (TAI) has allowed description of a number of pathological changes b...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.1999.16.1225

    authors: Maxwell WL,Donnelly S,Sun X,Fenton T,Puri N,Graham DI

    更新日期:1999-12-01 00:00:00

  • The effects of L-arginine on cerebral hemodynamics after controlled cortical impact injury in the mouse.

    abstract::Traumatic brain injury (TBI) induces vascular changes that may influence neurological outcome by causing the brain to be more susceptible to secondary ischemic insults. In rat models of TBI, L-arginine administration has been shown to restore cerebral blood flow and improve neurological outcome. The purpose of this st...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/089771502753594891

    authors: Liu H,Goodman JC,Robertson CS

    更新日期:2002-03-01 00:00:00

  • Distributions of Magnetic Resonance Diffusion and Spectroscopy Measures with Traumatic Brain Injury.

    abstract::Magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) studies have demonstrated that measures of altered metabolism and axonal injury can be detected following traumatic brain injury. The aim of this study was to characterize and compare the distributions of altered image parameters obtained by thes...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2014.3505

    authors: Maudsley AA,Govind V,Levin B,Saigal G,Harris L,Sheriff S

    更新日期:2015-07-15 00:00:00

  • Increased Sleep Need and Reduction of Tuberomammillary Histamine Neurons after Rodent Traumatic Brain Injury.

    abstract::Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological ...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2017.5067

    authors: Noain D,Büchele F,Schreglmann SR,Valko PO,Gavrilov YV,Morawska MM,Imbach LL,Baumann CR

    更新日期:2018-01-01 00:00:00

  • Early Decompression following Cervical Spinal Cord Injury: Examining the Process of Care from Accident Scene to Surgery.

    abstract::Early decompression may improve neurological outcome after spinal cord injury (SCI), but is often difficult to achieve because of logistical issues. The aims of this study were to 1) determine the time to decompression in cases of isolated cervical SCI in Australia and New Zealand and 2) determine where substantial de...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2015.4207

    authors: Battistuzzo CR,Armstrong A,Clark J,Worley L,Sharwood L,Lin P,Rooke G,Skeers P,Nolan S,Geraghty T,Nunn A,Brown DJ,Hill S,Alexander J,Millard M,Cox SF,Rao S,Watts A,Goods L,Allison GT,Agostinello J,Cameron PA,Mo

    更新日期:2016-06-15 00:00:00

  • Androgen regulates neuritin mRNA levels in an in vivo model of steroid-enhanced peripheral nerve regeneration.

    abstract::Following crush injury to the facial nerve in Syrian hamsters, treatment with androgens enhances axonal regeneration rates and decreases time to recovery. It has been demonstrated in vitro that the ability of androgen to enhance neurite outgrowth in motoneurons is dependent on neuritin-a protein that is involved in th...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2007.0466

    authors: Fargo KN,Alexander TD,Tanzer L,Poletti A,Jones KJ

    更新日期:2008-05-01 00:00:00

  • The impact of co-morbidities on age-related differences in mortality after acute traumatic spinal cord injury.

    abstract::Despite the shift in demographics of spinal cord injury (SCI) due to an aging population, relatively little has been reported regarding the effect of age on outcomes after SCI. This study examines the potential confounding effect of co-morbidities on the age-related differences in the hospital mortality following acut...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2008.0764

    authors: Furlan JC,Kattail D,Fehlings MG

    更新日期:2009-08-01 00:00:00

  • Changes in local microvascular permeability and in the effect of intervention with 21-aminosteroid (Tirilazad) in a new experimental model of focal cortical injury in the rat.

    abstract::In a new, reproducible model of rodent focal cortical injury, we have shown that in the absence of early traumatic disruption of the microvasculature and subsequent hemorrhage, delayed perivascular protein leakage and polymorphonuclear leukocyte infiltration of the injured cortex occur. In this study we employed a sen...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.1996.13.465

    authors: Mathew P,Bullock R,Teasdale G,McCulloch J

    更新日期:1996-08-01 00:00:00

  • Spinal cord contusion causes acute plasma membrane damage.

    abstract::Spinal cord injury (SCI) launches a complex cascade of events that leads to progressive damage and loss of function. Compromise of plasma membrane integrity due to the mechanical impact is an acute event that may contribute to cellular dysfunction. Therefore, the objective of this study was to better understand the ex...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2008.0523

    authors: Simon CM,Sharif S,Tan RP,LaPlaca MC

    更新日期:2009-04-01 00:00:00

  • Effect of Sex on Motor Function, Lesion Size, and Neuropathic Pain after Contusion Spinal Cord Injury in Mice.

    abstract::Spinal cord injury (SCI) causes neurodegeneration, impairs locomotor function, and impacts the quality of life particularly in those individuals in whom neuropathic pain develops. Whether the time course of neurodegeneration, locomotor impairment, or neuropathic pain varies with sex, however, remains understudied. The...

    journal_title:Journal of neurotrauma

    pub_type: 杂志文章

    doi:10.1089/neu.2019.6931

    authors: McFarlane K,Otto TE,Bailey WM,Veldhorst AK,Donahue RR,Taylor BK,Gensel JC

    更新日期:2020-09-15 00:00:00