Motoneuron loss associated with chronic locomotion impairments after spinal cord contusion in the rat.

abstract：:Microarray-based transcriptional profiling was used to determine the effect of progesterone in the cortical contusion (CCI) model. Gene ontology (GO) analysis then evaluated the effect of dose on relevant biological pathways. Treatment (vehicle, progesterone 10 mg/kg or 20 mg/kg given i.p.) was started 4 h post-injury...

journal_title：Journal of neurotrauma

authors： Anderson GD,Farin FM,Bammler TK,Beyer RP,Swan AA,Wilkerson HW,Kantor ED,Hoane MR

更新日期：2011-09-01 00:00:00

abstract：:Peptides related to melanotropin (alphaMSH) and corticotropin (ACTH), collectively termed melanocortins, are known to improve the postlesion repair of injured peripheral nerves. In addition, melanocortins exert trophic effects on the outgrowth of neurites from central nervous system neurons in vitro. Here we report, f...

journal_title：Journal of neurotrauma

authors： Joosten EA,Majewska B,Houweling DA,Bär PR,Gispen WH

更新日期：1999-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) causes damage to the hypothalamo-hypophyseal axis, leading to endocrine dysregulation in up to 40% of TBI patients. Hence, there is an urgent need to identify non-invasive biomarkers for TBI-associated hypothalamo-hypophyseal pathology. Sushi repeat-containing protein X-linked 2 (SRPX2) is...

journal_title：Journal of neurotrauma

authors： Anwer M,Lara-Valderrabano L,Karttunen J,Ndode-Ekane XE,Puhakka N,Pitkänen A

更新日期：2020-04-01 00:00:00

abstract：:Heterogeneity within brain injury presents a challenge to the development of informative molecular diagnostics. Recent studies show progress, particularly in cerebrospinal fluid, with biomarker assays targeting one or a few structural proteins. Protein-based assays in peripheral fluids, however, have been more challen...

journal_title：Journal of neurotrauma

authors： Ottens AK,Stafflinger JE,Griffin HE,Kunz RD,Cifu DX,Niemeier JP

更新日期：2014-04-15 00:00:00

abstract：:The neuroprotective effects of 17 beta -estradiol have been shown in models of central nervous system injury, including ischemia, brain injury, and more recently, spinal cord injury (SCI). Recent epidemiological trends suggest that SCIs in elderly women are increasing; however, the effects of menopause on estrogen-med...

journal_title：Journal of neurotrauma

authors： Chaovipoch P,Jelks KA,Gerhold LM,West EJ,Chongthammakun S,Floyd CL

更新日期：2006-06-01 00:00:00

abstract：:The generation of oxygen radicals and the process of lipid peroxidation have become a focus of attention for investigators in the fields of central nervous system (CNS) injury and stroke (e.g., ischemia). While absolute proof for their involvement in the pathophysiology of traumatic and ischemic damage to the CNS rema...

journal_title：Journal of neurotrauma

authors： Braughler JM,Hall ED

更新日期：1992-03-01 00:00:00

abstract：:Persistent pain is experienced by more than 50% of persons who sustain a traumatic brain injury (TBI), and more than 30% experience significant pain as early as 6 weeks after injury. Although neuropathic pain is a common consequence after CNS injuries, little attention has been given to neuropathic pain symptoms after...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Govind V,Adcock JP,Levin BE,Maudsley AA

更新日期：2016-07-15 00:00:00

abstract：:Prior studies have shown that neurons within the spinal cord are sensitive to response-outcome relations, a form of instrumental learning. Spinally transected rats that receive shock to one hind leg learn to maintain the leg in a flexed position that minimizes net shock exposure (controllable shock). Prior exposure to...

journal_title：Journal of neurotrauma

authors： Grau JW,Washburn SN,Hook MA,Ferguson AR,Crown ED,Garcia G,Bolding KA,Miranda RC

更新日期：2004-12-01 00:00:00

abstract：:Traumatic microvascular injury (tMVI) is a universal endophenotype of traumatic brain injury (TBI) that is responsible for significant neurological morbidity and mortality. The mechanism underlying tMVI is not fully understood. The present study aims to determine plasma levels of von Willebrand factor (VWF), a disinte...

journal_title：Journal of neurotrauma

authors： Kumar MA,Cao W,Pham HP,Raju D,Nawalinski K,Maloney-Wilensky E,Schuster J,Zheng XL

更新日期：2019-01-15 00:00:00

abstract：:Although mild therapeutic hypothermia is an effective neuroprotective strategy for cardiac arrest/resuscitated patients, and asphyxic newborns, recent randomized controlled trials (RCTs) have equally shown good neurological outcome between targeted temperature management at 33 °C versus 36 °C, and have not shown consi...

journal_title：Journal of neurotrauma

authors： Maekawa T,Yamashita S,Nagao S,Hayashi N,Ohashi Y,Brain-Hypothermia Study Group.

更新日期：2015-04-01 00:00:00

abstract：:The object of this study was to investigate the relationships of age on neurologic and functional outcome, hospitalization length of stay (LOS), and hospital charges after spinal cord injury (SCI). At 20 medical centers, 2,169 consecutive adult patients with paraplegia SCI were assessed in acute care and inpatient reh...

journal_title：Journal of neurotrauma

authors： Cifu DX,Huang ME,Kolakowsky-Hayner SA,Seel RT

更新日期：1999-09-01 00:00:00

abstract：:Dementia pugilistica (DP) is associated with chronic traumatic brain injury (CTBI), and leads to a "punch drunk" syndrome characterized by impairments in memory and executive function, behavioral changes, and motor signs. Microscopic features include the accumulation of neurofibrillary tangles (NFTs), beta-amyloid (Aβ...

journal_title：Journal of neurotrauma

authors： Saing T,Dick M,Nelson PT,Kim RC,Cribbs DH,Head E

更新日期：2012-04-10 00:00:00

abstract：:It remains unclear whether the benefits of early surgical timing are significant in neurologically complete spinal cord injury (SCI). We wanted to compare the effects of early and late surgical timing on non-neurological outcomes in persons with traumatic complete SCI. All cases of traumatic complete SCI referred to a...

journal_title：Journal of neurotrauma

authors： Bourassa-Moreau E,Mac-Thiong JM,Feldman DE,Thompson C,Parent S

更新日期：2013-09-15 00:00:00

abstract：:Phosphorus 31 magnetic resonance spectroscopy (31P MRS) was used to study noninvasively the intracellular free Mg2+ concentration and cellular bioenergetic state of rat brain in vivo before and after fluid percussion-induced traumatic brain injury of graded severity. Brain injury was induced at four levels: low (1.0 +...

journal_title：Journal of neurotrauma

authors： Vink R,Faden AI,McIntosh TK

更新日期：1988-01-01 00:00:00

abstract：:Moderate hypothermia may reduce subsequent neuronal damage after traumatic brain injury. Interleukin (IL)-6 may have a role in the pathogenesis of traumatic neuronal damage or repair. Using the enzyme-linked immunological sorbent assay (ELISA), we serially measured IL-6 levels in plasma obtained from the radial artery...

journal_title：Journal of neurotrauma

authors： Aibiki M,Maekawa S,Ogura S,Kinoshita Y,Kawai N,Yokono S

更新日期：1999-03-01 00:00:00

abstract：:Penetrating brain injury (PBI) is the most devastating type of traumatic brain injury. Development of coagulopathy in the acute setting of PBI, though common, remains of unclear significance as does its reversal. The aim of this study is to investigate the relationship between coagulopathy and clinical presentation, r...

journal_title：Journal of neurotrauma

authors： Mansour A,Loggini A,Goldenberg FD,Kramer C,Naidech AM,Ammar FE,Vasenina V,Castro B,Das P,Horowitz PM,Karrison T,Zakrison T,Hampton D,Rogers SO,Lazaridis C

更新日期：2021-01-20 00:00:00

abstract：:The effectiveness of cerebrospinal fluid (CSF) drainage in lowering high intracranial pressure (ICP) is well established in severe traumatic brain injury (TBI). Recently, however, the use of external ventricular drains (EVDs) and ICP monitors in TBI has come under question. The aim of this retrospective study was to i...

journal_title：Journal of neurotrauma

authors： Akbik OS,Krasberg M,Nemoto EM,Yonas H

更新日期：2017-11-15 00:00:00

abstract：:Studies measuring the volume of infarcted tissue and survival after pharmacologic intervention in stroke are complicated by the potential effect of survival time on infarct volume. In this study, the volume of infarcted tissue as defined by 2,3,5-triphenyltetrazolium chloride staining was determined in rabbits at 28 h...

journal_title：Journal of neurotrauma

authors： Browning JL,Widmayer MA,Hoffmann KK,Dudley AW Jr,Baskin DS

更新日期：1996-10-01 00:00:00

abstract：:Urokinase (uPA) and tissue plasminogen activator (tPA) are serine proteases implicated in fibrinolysis, but their role in the regulation of the cerebrovascular response to brain trauma has not been investigated. This study was designed to (1) characterize the cerebrovascular activity of uPA and tPA, (2) investigate th...

journal_title：Journal of neurotrauma

authors： Armstead WM,Cines DB,Al-Roof Higazi A

更新日期：2004-09-01 00:00:00

abstract：:We measured quantitative cortical mantle cerebral blood flow (CBF) by stable xenon computed tomography (CT) within the first 12 h after severe traumatic brain injury (TBI) to determine whether neurologic outcome can be predicted by CBF stratification early after injury. Stable xenon CT was used for quantitative measur...

journal_title：Journal of neurotrauma

authors： Kaloostian P,Robertson C,Gopinath SP,Stippler M,King CC,Qualls C,Yonas H,Nemoto EM

更新日期：2012-03-20 00:00:00

abstract：:Although experience suggests a shift in the epidemiology of spinal cord injury (SCI) toward an older demographic, population studies are lacking. We aimed to evaluate (1) how the epidemiology and age profile of SCI have changed over time, and (2) how increased age impacts health outcomes up to 15 years post-injury. A ...

journal_title：Journal of neurotrauma

authors： Wilson JR,Cronin S,Fehlings MG,Kwon BK,Badhiwala JH,Ginsberg HJ,Witiw C,Jaglal S

更新日期：2020-08-01 00:00:00

abstract：:Increasing evidence indicates that post-traumatic stress disorder (PTSD) may develop following traumatic brain injury (TBI), despite most patients having no conscious memory of their accident. This prospective study examined the frequency, timing of onset, symptom profile, and trajectory of PTSD and its psychiatric co...

journal_title：Journal of neurotrauma

authors： Alway Y,Gould KR,McKay A,Johnston L,Ponsford J

更新日期：2016-05-01 00:00:00

abstract：:Traumatic injury to the central nervous system (CNS) is accompanied by the spreading damage of secondary degeneration, resulting in further loss of neurons and function. Partial transection of the optic nerve (ON) has been used as a model of secondary degeneration, in which axons of retinal ganglion cells in the ventr...

journal_title：Journal of neurotrauma

authors： Fitzgerald M,Bartlett CA,Payne SC,Hart NS,Rodger J,Harvey AR,Dunlop SA

更新日期：2010-11-01 00:00:00

abstract：:Striatal-enriched tyrosine phosphatase (STEP) has been identified as a component of physiological and pathophysiological signaling pathways mediated by N-methyl-d-aspartate (NMDA) receptor/calcineurin/calpain activation. Activation of these pathways produces a subsequent change in STEP isoform expression or activation...

journal_title：Journal of neurotrauma

authors： Mesfin MN,von Reyn CR,Mott RE,Putt ME,Meaney DF

更新日期：2012-07-01 00:00:00

abstract：:Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. They mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation o...

journal_title：Journal of neurotrauma

authors： Eldadah BA,Faden AI

更新日期：2000-10-01 00:00:00

abstract：:The rat hippocampus is hypersensitive to secondary cerebral ischemia after mild traumatic brain injury (TBI). An unconfirmed assumption in previous studies of mild TBI followed by forebrain ischemia has been that antecedent TBI did not alter cerebral blood flow (CBF) dynamics in response to secondary ischemia. Using l...

journal_title：Journal of neurotrauma

authors： Davis KL,Jenkins LW,DeWitt DS,Prough DS

更新日期：1998-08-01 00:00:00

abstract：:An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of these are administered as soon as possible after injury with the hope of attenuating secondary damage and maximizing the extent of spared neurologic tissue. In thi...

journal_title：Journal of neurotrauma

authors： Kwon BK,Okon EB,Plunet W,Baptiste D,Fouad K,Hillyer J,Weaver LC,Fehlings MG,Tetzlaff W

更新日期：2011-08-01 00:00:00

abstract：:The Basso, Bresnahan and Beattie (BBB) locomotor scale has not been tested to evaluate functional consequences of peripheral nerve lesions. Alternative methods to evaluate animal functional recovery after sciatic nerve injury are desirable. Male Wistar rats had a right sciatic nerve segment exposed and were divided in...

journal_title：Journal of neurotrauma

authors： Schiaveto de Souza A,da Silva CA,Del Bel EA

更新日期：2004-05-01 00:00:00

abstract：:Fluid percussion (FP) brain injury causes spatial memory dysfunction in rats regardless of injury location (midline vs. lateral). Standard histological analysis of the injured brains shows hippocampal neuronal loss after lateral, but not midline FP injury. We have used the optical volume fractionator (OVF) stereologic...

journal_title：Journal of neurotrauma

authors： Grady MS,Charleston JS,Maris D,Witgen BM,Lifshitz J

更新日期：2003-10-01 00:00:00

abstract：:Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...

journal_title：Journal of neurotrauma

authors： Schwab JM,Seid K,Schluesener HJ

更新日期：2001-09-01 00:00:00