Influence of combat blast-related mild traumatic brain injury acute symptoms on mental health and service discharge outcomes.

abstract：:Traumatic spinal cord injury (SCI) can cause permanent disabilities that seriously reduce quality of life. We evaluated the effects of chronic hyperglycemia before SCI on inflammatory markers and functional recovery after SCI in human patients and a rat model. In the human study, multivariate logistical regression ana...

journal_title：Journal of neurotrauma

authors： Park KS,Kim JB,Keung M,Seo YJ,Seo SY,Mun SA,Lee YS,Cho DC,Hwang JH,Han I,Kim CH,Kim KT

更新日期：2020-05-01 00:00:00

abstract：:Return to living at home is an important patient-reported outcome following traumatic spinal cord injury (tSCI). Specialized inpatient rehabilitation assists such patients in maximizing function and independence. Our project aim was to describe those patients receiving specialized rehabilitation after tSCI in Canada, ...

journal_title：Journal of neurotrauma

authors： Cheng CL,Plashkes T,Shen T,Fallah N,Humphreys S,O'Connell C,Linassi AG,Ho C,Short C,Ethans K,Charbonneau R,Paquet J,Noonan VK

更新日期：2017-10-15 00:00:00

abstract：:Traumatic brain injuries (TBI) impose a significant burden on the health care system. The aim of the current study was to explore variation in costs in a group of rehabilitation patients in Victoria, Australia, following complicated mild-to-severe TBI treated under the accident compensation system administered by the ...

journal_title：Journal of neurotrauma

authors： Ponsford JL,Spitz G,Cromarty F,Gifford D,Attwood D

更新日期：2013-09-01 00:00:00

abstract：:Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we "speak the same language." Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons betwe...

journal_title：Journal of neurotrauma

authors： Maas AI,Harrison-Felix CL,Menon D,Adelson PD,Balkin T,Bullock R,Engel DC,Gordon W,Langlois-Orman J,Lew HL,Robertson C,Temkin N,Valadka A,Verfaellie M,Wainwright M,Wright DW,Schwab K

更新日期：2011-02-01 00:00:00

abstract：:Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological ...

journal_title：Journal of neurotrauma

authors： Noain D,Büchele F,Schreglmann SR,Valko PO,Gavrilov YV,Morawska MM,Imbach LL,Baumann CR

更新日期：2018-01-01 00:00:00

abstract：:Predicting outcome after pediatric traumatic brain injury (TBI) is important for providing information to families and prescribing rehabilitation services. The study objective was to assess whether biomarkers concentrations obtained at the time of injury are associated with outcome. Serial serum concentrations of neur...

journal_title：Journal of neurotrauma

authors： Berger RP,Beers SR,Richichi R,Wiesman D,Adelson PD

更新日期：2007-12-01 00:00:00

abstract：:Noise exposure is known to induce cell death signaling in the cochlea. Since c-Jun N-terminal kinase (JNK) signaling is known to induce both cell survival and apoptosis, the present study focused on early changes (within 24 h) after impulse noise exposure, inquiring whether cell death is always related to phosphorylat...

journal_title：Journal of neurotrauma

authors： Murai N,Kirkegaard M,Järlebark L,Risling M,Suneson A,Ulfendahl M

更新日期：2008-01-01 00:00:00

abstract：:Levetiracetam (LEV) is an antiepileptic agent targeting novel pathways. Coupled with a favorable safety profile and increasing empirical clinical use, it was the fifth drug tested by Operation Brain Trauma Therapy (OBTT). We assessed the efficacy of a single 15 min post-injury intravenous (IV) dose (54 or 170 mg/kg) o...

journal_title：Journal of neurotrauma

authors： Browning M,Shear DA,Bramlett HM,Dixon CE,Mondello S,Schmid KE,Poloyac SM,Dietrich WD,Hayes RL,Wang KK,Povlishock JT,Tortella FC,Kochanek PM

更新日期：2016-03-15 00:00:00

abstract：:Participation in contact sports places athletes at elevated risk for repeated head injuries and is associated with negative mental health outcomes later in life. The current study identified changes observable on neuroimaging that persisted beyond the apparent resolution of acute symptoms of concussion. Sixteen young ...

journal_title：Journal of neurotrauma

authors： Orr CA,Albaugh MD,Watts R,Garavan H,Andrews T,Nickerson JP,Gonyea J,Hipko S,Zweber C,Logan K,Hudziak JJ

更新日期：2016-05-01 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:Controlled cortical impact (CCI) produces blood-brain barrier (BBB) permeability and an acute inflammatory response in injured brain, associated with upregulation of cell adhesion molecules and accumulation of neutrophils. Nevertheless, the role of acute inflammation in the pathogenesis of BBB permeability after traum...

journal_title：Journal of neurotrauma

authors： Whalen MJ,Carlos TM,Kochanek PM,Clark RS,Heineman S,Schiding JK,Franicola D,Memarzadeh F,Lo W,Marion DW,Dekosky ST

更新日期：1999-07-01 00:00:00

abstract：:Secondary insults, such as hemorrhagic shock (HS), worsen outcome from traumatic brain injury (TBI). Both TBI and HS modulate levels of inflammatory mediators. We evaluated the addition of HS on the inflammatory response to TBI. Adult male C57BL6J mice were randomized into five groups (n=4 [naïve] or 8/group): naïve; ...

journal_title：Journal of neurotrauma

authors： Shein SL,Shellington DK,Exo JL,Jackson TC,Wisniewski SR,Jackson EK,Vagni VA,Bayır H,Clark RS,Dixon CE,Janesko-Feldman KL,Kochanek PM

更新日期：2014-08-15 00:00:00

abstract：:Adolescents are one of the highest groups at risk for sustaining both traumatic brain injury (TBI) and repeat TBI (RTBI). Consequences of endocrine dysfunction following TBI have been routinely explored in adults, but studies in adolescents are limited, and show an incidence rate of endocrine dysfunction in 16-61% in ...

journal_title：Journal of neurotrauma

authors： Greco T,Hovda D,Prins M

更新日期：2013-12-01 00:00:00

abstract：:Lesions in specific areas of the rat motor cortex generate deficits related to fine movement performance affecting the forelimb. We have previously shown that transplants of embryonic frontal cortex ameliorate these motor deficits. Amelioration has been associated with a functional integration of the transplant due to...

journal_title：Journal of neurotrauma

authors： Santos-Torres J,Heredia M,Riolobos AS,Jiménez-Díaz L,Gómez-Bautista V,de la Fuente A,Criado JM,Navarro-López J,Yajeya J

更新日期：2009-09-01 00:00:00

abstract：:Neuropsychological studies in electrical injury patients have reported deficits in attention, learning, and working memory, but the neural substrates of these deficits remain poorly characterized. In this study we sought to examine whether electrical injury subjects demonstrate abnormal patterns of brain activation du...

journal_title：Journal of neurotrauma

authors： Ramati A,Pliskin NH,Keedy S,Erwin RJ,Fink JW,Bodnar EN,Lee RC,Cooper MA,Kelley K,Sweeney JA

更新日期：2009-10-01 00:00:00

abstract：:Abstract Although several functional magnetic resonance imaging (fMRI) studies have been conducted in human models of mild traumatic brain injury (mTBI), to date no studies have explicitly examined how injury may differentially affect both the positive phase of the hemodynamic response function (HRF) as well as the po...

journal_title：Journal of neurotrauma

authors： Mayer AR,Toulouse T,Klimaj S,Ling JM,Pena A,Bellgowan PS

更新日期：2014-01-15 00:00:00

abstract：:Improving survival and brain function after initial resuscitation from cardiac arrest remains a critical challenge with few therapeutic options. The publication of several randomized controlled trials supporting the use of therapeutic hypothermia in cardiac arrest survivors has provided a remarkable opportunity to red...

journal_title：Journal of neurotrauma

authors： Sugerman NT,Abella BS

更新日期：2009-03-01 00:00:00

abstract：:The majority of clinical spinal cord injuries (SCIs) are contusive and occur at the cervical level of the spinal cord. Most scientists and clinicians agree that the preclinical evaluation of novel candidate treatments should include testing in a cervical SCI contusion model. Because mice are increasingly used because ...

journal_title：Journal of neurotrauma

authors： Streijger F,Beernink TM,Lee JH,Bhatnagar T,Park S,Kwon BK,Tetzlaff W

更新日期：2013-05-15 00:00:00

abstract：:Post-traumatic epilepsy (PTE) is a consequence of traumatic brain injury (TBI), occurring in 10-25% of patients with moderate to severe injuries. The development of animal models for testing antiepileptogenic therapies and validation of biomarkers to follow epileptogenesis in humans necessitates sophisticated understa...

journal_title：Journal of neurotrauma

authors： Gupta PK,Sayed N,Ding K,Agostini MA,Van Ness PC,Yablon S,Madden C,Mickey B,D'Ambrosio R,Diaz-Arrastia R

更新日期：2014-08-15 00:00:00

abstract：:Here we investigate the effect of hypothermia on the expression of apoptosis-regulating protein TIMP-3 after fluid percussion traumatic brain injury (TBI) in rats. We began with 210 adult male Sprague-Dawley rats and randomly assigned them to three groups: TBI with hypothermia treatment (32°C), TBI with normothermia (...

journal_title：Journal of neurotrauma

authors： Jia F,Mao Q,Liang YM,Jiang JY

更新日期：2014-02-15 00:00:00

abstract：:The mechanism by which mechanical impact to brain tissue is transduced to neuronal impairment remains poorly understood. Using an in vitro model of neuronal stretch, we found that mechanical stretch of neurons resulted in a transient plasma membrane permeability increase. Primary cortical neurons, seeded on silicone s...

journal_title：Journal of neurotrauma

authors： Geddes DM,Cargill RS 2nd,LaPlaca MC

更新日期：2003-10-01 00:00:00

abstract：:The role of Ca2+ in cellular injury has received particular attention in studies of acute spinal cord trauma. In this context, the spatial and temporal distribution of extracellular Ca2+ ([Ca2+]e) may have an important bearing on the development of secondary tissue injury. We therefore studied the spatial-temporal dis...

journal_title：Journal of neurotrauma

authors： Moriya T,Hassan AZ,Young W,Chesler M

更新日期：1994-06-01 00:00:00

abstract：:Chronic pain and dysesthesias are debilitating conditions that can arise following spinal cord injury (SCI). Research studies frequently employ rodent models of SCI to better understand the underlying mechanisms and develop better treatments for these phenomena. While evoked withdrawal tests can assess hypersensitivit...

journal_title：Journal of neurotrauma

authors： Hoschouer EL,Finseth T,Flinn S,Basso DM,Jakeman LB

更新日期：2010-05-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has been shown to protect cranial and spinal motoneurons, which suggests potential uses of GDNF in the treatment of spinal cord injury (SCI) and motor neuron disease. We examined neuroprotective effect of cationic liposome-mediated GDNF gene transfer in vivo on axonal...

journal_title：Journal of neurotrauma

authors： Lu KW,Chen ZY,Jin DD,Hou TS,Cao L,Fu Q

更新日期：2002-09-01 00:00:00

abstract：:Physician prescribed rest after traumatic brain injury (TBI) is both commonplace and an increasingly scrutinized approach to TBI treatment. Although this practice remains a standard of patient care for TBI, research of patient outcomes reveals little to no benefit of prescribed rest after TBI, and in some cases prolon...

journal_title：Journal of neurotrauma

authors： Karelina K,Schneiderman K,Shah S,Fitzgerald J,Velazquez Cruz R,Oliverio R,Whitehead B,Yang J,Weil Z

更新日期：2021-01-20 00:00:00

abstract：:Acupressure is a complementary and alternative medicine (CAM) treatment using fingertips to stimulate acupoints on the skin. Although suggested to improve cognitive function, acupressure has not been previously investigated with a controlled design in traumatic brain injury (TBI) survivors, who could particularly bene...

journal_title：Journal of neurotrauma

authors： McFadden KL,Healy KM,Dettmann ML,Kaye JT,Ito TA,Hernández TD

更新日期：2011-01-01 00:00:00

abstract：:Carbon dioxide is perhaps the most potent available modulator of cerebrovascular tone and thus cerebral blood flow (CBF). These experiments evaluate the impact of induced hypercarbia on the matching of blood flow and metabolism in the injured brain. We explore the hypothesis that hypercarbia will restore the relations...

journal_title：Journal of neurotrauma

authors： Glass TF,Fabian MJ,Schweitzer JB,Weinberg JA,Proctor KG

更新日期：2001-01-01 00:00:00

abstract：:Patients with head injury must overcome central as well as peripheral metabolic insults. In addition to specific tissue damage to the brain, a cellular biochemical cascade occurs that can negatively affect organ function, cause a systemic response to injury, and may cause secondary tissue injury. The metabolites invol...

journal_title：Journal of neurotrauma

authors： Ott L,McClain CJ,Gillespie M,Young B

更新日期：1994-10-01 00:00:00

abstract：:The expression of the heat shock proteins hsp27 and hsp70 was examined in the spinal cord and sciatic nerves of developing rats. Using immunohistochemistry, we found that hsp27 is present in many motoneurones at birth. With development, the intensity of staining increases, reaching adult levels by 21 days, when all sc...

journal_title：Journal of neurotrauma

authors： Kalmár B,Burnstock G,Vrbová G,Greensmith L

更新日期：2002-05-01 00:00:00

abstract：:Older adults tend to have poorer outcomes compared to younger adults following moderate-to-severe traumatic brain injury (TBI). Currently, there is a need for research focusing on how elderly TBI has changed as the U.S. population shifts. This study provides a statewide account of moderate-to-severe TBI in regard to i...

journal_title：Journal of neurotrauma

authors： Ramanathan DM,McWilliams N,Schatz P,Hillary FG

更新日期：2012-05-01 00:00:00