Effects of ethanol in traumatic brain injury.

abstract：:Stretching of cultured neurons has been used to model diffuse axonal injury associated with brain trauma. N-Methyl-D-aspartate receptor (NMDAR) activation and group I metabotropic glutamate receptors (mGluRs) are implicated in the pathophysiology of such injury. Here we detail the effects of culture condition and mGlu...

journal_title：Journal of neurotrauma

authors： Lea PM 4th,Custer SJ,Stoica BA,Faden AI

更新日期：2003-11-01 00:00:00

abstract：:Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur i...

journal_title：Journal of neurotrauma

authors： Abu Hamdeh S,Ciuculete DM,Sarkisyan D,Bakalkin G,Ingelsson M,Schiöth HB,Marklund N

更新日期：2021-01-08 00:00:00

abstract：:Traumatic brain injury (TBI) affects millions of individuals each year and is a leading cause of death and disability worldwide. TBI is heterogeneous and outcome is influenced by a combination of factors that include injury location, severity, genetics, and environmental factors. More recently, sex as a biological var...

journal_title：Journal of neurotrauma

authors： Giordano KR,Rojas-Valencia LM,Bhargava V,Lifshitz J

更新日期：2020-12-01 00:00:00

abstract：:The relationship between brain injury and attentional control (AC) long after a childhood traumatic brain injury (TBI) has received limited investigation. The aim of this article was to investigate the impact that lesion presence, location, and severity has on AC in a group of young persons who had sustained a moderat...

journal_title：Journal of neurotrauma

authors： Cooper JM,Catroppa C,Beauchamp MH,Eren S,Godfrey C,Ditchfield M,Anderson VA

更新日期：2014-04-15 00:00:00

abstract：:Post-traumatic epilepsy (PTE) is a consequence of traumatic brain injury (TBI), occurring in 10-25% of patients with moderate to severe injuries. The development of animal models for testing antiepileptogenic therapies and validation of biomarkers to follow epileptogenesis in humans necessitates sophisticated understa...

journal_title：Journal of neurotrauma

authors： Gupta PK,Sayed N,Ding K,Agostini MA,Van Ness PC,Yablon S,Madden C,Mickey B,D'Ambrosio R,Diaz-Arrastia R

更新日期：2014-08-15 00:00:00

abstract：:This paper encompasses the prediction of early and late recovery from traumatic brain injury (TBI). Predictors of the duration of coma and the utilization of posttraumatic amnesia duration to predict residual memory function are discussed. The issues surrounding prediction of long-term neurobehavioral recovery from TB...

journal_title：Journal of neurotrauma

authors： Levin HS

更新日期：1995-10-01 00:00:00

abstract：:Diffuse axonal injury (DAI) secondary to traumatic brain injury (TBI) contributes to long-term functional morbidity. The corpus callosum (CC) is particularly vulnerable to this type of injury. Magnetic resonance spectroscopy (MRS) was used to characterize the metabolic status of two CC regions of interest (ROIs) (ante...

journal_title：Journal of neurotrauma

authors： Babikian T,Marion SD,Copeland S,Alger JR,O'Neill J,Cazalis F,Mink R,Giza CC,Vu JA,Hilleary SM,Kernan CL,Newman N,Asarnow RF

更新日期：2010-03-01 00:00:00

abstract：:Persistent pain is experienced by more than 50% of persons who sustain a traumatic brain injury (TBI), and more than 30% experience significant pain as early as 6 weeks after injury. Although neuropathic pain is a common consequence after CNS injuries, little attention has been given to neuropathic pain symptoms after...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Govind V,Adcock JP,Levin BE,Maudsley AA

更新日期：2016-07-15 00:00:00

abstract：:An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In thi...

journal_title：Journal of neurotrauma

authors： Kwon BK,Okon EB,Plunet W,Baptiste D,Fouad K,Hillyer J,Weaver LC,Fehlings MG,Tetzlaff W

更新日期：2011-08-01 00:00:00

abstract：:The severity of injury to cardiovascular autonomic pathways following clinical spinal cord injury (SCI) can be evaluated with spectral analyses. Whether this technique provides a translatable assessment of cardiovascular autonomic function in rodent SCI is unknown. Beat-to-beat blood pressure and pulse interval were m...

journal_title：Journal of neurotrauma

authors： Inskip JA,Ramer LM,Ramer MS,Krassioukov AV,Claydon VE

更新日期：2012-05-20 00:00:00

abstract：:Traumatic brain injuries (TBI) are one of the least understood injuries to the body. Finite element (FE) models of the brain have been crucial for understanding concussion and for developing injury mitigation systems; however, the experimental brain deformation data currently used to validate these models are limited....

journal_title：Journal of neurotrauma

authors： Alshareef A,Giudice JS,Forman J,Salzar RS,Panzer MB

更新日期：2018-03-01 00:00:00

abstract：:Previous meta-analyses of methylprednisolone (MPS) for patients with acute traumatic spinal cord injuries (TSCIs) have not addressed confidence in the quality of evidence used for pooled effect estimates, and new primary studies have been recently published. We aimed to determine whether MPS improves motor recovery an...

journal_title：Journal of neurotrauma

authors： Evaniew N,Belley-Côté EP,Fallah N,Noonan VK,Rivers CS,Dvorak MF

更新日期：2016-03-01 00:00:00

abstract：:Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for autoantibodies to glial fibrillary acidic protein (GFAP) and collapsin response mediator protein-2 (CRMP2) and evaluated their relationship to the development of n...

journal_title：Journal of neurotrauma

authors： Hergenroeder GW,Redell JB,Choi HA,Schmitt L,Donovan W,Francisco GE,Schmitt K,Moore AN,Dash PK

更新日期：2018-11-01 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:A retrospective case-control study was undertaken to determine the best technique to measure neural canal encroachment at each lumbar level following burst fracture and its relationship to the presence of neurologic deficit. Only patients with postinjury CT scans demonstrating a disrupted posterior body with a retropu...

journal_title：Journal of neurotrauma

authors： Rasmussen PA,Rabin MH,Mann DC,Perl JR 2nd,Lorenz MA,Vrbos LA

更新日期：1994-12-01 00:00:00

abstract：:The inflammatory response to moderate-severe controlled cortical impact (CCI) in adult male mice has been shown to exhibit greater glial activation compared with age-matched female mice. However, the relative contributions of resident microglia and infiltrating peripheral myeloid cells to this sexually dimorphic neuro...

journal_title：Journal of neurotrauma

authors： Doran SJ,Ritzel RM,Glaser EP,Henry RJ,Faden AI,Loane DJ

更新日期：2019-04-01 00:00:00

abstract：:Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. They mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation o...

journal_title：Journal of neurotrauma

authors： Eldadah BA,Faden AI

更新日期：2000-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of death and disability and impairs health-related quality of life (HRQOL). Psychiatric disorders have been recognized as major components of TBI morbidity, yet few studies have addressed the relationship between these outcomes. Sample size, selection bias, and retrospecti...

journal_title：Journal of neurotrauma

authors： Diaz AP,Schwarzbold ML,Thais ME,Hohl A,Bertotti MM,Schmoeller R,Nunes JC,Prediger R,Linhares MN,Guarnieri R,Walz R

更新日期：2012-04-10 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) has several different actions in the nervous system. Numerous studies have shown its neuroprotective effects both in vitro and in vivo. Previously, it has been demonstrated that PACAP reduces brain damage in rat models of global and focal cerebral ischemia. Ba...

journal_title：Journal of neurotrauma

authors： Tamás A,Zsombok A,Farkas O,Reglödi D,Pál J,Büki A,Lengvári I,Povlishock JT,Dóczi T

更新日期：2006-05-01 00:00:00

abstract：:The potential pathophysiological role of circulating microparticles (MPs) has been recognized in various conditions, such as cardiovascular and thrombotic diseases. Traumatic brain injury (TBI) has a complex pathophysiology that involves coagulopathy and inflammation. We investigated endothelial-, platelet-, and leuko...

journal_title：Journal of neurotrauma

authors： Nekludov M,Mobarrez F,Gryth D,Bellander BM,Wallen H

更新日期：2014-12-01 00:00:00

abstract：:In 1990, the Second National Acute Spinal Cord Injury Study reported that high-dosage methylprednisolone improves neurologic recovery in spinal-injured humans. The study showed that patients who received the drug within 8 hr after injury improved, whereas those who received the drug later did not. The drug significant...

journal_title：Journal of neurotrauma

authors： Young W,Bracken MB

更新日期：1992-03-01 00:00:00

abstract：:Death of Central Nervous System (CNS) neurons following traumatic brain injury (TBI) is a complex process arising from a combination of factors, many of which are still unknown. It has been found that inhibition of transient receptor potential (TRP) channels constitutes an effective strategy for preventing death of CN...

journal_title：Journal of neurotrauma

authors： Peters M,Trembovler V,Alexandrovich A,Parnas M,Birnbaumer L,Minke B,Shohami E

更新日期：2012-12-10 00:00:00

abstract：:Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of the large, heterogeneous data sets involved. In this sense, tra...

journal_title：Journal of neurotrauma

authors： Nielson JL,Guandique CF,Liu AW,Burke DA,Lash AT,Moseanko R,Hawbecker S,Strand SC,Zdunowski S,Irvine KA,Brock JH,Nout-Lomas YS,Gensel JC,Anderson KD,Segal MR,Rosenzweig ES,Magnuson DS,Whittemore SR,McTigue DM,Popovic

更新日期：2014-11-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) elicits a complex cascade of cellular and molecular inflammatory events. Although certain aspects of the inflammatory response are essential to wound healing and repair, post-SCI inflammation is, on balance, thought to be detrimental to recovery by causing "bystander damage" and the ...

journal_title：Journal of neurotrauma

authors： Gillespie ER,Ruitenberg MJ

更新日期：2020-08-26 00:00:00

abstract：:In various animal and human studies, early administration of 17β-estradiol, a strong antioxidant, anti-inflammatory, and anti-apoptotic agent, significantly decreases the severity of injury in the brain associated with cell death. Estrone, the predominant estrogen in postmenopausal women, has been shown to be a promis...

journal_title：Journal of neurotrauma

authors： Gatson JW,Liu MM,Abdelfattah K,Wigginton JG,Smith S,Wolf S,Simpkins JW,Minei JP

更新日期：2012-08-10 00:00:00

abstract：:Talampanel [(R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3] benzodiazepine] is an orally active noncompetitive antagonist of the AMPA subtype of glutamate excitatory amino acid receptors. The purpose of this study was to determine whether treatment with talampanel would protect in a rat ...

journal_title：Journal of neurotrauma

authors： Belayev L,Alonso OF,Liu Y,Chappell AS,Zhao W,Ginsberg MD,Busto R

更新日期：2001-10-01 00:00:00

abstract：:Contusion-type cervical spinal cord injury (SCI) is one of the most common forms of SCI observed in patients. In particular, injuries targeting the C3-C5 region affect the pool of phrenic motor neurons (PhMNs) that innervates the diaphragm, resulting in significant and often chronic respiratory dysfunction. Using a pr...

journal_title：Journal of neurotrauma

authors： Nicaise C,Frank DM,Hala TJ,Authelet M,Pochet R,Adriaens D,Brion JP,Wright MC,Lepore AC

更新日期：2013-06-15 00:00:00

abstract：:Spinal cord injury can have a range of debilitating effects, permanently impacting a patient's quality of life. Initially thought to be an immune privileged site, the spinal cord is able to mount a timely and well organized inflammatory response to injury. Intricate immune cell interactions are triggered, typically co...

journal_title：Journal of neurotrauma

authors： Bowes AL,Yip PK

更新日期：2014-11-01 00:00:00

abstract：:Previous studies from our laboratory have shown the neuroprotective potential of ketones after TBI in the juvenile brain. It is our premise that acutely after TBI, glucose may not be the optimum fuel and decreasing metabolism of glucose in the presence of an alternative substrate will improve cellular metabolism and r...

journal_title：Journal of neurotrauma

authors： Prins ML,Hovda DA

更新日期：2009-07-01 00:00:00

abstract：:Controlled cortical impact (CCI) is a contemporary model of experimental cerebral contusion. We examined the cerebrovascular and neuropathologic effects of a severe CCI in rats. The utility of magnetic resonance imaging (MRI) for the assessment of contusion volume after severe CCI was also established. Severe CCI (3.0...

journal_title：Journal of neurotrauma

authors： Kochanek PM,Marion DW,Zhang W,Schiding JK,White M,Palmer AM,Clark RS,O'Malley ME,Styren SD,Ho C

更新日期：1995-12-01 00:00:00