Abstract:
:Laser Doppler flowmetry (LDF) was used to study acute ipsilateral and contralateral disturbances of regional cerebral blood flow (rCBF) in a rat model of cerebral cortical contusion trauma. Twelve rats were intubated and artificially ventilated during and after trauma. Injury was produced with a weight drop technique (21 g from 35 cm) allowing 1.5 mm maximum compression of the right parietal cortex. Stationary laser Doppler probes were used for continuous blood flow measurements on the ipsilateral side adjacent to the traumatized tissue and on the contralateral side. Within 2 min blood flow decreased to 60% (+/- 9%) of the pretrauma rCBF level on the ipsilateral side and remained at this level for at least 20 min. On the contralateral side there was an initial increase to 172% (+/- 27%) at 4 min. This hyperperfusion phase was followed by a mild hypoperfusion phase with a flow of 78% (+/- 8%) of baseline, lasting approximately 60 min. An attempt was made to measure rCBF++ within the trauma site using a removable probe. We found that probe replacement in traumatized (as compared to control) animals caused a baseline shift with a considerable variability making interpretation difficult. However, the pattern of rCBF change did not differ from the measurements adjacent to the injury site. We tentatively conclude that the posttraumatic hypoperfusion phase was similar within the trauma region. The observed rCBF changes following trauma are similar to those seen following cortical spreading depression (CSD). We propose that CSD, known to occur on the ipsilateral side in our model, is one of the factors involved in acute blood flow decreases seen following cerebral trauma.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Nilsson P,Gazelius B,Carlson H,Hillered Ldoi
10.1089/neu.1996.13.201subject
Has Abstractpub_date
1996-04-01 00:00:00pages
201-7issue
4eissn
0897-7151issn
1557-9042journal_volume
13pub_type
杂志文章abstract::Arginine-vasopressin (AVP) V1 receptors are known to mediate brain edema formation after traumatic brain injury (TBI). So far, however, AVP V1 receptors were only inhibited by genetic deletion or prior to trauma. Therefore, the current study aimed to determine the therapeutic window of AVP V1 receptor antagonization a...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2016.4514
更新日期:2017-04-01 00:00:00
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journal_title:Journal of neurotrauma
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doi:10.1089/neu.2020.7229
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abstract::Spinal cord injury (SCI) causes neurodegeneration, impairs locomotor function, and impacts the quality of life particularly in those individuals in whom neuropathic pain develops. Whether the time course of neurodegeneration, locomotor impairment, or neuropathic pain varies with sex, however, remains understudied. The...
journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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doi:10.1089/neu.2017.5360
更新日期:2018-04-15 00:00:00
abstract::Cytokine measurement directly from the brain parenchyma by means of microdialysis has documented the activation of certain procedures in vivo, after brain trauma in humans. However, the intercalation of the micro-catheter insertion with the phenomena triggered by the head trauma renders the assessment of the findings ...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2011.1790
更新日期:2011-11-18 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,多中心研究
doi:10.1089/neu.2011.2044
更新日期:2012-01-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2013.2957
更新日期:2013-09-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2014.3690
更新日期:2014-11-11 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2011.2255
更新日期:2012-05-20 00:00:00
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pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.1998.15.199
更新日期:1998-03-01 00:00:00
abstract::Individuals with a mild traumatic brain injury (mTBI) often have executive control deficits; however, the underlying neural mechanisms of such deficits are yet to be clarified. Inhibitory control and cognitive monitoring are two fundamental aspects of executive control processes. This study investigated the executive ...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2018.6122
更新日期:2020-01-01 00:00:00
abstract::We sought to determine whether the exposure to the sub-concussive blows that occur during division III collegiate collision sports affect later life neurobehavioral quality-of-life measures. We conducted a cross-sectional study of alumni from four division III colleges, targeting those between the ages of 40-70 years,...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2015.3930
更新日期:2016-01-15 00:00:00
abstract::Athletes who sustain a concussion demonstrate a variety of symptoms and neuropsychological alterations that could be brought on by neurometabolic abnormalities. However, no study has yet investigated these aspects in female athletes using magnetic resonance spectroscopy. The present study investigated the neurometabol...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2013.3083
更新日期:2014-02-15 00:00:00
abstract::We measured quantitative cortical mantle cerebral blood flow (CBF) by stable xenon computed tomography (CT) within the first 12 h after severe traumatic brain injury (TBI) to determine whether neurologic outcome can be predicted by CBF stratification early after injury. Stable xenon CT was used for quantitative measur...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2011.2147
更新日期:2012-03-20 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2016.4479
更新日期:2017-02-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2006.0119
更新日期:2007-03-01 00:00:00
abstract::Striatal-enriched tyrosine phosphatase (STEP) has been identified as a component of physiological and pathophysiological signaling pathways mediated by N-methyl-d-aspartate (NMDA) receptor/calcineurin/calpain activation. Activation of these pathways produces a subsequent change in STEP isoform expression or activation...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2011.2253
更新日期:2012-07-01 00:00:00
abstract::In a new, reproducible model of rodent focal cortical injury, we have shown that in the absence of early traumatic disruption of the microvasculature and subsequent hemorrhage, delayed perivascular protein leakage and polymorphonuclear leukocyte infiltration of the injured cortex occur. In this study we employed a sen...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.1996.13.465
更新日期:1996-08-01 00:00:00
abstract::Assessment of acute mild traumatic brain injury (mTBI) symptoms after a combat blast could aid diagnosis and guide follow-up care. Our objective was to document acute mTBI symptoms following a combat blast and to examine associations between acute symptoms and mental health and service discharge outcomes. A retrospect...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2012.2537
更新日期:2013-08-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2006.0222
更新日期:2007-06-01 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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doi:10.1089/neu.2009.1234
更新日期:2010-07-01 00:00:00
abstract::Prior studies have shown that neurons within the spinal cord are sensitive to response-outcome relations, a form of instrumental learning. Spinally transected rats that receive shock to one hind leg learn to maintain the leg in a flexed position that minimizes net shock exposure (controllable shock). Prior exposure to...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2004.21.1795
更新日期:2004-12-01 00:00:00
abstract::Predicting outcome after pediatric traumatic brain injury (TBI) is important for providing information to families and prescribing rehabilitation services. The study objective was to assess whether biomarkers concentrations obtained at the time of injury are associated with outcome. Serial serum concentrations of neur...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2007.0316
更新日期:2007-12-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2019.6670
更新日期:2020-02-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2008.0702
更新日期:2009-09-01 00:00:00
abstract::Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in axonal damage and subsequent loss of communication between neuronal networks, causing long-term functional deficits. For CNS regeneration, repair strategies need ...
journal_title:Journal of neurotrauma
pub_type: 杂志文章,评审
doi:10.1089/neu.2006.23.468
更新日期:2006-03-01 00:00:00
abstract::Poor response inhibition is a hallmark of pediatric traumatic brain injury (TBI). We assessed motor response inhibition by measuring commission error rates on Simple (minimized cognitive demands) and Motivation (monetary reward) Go/No-Go tasks, comparing 17 children with chronic TBI (>1 year post-injury) and 14 matche...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2017.5081
更新日期:2017-11-15 00:00:00
abstract::Noise exposure is known to induce cell death signaling in the cochlea. Since c-Jun N-terminal kinase (JNK) signaling is known to induce both cell survival and apoptosis, the present study focused on early changes (within 24 h) after impulse noise exposure, inquiring whether cell death is always related to phosphorylat...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2007.0346
更新日期:2008-01-01 00:00:00