Postinjury administration of pituitary adenylate cyclase activating polypeptide (PACAP) attenuates traumatically induced axonal injury in rats.

abstract：:Repair of the spinal cord and improvement of mobility after injury has been a matter of basic and clinical research for several decades. A number of repair approaches were performed in animals, mainly rodent models of spinal cord injury (SCI). Some of these experimental therapies resulted in significant regeneration o...

journal_title：Journal of neurotrauma

authors： Dietz V,Schwab ME

更新日期：2017-05-01 00:00:00

abstract：:Neuroprotection, recovery of function, and gene expression were evaluated in an animal model of traumatic brain injury (TBI) after a combination treatment of nicotinamide (NAM) and progesterone (Prog). Animals received a cortical contusion injury over the sensorimotor cortex, and were treated with either Vehicle, NAM,...

journal_title：Journal of neurotrauma

authors： Peterson TC,Hoane MR,McConomy KS,Farin FM,Bammler TK,MacDonald JW,Kantor ED,Anderson GD

更新日期：2015-06-01 00:00:00

abstract：:To assess the safety and accuracy of the Camino intraparenchymal sensor, we prospectively evaluated hemorrhagic complications, zero-drift, infection, and system malfunction in 163 patients monitored after a severe head injury. Mean duration of intracranial pressure (ICP) monitoring was 5 +/- 2.2 days (range: 12 h to 1...

journal_title：Journal of neurotrauma

authors： Poca MA,Sahuquillo J,Arribas M,Báguena M,Amorós S,Rubio E

更新日期：2002-04-01 00:00:00

abstract：:It remains unclear whether the benefits of early surgical timing are significant in neurologically complete spinal cord injury (SCI). We wanted to compare the effects of early and late surgical timing on non-neurological outcomes in persons with traumatic complete SCI. All cases of traumatic complete SCI referred to a...

journal_title：Journal of neurotrauma

authors： Bourassa-Moreau E,Mac-Thiong JM,Feldman DE,Thompson C,Parent S

更新日期：2013-09-15 00:00:00

abstract：:Paralysis is an indication for trauma patients to be preferentially triaged by emergency services to designated level I or II trauma centers (TC). We sought to describe triage practices for patients with acute traumatic spinal cord injury (TSCI) and its associated emergency department (ED) outcomes. Adults ages ≥ 18 y...

journal_title：Journal of neurotrauma

authors： Selvarajah S,Haider AH,Schneider EB,Sadowsky CL,Becker D,Hammond ER

更新日期：2015-12-15 00:00:00

abstract：:Moderate to severe traumatic brain injury (TBI) in humans and rats induces measurable metabolic changes, including a sustained depression in cerebral glucose uptake. However, the effect of a mild TBI on brain glucose uptake is unclear, particularly in rodent models. This study aimed to determine the glucose uptake pat...

journal_title：Journal of neurotrauma

authors： Selwyn R,Hockenbury N,Jaiswal S,Mathur S,Armstrong RC,Byrnes KR

更新日期：2013-12-01 00:00:00

abstract：:Adolescents are one of the highest groups at risk for sustaining both traumatic brain injury (TBI) and repeat TBI (RTBI). Consequences of endocrine dysfunction following TBI have been routinely explored in adults, but studies in adolescents are limited, and show an incidence rate of endocrine dysfunction in 16-61% in ...

journal_title：Journal of neurotrauma

authors： Greco T,Hovda D,Prins M

更新日期：2013-12-01 00:00:00

abstract：:Despite its importance to care, clinicians and researchers often discount patient-reported outcomes in favor of proxy reports, in persons with traumatic brain injury (TBI). The rationale relates to concerns about lack of awareness of patients regarding their functioning. However, although lack of awareness occurs in s...

journal_title：Journal of neurotrauma

authors： Machamer J,Temkin N,Dikmen S

更新日期：2013-11-15 00:00:00

abstract：:Hearing impairment can be one of the more subtle deficits seen after closed head injury (CHI), and it may not be diagnosed until late in the recovery phase if at all. Most studies have assessed patients immediately after CHI. Repeated assessments at regular intervals were not performed in the majority of studies done ...

journal_title：Journal of neurotrauma

authors： Munjal SK,Panda NK,Pathak A

更新日期：2010-02-01 00:00:00

abstract：:Controlled cortical impact (CCI) produces blood-brain barrier (BBB) permeability and an acute inflammatory response in injured brain, associated with upregulation of cell adhesion molecules and accumulation of neutrophils. Nevertheless, the role of acute inflammation in the pathogenesis of BBB permeability after traum...

journal_title：Journal of neurotrauma

authors： Whalen MJ,Carlos TM,Kochanek PM,Clark RS,Heineman S,Schiding JK,Franicola D,Memarzadeh F,Lo W,Marion DW,Dekosky ST

更新日期：1999-07-01 00:00:00

abstract：:A significant outflow of neurotransmitters and metabolites with associated enhanced cortical excitation occurs after concussive head trauma. Cellular changes in the acute post-injury period cannot be observed directly in humans, and as such, require indirect evidence from systems sufficiently sensitive to central neur...

journal_title：Journal of neurotrauma

authors： La Fountaine MF,Toda M,Testa A,Bauman WA

更新日期：2016-05-01 00:00:00

abstract：:Acute changes in cerebral perfusion and metabolism after subarachnoid hemorrhage (SAH) have been shown to contribute significantly to acute brain injury. The purpose of this study was to examine the effects of moderate hypothermia on the acute changes after massive experimental SAH as evaluated by diffusion-weighted i...

journal_title：Journal of neurotrauma

authors： Schubert GA,Poli S,Schilling L,Heiland S,Thomé C

更新日期：2008-07-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS) is still not well known. Previous data show conflicting results regarding the association between MS and prior brain trauma. This study aims to investigate the risk for MS following a traumatic brain injury (TBI) using a large-scale cohort study design. This study used data from...

journal_title：Journal of neurotrauma

authors： Kang JH,Lin HC

更新日期：2012-01-01 00:00:00

abstract：:Spinal cord injury (SCI) is less common in children than in adults, but in children it is generally more severe. Spinal loading conditions (speed and displacement) are also thought to affect SCI severity, but the relationship between these parameters is not well understood. This study aimed to investigate the effects ...

journal_title：Journal of neurotrauma

authors： Lau NS,Gorrie CA,Chia JY,Bilston LE,Clarke EC

更新日期：2013-08-01 00:00:00

abstract：:Improving survival and brain function after initial resuscitation from cardiac arrest remains a critical challenge with few therapeutic options. The publication of several randomized controlled trials supporting the use of therapeutic hypothermia in cardiac arrest survivors has provided a remarkable opportunity to red...

journal_title：Journal of neurotrauma

authors： Sugerman NT,Abella BS

更新日期：2009-03-01 00:00:00

abstract：:Experimental enhancement of noradrenergic activity following traumatic brain injury (TBI) accelerates behavioral recovery if performed at a time when brain norepinephrine (NE) turnover is decreased. But, since NE turnover is markedely increased immediately after TBI, the present study was undertaken to evaluate the ef...

journal_title：Journal of neurotrauma

authors： Dunn-Meynell AA,Yarlagadda Y,Levin BE

更新日期：1997-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging and the onset of AD pathology is not known. In this study, we have ex...

journal_title：Journal of neurotrauma

authors： Collins JM,King AE,Woodhouse A,Kirkcaldie MTK,Vickers JC

更新日期：2019-06-01 00:00:00

abstract：:This study characterizes the histological and immunohistochemical changes in the adult rat spinal cord following photochemically induced spinal cord lesions. The spinal cord was exposed by laminectomy (T12-L1 vertebrae) and bathed with 1.5% rose bengal solution for 10 min. The excess dye was removed by saline rinse an...

journal_title：Journal of neurotrauma

authors： Verdú E,García-Alías G,Forés J,Vela JM,Cuadras J,López-Vales R,Navarro X

更新日期：2003-05-01 00:00:00

abstract：:Neuropathic pain and motor deficits are detrimental consequences of injury to the spinal cord. In experimental settings, numerous neuroprotective agents are being explored for their therapeutic benefits. Vascular endothelial growth factor (VEGF) is an interesting candidate molecule in this respect since it is not only...

journal_title：Journal of neurotrauma

authors： van Neerven S,Joosten EA,Brook GA,Lambert CA,Mey J,Weis J,Marcus MA,Steinbusch HW,van Kleef M,Patijn J,Deumens R

更新日期：2010-10-01 00:00:00

abstract：:This study evaluated the utility of the Balance Error Scoring System (BESS) and the Sensory Organization Test (SOT) as tools for the screening and monitoring of Service members (SMs) with mild traumatic brain injury (mTBI) in a deployed setting during the acute and subacute phases of recovery. Patient records (N = 699...

journal_title：Journal of neurotrauma

authors： Haran FJ,Slaboda JC,King LA,Wright WG,Houlihan D,Norris JN

更新日期：2016-04-01 00:00:00

abstract：:A retrospective case-control study was undertaken to determine the best technique to measure neural canal encroachment at each lumbar level following burst fracture and its relationship to the presence of neurologic deficit. Only patients with postinjury CT scans demonstrating a disrupted posterior body with a retropu...

journal_title：Journal of neurotrauma

authors： Rasmussen PA,Rabin MH,Mann DC,Perl JR 2nd,Lorenz MA,Vrbos LA

更新日期：1994-12-01 00:00:00

abstract：:Midcervical contusion injuries disrupt descending ipsilateral excitatory bulbospinal projections to phrenic motoneurons, compromising ventilation. We hypothesized that a unilateral contusion injury at C3 versus C5 would differentially impact phrenic activity reflecting more prominent disruption of ipsilateral descendi...

journal_title：Journal of neurotrauma

authors： Alvarez-Argote S,Gransee HM,Mora JC,Stowe JM,Jorgenson AJ,Sieck GC,Mantilla CB

更新日期：2016-03-01 00:00:00

abstract：:The clinical manifestations that occur after traumatic brain injury (TBI) include a wide range of cognitive, emotional, and behavioral deficits. The loss of excitatory synapses could potentially explain why such diverse symptoms occur after TBI, and a recent preclinical study has demonstrated a loss of dendritic spine...

journal_title：Journal of neurotrauma

authors： Winston CN,Chellappa D,Wilkins T,Barton DJ,Washington PM,Loane DJ,Zapple DN,Burns MP

更新日期：2013-12-01 00:00:00

abstract：:Traumatic injury is a common cause of coagulopathy, primarily due to blood loss and hemodilution secondary to fluid resuscitation. Traumatic injury-associated coagulopathy often follows a course of transition from hyper- to hypocoagulable state exemplified in disseminated intravascular coagulation. The incidence of co...

journal_title：Journal of neurotrauma

authors： Zhang J,Jiang R,Liu L,Watkins T,Zhang F,Dong JF

更新日期：2012-11-20 00:00:00

abstract：:It is the aim of the present paper to correlate clinical symptoms of auditory dysfunction (tinnitus, hyperacusis, hearing loss) one year on average after a blunt trauma of the head with objective audiological test results (otoacoustic emission and auditory brainstem response testing, impedance audiometry) and to compa...

journal_title：Journal of neurotrauma

authors： Nölle C,Todt I,Seidl RO,Ernst A

更新日期：2004-03-01 00:00:00

abstract：:Few studies have assessed the long-term functional outcomes of patients with a disorder of consciousness due to traumatic brain injury (TBI). This study examined functional status during the first 10 years after TBI among a cohort with disorders of consciousness (i.e., coma, vegetative state, minimally conscious state...

journal_title：Journal of neurotrauma

authors： Hammond FM,Giacino JT,Nakase Richardson R,Sherer M,Zafonte RD,Whyte J,Arciniegas DB,Tang X

更新日期：2019-04-01 00:00:00

abstract：:Increasing evidence indicates that post-traumatic stress disorder (PTSD) may develop following traumatic brain injury (TBI), despite most patients having no conscious memory of their accident. This prospective study examined the frequency, timing of onset, symptom profile, and trajectory of PTSD and its psychiatric co...

journal_title：Journal of neurotrauma

authors： Alway Y,Gould KR,McKay A,Johnston L,Ponsford J

更新日期：2016-05-01 00:00:00

abstract：:Determining the priorities of individuals with spinal cord injury (SCI) can assist in choosing research priorities that will ultimately improve their quality of life. This systematic review examined studies that directly surveyed people with SCI to ascertain their health priorities and life domains of importance. Twen...

journal_title：Journal of neurotrauma

authors： Simpson LA,Eng JJ,Hsieh JT,Wolfe DL,Spinal Cord Injury Rehabilitation Evidence Scire Research Team.

更新日期：2012-05-20 00:00:00

abstract：:Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...

journal_title：Journal of neurotrauma

authors： Schwab JM,Seid K,Schluesener HJ

更新日期：2001-09-01 00:00:00

abstract：:Central nervous system injuries such as focal brain ischemia and trauma are known to initiate inflammatory reactions. To demonstrate the involvement of adhesion molecules in these inflammatory responses, we have observed significant increases of ICAM-1 and ELAM-1 mRNA expression in the ischemic cortex of rats by means...

journal_title：Journal of neurotrauma

authors： Wang X,Feuerstein GZ

更新日期：1995-10-01 00:00:00