Abstract:
:Adolescents are one of the highest groups at risk for sustaining both traumatic brain injury (TBI) and repeat TBI (RTBI). Consequences of endocrine dysfunction following TBI have been routinely explored in adults, but studies in adolescents are limited, and show an incidence rate of endocrine dysfunction in 16-61% in patients, 1-5 years after injury. Similar to in adults, the most commonly affected axis is growth hormone (GH) and insulin-like growth hormone 1 (IGF-1). Despite TBI being the primary cause of morbidity and mortality among the pediatric population, there are currently no experimental studies specifically addressing the occurrence of pituitary dysfunction in adolescents. The present study investigated whether a sham, single injury or four repeat injuries (24 h interval) delivered to adolescent rats resulted in disruption of the GH/IGF-1 axis. Circulating levels of basal GH and IGF-1 were measured at baseline, 24 h, 72 h, 1 week, and 1 month after injury, and vascular permeability of the pituitary gland was quantified via Evans Blue dye extravasation. Changes in weight and length of animals were measured as a potential consequence of GH and IGF-1 disruption. The results from the current study demonstrate that RTBI results in significant acute and chronic decreases in circulation of GH and IGF-1, reduction in weight gain and growth, and an increase in Evans Blue dye extravasation in the pituitary compared with sham and single injury animals. RTBI causes significant disruption of the GH/IGF-1 axis that may ultimately affect normal cognitive and physical development during adolescence.
journal_name
J Neurotraumajournal_title
Journal of neurotraumaauthors
Greco T,Hovda D,Prins Mdoi
10.1089/neu.2013.2990subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1983-90issue
23eissn
0897-7151issn
1557-9042journal_volume
30pub_type
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更新日期:2000-06-01 00:00:00
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/0897715041651060
更新日期:2004-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/neu.2018.6040
更新日期:2019-06-15 00:00:00
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pub_type: 杂志文章
doi:10.1089/neu.2018.5942
更新日期:2019-04-15 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章,多中心研究
doi:10.1089/neu.2011.1801
更新日期:2012-01-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2019.6952
更新日期:2020-08-26 00:00:00
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pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
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journal_title:Journal of neurotrauma
pub_type: 杂志文章
doi:10.1089/neu.2019.6955
更新日期:2020-03-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
doi:10.1089/neu.2015.4192
更新日期:2016-03-01 00:00:00
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更新日期:2016-01-15 00:00:00
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更新日期:2011-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:1995-08-01 00:00:00
abstract::Traumatic brain injury (TBI) affects millions of individuals each year and is a leading cause of death and disability worldwide. TBI is heterogeneous and outcome is influenced by a combination of factors that include injury location, severity, genetics, and environmental factors. More recently, sex as a biological var...
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pub_type: 杂志文章
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