Abstract:
:The severity of injury to cardiovascular autonomic pathways following clinical spinal cord injury (SCI) can be evaluated with spectral analyses. Whether this technique provides a translatable assessment of cardiovascular autonomic function in rodent SCI is unknown. Beat-to-beat blood pressure and pulse interval were measured in male rats 1 month after complete T3 or T10 SCI, and in uninjured control animals. Univariate autoregressive spectral analyses were performed and the power of the low frequency (LF), high frequency (HF), and very low frequency (VLF) peaks identified. Frequency domain variables were correlated with the severity of orthostatic hypotension (OH) and the severity of hypertension during autonomic dysreflexia (AD). Total heart rate variability (HRV) and blood pressure variability (BPV) were reduced in animals with T3, but not T10, SCI. VLF and LF HRV were reduced and HF HRV was increased in animals with T3 SCI compared to controls; there were no changes in animals with T10 SCI. BPV in the VLF and LF range was reduced in animals with T3 SCI, but not T10 SCI. In all animals with SCI, severity of OH was positively correlated with LF BPV, and negatively correlated with HF BPV. Severity of AD was positively correlated with HF BPV and HF HRV, and negatively correlated with VLF HRV. Spectral analyses can detect alterations in cardiovascular autonomic function in animals with SCI at rest. These parameters underscore the distinct cardiovascular ramifications of high- versus low-thoracic SCI, and correlate with the severity of AD and OH, clinically-relevant measures of abnormal blood pressure control.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Inskip JA,Ramer LM,Ramer MS,Krassioukov AV,Claydon VEdoi
10.1089/neu.2011.2145subject
Has Abstractpub_date
2012-05-20 00:00:00pages
1638-49issue
8eissn
0897-7151issn
1557-9042journal_volume
29pub_type
杂志文章abstract::The aim of this study was to investigate the time course and the correlation of neuron-specific enolase (NSE) serum levels to the severity of traumatic brain injury in rats. Sixty-five male Wistar rats were subjected to severe cortical impact injury (100 PSI, 2 mm deformation). Blood samples were drawn directly after ...
journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/089771501300227378
更新日期:2001-05-01 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
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更新日期:2021-01-20 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2012-07-20 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2019.6601
更新日期:2021-01-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,评审
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-03-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2014-04-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2020.7038
更新日期:2020-12-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 临床试验,杂志文章
doi:10.1089/089771501750291819
更新日期:2001-06-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2016.4941
更新日期:2017-09-01 00:00:00
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journal_title:Journal of neurotrauma
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doi:10.1089/neu.2008.0702
更新日期:2009-09-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2019.6974
更新日期:2020-09-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2005.356E
更新日期:2007-06-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2017.5395
更新日期:2018-09-15 00:00:00
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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journal_title:Journal of neurotrauma
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2013-11-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,meta分析,评审
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更新日期:2010-08-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2015.4392
更新日期:2017-01-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,评审
doi:
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00