tPA-S481A prevents neurotoxicity of endogenous tPA in traumatic brain injury.

abstract：:Participation in contact sports places athletes at elevated risk for repeated head injuries and is associated with negative mental health outcomes later in life. The current study identified changes observable on neuroimaging that persisted beyond the apparent resolution of acute symptoms of concussion. Sixteen young ...

journal_title：Journal of neurotrauma

authors： Orr CA,Albaugh MD,Watts R,Garavan H,Andrews T,Nickerson JP,Gonyea J,Hipko S,Zweber C,Logan K,Hudziak JJ

更新日期：2016-05-01 00:00:00

abstract：:Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we "speak the same language." Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons betwe...

journal_title：Journal of neurotrauma

authors： Maas AI,Harrison-Felix CL,Menon D,Adelson PD,Balkin T,Bullock R,Engel DC,Gordon W,Langlois-Orman J,Lew HL,Robertson C,Temkin N,Valadka A,Verfaellie M,Wainwright M,Wright DW,Schwab K

更新日期：2011-02-01 00:00:00

abstract：:The present study evaluated the survival and integration of human postmitotic neurons (hNT) following transplantation into the traumatically injured rodent brain. Anesthetized male Sprague-Dawley rats (n = 47) were subjected to lateral fluid percussion brain injury of moderate severity (2.4-2.6 atm). Sham animals (n =...

journal_title：Journal of neurotrauma

authors： Muir JK,Raghupathi R,Saatman KE,Wilson CA,Lee VM,Trojanowski JQ,Philips MF,McIntosh TK

更新日期：1999-05-01 00:00:00

abstract：:The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great promise for neural repair and regeneration. However, direct evidence to support their use as a cell replacement therapy for neural injuries...

journal_title：Journal of neurotrauma

authors： Sun MK,Passaro AP,Latchoumane CF,Spellicy SE,Bowler M,Goeden M,Martin WJ,Holmes PV,Stice SL,Karumbaiah L

更新日期：2020-06-01 00:00:00

abstract：:The family of the collapsin response mediator proteins (CRMPs) plays a significant physiological role in neuronal cell bodies and axons within the integrated mammalian central nervous system (CNS). Trauma-induced damage to the CNS results in variable degrees of axonal degeneration, and this may lead to neuronal cell d...

journal_title：Journal of neurotrauma

authors： Taghian K,Lee JY,Petratos S

更新日期：2012-06-10 00:00:00

abstract：:Abstract Although several functional magnetic resonance imaging (fMRI) studies have been conducted in human models of mild traumatic brain injury (mTBI), to date no studies have explicitly examined how injury may differentially affect both the positive phase of the hemodynamic response function (HRF) as well as the po...

journal_title：Journal of neurotrauma

authors： Mayer AR,Toulouse T,Klimaj S,Ling JM,Pena A,Bellgowan PS

更新日期：2014-01-15 00:00:00

abstract：:The purpose of this study was to compare spontaneous functional recovery after different spinal motor tract lesions in the rat spinal cord using three methods of analysis, the BBB, the rope test, and the CatWalk. We transected the dorsal corticospinal tract (CSTx) or the rubrospinal tract (RSTx) or the complete dorsal...

journal_title：Journal of neurotrauma

authors： Hendriks WT,Eggers R,Ruitenberg MJ,Blits B,Hamers FP,Verhaagen J,Boer GJ

更新日期：2006-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a health threat that affects every year millions of people involved in motor vehicle and sporting accidents, and thousands of soldiers in battlefields. Diffuse axonal injury (DAI) is one of the most frequent types of TBI leading to death. In DAI, the initial traumatic event is followed ...

journal_title：Journal of neurotrauma

authors： Zhu F,Gatti DL,Yang KH

更新日期：2016-05-01 00:00:00

abstract：:Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxation magnetic resonance imaging (MRI) predicts the progression of perilesional cortical pathology and epileptogenesis. The ...

journal_title：Journal of neurotrauma

authors： Manninen E,Chary K,Lapinlampi N,Andrade P,Paananen T,Sierra A,Tohka J,Gröhn O,Pitkänen A

更新日期：2020-12-01 00:00:00

abstract：:Despite the shift in demographics of spinal cord injury (SCI) due to an aging population, relatively little has been reported regarding the effect of age on outcomes after SCI. This study examines the potential confounding effect of co-morbidities on the age-related differences in the hospital mortality following acut...

journal_title：Journal of neurotrauma

authors： Furlan JC,Kattail D,Fehlings MG

更新日期：2009-08-01 00:00:00

abstract：:Previous studies have resulted in conflicting results regarding the predictive effect of various clinical symptoms, signs, and plain imaging for intracranial pathology in adults with minor head injury. We sought to perform a meta-analysis of the literature to assess the significance of these factors for the prediction...

journal_title：Journal of neurotrauma

authors： Dunning J,Stratford-Smith P,Lecky F,Batchelor J,Hogg K,Browne J,Sharpin C,Mackway-Jones K,Emergency Medicine Research Group.

更新日期：2004-07-01 00:00:00

abstract：:We measured quantitative cortical mantle cerebral blood flow (CBF) by stable xenon computed tomography (CT) within the first 12 h after severe traumatic brain injury (TBI) to determine whether neurologic outcome can be predicted by CBF stratification early after injury. Stable xenon CT was used for quantitative measur...

journal_title：Journal of neurotrauma

authors： Kaloostian P,Robertson C,Gopinath SP,Stippler M,King CC,Qualls C,Yonas H,Nemoto EM

更新日期：2012-03-20 00:00:00

abstract：:Central nervous system (CNS) destruction in spinal cord injury (SCI) is caused by a complex series of cellular and molecular events. Recent studies have concentrated on signaling by receptors in the tumor necrosis factor receptor (TNFR) superfamily that mediate diverse biological outcomes ranging from inflammation to ...

journal_title：Journal of neurotrauma

authors： Keane RW,Davis AR,Dietrich WD

更新日期：2006-03-01 00:00:00

abstract：:Determining the priorities of individuals with spinal cord injury (SCI) can assist in choosing research priorities that will ultimately improve their quality of life. This systematic review examined studies that directly surveyed people with SCI to ascertain their health priorities and life domains of importance. Twen...

journal_title：Journal of neurotrauma

authors： Simpson LA,Eng JJ,Hsieh JT,Wolfe DL,Spinal Cord Injury Rehabilitation Evidence Scire Research Team.

更新日期：2012-05-20 00:00:00

abstract：:Inflammatory cellular responses to brain injury are promoted by proinflammatory messengers. Cyclooxygenases (prostaglandin endoperoxide H synthases [PGH]) are key enzymes in the conversion of arachidonic acid into prostanoids, which mediate immunomodulation, mitogenesis, apoptosis, blood flow, secondary injury (lipid ...

journal_title：Journal of neurotrauma

authors： Schwab JM,Seid K,Schluesener HJ

更新日期：2001-09-01 00:00:00

abstract：:Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI); however, the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following T...

journal_title：Journal of neurotrauma

authors： Wolf JA,Johnson BN,Johnson VE,Putt ME,Browne KD,Mietus CJ,Brown DP,Wofford KL,Smith DH,Grady MS,Cohen AS,Cullen DK

更新日期：2017-07-15 00:00:00

abstract：:The optimum spinal cord perfusion pressure (SCPP) after traumatic spinal cord injury (TSCI) is unknown. Here, we describe techniques to compute and display the optimum SCPP in real time. We recruited adults within 72 h of severe TSCI (American Spinal Injuries Association [ASIA] grades A-C). A pressure probe and a micr...

journal_title：Journal of neurotrauma

authors： Chen S,Smielewski P,Czosnyka M,Papadopoulos MC,Saadoun S

更新日期：2017-11-01 00:00:00

abstract：:ICP monitoring per se has never been subjected to a prospective randomized clinical trial (PRCT) to establish its efficacy (or lack thereof) in improving outcome from severe head injury. Hence, there are insufficient data to support its use as a standard. However, there is a large body of published clinical experience...

journal_title：Journal of neurotrauma

authors：

更新日期：2000-06-01 00:00:00

abstract：:Symptoms persisting beyond the acute phase (>2 months) after a mild traumatic brain injury (MTBI) are often reported, but their origin remains controversial. Some investigators evoke dysfunctional cerebral mechanisms, while others ascribe them to the psychological consequences of the injury. We address this controvers...

journal_title：Journal of neurotrauma

authors： Gosselin N,Bottari C,Chen JK,Petrides M,Tinawi S,de Guise E,Ptito A

更新日期：2011-03-01 00:00:00

abstract：:Persistent post-traumatic headache (PPTH) is often the most common injury after mild traumatic brain injury (mTBI), reported by 47-95% of patients. Progressive muscle relaxation (PMR) has level A evidence in preventing migraine and tension headaches. However, research on this behavioral therapy for PPTH, let alone sma...

journal_title：Journal of neurotrauma

authors： Usmani S,Balcer L,Galetta S,Minen M

更新日期：2021-01-01 00:00:00

abstract：:Central nervous system (CNS) axons recover poorly following injury because of the expression of myelin-derived inhibitors of axonal outgrowth such as Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), all of which bind to the Nogo-66 receptor 1 (NgR1). Herein we examine the rol...

journal_title：Journal of neurotrauma

authors： Tong J,Liu W,Wang X,Han X,Hyrien O,Samadani U,Smith DH,Huang JH

更新日期：2013-02-15 00:00:00

abstract：:Closed head injury often has a devastating outcome, partly because the insult, like other injuries to the central nervous system (CNS), triggers self-destructive processes. During studies of the response to other CNS insults, it was unexpectedly discovered that the immune system, if well controlled, provides protectio...

journal_title：Journal of neurotrauma

authors： Kipnis J,Nevo U,Panikashvili D,Alexandrovich A,Yoles E,Akselrod S,Shohami E,Schwartz M

更新日期：2003-06-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous pre-clinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion c...

journal_title：Journal of neurotrauma

authors： Motovylyak A,Skinner NP,Schmit BD,Wilkins N,Kurpad SN,Budde MD

更新日期：2019-05-01 00:00:00

abstract：:Clinical scenario: A 37-year-old man suffered a complete spinal cord injury (C8, American Spinal Injury Association Impairment Scale [ASIA] score A) 10 years ago in a car accident. Should primary prevention of cardiovascular disease be a priority in this patient? In order to answer this question, we performed a system...

journal_title：Journal of neurotrauma

authors： Cragg JJ,Stone JA,Krassioukov AV

更新日期：2012-07-20 00:00:00

abstract：:Growing evidence suggests that temporally proximal acute concussions and repetitive subconcussive head injuries may lead to long-term neurological deficits. However, the underlying mechanisms of injury and their relative time-scales are not well documented in human injury models. The current study therefore investigat...

journal_title：Journal of neurotrauma

authors： Mayer AR,Ling JM,Dodd AB,Gasparovic C,Klimaj SD,Meier TB

更新日期：2015-11-15 00:00:00

abstract：:Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal ribonucleic acid (RNA) expression in 54 mouse strains 5 days after a single 50-psi overpressure air wave blast...

journal_title：Journal of neurotrauma

authors： Struebing FL,King R,Li Y,Chrenek MA,Lyuboslavsky PN,Sidhu CS,Iuvone PM,Geisert EE

更新日期：2018-01-01 00:00:00

abstract：:Penetrating ballistic brain injury involves a leading shockwave producing a temporary cavity causing substantial secondary injury. In response to the prevalence of this type of brain trauma in the military, a rat model of penetrating ballistic-like brain injury (PBBI) was established. This study focuses on cerebral ph...

journal_title：Journal of neurotrauma

authors： Wei G,Lu XC,Yang X,Tortella FC

更新日期：2010-09-01 00:00:00

abstract：:The increase in the volume of a traumatic intracerebral hemorrhage (TICH) is a widely studied phenomenon that has a direct impact on the prognosis of patients. The objective of this study was to identify the risk factors associated with the progression of TICH. We retrospectively analyzed the records of 1970 adult pat...

journal_title：Journal of neurotrauma

authors： Cepeda S,Gómez PA,Castaño-Leon AM,Martínez-Pérez R,Munarriz PM,Lagares A

更新日期：2015-08-15 00:00:00

abstract：:The purpose of this study was to determine the relationship between endothelin-1 (ET-1), a prominent vasoactive agent, and the breakdown of the blood-spinal cord barrier along the axis of the cord after a moderate spinal cord injury. In the first study rats (n = 10) were euthanized 24 h after spinal cord injury and co...

journal_title：Journal of neurotrauma

authors： McKenzie AL,Hall JJ,Aihara N,Fukuda K,Noble LJ

更新日期：1995-06-01 00:00:00

abstract：:Accumulating evidence suggests that the extent of brain injury and the clinical outcome after traumatic brain injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of ...

journal_title：Journal of neurotrauma

authors： Dardiotis E,Paterakis K,Tsivgoulis G,Tsintou M,Hadjigeorgiou GF,Dardioti M,Grigoriadis S,Simeonidou C,Komnos A,Kapsalaki E,Fountas K,Hadjigeorgiou GM

更新日期：2014-12-01 00:00:00